Strain Name:
C57BL/6J-MtgxR5082Btlr/Mmmh
Stock Number:
042671-MU
Citation ID:
RRID:MMRRC_042671-MU
Other Names:
R5082 (G1), C57BL/6J-MtgxR5082Btlr
Major Collection:

Gene Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 29808
Homologene: 49351
Pfdn1
Name: prefoldin 1
Synonyms: 2700086I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67199
VEGA: 18
HGNC: HGNC:8866
Homologene: 37644
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, D130001D01Rik, 2310003N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108912
Homologene: 18444
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, HELIC2, A330064G03Rik, Ascc3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320632
Homologene: 5859
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226562
Homologene: 41015
Ptbp2
Name: polypyrimidine tract binding protein 2
Synonyms: brPTB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56195
Homologene: 23162
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, Aspm, D330028K02Rik, MCPH5, Calmbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: 4933422O15Rik, C030034J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Prom1
Name: prominin 1
Synonyms: AC133, CD133, Prom, 4932416E19Rik, Prom-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: TAFII150, CIF150, TAF2B, 4732460C16Rik, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, 8030453L17Rik, E430018P19Rik, KMT2H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192195
Homologene: 10225
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99480
Homologene: 124162
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: Bic-C, jcpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83675
Homologene: 12856
Aftph
Name: aftiphilin
Synonyms: 9130023F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216549
Homologene: 9764
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: 9030408O17Rik, Mcmdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Ube2l3
Name: ubiquitin-conjugating enzyme E2L 3
Synonyms: UbcM4, Ubce7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22195
Homologene: 43226
Calcoco1
Name: calcium binding and coiled coil domain 1
Synonyms: 1810009B06Rik, CoCoA, Gcap11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67488
Homologene: 10845
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Nectin2
Name: nectin cell adhesion molecule 2
Synonyms: nectin-2, MPH, Cd112, Pvs, Pvrl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19294
HGNC: HGNC:9707
Homologene: 86092
Ccng1
Name: cyclin G1
Synonyms: cyclin G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12450
HGNC: HGNC:1592
Homologene: 2995
Kif22
Name: kinesin family member 22
Synonyms: Kif22a, Kid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 110033
HGNC: HGNC:6391
Homologene: 32011
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Ibtk
Name: inhibitor of Bruton agammaglobulinemia tyrosine kinase
Synonyms: 5430411K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108837
Homologene: 34661
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 8030475K17Rik, A330041G23Rik, 2610202E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: D2Ertd794e, 5830435C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Irak2
Name: interleukin-1 receptor-associated kinase 2
Synonyms: 6330415L08Rik, IRAK-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108960
HGNC: HGNC:6113
Homologene: 1207
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Gbp5
Name: guanylate binding protein 5
Synonyms: 5330409J06Rik, Gbp5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229898
Homologene: 14183
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234686
Homologene: 136406
Tnfaip3
Name: tumor necrosis factor, alpha-induced protein 3
Synonyms: A20, zinc finger protein A20, Tnfip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21929
Homologene: 4582
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19886
Homologene: 2207
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Plbd2
Name: phospholipase B domain containing 2
Synonyms: 66.3 kDa, p76, 1300012G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71772
Homologene: 41528
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Olfr711
Name: olfactory receptor 711
Synonyms: GA_x6K02T2PBJ9-9352783-9351839, MOR103-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259037
Homologene: 128111
Sh2d2a
Name: SH2 domain containing 2A
Synonyms: TSAd, Lck-associated adapter protein, Lad, RIBP, Rlk/Itk-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 27371
Homologene: 2958
Erlin2
Name: ER lipid raft associated 2
Synonyms: Spfh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244373
