Strain Name:
C57BL/6J-MtgxR5182Btlr/Mmmh
Stock Number:
042853-MU
Citation ID:
RRID:MMRRC_042853-MU
Other Names:
R5182 (G1), C57BL/6J-MtgxR5182Btlr
Major Collection:

Gene Information

Pax4
Name: paired box 4
Synonyms: Pax-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18506
HGNC: HGNC:8618
Homologene: 4515
Dst
Name: dystonin
Synonyms: Bpag1, Bpag, 2310001O04Rik, nmf339, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, Macf2, nmf203, bullous pemphigoid antigen 1, athetoid, A830042E19Rik, ah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ubxn2a
Name: UBX domain protein 2A
Synonyms: Ubxd4, 6330407P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217379
Homologene: 17076
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: rabaptin-5, neurocrescin, RAB5 effector protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54189
Homologene: 3451
Rad51c
Name: RAD51 paralog C
Synonyms: Rad51l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 114714
HGNC: HGNC:9820
Homologene: 14238
Auts2
Name: autism susceptibility candidate 2
Synonyms: 2700063G02Rik, A730011F23Rik, D830032G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319974
Homologene: 22907
Kdm5a
Name: lysine (K)-specific demethylase 5A
Synonyms: Jarid1a, RBP2, Rbbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Ptprg
Name: protein tyrosine phosphatase, receptor type, G
Synonyms: RPTPgamma, 5430405N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Psmd12
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Synonyms: P55, 1500002F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66997
HGNC: HGNC:9557
Homologene: 2109
Ube4b
Name: ubiquitination factor E4B
Synonyms: 4930551I19Rik, UFD2, 4933406G05Rik, D4Bwg0973e, UFD2a, Ufd2p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 63958
Homologene: 107623
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: 2610014N07Rik, Uchrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22224
Homologene: 31294
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74081
Homologene: 8879
Abcg8
Name: ATP binding cassette subfamily G member 8
Synonyms: 1300003C16Rik, Sterolin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67470
Homologene: 23361
1110059E24Rik
Name: RIKEN cDNA 1110059E24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66206
Homologene: 11933
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, A930009M04Rik, EFG2, 6530419G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320806
Homologene: 6238
Ankrd27
Name: ankyrin repeat domain 27 (VPS9 domain)
Synonyms: Varp, D330003H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 245886
Homologene: 12956
Rbck1
Name: RanBP-type and C3HC4-type zinc finger containing 1
Synonyms: HOIL-1L, Ubce7ip3, HOIL-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24105
Homologene: 32448
St7
Name: suppression of tumorigenicity 7
Synonyms: TSG7, 9430001H04Rik, Fam4a2, HELG, RAY1, SEN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64213
Homologene: 10185
Coq5
Name: coenzyme Q5 methyltransferase
Synonyms: 1810014G04Rik, D5Ertd33e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52064
Homologene: 6559
Eng
Name: endoglin
Synonyms: Endo, CD105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13805
HGNC: HGNC:3349
Homologene: 92
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: KCC1, K-Cl Co-transporter-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20498
Homologene: 21056
Nmd3
Name: NMD3 ribosome export adaptor
Synonyms: C87860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97112
Homologene: 6127
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: D330038K10Rik, 4930543C13Rik, 4930516E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Ift172
Name: intraflagellar transport 172
Synonyms: avc1, 4930553F24Rik, wim
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67661
Homologene: 15202
Sdc3
Name: syndecan 3
Synonyms: Synd3, syn-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20970
Homologene: 7965
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Grn
Name: granulin
Synonyms: acrogranulin, Pgrn, PC cell-derived growth factor, epithelin, progranulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14824
HGNC: HGNC:4601
Homologene: 1577
Sirpa
Name: signal-regulatory protein alpha
Synonyms: CD172a, SHPS-1, Bit, SIRP, Ptpns1, P84
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19261
HGNC: HGNC:9662
Homologene: 7246
Prkg2
Name: protein kinase, cGMP-dependent, type II
Synonyms: Prkgr2, cGK-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19092
HGNC: HGNC:9416
Homologene: 4556
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1154Clo, b2b1537Clo, Dnahc5, b2b3491Clo, b2b1565Clo, Mdnah5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ttn
Name: titin
Synonyms: mdm, 2310036G12Rik, D830007G01Rik, shru, L56, 2310074I15Rik, 2310057K23Rik, connectin, D330041I19Rik, 1100001C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Snx7
Name: sorting nexin 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76561
Homologene: 22941
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, Ushrn, Ush2a, LOC269160, LOC381317, A930037M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Nkpd1
Name: NTPase, KAP family P-loop domain containing 1
Synonyms: 2310015G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69547
Homologene: 18876
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234686
Homologene: 136406
Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
Synonyms: 6330541J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14756
HGNC: HGNC:4459
Homologene: 1152
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269585
Homologene: 51463
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: X83337, ESTM15, 1810073P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75607
Homologene: 19155
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665033
