Strain Name:
C57BL/6J-MtgxR5275Btlr/Mmmh
Stock Number:
042838-MU
Citation ID:
RRID:MMRRC_042838-MU
Other Names:
R5275 (G1), C57BL/6J-MtgxR5275Btlr
Major Collection:

Gene Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, Gm4392, Ank-2, ankyrin B, Ankyrin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109676
HGNC: HGNC:493
Dst
Name: dystonin
Synonyms: A830042E19Rik, 2310001O04Rik, Macf2, bullous pemphigoid antigen 1, BPAG1-n, BPAG1, athetoid, Bpag, ah, bullous pemphigoid antigen 1, Bpag1, nmf339, nmf203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 2310004H21Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72313
Homologene: 103956
Tdh
Name: L-threonine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 58865
Homologene: 10987
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 22330
VEGA: 14
Homologene: 7594
Snx6
Name: sorting nexin 6
Synonyms: 2010006G21Rik, 2610032J07Rik, 2810425K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 72183
VEGA: 12
Homologene: 12304
Atp5c1
Name: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Synonyms: F1 gamma, 1700094F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11949
HGNC: HGNC:833
Homologene: 3792
Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Synonyms: 1200011N24Rik, optic atrophy 1, lilr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74143
HGNC: HGNC:8140
Homologene: 14618
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228012
Homologene: 130657
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 84585
Homologene: 11112
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229681
Homologene: 14910
Scfd1
Name: Sec1 family domain containing 1
Synonyms: RA410, STXBP1L2, 3110021P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 76983
VEGA: 12
Homologene: 5650
Cep135
Name: centrosomal protein 135
Synonyms: Cep4, LOC381644
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381644
Homologene: 45709
Arhgef1
Name: Rho guanine nucleotide exchange factor (GEF) 1
Synonyms: Lsc, Lbcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Zbtb2
Name: zinc finger and BTB domain containing 2
Synonyms: LOC381990
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 381990
VEGA: 10
Homologene: 10837
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Klkbp, 1A1, Kalbp, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Tnc
Name: tenascin C
Synonyms: hexabrachion, Hxb, cytotactin, tenascin-C, C130033P17Rik, TN-C, TN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, 2900010L19Rik, Sorla, mSorLA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20660
Homologene: 2336
Psrc1
Name: proline/serine-rich coiled-coil 1
Synonyms: 5430413I02Rik, DDA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56742
Homologene: 49603
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71389
Homologene: 32772
Ppan
Name: peter pan homolog
Synonyms: SSF1, A230087P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235036
HGNC: HGNC:9227
Homologene: 5690
Dnajc16
Name: DnaJ heat shock protein family (Hsp40) member C16
Synonyms: 2900037O03Rik, 4732437J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 214063
Homologene: 45414
Pcdh12
Name: protocadherin 12
Synonyms: vascular endothelial cadherin-2, VE-cadherin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 53601
HGNC: HGNC:8657
Homologene: 9574
Plvap
Name: plasmalemma vesicle associated protein
Synonyms: MECA32, PV-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 84094
Homologene: 10578
2410017I17Rik
Name: RIKEN cDNA 2410017I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 675325
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17876
Homologene: 69079
Cma1
Name: chymase 1, mast cell
Synonyms: Mcp-5, Mcp5, MMCP-5, Mcpt5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 17228
VEGA: 14
HGNC: HGNC:2097
Homologene: 55606
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80797
Homologene: 77224
4930402H24Rik
Name: RIKEN cDNA 4930402H24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228602
Homologene: 12623
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74183
Homologene: 135954
Olfr1344
Name: olfactory receptor 1344
Synonyms: MOR124-1, GA_x6K02T2QGBW-3169916-3170881, 4930415J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 257882
Serpinb6c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6c
Synonyms: Spi3C, ovalbumin, SPIC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 97848
HGNC: HGNC:8950
Olfr1309
Name: olfactory receptor 1309
Synonyms: MOR245-5, GA_x6K02T2Q125-73031456-73030518
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258439
Homologene: 74054
Elovl4
Name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83603
Homologene: 41488
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 382407
VEGA: 10
Abcc1
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms: Abcc1a, Mrp1, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Prss54
Name: protease, serine 54