HGNC: HGNC:1356
Homologene: 5193
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620697
Homologene: 115466
Klhl9
Name: kelch-like 9
Synonyms: C530050O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242521
Homologene: 23125
Ecd
Name: ecdysoneless cell cycle regulator
Synonyms: 5730461K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70601
VEGA: 14
Homologene: 5256
Maip1
Name: matrix AAA peptidase interacting protein 1
Synonyms: 9430016H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68115
Homologene: 11565
Entpd1
Name: ectonucleoside triphosphate diphosphohydrolase 1
Synonyms: NTPDase-1, Cd39, ectoapyrase, 2610206B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12495
HGNC: HGNC:3363
Homologene: 20423
Gm10322
Name: predicted gene 10322
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Hesx1
Name: homeobox gene expressed in ES cells
Synonyms: Rpx, HES-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15209
HGNC: HGNC:4877
Homologene: 20831
Hgh1
Name: HGH1 homolog
Synonyms: D15Ertd741e, Brp16, Fam203a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 59053
VEGA: 15
Homologene: 48742
Mfsd13b
Name: major facilitator superfamily domain containing 13B
Synonyms: 4933427G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74466
Homologene: 62261
Gm14295
Name: predicted gene 14295
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100039123
Homologene: 133105
Olfr922
Name: olfactory receptor 922
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Scrn3
Name: secernin 3
Synonyms: 4833415E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74616
Homologene: 11601
Vmn2r129
Name: vomeronasal 2, receptor 129
Synonyms: V2r8, V2r9, Vmn2r-ps160, Vmn2r-ps159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22314
Gm7347
Name: predicted gene 7347
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 664804
Homologene: 69402
Gm10425
Name: predicted gene 10425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 57,411,851 bp
  • T to A, chromosome 1 at 139,478,676 bp
  • T to A, chromosome 1 at 162,684,065 bp
  • T to A, chromosome 2 at 59,901,491 bp
  • T to C, chromosome 2 at 70,258,030 bp
  • T to A, chromosome 2 at 73,331,058 bp
  • T to A, chromosome 2 at 119,903,344 bp
  • C to T, chromosome 2 at 127,226,370 bp
  • T to A, chromosome 2 at 176,807,417 bp
  • A to G, chromosome 3 at 87,851,784 bp
  • G to A, chromosome 3 at 88,966,234 bp
  • A to T, chromosome 3 at 97,209,902 bp
  • G to A, chromosome 3 at 98,100,374 bp
  • T to A, chromosome 3 at 119,752,964 bp
  • A to T, chromosome 3 at 122,275,941 bp
  • G to T, chromosome 3 at 142,503,943 bp
  • A to T, chromosome 4 at 88,721,385 bp
  • T to C, chromosome 4 at 156,336,911 bp
  • T to C, chromosome 5 at 21,896,077 bp
  • T to A, chromosome 5 at 26,057,374 bp
  • T to C, chromosome 5 at 44,000,832 bp
  • G to T, chromosome 5 at 120,491,184 bp
  • T to C, chromosome 6 at 113,672,844 bp
  • T to C, chromosome 6 at 116,413,921 bp
  • A to T, chromosome 7 at 19,738,124 bp
  • C to T, chromosome 7 at 85,233,868 bp
  • G to A, chromosome 7 at 106,971,664 bp
  • A to T, chromosome 7 at 120,998,978 bp
  • G to A, chromosome 7 at 123,000,702 bp
  • G to A, chromosome 7 at 127,033,377 bp
  • T to C, chromosome 8 at 27,033,407 bp
  • T to C, chromosome 8 at 71,717,185 bp
  • T to A, chromosome 8 at 105,330,513 bp
  • T to C, chromosome 9 at 38,816,145 bp
  • T to C, chromosome 9 at 85,726,688 bp
  • T to C, chromosome 10 at 19,005,284 bp
  • T to A, chromosome 10 at 52,163,941 bp
  • T to A, chromosome 10 at 53,538,060 bp
  • A to T, chromosome 10 at 59,616,268 bp
  • G to T, chromosome 10 at 70,940,522 bp
  • T to A, chromosome 10 at 75,738,330 bp
  • A to T, chromosome 10 at 77,996,408 bp
  • T to C, chromosome 11 at 20,727,100 bp
  • A to G, chromosome 11 at 40,752,188 bp
  • G to A, chromosome 11 at 60,185,919 bp
  • T to A, chromosome 11 at 110,131,868 bp
  • G to T, chromosome 12 at 13,220,435 bp
  • A to G, chromosome 12 at 111,427,990 bp
  • C to T, chromosome 14 at 20,324,368 bp
  • T to C, chromosome 14 at 27,000,774 bp
  • G to A, chromosome 14 at 67,705,670 bp
  • G to T, chromosome 15 at 55,060,045 bp
  • A to T, chromosome 15 at 58,971,019 bp
  • T to A, chromosome 15 at 76,369,552 bp
  • A to G, chromosome 15 at 102,710,382 bp
  • T to G, chromosome 16 at 17,158,528 bp
  • C to A, chromosome 18 at 34,651,689 bp
  • G to T, chromosome 18 at 36,404,413 bp
  • A to T, chromosome 19 at 16,744,893 bp
  • A to G, chromosome 19 at 40,725,029 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5082 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042671-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.