Homologene: 122792
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240690
Homologene: 8792
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 666002
Homologene: 86604
Vmn1r222
Name: vomeronasal 1 receptor 222
Synonyms: V1rh16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171274
Homologene: 110880
Hrnr
Name: hornerin
Synonyms: S100a18, A530063N20Rik, 1110033K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68723
Homologene: 138092
Tas2r137
Name: taste receptor, type 2, member 137
Synonyms: mt2r41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 574417
Homologene: 23231
Tgm6
Name: transglutaminase 6
Synonyms: TGM3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241636
Homologene: 27970
Fignl1
Name: fidgetin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 60530
Homologene: 11063
Clca3b
Name: chloride channel accessory 3B
Synonyms: Clca4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229927
Homologene: 135610
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Pdc
Name: phosducin
Synonyms: Rpr-1, Rpr1, Pdc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20028
HGNC: HGNC:8759
Homologene: 1950
Fam102b
Name: family with sequence similarity 102, member B
Synonyms: B430201A12Rik, 1600010D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329739
Homologene: 46568
Klk6
Name: kallikrein related-peptidase 6
Synonyms: Prss18, Bssp, Klk29, Prss9, neurosin, protease M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19144
HGNC: HGNC:6367
Homologene: 68279
Zfp936
Name: zinc finger protein 936
Synonyms: I1C0022H11Rik, Gm9272, EG435970
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668620
Dpf3
Name: D4, zinc and double PHD fingers, family 3
Synonyms: CERD4, cer-d4, 2810403B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70127
Homologene: 129842
Olfr131
Name: olfactory receptor 131
Synonyms: MOR256-4, GA_x6K02T2PSCP-2531299-2530355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258867
Homologene: 105889
Gsdmc4
Name: gasdermin C4
Synonyms: 9030605I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74548
HGNC: HGNC:7151
Homologene: 69487
Rab43
Name: RAB43, member RAS oncogene family
Synonyms: 1810048P08Rik, 2500004H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69834
Homologene: 43122
Bak1
Name: BCL2-antagonist/killer 1
Synonyms: N-Bak, Bak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12018
HGNC: HGNC:949
Homologene: 917
Olfr566
Name: olfactory receptor 566
Synonyms: MOR14-7P, GA_x6K02T2PBJ9-5560696-5559746
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258168
Homologene: 133721
Gm26592
Name: predicted gene, 26592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 101055759
Pnma1
Name: paraneoplastic antigen MA1
Synonyms: 5730402C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70481
HGNC: HGNC:9158
Homologene: 4399
Gm12116
Name: predicted gene 12116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 6,817,653 bp
  • C to A, chromosome 1 at 34,179,086 bp
  • T to C, chromosome 1 at 150,333,354 bp
  • A to C, chromosome 1 at 155,858,108 bp
  • A to G, chromosome 1 at 188,542,740 bp
  • T to C, chromosome 2 at 32,672,959 bp
  • C to T, chromosome 2 at 76,870,429 bp
  • T to C, chromosome 2 at 112,755,150 bp
  • G to A, chromosome 2 at 129,615,732 bp
  • A to T, chromosome 2 at 130,141,302 bp
  • G to A, chromosome 2 at 152,322,256 bp
  • T to C, chromosome 3 at 28,045,081 bp
  • T to A, chromosome 3 at 69,722,468 bp
  • A to T, chromosome 3 at 93,332,143 bp
  • A to C, chromosome 3 at 100,647,017 bp
  • T to C, chromosome 3 at 108,985,351 bp
  • A to G, chromosome 3 at 117,832,857 bp
  • A to G, chromosome 3 at 144,828,015 bp
  • G to T, chromosome 4 at 128,586,711 bp
  • A to G, chromosome 4 at 130,821,684 bp
  • A to C, chromosome 4 at 149,381,242 bp
  • T to A, chromosome 5 at 31,267,614 bp
  • C to A, chromosome 5 at 96,636,173 bp
  • T to A, chromosome 5 at 99,024,709 bp
  • G to A, chromosome 5 at 115,279,756 bp
  • T to C, chromosome 5 at 131,475,081 bp
  • A to G, chromosome 6 at 17,846,237 bp
  • C to T, chromosome 6 at 28,444,369 bp
  • A to T, chromosome 6 at 40,491,932 bp
  • A to G, chromosome 6 at 87,794,655 bp
  • T to A, chromosome 6 at 120,388,105 bp
  • A to G, chromosome 7 at 19,523,256 bp
  • A to G, chromosome 7 at 35,628,487 bp
  • G to A, chromosome 7 at 43,189,907 bp
  • A to G, chromosome 7 at 43,828,660 bp
  • A to T, chromosome 7 at 102,856,969 bp
  • G to A, chromosome 7 at 105,703,209 bp
  • T to C, chromosome 8 at 105,347,815 bp
  • G to A, chromosome 8 at 105,944,606 bp
  • G to A, chromosome 8 at 119,956,681 bp
  • A to G, chromosome 9 at 21,034,810 bp
  • C to A, chromosome 9 at 105,857,332 bp
  • A to T, chromosome 11 at 11,801,717 bp
  • A to T, chromosome 11 at 33,219,287 bp
  • C to T, chromosome 11 at 70,904,628 bp
  • T to G, chromosome 11 at 87,397,719 bp
  • C to A, chromosome 11 at 102,430,554 bp
  • T to C, chromosome 11 at 107,479,659 bp
  • G to A, chromosome 12 at 4,880,634 bp
  • T to C, chromosome 12 at 83,370,596 bp
  • T to C, chromosome 12 at 84,147,045 bp
  • A to G, chromosome 13 at 23,232,497 bp
  • A to T, chromosome 13 at 24,984,070 bp
  • G to T, chromosome 13 at 49,061,161 bp
  • T to C, chromosome 13 at 97,162,893 bp
  • A to G, chromosome 14 at 12,154,174 bp
  • T to G, chromosome 15 at 28,311,278 bp
  • C to A, chromosome 15 at 63,893,804 bp
  • G to A, chromosome 17 at 3,438,721 bp
  • A to G, chromosome 17 at 23,291,658 bp
  • G to A, chromosome 17 at 27,022,748 bp
  • A to G, chromosome 17 at 38,082,114 bp
  • T to C, chromosome 17 at 84,692,744 bp
  • A to G, chromosome 19 at 16,695,499 bp
  • A to G, chromosome 19 at 21,630,765 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5182 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042853-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.