Synonyms: 4931432M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 70993
Homologene: 19278
Elf5
Name: E74-like factor 5
Synonyms: ESE-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13711
HGNC: HGNC:3320
Homologene: 135967
Gm8882
Name: predicted gene 8882
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 667929
Vmn1r84
Name: vomeronasal 1 receptor 84
Synonyms: V1rg11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 171267
Homologene: 74328
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74691
Homologene: 14311
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 70941
Homologene: 52843
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: Aatyk3, AATYK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381983
Homologene: 79449
Alpl
Name: alkaline phosphatase, liver/bone/kidney
Synonyms: TNSALP, TNAP, Akp-2, Akp2, ALP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11647
HGNC: HGNC:438
Homologene: 37314
Rergl
Name: RERG/RAS-like
Synonyms: EG632971
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 632971
Homologene: 41583
Ears2
Name: glutamyl-tRNA synthetase 2, mitochondrial
Synonyms: 3230401I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67417
Homologene: 6907
Prl7d1
Name: prolactin family 7, subfamily d, member 1
Synonyms: Plfr, PRP, PLF-RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18814
Homologene: 7894
Apold1
Name: apolipoprotein L domain containing 1
Synonyms: LOC381823
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 381823
Homologene: 12781
Olfr728
Name: olfactory receptor 728
Synonyms: GA_x6K02T2PMLR-5831021-5830086, MOR246-1P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258039
Homologene: 74224
Ccr10
Name: chemokine (C-C motif) receptor 10
Synonyms: CCR10, Cmkbr9, GPR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12777
HGNC: HGNC:4474
Homologene: 7271
Ptpn20
Name: protein tyrosine phosphatase, non-receptor type 20
Synonyms: typ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 19256
VEGA: 14
Homologene: 74905
Gm5117
Name: predicted gene 5117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 330731
Gm38100
Name: predicted gene, 38100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Lsm7
Name: LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms: 0910001B06Rik, 1110033F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 66094
VEGA: 10
Homologene: 6781
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,180,148 bp
  • A to G, chromosome 1 at 175,920,770 bp
  • T to C, chromosome 2 at 10,068,733 bp
  • C to T, chromosome 2 at 70,752,205 bp
  • C to T, chromosome 2 at 103,430,331 bp
  • T to A, chromosome 2 at 111,983,829 bp
  • C to T, chromosome 2 at 125,085,861 bp
  • A to G, chromosome 2 at 130,791,882 bp
  • A to G, chromosome 2 at 160,969,363 bp
  • T to C, chromosome 2 at 161,052,804 bp
  • A to T, chromosome 3 at 104,891,552 bp
  • A to G, chromosome 3 at 108,386,359 bp
  • T to C, chromosome 3 at 127,032,183 bp
  • A to G, chromosome 3 at 144,813,579 bp
  • G to A, chromosome 4 at 63,964,730 bp
  • C to T, chromosome 4 at 103,235,659 bp
  • T to C, chromosome 4 at 137,749,608 bp
  • T to C, chromosome 4 at 141,767,928 bp
  • T to C, chromosome 4 at 156,217,518 bp
  • T to C, chromosome 5 at 73,112,791 bp
  • T to A, chromosome 5 at 76,593,204 bp
  • T to G, chromosome 6 at 132,361,877 bp
  • G to T, chromosome 6 at 134,983,800 bp
  • A to G, chromosome 6 at 139,501,821 bp
  • A to T, chromosome 7 at 6,440,016 bp
  • A to T, chromosome 7 at 12,361,814 bp
  • G to A, chromosome 7 at 24,919,352 bp
  • G to A, chromosome 7 at 45,791,298 bp
  • T to C, chromosome 7 at 122,048,198 bp
  • T to A, chromosome 8 at 31,739,567 bp
  • T to C, chromosome 8 at 71,511,670 bp
  • T to C, chromosome 8 at 95,564,478 bp
  • T to A, chromosome 9 at 20,889,773 bp
  • A to T, chromosome 9 at 42,030,902 bp
  • G to A, chromosome 9 at 83,780,661 bp
  • AT to ATT, chromosome 9 at 108,064,003 bp
  • T to C, chromosome 10 at 4,368,508 bp
  • T to C, chromosome 10 at 80,854,620 bp
  • A to G, chromosome 10 at 99,444,889 bp
  • C to T, chromosome 11 at 101,174,285 bp
  • A to T, chromosome 12 at 51,415,589 bp
  • T to C, chromosome 12 at 54,784,022 bp
  • T to C, chromosome 12 at 104,148,378 bp
  • T to A, chromosome 12 at 112,051,912 bp
  • A to T, chromosome 13 at 27,709,247 bp
  • A to G, chromosome 13 at 33,893,817 bp
  • T to C, chromosome 14 at 21,010,078 bp
  • A to G, chromosome 14 at 33,631,192 bp
  • T to A, chromosome 14 at 50,140,496 bp
  • A to T, chromosome 14 at 55,941,700 bp
  • T to C, chromosome 14 at 63,496,109 bp
  • C to T, chromosome 16 at 14,466,186 bp
  • C to T, chromosome 16 at 29,611,579 bp
  • T to C, chromosome 17 at 36,161,675 bp
  • T to A, chromosome 18 at 38,284,101 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5275 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042838-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.