Strain Name:
C57BL/6J-MtgxR5292Btlr/Mmmh
Stock Number:
042875-MU
Citation ID:
RRID:MMRRC_042875-MU
Other Names:
R5292 (G1), C57BL/6J-MtgxR5292Btlr
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: Ptprz, Ptpz, Rptpbeta, RPTPz, DSD-1-PG, PTPbeta, phosphacan, PTPzeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20116
Homologene: 133143
Rtn4
Name: reticulon 4
Synonyms: 1110020G17Rik, NgA, C130026I10Rik, Nogo-A, Nogo-B, NOGO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68585
Homologene: 10743
Rnf40
Name: ring finger protein 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233900
Homologene: 8856
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, A130082H20Rik, D430004I05Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Depdc1b
Name: DEP domain containing 1B
Synonyms: XTP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218581
Homologene: 10157
Hip1
Name: huntingtin interacting protein 1
Synonyms: E130315I21Rik, 2610109B09Rik, HIP-1, A930014B11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Smoc2
Name: SPARC related modular calcium binding 2
Synonyms: Smoc2l, 1700056C05Rik, 5430426J21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64074
VEGA: 17
Homologene: 11150
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Zkscan5
Name: zinc finger with KRAB and SCAN domains 5
Synonyms: Zfp95, hKraba1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22757
Homologene: 8734
Peg3
Name: paternally expressed 3
Synonyms: Zfp102, End4, Gcap4, Pw1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Dcc
Name: DCC netrin 1 receptor
Synonyms: C030036D22Rik, deleted in colorectal carcinoma, Igdcc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: rh-bmh, bldy, N, rh, ba
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Gfpt1
Name: glutamine fructose-6-phosphate transaminase 1
Synonyms: GFAT, GFAT1, 2810423A18Rik, GFA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14583
HGNC: HGNC:4241
Homologene: 68220
Ppie
Name: peptidylprolyl isomerase E (cyclophilin E)
Synonyms: 2010010D16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56031
HGNC: HGNC:9258
Homologene: 38142
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: LOC385628, 2210409B11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70144
Homologene: 13111
Osbpl7
Name: oxysterol binding protein-like 7
Synonyms: 4933437E18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71240
Homologene: 79672
Akap2
Name: A kinase (PRKA) anchor protein 2
Synonyms: B230340M18Rik, AKAP-KL
Type: Gene
Species: Mouse
Chromosome: 4
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Astn1
Name: astrotactin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, Kif16a, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Gata3
Name: GATA binding protein 3
Synonyms: jal, Gata-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68915
Homologene: 57502
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: 2310067L16Rik, C80743
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69700
Homologene: 43567
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, 9530006G20Rik, Myo, 2310068J10Rik, 1110069I04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 118449
Homologene: 15400
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Hhipl1
Name: hedgehog interacting protein-like 1
Synonyms: 1600002O04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 214305
VEGA: 12
Homologene: 81985
Palmd
Name: palmdelphin
Synonyms: PALML, 4631423C22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114301
Homologene: 9804
Hrnr
Name: hornerin
Synonyms: A530063N20Rik, S100a18, 1110033K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68723
Homologene: 138092
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: sodium glucose cotransporter 1, Sglt1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20537
Homologene: 55456
Or10g1
Name: olfactory receptor family 10 subfamily G member 1
Synonyms: GA_x6K02T2RJGY-583652-584608, Olfr1510, MOR223-6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Krt80
Name: keratin 80
Synonyms: Kb20, 2310041I20Rik, 1200016G03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74127
VEGA: 15
Homologene: 66610
Zfp936
Name: zinc finger protein 936
Synonyms: Gm9272, EG435970, I1C0022H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668620
Zfp39
Name: zinc finger protein 39
Synonyms: Zfp-39, CTfin33
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22698
Homologene: 69102
Slc37a2
