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Strain Name:
C57BL/6J-MtgxR5119Btlr/Mmmh
Stock Number:
042707-MU
Citation ID:
RRID:MMRRC_042707-MU
Other Names:
R5119 (G1), C57BL/6J-MtgxR5119Btlr
Major Collection:

Strain Information

Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
Becn1
Name: beclin 1, autophagy related
Synonyms: Atg6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56208
HGNC: HGNC:1034
Homologene: 2794
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27388
Homologene: 8462
Nub1
Name: negative regulator of ubiquitin-like proteins 1
Synonyms: BS4, NY-REN-18, 4931404D21Rik, 6330412F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53312
Homologene: 41108
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66011
Homologene: 36409
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: RBBP1L1, SAP180, BRCAA1, Rbp1l1, 6720480E17Rik, 6330417L24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 10,126,463 bp
  • A to T, chromosome 1 at 34,195,969 bp
  • A to T, chromosome 1 at 53,698,692 bp
  • G to A, chromosome 1 at 58,188,524 bp
  • A to T, chromosome 1 at 80,567,994 bp
  • T to A, chromosome 1 at 87,151,139 bp
  • C to A, chromosome 1 at 136,163,100 bp
  • A to G, chromosome 1 at 160,120,552 bp
  • T to C, chromosome 1 at 162,705,440 bp
  • A to T, chromosome 1 at 173,755,668 bp
  • G to T, chromosome 1 at 191,541,506 bp
  • G to T, chromosome 2 at 25,909,322 bp
  • A to G, chromosome 2 at 53,144,849 bp
  • A to T, chromosome 2 at 82,988,191 bp
  • A to T, chromosome 2 at 89,943,803 bp
  • A to G, chromosome 2 at 105,378,808 bp
  • A to T, chromosome 2 at 118,694,548 bp
  • G to A, chromosome 2 at 120,034,643 bp
  • T to C, chromosome 2 at 164,589,451 bp
  • G to A, chromosome 2 at 167,065,387 bp
  • A to G, chromosome 2 at 167,457,432 bp
  • C to A, chromosome 2 at 170,579,585 bp
  • T to A, chromosome 2 at 174,705,310 bp
  • C to T, chromosome 3 at 8,923,696 bp
  • A to T, chromosome 3 at 25,433,794 bp
  • A to T, chromosome 3 at 78,966,400 bp
  • G to A, chromosome 3 at 89,352,841 bp
  • A to T, chromosome 3 at 95,011,676 bp
  • T to A, chromosome 3 at 101,439,361 bp
  • A to T, chromosome 3 at 136,234,682 bp
  • G to T, chromosome 4 at 43,836,433 bp
  • A to G, chromosome 4 at 45,914,603 bp
  • A to G, chromosome 4 at 57,218,513 bp
  • G to A, chromosome 4 at 121,147,455 bp
  • A to C, chromosome 4 at 131,937,436 bp
  • A to G, chromosome 4 at 136,543,397 bp
  • A to G, chromosome 4 at 145,105,898 bp
  • A to G, chromosome 4 at 155,754,016 bp
  • T to A, chromosome 5 at 21,971,870 bp
  • C to T, chromosome 5 at 24,695,506 bp
  • A to G, chromosome 5 at 64,954,301 bp
  • A to T, chromosome 5 at 88,954,862 bp
  • T to C, chromosome 5 at 122,313,781 bp
  • T to C, chromosome 5 at 124,779,258 bp
  • A to T, chromosome 5 at 146,283,627 bp
  • A to T, chromosome 6 at 67,466,316 bp
  • T to C, chromosome 6 at 83,055,134 bp
  • G to A, chromosome 6 at 86,524,915 bp
  • A to G, chromosome 6 at 97,300,314 bp
  • C to T, chromosome 7 at 21,260,247 bp
  • G to T, chromosome 7 at 28,316,370 bp
  • A to G, chromosome 7 at 35,371,124 bp
  • A to G, chromosome 7 at 47,981,718 bp
  • A to G, chromosome 7 at 75,687,252 bp
  • T to G, chromosome 7 at 83,615,010 bp
  • A to G, chromosome 7 at 130,905,364 bp
