Strain Name:
C57BL/6J-MtgxR5286Btlr/Mmmh
Stock Number:
042870-MU
Citation ID:
RRID:MMRRC_042870-MU
Other Names:
R5286 (G1), C57BL/6J-MtgxR5286Btlr
Major Collection:

Strain Information

Rgs9
Name: regulator of G-protein signaling 9
Synonyms: Rgs9-2, RGS9-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19739
Homologene: 2845
Itk
Name: IL2 inducible T cell kinase
Synonyms: Tsk, Emt, Tcsk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051
Wdr73
Name: WD repeat domain 73
Synonyms: 2410008B13Rik, 1200011I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71968
Homologene: 41899
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330177
Homologene: 83279
Dlgap4
Name: DLG associated protein 4
Synonyms: SAP90/PSD-95-associated protein 4, WBP16, PSD-95/SAP90 binding protein 4, DAP4, Sapap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228836
Homologene: 8935
Rev1
Name: REV1, DNA directed polymerase
Synonyms: Rev1l, REV1, 1110027I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56210
Homologene: 32309
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: A430032G04Rik, apollon, Bruce, A430040A19Rik, D630005A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Brd2
Name: bromodomain containing 2
Synonyms: Rnf3, D17H6S113E, Fsrg1, Ring3, Frg-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14312
HGNC: HGNC:1103
Homologene: 74540
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: DAL1P, 4.1B, NBL3, Epb4.1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Dbf4
Name: DBF4 zinc finger
Synonyms: Ask
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27214
Homologene: 40892
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27204
Homologene: 68320
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381314
Homologene: 7118
Xpo5
Name: exportin 5
Synonyms: Exp5, 2700038C24Rik, 2410004H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72322
VEGA: 17
Homologene: 69316
Rps13
Name: ribosomal protein S13
Synonyms: 2700063M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68052
Homologene: 128182
Zbtb2
Name: zinc finger and BTB domain containing 2
Synonyms: LOC381990
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 381990
VEGA: 10
Homologene: 10837
Cables1
Name: CDK5 and Abl enzyme substrate 1
Synonyms: interactor-1 with cdk3, ik3-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 63955
VEGA: 18
Homologene: 11097
Knop1
Name: lysine rich nucleolar protein 1
Synonyms: Tsg118, 2310008H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66356
Homologene: 49729
Fbxo7
Name: F-box protein 7
Synonyms: A230052G17Rik, 2410015K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69754
Homologene: 8136
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: Ccdc128, 1110018J12Rik, Klraq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73825
Homologene: 44811
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104570
Homologene: 68886
Mir431
Name: microRNA 431
Synonyms: mir 431, Mirn431, mmu-mir-431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 723866
VEGA: 12
Gprc5b
Name: G protein-coupled receptor, family C, group 5, member B
Synonyms: hypothetical protein, clone 2-63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64297
Homologene: 9435
Ccdc181
Name: coiled-coil domain containing 181
Synonyms: 4930455F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74895
Homologene: 10912
Mycbpap
Name: MYCBP associated protein
Synonyms: AMAP-1, 4932408B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104601
Homologene: 49982
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: 4921511C04Rik, A230074B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70853
Homologene: 27053
Ttn
Name: titin
Synonyms: D330041I19Rik, 2310057K23Rik, connectin, shru, 1100001C23Rik, L56, mdm, D830007G01Rik, 2310074I15Rik, 2310036G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: Cacnl1a2, D-LTCC, C79217, Cchl1a2, Cav1.3alpha1, Cchl1a, 8430418G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: 4831403C07Rik, Kif16a, E230025N21Rik, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Adad1
Name: adenosine deaminase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21744
Homologene: 7569
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: 9330180L21Rik, 4930442N21Rik, Smr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54650
Homologene: 9472
Plce1
Name: phospholipase C, epsilon 1
Synonyms: PLCepsilon, 4933403A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74055
Homologene: 9478
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: Tims2, ephexin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Acad12
Name: acyl-Coenzyme A dehydrogenase family, member 12
Synonyms: 9330129D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 338350
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Gpr106, LGR8, Great
