Strain Name:
C57BL/6J-MtgxR5293Btlr/Mmmh
Stock Number:
042876-MU
Citation ID:
RRID:MMRRC_042876-MU
Other Names:
R5293 (G1), C57BL/6J-MtgxR5293Btlr
Major Collection:

Gene Information

Kcnc1
Name: potassium voltage gated channel, Shaw-related subfamily, member 1
Synonyms: Kv3.1, KV4, NGK2, KShIIIB, Kcr2-1, Shaw, C230009H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16502
HGNC: HGNC:6233
Homologene: 68134
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56381
Homologene: 124461
Inpp5k
Name: inositol polyphosphate 5-phosphatase K
Synonyms: C62, PI-5-phosphatase related, putative PI-5-phosphatase, Pps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19062
Homologene: 75059
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76464
Homologene: 44890
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: SLC41A1-L2, 1010001P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71699
Homologene: 23052
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Copg2
Name: coatomer protein complex, subunit gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54160
HGNC: HGNC:2237
Homologene: 56292
Crtc2
Name: CREB regulated transcription coactivator 2
Synonyms: 4632407F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74343
Homologene: 18765
Plcxd2
Name: phosphatidylinositol-specific phospholipase C, X domain containing 2
Synonyms: EG433022
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 433022
Homologene: 44374
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20739
Homologene: 74460
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320714
Homologene: 11076
Ccdc116
Name: coiled-coil domain containing 116
Synonyms: 4930432J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 76872
Homologene: 51873
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71096
Homologene: 56834
Psmc1
Name: protease (prosome, macropain) 26S subunit, ATPase 1
Synonyms: P26s4, S4, rpt2, Rpt2/S4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19179
VEGA: 12
HGNC: HGNC:9547
Homologene: 2095
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: PYPAF2, E330007A02Rik, Nalp2, Pan1, Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69847
Homologene: 13020
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: A230020K05Rik, 2810407D09Rik, 3321401G04Rik, Fam115a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77574
Homologene: 8815
Foxa2
Name: forkhead box A2
Synonyms: Hnf-3b, Tcf-3b, Tcf3b, Hnf3b, HNF3beta, HNF3-beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15376
HGNC: HGNC:5022
Homologene: 7762
Spag4
Name: sperm associated antigen 4
Synonyms: 1700041K21Rik, Sun4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 245865
Homologene: 2343
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, Tj6, ATP6a2, Atp6n2, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21871
Homologene: 56523
Atxn1
Name: ataxin 1
Synonyms: Atx1, Sca1, 2900016G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Ybx2
Name: Y box protein 2
Synonyms: MSY2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53422
Homologene: 22942
Mmp19
Name: matrix metallopeptidase 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 58223
VEGA: 10
HGNC: HGNC:7165
Homologene: 1820
Olfr1309
Name: olfactory receptor 1309
Synonyms: GA_x6K02T2Q125-73031456-73030518, MOR245-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258439
Homologene: 74054
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: 4931400F03Rik, eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74053
Homologene: 12938
Ssrp1
Name: structure specific recognition protein 1
Synonyms: T160, Hmgi-rs3, Hmgox, Hmg1-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
Mrpl38
Name: mitochondrial ribosomal protein L38
Synonyms: MRP-L3, Rpml3, 4733401F03Rik, 1110036N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 60441
Homologene: 11476
Olfr131
Name: olfactory receptor 131
Synonyms: MOR256-4, GA_x6K02T2PSCP-2531299-2530355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258867
Homologene: 105889
Duoxa1
Name: dual oxidase maturation factor 1
Synonyms: Nip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 213696
Homologene: 16043
Spc25
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms: 2610205L13Rik, 2600017H08Rik, Spbc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66442
Homologene: 41387
Akr7a5
Name: aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)
Synonyms: 0610025K21Rik, Afar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110198
Homologene: 2737
Olfr668
Name: olfactory receptor 668
Synonyms: GA_x6K02T2PBJ9-7554614-7553658, MOR34-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259061
Homologene: 64947
Myl7
Name: myosin, light polypeptide 7, regulatory
Synonyms: RLC-A, MLC2a, MLC-2alpha, Mylc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17898
Homologene: 23290
Rbfa
Name: ribosome binding factor A
Synonyms: 1110032A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 68731
VEGA: 18
Homologene: 11725
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 8,595,533 bp
  • T to C, chromosome 1 at 20,509,076 bp
  • CCCTCCTCCTCCTCCTCCTCCTCCTC to CCCTCCTCCTCCTCCTCCTCCTC, chromosome 1 at 87,503,429 bp
  • T to C, chromosome 1 at 174,195,985 bp
  • A to G, chromosome 2 at 69,202,652 bp
  • T to C, chromosome 2 at 76,740,932 bp
  • T to A, chromosome 2 at 85,042,252 bp
  • T to G, chromosome 2 at 111,983,266 bp
  • T to C, chromosome 2 at 119,069,695 bp
  • C to T, chromosome 2 at 122,305,636 bp
  • T to C, chromosome 2 at 148,044,002 bp
  • A to G, chromosome 2 at 156,066,191 bp
  • A to G, chromosome 3 at 90,263,564 bp
  • G to T, chromosome 4 at 139,314,206 bp
  • G to A, chromosome 4 at 141,472,406 bp
  • C to T, chromosome 5 at 3,948,687 bp
  • A to T, chromosome 5 at 124,646,709 bp
  • T to A, chromosome 6 at 30,826,227 bp
  • T to C, chromosome 6 at 42,678,823 bp
  • T to A, chromosome 6 at 90,626,444 bp
  • A to C, chromosome 7 at 5,327,615 bp
  • A to G, chromosome 7 at 46,397,811 bp
  • GGCCAGC to G, chromosome 7 at 80,098,349 bp
  • T to C, chromosome 7 at 104,925,279 bp
  • A to G, chromosome 8 at 24,810,706 bp
  • G to A, chromosome 8 at 47,493,342 bp
  • T to C, chromosome 10 at 119,897,735 bp
  • T to A, chromosome 10 at 128,791,101 bp
  • T to A, chromosome 11 at 5,898,521 bp
  • T to C, chromosome 11 at 69,941,066 bp
  • T to C, chromosome 11 at 75,637,363 bp
  • C to T, chromosome 11 at 83,981,499 bp
  • T to G, chromosome 11 at 101,275,197 bp
  • T to C, chromosome 11 at 116,132,773 bp
  • C to T, chromosome 12 at 100,115,472 bp
  • C to T, chromosome 13 at 45,568,368 bp
  • T to C, chromosome 15 at 44,535,750 bp
  • C to G, chromosome 15 at 76,199,583 bp
  • A to G, chromosome 15 at 100,703,501 bp
  • A to T, chromosome 16 at 17,141,787 bp
  • G to T, chromosome 16 at 45,980,343 bp
  • T to A, chromosome 17 at 38,082,240 bp
  • T to C, chromosome 18 at 80,192,766 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5293 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042876-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.