Strain Name:
C57BL/6J-MtgxR5292Btlr/Mmmh
Stock Number:
042875-MU
Citation ID:
RRID:MMRRC_042875-MU
Other Names:
R5292 (G1), C57BL/6J-MtgxR5292Btlr
Major Collection:

Gene Information

Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20116
Homologene: 133143
Rtn4
Name: reticulon 4
Synonyms: 1110020G17Rik, C130026I10Rik, NOGO, NgA, Nogo-B, Nogo-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68585
Homologene: 10743
Rnf40
Name: ring finger protein 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233900
Homologene: 8856
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, A130082H20Rik, D430004I05Rik, TIF1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21848
Homologene: 20830
Depdc1b
Name: DEP domain containing 1B
Synonyms: XTP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218581
Homologene: 10157
Hip1
Name: huntingtin interacting protein 1
Synonyms: 2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329908
Homologene: 35420
Smoc2
Name: SPARC related modular calcium binding 2
Synonyms: 1700056C05Rik, 5430426J21Rik, Smoc2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64074
VEGA: 17
Homologene: 11150
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Zkscan5
Name: zinc finger with KRAB and SCAN domains 5
Synonyms: hKraba1, Zfp95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22757
Homologene: 8734
Peg3
Name: paternally expressed 3
Synonyms: Pw1, Zfp102, End4, Gcap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Dcc
Name: deleted in colorectal carcinoma
Synonyms: C030036D22Rik, Igdcc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, ba, rh, rh-bmh, bldy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Gfpt1
Name: glutamine fructose-6-phosphate transaminase 1
Synonyms: GFAT, GFA, GFAT1, 2810423A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14583
HGNC: HGNC:4241
Homologene: 68220
Ppie
Name: peptidylprolyl isomerase E (cyclophilin E)
Synonyms: 2010010D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56031
HGNC: HGNC:9258
Homologene: 38142
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: LOC385628, 2210409B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70144
Homologene: 13111
Osbpl7
Name: oxysterol binding protein-like 7
Synonyms: 4933437E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71240
Homologene: 79672
Akap2
Name: A kinase (PRKA) anchor protein 2
Synonyms: B230340M18Rik, AKAP-KL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 72432
Homologene: 4987
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Gata3
Name: GATA binding protein 3
Synonyms: Gata-3, jal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68915
Homologene: 57502
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: C80743, 2310067L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69700
Homologene: 43567
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, Myo, 1110069I04Rik, 9530006G20Rik, 2310068J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 118449
Homologene: 15400
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50720
Hhipl1
Name: hedgehog interacting protein-like 1
Synonyms: 1600002O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 214305
VEGA: 12
Homologene: 81985
Palmd
Name: palmdelphin
Synonyms: PALML, 4631423C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114301
Homologene: 9804
Hrnr
Name: hornerin
Synonyms: 1110033K19Rik, A530063N20Rik, S100a18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68723
Homologene: 138092
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20537
Homologene: 55456
Olfr1510
Name: olfactory receptor 1510
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Krt80
Name: keratin 80
Synonyms: 2310041I20Rik, 1200016G03Rik, Kb20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74127
VEGA: 15
Homologene: 66610
Zfp936
Name: zinc finger protein 936
Synonyms: EG435970, I1C0022H11Rik, Gm9272
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668620
Zfp39
Name: zinc finger protein 39
Synonyms: CTfin33, Zfp-39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22698
Homologene: 69102
Slc37a2
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Synonyms: G3PP, cI-2, Slc37a1, ci2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56857
Homologene: 41357
Olfr401
Name: olfactory receptor 401
