Strain Name:
C57BL/6J-MtgxR5140Btlr/Mmmh
Stock Number:
042726-MU
Citation ID:
RRID:MMRRC_042726-MU
Other Names:
R5140 (G1), C57BL/6J-MtgxR5140Btlr
Major Collection:

Gene Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268281
Homologene: 6489
Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Sparcl1
Name: SPARC-like 1
Synonyms: Sc1, hevin, mast9, Ecm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13602
Homologene: 3438
Abhd17b
Name: abhydrolase domain containing 17B
Synonyms: 5730446C15Rik, Fam108b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226016
VEGA: 19
Homologene: 41089
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100763
Homologene: 8783
Aebp2
Name: AE binding protein 2
Synonyms: B230313N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11569
Homologene: 40690
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235626
Homologene: 56493
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Cacul1
Name: CDK2 associated, cullin domain 1
Synonyms: 2810417M16Rik, D130033C15Rik, 9830127L17Rik, 2700078E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 78832
VEGA: 19
Homologene: 17821
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224902
Homologene: 35210
Rnf26
Name: ring finger protein 26
Synonyms: 8030450I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 213211
Homologene: 12924
Nsmaf
Name: neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms: Fan, factor associated with N-SMase activation
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18201
HGNC: HGNC:8017
Homologene: 2652
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Tulip1, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Slc25a40
Name: solute carrier family 25, member 40
Synonyms: B230315F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319653
Homologene: 6040
Cald1
Name: caldesmon 1
Synonyms: 4833423D12Rik, C920027I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109624
HGNC: HGNC:1441
Homologene: 137254
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Arhgap33
Name: Rho GTPase activating protein 33
Synonyms: Tcgap, Snx26, NOMA-GAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233071
Homologene: 76448
Uimc1
Name: ubiquitin interaction motif containing 1
Synonyms: D630032M02Rik, D330018D10Rik, 9430016E08Rik, Rxrip110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20184
Homologene: 9455
Dnajc16
Name: DnaJ heat shock protein family (Hsp40) member C16
Synonyms: 2900037O03Rik, 4732437J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214063
Homologene: 45414
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216850
Homologene: 18945
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: PC-1, NPP1, Npps, Pca-1, Pca, Ly-41, Pdnp1, twy, CD203c, E-NPP1, 4833416E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
F2
Name: coagulation factor II
Synonyms: prothrombin, Cf-2, Cf2, FII, thrombin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14061
HGNC: HGNC:3535
Homologene: 426
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Gm3985
Name: predicted gene 3985
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100042715
Krt35
Name: keratin 35
Synonyms: Ha5, Krt1-24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53617
HGNC: HGNC:6453
Homologene: 1715
Galnt16
Name: polypeptide N-acetylgalactosaminyltransferase 16
Synonyms: 5730405L21Rik, Galntl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 108760
VEGA: 12
Homologene: 18907
Usp17le
Name: ubiquitin specific peptidase 17-like E
Synonyms: Gm6596, Dub3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 625530
Homologene: 131315
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20274
Homologene: 2237
Npas3
Name: neuronal PAS domain protein 3
Synonyms: 4930423H22Rik, bHLHe12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Prkce
Name: protein kinase C, epsilon
Synonyms: PKC[e], Pkce, 5830406C15Rik, PKCepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18754
HGNC: HGNC:9401
Homologene: 48343
Fmnl1
Name: formin-like 1
Synonyms: 8030453N10Rik, formin-related gene in leukocytes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57778
HGNC: HGNC:1212
Homologene: 135620
Glmn
Name: glomulin, FKBP associated protein
Synonyms: Fap68, Fap48, 9330160J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170823
Homologene: 14239
Olfr1224-ps1
Name: olfactory receptor 1224, pseudogene 1
Synonyms: GA_x6K02T2Q125-50635980-50635046, MOR233-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258026
Olfr347
Name: olfactory receptor 347
Synonyms: GA_x6K02T2NLDC-33428755-33429693, MOR136-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258945
Homologene: 51790
Lhpp
Name: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonyms: 2310007H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76429
Homologene: 41469
Kiss1r
Name: KISS1 receptor
Synonyms: Gpr54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 114229
VEGA: 10
HGNC: HGNC:4510
Homologene: 11411
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627111