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140498
Homologene: 15402
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 328643
Homologene: 28056
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Rnf31
Name: ring finger protein 31
Synonyms: Paul, HOIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268749
Homologene: 33228
Nt5dc3
Name: 5'-nucleotidase domain containing 3
Synonyms: Gnn, C630002B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103466
VEGA: 10
Homologene: 9571
Lrif1
Name: ligand dependent nuclear receptor interacting factor 1
Synonyms: 4933421E11Rik, 2010012G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 321000
Homologene: 10160
Klra6
Name: killer cell lectin-like receptor, subfamily A, member 6
Synonyms: Ly49F, Ly49f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16637
Homologene: 110821
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Agmo
Name: alkylglycerol monooxygenase
Synonyms: Tmem195, A530016O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319660
Homologene: 45620
Ppl
Name: periplakin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Mfap3l
Name: microfibrillar-associated protein 3-like
Synonyms: NYD-sp9, 5430405D20Rik, 4933428A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71306
Homologene: 11013
Hddc3
Name: HD domain containing 3
Synonyms: 1110033O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68695
Homologene: 12279
Or9s13
Name: olfactory receptor family 9 subfamily S member 13
Synonyms: MOR208-5, GA_x6K02T2R7CC-81134096-81133095, Olfr12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 257890
Homologene: 114777
Tspan4
Name: tetraspanin 4
Synonyms: Tspan-4, Tm4sf7, D130042I01Rik, novel antigen 2, NAG-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64540
Homologene: 2453
Ift25
Name: intraflagellar transport 25
Synonyms: 2900042B11Rik, Hspb11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72938
Homologene: 22947
Rnf5
Name: ring finger protein 5
Synonyms: 2410131O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54197
Homologene: 56004
8430423G03Rik
Name: RIKEN cDNA 8430423G03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71473
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,045,039 bp
  • T to A, chromosome 1 at 38,055,326 bp
  • T to C, chromosome 1 at 87,545,830 bp
  • T to C, chromosome 1 at 92,620,362 bp
  • T to C, chromosome 1 at 135,967,861 bp
  • A to G, chromosome 1 at 164,278,241 bp
  • T to C, chromosome 1 at 185,323,121 bp
  • A to G, chromosome 2 at 31,918,596 bp
  • C to A, chromosome 2 at 76,854,186 bp
  • T to A, chromosome 2 at 120,701,947 bp
  • T to G, chromosome 2 at 156,745,919 bp
  • T to C, chromosome 3 at 37,065,250 bp
  • A to G, chromosome 3 at 106,732,543 bp
  • T to A, chromosome 4 at 107,279,801 bp
  • A to G, chromosome 5 at 8,397,985 bp
  • T to C, chromosome 5 at 14,679,747 bp
  • T to A, chromosome 5 at 117,266,075 bp
  • T to C, chromosome 5 at 121,604,295 bp
  • A to C, chromosome 5 at 148,950,368 bp
  • T to C, chromosome 5 at 150,035,444 bp
  • G to A, chromosome 6 at 130,018,969 bp
  • G to T, chromosome 7 at 80,343,795 bp
  • A to T, chromosome 7 at 80,891,809 bp
  • A to G, chromosome 7 at 116,333,920 bp
  • C to T, chromosome 7 at 118,855,770 bp
  • A to T, chromosome 7 at 118,983,687 bp
  • G to A, chromosome 7 at 125,663,408 bp
  • A to G, chromosome 7 at 141,482,570 bp
  • A to G, chromosome 8 at 60,656,869 bp
  • A to G, chromosome 8 at 88,324,859 bp
  • G to T, chromosome 9 at 108,110,924 bp
  • C to T, chromosome 10 at 4,368,566 bp
  • T to C, chromosome 10 at 86,022,090 bp
  • T to C, chromosome 10 at 86,351,564 bp
  • T to C, chromosome 10 at 86,804,792 bp
  • T to A, chromosome 11 at 29,211,667 bp
  • A to C, chromosome 11 at 46,338,099 bp
  • G to A, chromosome 11 at 94,506,496 bp
  • T to G, chromosome 11 at 109,239,451 bp
  • T to A, chromosome 12 at 37,242,086 bp
  • A to G, chromosome 12 at 109,590,490 bp
  • T to G, chromosome 13 at 92,131,433 bp
  • A to T, chromosome 14 at 30,350,725 bp
  • G to A, chromosome 14 at 30,816,820 bp
  • T to C, chromosome 14 at 55,592,236 bp
  • C to T, chromosome 15 at 44,514,972 bp
  • G to A, chromosome 16 at 5,089,123 bp
  • A to T, chromosome 16 at 20,596,308 bp
  • T to A, chromosome 17 at 34,115,231 bp
  • A to C, chromosome 17 at 34,603,363 bp
  • A to G, chromosome 17 at 46,234,480 bp
  • G to A, chromosome 17 at 69,262,273 bp
  • G to A, chromosome 17 at 74,670,247 bp
  • A to G, chromosome 17 at 88,565,714 bp
  • A to G, chromosome 18 at 11,924,827 bp
  • T to C, chromosome 19 at 38,739,376 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5286 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042870-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.