Strain Name:
C57BL/6J-MtgxR5379Btlr/Mmmh
Stock Number:
042954-MU
Citation ID:
RRID:MMRRC_042954-MU
Other Names:
R5379 (G1), C57BL/6J-MtgxR5379Btlr
Major Collection:

Gene Information

B4galt6
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 56386
VEGA: 18
HGNC: HGNC:929
Homologene: 3506
Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms: Atpa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11928
HGNC: HGNC:799
Homologene: 564
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 2610019N13Rik, 0610009J05Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69207
Homologene: 36164
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: rabaptin-5, neurocrescin, RAB5 effector protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54189
Homologene: 3451
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: 2810001M05Rik, Prp10, Targ4, SF3b155, SAP155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 81898
Homologene: 6696
Larp4b
Name: La ribonucleoprotein domain family, member 4B
Synonyms: Larp5, D13Wsu64e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217980
Homologene: 18195
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
R3hdm2
Name: R3H domain containing 2
Synonyms: 1300003K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71750
Homologene: 8954
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109331
Homologene: 5571
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, Ki67, D630048A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: coronin 3, CRN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: Sin3, mSin3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20466
Homologene: 32124
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: D12Ertd549e, 2810011H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Adcy1
Name: adenylate cyclase 1
Synonyms: D11Bwg1392e, I-AC, AC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235604
Homologene: 56983
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Wcrf180, Acf1, Gtl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Sema4a
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Synonyms: Semab, SemB, SemB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20351
Homologene: 8425
Ttyh1
Name: tweety family member 1
Synonyms: tty, 4930459B04Rik, 6330408P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57776
Homologene: 10779
Fbxo33
Name: F-box protein 33
Synonyms: 5730501N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70611
Homologene: 16501
Trpc7
Name: transient receptor potential cation channel, subfamily C, member 7
Synonyms: Trrp8, TRP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26946
Homologene: 22689
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Bmper
Name: BMP-binding endothelial regulator
Synonyms: Cv2, 3110056H04Rik, crossveinless-2, CV-2, Crim3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73230
VEGA: 9
Homologene: 12494
Nlrc4
Name: NLR family, CARD domain containing 4
Synonyms: Card12, 9530011P19Rik, Ipaf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268973
VEGA: 17
Homologene: 10924
Itgam
Name: integrin alpha M
Synonyms: CR3, Mac-1a, Ly-40, CD11b/CD18, Mac-1, F730045J24Rik, Cd11b, Mac-1 alpha, CD11B (p170), complement component receptor 3 alpha, complement receptor type 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Fat2
Name: FAT atypical cadherin 2
Synonyms: Fath2, EMI2, mKIAA0811, LOC245827
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, 1110021D17Rik, Polydom, D430029O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Afap1l1
Name: actin filament associated protein 1-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106877
Homologene: 18728
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Hc
Name: hemolytic complement
Synonyms: C5, C5a, Hfib2, He
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Kif9
Name: kinesin family member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16578
Homologene: 65620
Farp1
Name: FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Synonyms: Cdep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Tnfaip3
Name: tumor necrosis factor, alpha-induced protein 3
Synonyms: A20, Tnfip3, zinc finger protein A20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21929
Homologene: 4582
Gm13023
Name: predicted gene 13023
Synonyms: MGC:91194
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194227
Homologene: 103830
Gtf2ird2
Name: GTF2I repeat domain containing 2
Synonyms: 1700012P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 114674
Homologene: 24941
Vmn1r170
Name: vomeronasal 1 receptor 170
Synonyms: Gm5999
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546944
Homologene: 128341
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: equatorin, 1700028B15Rik, 4930579C15Rik, Afaf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Zfp454
Name: zinc finger protein 454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237758
Homologene: 72226
Ranbp6
Name: RAN binding protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240614
HGNC: HGNC:9851
Homologene: 18935
Sp140
Name: Sp140 nuclear body protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 434484
Homologene: 128391
Olfr933