Homologene: 115024
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93880
Homologene: 87124
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: ovalbumin, PI-9, Spi6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Foxn1
Name: forkhead box N1
Synonyms: whn, Hfh11, D11Bhm185e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15218
Homologene: 2664
Olfr1247
Name: olfactory receptor 1247
Synonyms: GA_x6K02T2Q125-51051555-51050611, MOR231-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258968
Homologene: 121536
Idua
Name: iduronidase, alpha-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15932
HGNC: HGNC:5391
Homologene: 170
Gm9116
Name: predicted gene 9116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 668344
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338365
Homologene: 9870
Hs3st6
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328779
VEGA: 17
Homologene: 84633
Krt36
Name: keratin 36
Synonyms: HRa-1, Krt1-22, keratin 5, Krt1-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16673
HGNC: HGNC:6454
Homologene: 88459
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Sergef
Name: secretion regulating guanine nucleotide exchange factor
Synonyms: DelGEF, Gef, Gnefr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27414
Homologene: 40812
Gbp11
Name: guanylate binding protein 11
Synonyms: Gm7141
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 634650
Homologene: 128731
Sult1c1
Name: sulfotransferase family, cytosolic, 1C, member 1
Synonyms: (PST)G, mOLFST, P-SULT, Stp2, Sult1a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20888
Homologene: 56817
Olfr661
Name: olfactory receptor 661
Synonyms: GA_x6K02T2PBJ9-7316375-7317334, MOR40-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258743
Homologene: 17376
Olfr455
Name: olfactory receptor 455
Synonyms: GA_x6K02T2P3E9-5021913-5022918, MOR0-2P, MOR0-17_p, MORO-2, EG546896, Olfr455-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 546896
Homologene: 67366
Ccdc9b
Name: coiled-coil domain containing 9B
Synonyms: A430105I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214239
Homologene: 128188
Spcs1
Name: signal peptidase complex subunit 1 homolog (S. cerevisiae)
Synonyms: 1810004F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69019
Homologene: 40915
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 71,651,525 bp
  • A to G, chromosome 1 at 153,249,864 bp
  • T to A, chromosome 2 at 36,734,498 bp
  • C to T, chromosome 2 at 66,565,167 bp
  • T to C, chromosome 2 at 89,157,107 bp
  • T to C, chromosome 2 at 89,609,283 bp
  • CAGAAAG to CAG, chromosome 2 at 91,634,957 bp
  • T to A, chromosome 2 at 118,758,609 bp
  • C to T, chromosome 3 at 93,910,531 bp
  • A to G, chromosome 4 at 6,398,852 bp
  • C to T, chromosome 4 at 118,386,981 bp
  • T to G, chromosome 4 at 141,764,683 bp
  • A to C, chromosome 4 at 148,038,317 bp
  • T to C, chromosome 5 at 8,430,486 bp
  • T to A, chromosome 5 at 8,702,154 bp
  • T to A, chromosome 5 at 29,635,711 bp
  • C to T, chromosome 5 at 104,085,763 bp
  • T to C, chromosome 5 at 105,331,053 bp
  • A to G, chromosome 5 at 107,570,200 bp
  • T to A, chromosome 5 at 108,680,314 bp
  • T to A, chromosome 6 at 34,753,580 bp
  • T to C, chromosome 6 at 42,538,515 bp
  • T to A, chromosome 6 at 140,633,806 bp
  • A to G, chromosome 7 at 30,528,301 bp
  • A to G, chromosome 7 at 46,635,602 bp
  • T to C, chromosome 7 at 104,688,900 bp
  • C to T, chromosome 7 at 104,769,438 bp
  • A to T, chromosome 7 at 114,246,800 bp
  • T to C, chromosome 7 at 132,705,632 bp
  • A to G, chromosome 8 at 32,890,665 bp
  • C to A, chromosome 9 at 44,112,774 bp
  • C to A, chromosome 9 at 110,551,129 bp
  • T to A, chromosome 10 at 11,154,705 bp
  • T to C, chromosome 10 at 24,652,852 bp
  • T to C, chromosome 10 at 79,921,627 bp
  • A to G, chromosome 10 at 83,297,291 bp
  • T to C, chromosome 11 at 69,400,055 bp
  • T to C, chromosome 11 at 78,361,633 bp
  • T to C, chromosome 11 at 100,094,517 bp
  • C to T, chromosome 11 at 100,103,502 bp
  • C to T, chromosome 11 at 103,195,325 bp
  • C to T, chromosome 11 at 118,086,945 bp
  • T to A, chromosome 12 at 53,501,114 bp
  • C to T, chromosome 12 at 55,665,674 bp
  • C to T, chromosome 12 at 55,776,152 bp
  • T to A, chromosome 12 at 80,581,299 bp
  • G to A, chromosome 13 at 33,006,561 bp
  • A to G, chromosome 13 at 55,075,517 bp
  • A to G, chromosome 14 at 31,000,613 bp
  • G to A, chromosome 17 at 18,152,050 bp
  • A to T, chromosome 17 at 24,758,547 bp
  • T to C, chromosome 17 at 53,969,715 bp
  • T to C, chromosome 17 at 56,577,901 bp
  • T to C, chromosome 17 at 86,482,142 bp
  • T to G, chromosome 18 at 37,401,133 bp
  • T to A, chromosome 18 at 63,027,929 bp
  • T to C, chromosome 19 at 21,684,181 bp
  • C to T, chromosome 19 at 60,563,181 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5140 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042726-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.