Strain Name:
C57BL/6J-MtgxR5342Btlr/Mmmh
Stock Number:
042921-MU
Citation ID:
RRID:MMRRC_042921-MU
Other Names:
R5342 (G1), C57BL/6J-MtgxR5342Btlr
Major Collection:

Gene Information

Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224273
Homologene: 28544
Prkca
Name: protein kinase C, alpha
Synonyms: Pkca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18750
HGNC: HGNC:9393
Homologene: 55679
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, C030004M05Rik, 2410024A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Vim
Name: vimentin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22352
Homologene: 2538
Eif3b
Name: eukaryotic translation initiation factor 3, subunit B
Synonyms: EIF3-P116, D5Wsu45e, Eif3s9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27979
HGNC: HGNC:3280
Homologene: 2780
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224585
VEGA: 17
Homologene: 137372
Unc5b
Name: unc-5 netrin receptor B
Synonyms: 6330415E02Rik, Unc5h2, D10Bwg0792e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Peg3
Name: paternally expressed 3
Synonyms: Pw1, Zfp102, End4, Gcap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Morc1
Name: microrchidia 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17450
VEGA: 16
HGNC: HGNC:7198
Homologene: 7843
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69710
Homologene: 12326
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 214764
Homologene: 27985
Klhl26
Name: kelch-like 26
Synonyms: C630013N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234378
Homologene: 41247
Raver2
Name: ribonucleoprotein, PTB-binding 2
Synonyms: A430091O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242570
Homologene: 18829
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, SEC3, A730011E05Rik, 2810407P21Rik, Sec3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69940
Homologene: 41241
Dusp27
Name: dual specificity phosphatase 27 (putative)
Synonyms: C130085G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240892
Homologene: 18949
Scn2b
Name: sodium channel, voltage-gated, type II, beta
Synonyms: LOC214238, 2810451E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72821
VEGA: 9
Homologene: 3373
Pak2
Name: p21 (RAC1) activated kinase 2
Synonyms: PAK-2, A130002K10Rik, D16Ertd269e, 5330420P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224105
HGNC: HGNC:8591
Homologene: 99711
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408066
Apol7d
Name: apolipoprotein L 7d
Synonyms: ENSMUSG00000073652, Gm15456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100042814
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Dcdc5
Name: doublecortin domain containing 5
Synonyms: 4732421G10Rik, EG436559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329482
Homologene: 79722
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Olfr457
Name: olfactory receptor 457
Synonyms: GA_x6K02T2P3E9-5088893-5089834, MOR257-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258989
Homologene: 133701
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Sdr16c6
Name: short chain dehydrogenase/reductase family 16C, member 6
Synonyms: 4833413O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242286
Homologene: 135698
Klhl42
Name: kelch-like 42
Synonyms: C230080I20Rik, Klhdc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232539
Homologene: 45842
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 77945
Homologene: 10679
Nxpe5
Name: neurexophilin and PC-esterase domain family, member 5
Synonyms: Fam55 related, BC055004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381680
Homologene: 134143
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74711
Homologene: 41769
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 9430041O17Rik, 2010203O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234214
Homologene: 83295
Clec2g
Name: C-type lectin domain family 2, member g
Synonyms: 4632413B12Rik, Ocilrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70809
Homologene: 136309
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244810
Atp1b2
Name: ATPase, Na+/K+ transporting, beta 2 polypeptide
Synonyms: Atpb-2, Amog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11932
HGNC: HGNC:805
Homologene: 36075
Ces4a
Name: carboxylesterase 4A
Synonyms: Ces8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234677
Homologene: 71949
Gm7334
Name: predicted gene 7334
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 654432