Name: olfactory receptor 933
Synonyms: MOR171-22, GA_x6K02T2PVTD-32671531-32672457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258433
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Chst8
Name: carbohydrate sulfotransferase 8
Synonyms: 1500011J21Rik, GalNAc4ST-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68947
Homologene: 41483
Parva
Name: parvin, alpha
Synonyms: CH-ILKBP, actopaxin, 2010012A22Rik, 5430400F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57342
Homologene: 10077
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230025
Homologene: 11000
Zfp184
Name: zinc finger protein 184 (Kruppel-like)
Synonyms: 4930500C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 193452
Homologene: 113602
Proca1
Name: protein interacting with cyclin A1
Synonyms: 4933404M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216974
Homologene: 51856
Fndc5
Name: fibronectin type III domain containing 5
Synonyms: Pxp, PeP, 1500001L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 384061
Homologene: 17812
Tex47
Name: testis expressed 47
Synonyms: 4921511H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70920
Homologene: 41723
Fancg
Name: Fanconi anemia, complementation group G
Synonyms: Xrcc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 60534
HGNC: HGNC:3588
Homologene: 3402
Orm1
Name: orosomucoid 1
Synonyms: Orm-1, Agp-1, Agp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18405
HGNC: HGNC:8499
Homologene: 130632
Olfr836
Name: olfactory receptor 836
Synonyms: MOR152-3, GA_x6K02T2PVTD-12857805-12858749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258557
Homologene: 115507
Dpf1
Name: D4, zinc and double PHD fingers family 1
Synonyms: Neud4, neuro-d4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29861
Homologene: 3415
Olfr157
Name: olfactory receptor 157
Synonyms: Olfr37c, OR37C, mOR37c, MOR262-12, GA_x6K02T2N78B-16110014-16110970
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100040268
Homologene: 133619
Ighv1-82
Name: immunoglobulin heavy variable 1-82
Synonyms: Gm16747
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100775175
Dnajb1
Name: DnaJ heat shock protein family (Hsp40) member B1
Synonyms: 0610007I11Rik, Hsp40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 81489
HGNC: HGNC:5270
Homologene: 55957
Mrgprb13
Name: MAS-related GPR, member B13
Synonyms: MrgB13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620137
Homologene: 83620
Gm11738
Name: predicted gene 11738
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 55,003,150 bp
  • T to A, chromosome 1 at 85,610,828 bp
  • G to A, chromosome 2 at 31,409,011 bp
  • A to T, chromosome 2 at 34,991,065 bp
  • T to A, chromosome 2 at 181,235,069 bp
  • T to C, chromosome 3 at 88,437,194 bp
  • T to A, chromosome 3 at 101,582,095 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • T to C, chromosome 4 at 21,678,977 bp
  • A to G, chromosome 4 at 43,002,998 bp
  • A to G, chromosome 4 at 43,836,010 bp
  • T to A, chromosome 4 at 49,652,639 bp
  • A to G, chromosome 4 at 58,072,991 bp
  • A to G, chromosome 4 at 63,345,993 bp
  • A to G, chromosome 4 at 94,907,588 bp
  • A to T, chromosome 4 at 129,142,094 bp
  • A to G, chromosome 4 at 143,794,923 bp
  • G to A, chromosome 5 at 7,304,843 bp
  • A to G, chromosome 5 at 113,845,382 bp
  • G to C, chromosome 5 at 134,217,468 bp
  • C to T, chromosome 7 at 4,133,393 bp
  • A to T, chromosome 7 at 23,606,629 bp
  • A to G, chromosome 7 at 29,304,108 bp
  • A to G, chromosome 7 at 34,675,854 bp
  • A to T, chromosome 7 at 48,311,748 bp
  • A to T, chromosome 7 at 112,579,720 bp
  • A to G, chromosome 7 at 128,112,388 bp
  • T to C, chromosome 7 at 135,697,461 bp
  • C to T, chromosome 8 at 83,608,506 bp
  • A to T, chromosome 9 at 19,121,077 bp
  • T to A, chromosome 9 at 23,297,224 bp
  • T to C, chromosome 9 at 38,975,855 bp
  • T to C, chromosome 9 at 57,110,988 bp
  • T to C, chromosome 9 at 107,945,346 bp
  • T to C, chromosome 9 at 110,521,303 bp
  • T to A, chromosome 10 at 19,004,863 bp
  • T to C, chromosome 10 at 127,471,902 bp
  • T to A, chromosome 11 at 7,146,532 bp
  • T to C, chromosome 11 at 50,883,802 bp
  • T to C, chromosome 11 at 55,303,941 bp
  • A to T, chromosome 11 at 70,908,421 bp
  • C to A, chromosome 11 at 78,205,266 bp
  • G to A, chromosome 11 at 97,669,500 bp
  • T to C, chromosome 11 at 118,117,203 bp
  • T to G, chromosome 12 at 54,894,348 bp
  • A to G, chromosome 12 at 59,219,460 bp
  • T to C, chromosome 12 at 111,543,555 bp
  • T to C, chromosome 12 at 115,952,677 bp
  • T to C, chromosome 13 at 3,588,496 bp
  • C to A, chromosome 13 at 9,136,909 bp
  • A to G, chromosome 13 at 21,959,881 bp
  • A to G, chromosome 13 at 56,804,550 bp
  • T to C, chromosome 14 at 121,256,757 bp
  • C to A, chromosome 15 at 47,636,450 bp
  • A to T, chromosome 17 at 74,448,083 bp
  • A to C, chromosome 17 at 86,001,536 bp
  • T to C, chromosome 18 at 20,689,239 bp
  • T to C, chromosome 18 at 61,758,650 bp
  • A to G, chromosome 19 at 29,811,683 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5379 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042954-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.