Synonyms: GA_x6K02T2P1NL-4278037-4278984, MOR255-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258701
HGNC: HGNC:8282
Homologene: 73922
E430018J23Rik
Name: RIKEN cDNA E430018J23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101604
Homologene: 138471
Gcm1
Name: glial cells missing homolog 1
Synonyms: glial cell deficient, glide, Gcm a, Gcm 1, Gcm1-rs1, GCMa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Bend7
Name: BEN domain containing 7
Synonyms: 1110017O21Rik, E130319B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209645
Homologene: 17660
Crtc3
Name: CREB regulated transcription coactivator 3
Synonyms: 6332415K15Rik, 2610312F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70461
Homologene: 11248
Akr1e1
Name: aldo-keto reductase family 1, member E1
Synonyms: 1810061I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56043
Homologene: 74313
Gm5174
Name: predicted gene 5174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382395
VEGA: 10
Homologene: 141143
Olfr1133
Name: olfactory receptor 1133
Synonyms: GA_x6K02T2Q125-49151278-49150337, MOR176-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258348
Spint4
Name: serine protease inhibitor, Kunitz type 4
Synonyms: Spint4, 9230105I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78239
Homologene: 49932
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622486
Homologene: 128738
Gm10723
Name: predicted gene 10723
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Igkv10-94
Name: immunoglobulin kappa variable 10-94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667550
Gm14205
Name: predicted gene 14205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Rpl21-ps12
Name: ribosomal protein L21, pseudogene 12
Synonyms: Gm16376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043646
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 87,881,897 bp
  • T to C, chromosome 1 at 158,580,363 bp
  • G to A, chromosome 2 at 4,763,241 bp
  • A to G, chromosome 2 at 9,868,874 bp
  • T to A, chromosome 2 at 87,645,995 bp
  • A to G, chromosome 2 at 120,699,145 bp
  • A to G, chromosome 2 at 158,611,387 bp
  • T to C, chromosome 2 at 164,700,859 bp
  • T to A, chromosome 3 at 68,408,227 bp
  • T to C, chromosome 3 at 93,331,892 bp
  • T to C, chromosome 3 at 116,923,744 bp
  • C to A, chromosome 3 at 123,114,060 bp
  • T to G, chromosome 4 at 57,855,356 bp
  • A to G, chromosome 4 at 106,418,263 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • A to G, chromosome 4 at 123,139,908 bp
  • G to T, chromosome 5 at 33,158,241 bp
  • G to A, chromosome 5 at 135,429,247 bp
  • A to C, chromosome 5 at 138,065,184 bp
  • G to T, chromosome 5 at 145,218,641 bp
  • A to G, chromosome 6 at 23,002,582 bp
  • A to G, chromosome 6 at 37,903,604 bp
  • C to T, chromosome 6 at 68,704,598 bp
  • A to G, chromosome 6 at 87,076,255 bp
  • G to T, chromosome 6 at 90,845,287 bp
  • T to A, chromosome 7 at 6,708,260 bp
  • T to A, chromosome 7 at 43,189,335 bp
  • T to C, chromosome 7 at 80,618,610 bp
  • T to C, chromosome 7 at 127,392,487 bp
  • T to C, chromosome 7 at 127,595,948 bp
  • A to T, chromosome 9 at 37,239,157 bp
  • T to C, chromosome 9 at 78,061,426 bp
  • G to T, chromosome 10 at 86,656,698 bp
  • T to C, chromosome 11 at 29,707,924 bp
  • T to C, chromosome 11 at 58,900,589 bp
  • T to A, chromosome 11 at 74,122,051 bp
  • A to G, chromosome 11 at 97,067,953 bp
  • A to T, chromosome 12 at 8,005,912 bp
  • A to G, chromosome 12 at 108,327,778 bp
  • T to C, chromosome 13 at 4,607,547 bp
  • T to C, chromosome 13 at 108,373,842 bp
  • A to T, chromosome 14 at 52,410,445 bp
  • A to G, chromosome 14 at 61,211,983 bp
  • C to A, chromosome 14 at 70,571,992 bp
  • A to T, chromosome 15 at 44,529,566 bp
  • T to C, chromosome 15 at 71,970,336 bp
  • G to A, chromosome 15 at 101,352,185 bp
  • T to C, chromosome 16 at 32,975,807 bp
  • A to G, chromosome 16 at 37,061,383 bp
  • A to G, chromosome 17 at 14,336,573 bp
  • A to G, chromosome 17 at 35,660,786 bp
  • C to A, chromosome 18 at 44,006,454 bp
  • T to C, chromosome 18 at 71,306,088 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5292 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042875-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.