VEGA: 17
Ercc3
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3
Synonyms: XPB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13872
HGNC: HGNC:3435
Homologene: 96
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Olfr857
Name: olfactory receptor 857
Synonyms: GA_x6K02T2PVTD-13452606-13453535, MOR146-8P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257963
Homologene: 134093
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Olfr617
Name: olfactory receptor 617
Synonyms: GA_x6K02T2PBJ9-6306819-6307775, MOR31-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258838
Homologene: 105208
Adrb3
Name: adrenergic receptor, beta 3
Synonyms: beta 3-AR, Beta-3 adrenoceptor, Beta-3 AR, beta3-adrenergic receptor, Adrb-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11556
HGNC: HGNC:288
Homologene: 37250
Eci2
Name: enoyl-Coenzyme A delta isomerase 2
Synonyms: HCA88, DRS1, ACBD2, Peci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 23986
Homologene: 38145
Gm6498
Name: predicted gene 6498
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 624367
Cdca7l
Name: cell division cycle associated 7 like
Synonyms: JPO2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217946
Homologene: 10285
Sgpp2
Name: sphingosine-1-phosphate phosphatase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433323
Homologene: 51848
BC023105
Name: cDNA sequence BC023105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667597
VEGA: 18
Mthfr-ps1
Name: 5,10-methylenetetrahydrofolate reductase, pseudogene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 387594
Stk16
Name: serine/threonine kinase 16
Synonyms: Embryo-Derived Protein Kinase, EDPK, Krct, PKL12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20872
Homologene: 2739
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 664821
Homologene: 133217
Gm14407
Name: predicted gene 14407
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108168840
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 71,660,806 bp
  • T to A, chromosome 1 at 75,212,965 bp
  • A to G, chromosome 1 at 78,360,188 bp
  • T to C, chromosome 1 at 166,110,250 bp
  • T to A, chromosome 2 at 13,580,013 bp
  • T to A, chromosome 2 at 67,513,461 bp
  • T to A, chromosome 2 at 106,385,504 bp
  • C to A, chromosome 2 at 152,991,652 bp
  • C to A, chromosome 2 at 177,085,598 bp
  • A to G, chromosome 3 at 122,426,649 bp
  • T to C, chromosome 4 at 4,069,923 bp
  • C to A, chromosome 4 at 101,102,692 bp
  • A to G, chromosome 5 at 76,567,014 bp
  • T to A, chromosome 5 at 78,474,432 bp
  • T to C, chromosome 5 at 138,239,241 bp
  • T to C, chromosome 5 at 140,425,280 bp
  • A to G, chromosome 6 at 42,471,902 bp
  • C to T, chromosome 6 at 128,948,751 bp
  • C to T, chromosome 6 at 147,092,286 bp
  • A to T, chromosome 7 at 6,709,970 bp
  • G to A, chromosome 7 at 101,404,960 bp
  • C to T, chromosome 7 at 103,584,828 bp
  • T to A, chromosome 7 at 133,651,910 bp
  • A to C, chromosome 8 at 27,226,781 bp
  • T to A, chromosome 8 at 45,796,013 bp
  • A to G, chromosome 8 at 70,455,565 bp
  • A to G, chromosome 8 at 105,146,143 bp
  • A to G, chromosome 9 at 19,713,037 bp
  • A to T, chromosome 9 at 39,594,551 bp
  • A to G, chromosome 9 at 45,125,518 bp
  • G to A, chromosome 9 at 72,910,627 bp
  • A to T, chromosome 9 at 73,930,823 bp
  • T to A, chromosome 10 at 60,778,267 bp
  • C to T, chromosome 11 at 69,602,828 bp
  • A to T, chromosome 11 at 108,192,154 bp
  • G to A, chromosome 12 at 17,369,620 bp
  • G to T, chromosome 12 at 105,658,916 bp
  • A to G, chromosome 12 at 117,877,033 bp
  • C to T, chromosome 13 at 34,978,724 bp
  • T to C, chromosome 13 at 95,041,990 bp
  • T to C, chromosome 13 at 113,366,269 bp
  • A to G, chromosome 14 at 48,227,391 bp
  • G to A, chromosome 14 at 52,145,209 bp
  • G to T, chromosome 15 at 4,914,133 bp
  • T to C, chromosome 16 at 32,044,488 bp
  • G to T, chromosome 16 at 48,618,509 bp
  • A to T, chromosome 16 at 59,522,149 bp
  • T to G, chromosome 17 at 14,001,098 bp
  • T to G, chromosome 17 at 21,020,733 bp
  • A to G, chromosome 17 at 50,698,754 bp
  • A to G, chromosome 18 at 32,245,595 bp
  • A to G, chromosome 18 at 36,974,671 bp
  • A to T, chromosome 18 at 49,951,235 bp
  • A to G, chromosome 18 at 60,441,934 bp
  • G to A, chromosome 19 at 48,796,472 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5342 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042921-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.