  • C to T, chromosome 7 at 141,153,079 bp
  • C to T, chromosome 8 at 70,115,025 bp
  • T to C, chromosome 8 at 91,280,816 bp
  • A to G, chromosome 8 at 113,699,010 bp
  • T to A, chromosome 8 at 119,565,867 bp
  • A to C, chromosome 8 at 119,768,143 bp
  • A to T, chromosome 9 at 45,147,758 bp
  • A to G, chromosome 9 at 59,714,320 bp
  • T to C, chromosome 9 at 65,890,780 bp
  • A to G, chromosome 9 at 104,901,521 bp
  • C to T, chromosome 9 at 110,890,819 bp
  • A to T, chromosome 10 at 13,556,906 bp
  • A to G, chromosome 10 at 39,048,054 bp
  • A to G, chromosome 10 at 41,922,148 bp
  • A to T, chromosome 10 at 70,569,074 bp
  • A to G, chromosome 10 at 79,710,223 bp
  • A to T, chromosome 10 at 89,725,855 bp
  • T to A, chromosome 10 at 129,046,842 bp
  • A to T, chromosome 11 at 33,404,181 bp
  • G to A, chromosome 11 at 46,407,036 bp
  • A to G, chromosome 11 at 67,298,358 bp
  • T to A, chromosome 11 at 69,563,932 bp
  • A to G, chromosome 11 at 69,914,791 bp
  • A to T, chromosome 11 at 73,940,552 bp
  • C to T, chromosome 11 at 83,982,243 bp
  • A to G, chromosome 11 at 86,776,636 bp
  • T to C, chromosome 11 at 87,433,813 bp
  • G to A, chromosome 11 at 94,122,722 bp
  • T to A, chromosome 11 at 101,020,515 bp
  • A to G, chromosome 11 at 101,291,395 bp
  • G to A, chromosome 11 at 102,438,733 bp
  • A to T, chromosome 11 at 103,387,315 bp
  • G to A, chromosome 12 at 8,227,237 bp
  • A to G, chromosome 12 at 29,832,303 bp
  • A to G, chromosome 12 at 40,328,688 bp
  • A to G, chromosome 12 at 69,296,962 bp
  • G to A, chromosome 13 at 14,164,281 bp
  • A to T, chromosome 13 at 27,633,581 bp
  • A to G, chromosome 13 at 73,268,921 bp
  • T to C, chromosome 13 at 81,419,427 bp
  • T to A, chromosome 13 at 103,752,556 bp
  • T to C, chromosome 14 at 50,515,509 bp
  • T to C, chromosome 14 at 54,075,521 bp
  • T to G, chromosome 14 at 64,757,453 bp
  • G to T, chromosome 14 at 121,954,863 bp
  • T to A, chromosome 15 at 54,870,305 bp
  • C to T, chromosome 15 at 76,051,753 bp
  • T to C, chromosome 15 at 76,716,000 bp
  • G to A, chromosome 15 at 80,646,144 bp
  • G to A, chromosome 15 at 98,847,194 bp
  • A to G, chromosome 16 at 4,001,199 bp
  • T to C, chromosome 16 at 20,618,631 bp
  • T to C, chromosome 16 at 26,624,199 bp
  • T to A, chromosome 16 at 85,899,578 bp
  • T to C, chromosome 17 at 15,498,262 bp
  • T to C, chromosome 17 at 23,387,164 bp
  • A to C, chromosome 17 at 24,603,280 bp
  • T to A, chromosome 17 at 33,937,120 bp
  • T to C, chromosome 17 at 34,033,588 bp
  • T to C, chromosome 17 at 37,048,438 bp
  • A to T, chromosome 17 at 45,589,541 bp
  • A to C, chromosome 18 at 46,506,369 bp
  • A to T, chromosome 18 at 60,943,136 bp
  • G to A, chromosome 18 at 61,307,654 bp
  • G to A, chromosome 19 at 5,706,324 bp
  • A to T, chromosome 19 at 8,217,830 bp
  • G to T, chromosome 19 at 9,013,644 bp
  • T to A, chromosome 19 at 10,676,689 bp
  • T to C, chromosome 19 at 10,902,755 bp
  • C to T, chromosome 19 at 13,471,546 bp
  • C to A, chromosome 19 at 39,460,621 bp
  • A to G, chromosome 19 at 41,130,509 bp
  • C to T, chromosome 19 at 41,281,976 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5119 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042707-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.