Strain Name:
C57BL/6J-MtgxR5178Btlr/Mmmh
Stock Number:
042758-MU
Citation ID:
RRID:MMRRC_042758-MU
Other Names:
R5178 (G1), C57BL/6J-MtgxR5178Btlr
Major Collection:

Gene Information

Sp4
Name: trans-acting transcription factor 4
Synonyms: 5730497N03Rik, HF1-b, HF-1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20688
VEGA: 12
Homologene: 2341
Wasf1
Name: WAS protein family, member 1
Synonyms: WAVE, WAVE-1, Scar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83767
Homologene: 2920
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212281
Homologene: 133713
Tpx2
Name: TPX2, microtubule-associated
Synonyms: 2610005B21Rik, REPP86, DIL2, p100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: 9030416H16Rik, E230024D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71521
Homologene: 22877
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, D030046N04Rik, BRIT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2a, D4Bwg0973e, 4933406G05Rik, 4930551I19Rik, Ufd2p, UFD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 63958
Homologene: 107623
Rsf1
Name: remodeling and spacing factor 1
Synonyms: C030033M12Rik, XAP8, p325, 4832420A03Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Ei24
Name: etoposide induced 2.4 mRNA
Synonyms: PIG8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13663
Homologene: 3588
Mmp17
Name: matrix metallopeptidase 17
Synonyms: MT4-MMP, membrane type-4 matrix metalloproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23948
HGNC: HGNC:7163
Homologene: 22669
Pan3
Name: PAN3 poly(A) specific ribonuclease subunit
Synonyms: A430027N15Rik, 2700050F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72587
Homologene: 6372
Fam171b
Name: family with sequence similarity 171, member B
Synonyms: D430039N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241520
Homologene: 18462
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78912
Homologene: 2340
Mcm4
Name: minichromosome maintenance complex component 4
Synonyms: Cdc21, Mcmd4, mCdc21, 19G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17217
VEGA: 16
HGNC: HGNC:6947
Homologene: 40496
Abt1
Name: activator of basal transcription 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 30946
Homologene: 134288
Tbc1d19
Name: TBC1 domain family, member 19
Synonyms: 2810453K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67249
Homologene: 10130
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Ppwd1
Name: peptidylprolyl isomerase domain and WD repeat containing 1
Synonyms: A330090G21Rik, 4632422M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238831
VEGA: 13
Homologene: 9099
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216766
Homologene: 9155
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Hephl1
Name: hephaestin-like 1
Synonyms: LOC244698, zyklopen, Zp, thd, cw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244698
Homologene: 9112
Cyp2c66
Name: cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms: 2010301M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69888
HGNC: HGNC:2623
Homologene: 133566
Slc22a26
Name: solute carrier family 22 (organic cation transporter), member 26
Synonyms: BC014805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 236149
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Vmn1r87
Name: vomeronasal 1 receptor 87
Synonyms: V1rk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171261
Homologene: 134023
Zfp976
Name: zinc finger protein 976
Synonyms: 9830147E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 208111
Homologene: 134004
Pfkm
Name: phosphofructokinase, muscle
Synonyms: Pfk-4, Pfkx, PFK-A, PFK-M, Pfk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18642
VEGA: 15
HGNC: HGNC:8877
Homologene: 20101
Lair1
Name: leukocyte-associated Ig-like receptor 1
Synonyms: Lair-1, mLair-1, D7Bwg0421e, 5133400O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52855
HGNC: HGNC:6477
Homologene: 48097
Maip1
Name: matrix AAA peptidase interacting protein 1
Synonyms: 9430016H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68115
Homologene: 11565
Vmn2r95
Name: vomeronasal 2, receptor 95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328759
Homologene: 115024
Exo5
Name: exonuclease 5
Synonyms: Dem1, 3110037I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73172
Homologene: 41497
Olfr868
Name: olfactory receptor 868
Synonyms: MOR145-4, GA_x6K02T2PVTD-13841888-13842802
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258552
Homologene: 74168
Olfr1178
Name: olfactory receptor 1178
Synonyms: MOR225-6P, GA_x6K02T2Q125-49870417-49871388
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258203
Homologene: 73979
Tmem200a
Name: transmembrane protein 200A
Synonyms: C030003D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77220
VEGA: 10
Homologene: 14175
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: D130029J02Rik, Rltpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234695
Homologene: 128439
Gpc2
Name: glypican 2 (cerebroglycan)
Synonyms: 2410016G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71951
HGNC: HGNC:4450
Homologene: 17657
Cndp2
Name: CNDP dipeptidase 2 (metallopeptidase M20 family)
Synonyms: Pep-1, Pep1, Dip-2, 0610010E05Rik, Cn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66054
VEGA: 18
Homologene: 10085
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Grin1os
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1), opposite strand
Synonyms: E130003G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320354
Trgc4
Name: T cell receptor gamma, constant 4
Synonyms: Tcrg-C4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107576
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 46,358,216 bp
  • G to A, chromosome 1 at 57,415,690 bp
  • T to C, chromosome 2 at 25,296,827 bp
  • T to C, chromosome 2 at 83,879,987 bp
  • C to T, chromosome 2 at 88,391,475 bp
  • T to A, chromosome 2 at 152,875,549 bp
  • A to T, chromosome 4 at 120,921,537 bp
  • T to C, chromosome 4 at 149,342,992 bp
  • T to A, chromosome 5 at 53,889,325 bp
  • T to C, chromosome 5 at 65,663,875 bp
  • T to A, chromosome 5 at 129,595,058 bp
  • C to A, chromosome 5 at 138,275,605 bp
  • T to A, chromosome 5 at 147,531,319 bp
  • T to A, chromosome 7 at 3,739,397 bp
  • G to A, chromosome 7 at 4,010,489 bp
  • G to T, chromosome 7 at 13,131,865 bp
  • A to G, chromosome 7 at 42,612,501 bp
  • A to G, chromosome 7 at 97,661,872 bp
  • T to A, chromosome 8 at 18,607,326 bp
  • G to T, chromosome 8 at 105,696,889 bp
  • T to A, chromosome 9 at 15,086,172 bp
  • T to A, chromosome 9 at 20,101,192 bp
  • T to A, chromosome 9 at 36,782,446 bp
  • T to C, chromosome 9 at 37,407,960 bp
  • T to C, chromosome 9 at 42,375,185 bp
  • T to A, chromosome 10 at 25,994,379 bp
  • G to A, chromosome 10 at 40,937,676 bp
  • T to A, chromosome 10 at 58,476,785 bp
  • A to T, chromosome 11 at 58,146,518 bp
  • G to T, chromosome 11 at 84,520,388 bp
  • A to G, chromosome 11 at 96,955,838 bp
  • A to G, chromosome 12 at 118,261,889 bp
  • A to G, chromosome 13 at 19,344,762 bp
  • G to T, chromosome 13 at 23,422,649 bp
  • A to G, chromosome 13 at 67,637,645 bp
  • A to T, chromosome 13 at 104,220,435 bp
  • T to G, chromosome 13 at 112,932,600 bp
  • A to T, chromosome 14 at 55,074,775 bp
  • A to G, chromosome 15 at 98,131,515 bp
  • T to A, chromosome 16 at 15,635,303 bp
  • A to G, chromosome 17 at 18,440,075 bp
  • G to A, chromosome 18 at 20,397,503 bp
  • A to T, chromosome 18 at 84,675,028 bp
  • T to C, chromosome 19 at 7,790,175 bp
  • A to G, chromosome 19 at 39,171,029 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5178 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042758-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.