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 2
Synonyms: ci2, Slc37a1, G3PP, cI-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56857
Homologene: 41357
Or3a1b
Name: olfactory receptor family 3 subfamily A member 1B
Synonyms: GA_x6K02T2P1NL-4278037-4278984, MOR255-6, Olfr401
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258701
HGNC: HGNC:8282
Homologene: 73922
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Gcm1
Name: glial cells missing homolog 1
Synonyms: GCMa, glide, Gcm a, glial cell deficient, Gcm1-rs1, Gcm 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Bend7
Name: BEN domain containing 7
Synonyms: 1110017O21Rik, E130319B15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209645
Homologene: 17660
Crtc3
Name: CREB regulated transcription coactivator 3
Synonyms: 6332415K15Rik, 2610312F20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70461
Homologene: 11248
Akr1e1
Name: aldo-keto reductase family 1, member E1
Synonyms: 1810061I10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56043
Homologene: 74313
Gm5174
Name: predicted gene 5174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382395
VEGA: 10
Homologene: 141143
Or5w1b
Name: olfactory receptor family 5 subfamily W member 1B
Synonyms: MOR176-2, GA_x6K02T2Q125-49151278-49150337, Olfr1133
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258348
Spint4
Name: serine protease inhibitor, Kunitz type 4
Synonyms: 9230105I15Rik, Spint4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78239
Homologene: 49932
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Gm10723
Name: predicted gene 10723
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Igkv10-94
Name: immunoglobulin kappa variable 10-94
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667550
Gm14205
Name: predicted gene 14205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Rpl21-ps12
Name: ribosomal protein L21, pseudogene 12
Synonyms: Gm16376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043646
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 87,881,897 bp
  • T to C, chromosome 1 at 158,580,363 bp
  • G to A, chromosome 2 at 4,763,241 bp
  • A to G, chromosome 2 at 9,868,874 bp
  • T to A, chromosome 2 at 87,645,995 bp
  • A to G, chromosome 2 at 120,699,145 bp
  • A to G, chromosome 2 at 158,611,387 bp
  • T to C, chromosome 2 at 164,700,859 bp
  • T to A, chromosome 3 at 68,408,227 bp
  • T to C, chromosome 3 at 93,331,892 bp
  • T to C, chromosome 3 at 116,923,744 bp
  • C to A, chromosome 3 at 123,114,060 bp
  • T to G, chromosome 4 at 57,855,356 bp
  • A to G, chromosome 4 at 106,418,263 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • A to G, chromosome 4 at 123,139,908 bp
  • G to T, chromosome 5 at 33,158,241 bp
  • G to A, chromosome 5 at 135,429,247 bp
  • A to C, chromosome 5 at 138,065,184 bp
  • G to T, chromosome 5 at 145,218,641 bp
  • A to G, chromosome 6 at 23,002,582 bp
  • A to G, chromosome 6 at 37,903,604 bp
  • C to T, chromosome 6 at 68,704,598 bp
  • A to G, chromosome 6 at 87,076,255 bp
  • G to T, chromosome 6 at 90,845,287 bp
  • T to A, chromosome 7 at 6,708,260 bp
  • T to A, chromosome 7 at 43,189,335 bp
  • T to C, chromosome 7 at 80,618,610 bp
  • T to C, chromosome 7 at 127,392,487 bp
  • T to C, chromosome 7 at 127,595,948 bp
  • A to T, chromosome 9 at 37,239,157 bp
  • T to C, chromosome 9 at 78,061,426 bp
  • G to T, chromosome 10 at 86,656,698 bp
  • T to C, chromosome 11 at 29,707,924 bp
  • T to C, chromosome 11 at 58,900,589 bp
  • T to A, chromosome 11 at 74,122,051 bp
  • A to G, chromosome 11 at 97,067,953 bp
  • A to T, chromosome 12 at 8,005,912 bp
  • A to G, chromosome 12 at 108,327,778 bp
  • T to C, chromosome 13 at 4,607,547 bp
  • T to C, chromosome 13 at 108,373,842 bp
  • A to T, chromosome 14 at 52,410,445 bp
  • A to G, chromosome 14 at 61,211,983 bp
  • C to A, chromosome 14 at 70,571,992 bp
  • A to T, chromosome 15 at 44,529,566 bp
  • T to C, chromosome 15 at 71,970,336 bp
  • G to A, chromosome 15 at 101,352,185 bp
  • T to C, chromosome 16 at 32,975,807 bp
  • A to G, chromosome 16 at 37,061,383 bp
  • A to G, chromosome 17 at 14,336,573 bp
  • A to G, chromosome 17 at 35,660,786 bp
  • C to A, chromosome 18 at 44,006,454 bp
  • T to C, chromosome 18 at 71,306,088 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5292 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042875-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.