Strain Name:
C57BL/6J-MtgxR5392Btlr/Mmmh
Stock Number:
042964-MU
Citation ID:
RRID:MMRRC_042964-MU
Other Names:
R5392 (G1), C57BL/6J-MtgxR5392Btlr
Major Collection:

Gene Information

Drd2
Name: dopamine receptor D2
Synonyms: D2 receptor, Drd-2, D2R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Mta1
Name: metastasis associated 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 116870
HGNC: HGNC:7410
Homologene: 3442
Kdsr
Name: 3-ketodihydrosphingosine reductase
Synonyms: 9430079B08Rik, Fvt1, 6330410P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70750
HGNC: HGNC:4021
Homologene: 1539
Kif15
Name: kinesin family member 15
Synonyms: Knsl7, HKLP2, 3930402I10Rik, 3110023M17Rik, N-10 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227800
Homologene: 49301
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Prss16
Name: protease, serine 16 (thymus)
Synonyms: TSSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 54373
HGNC: HGNC:9480
Homologene: 38106
Irak4
Name: interleukin-1 receptor-associated kinase 4
Synonyms: IRAK-4, 9330209D03Rik, 8430405M07Rik, NY-REN-64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 266632
Homologene: 41109
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: A330049M09Rik, C130039F11Rik, SYNE-1, nesprin-1, enaptin165
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Dcp1b
Name: decapping mRNA 1B
Synonyms: B930050E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319618
Homologene: 51881
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, 3110056M06Rik, LOC242555
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67299
Homologene: 23566
Fndc3b
Name: fibronectin type III domain containing 3B
Synonyms: fad104, 1600019O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72007
Homologene: 11244
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
Gfpt1
Name: glutamine fructose-6-phosphate transaminase 1
Synonyms: GFAT, 2810423A18Rik, GFAT1, GFA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14583
HGNC: HGNC:4241
Homologene: 68220
Syt2
Name: synaptotagmin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20980
Homologene: 22516
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
N4bp1
Name: NEDD4 binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80750
Homologene: 23703
Zp2
Name: zona pellucida glycoprotein 2
Synonyms: Zp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22787
Homologene: 48194
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Gm1027, Heatr8, LOC381538
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381538
Homologene: 19633
Kmt5b
Name: lysine methyltransferase 5B
Synonyms: Suv4-20h1, Suv420h1, C630029K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225888
Homologene: 32351
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Rad9b
Name: RAD9 checkpoint clamp component B
Synonyms: A630082N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231724
Homologene: 17006
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: ANG1, 3110041O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73166
Homologene: 68305
Arvcf
Name: armadillo repeat gene deleted in velocardiofacial syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11877
HGNC: HGNC:728
Homologene: 31046
Frmd4a
Name: FERM domain containing 4A
Synonyms: Gm13190, 2700017I06Rik, C230040M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Olfr215
Name: olfactory receptor 215
Synonyms: GA_x54KRFPKN04-58217732-58216800, MOR119-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258438
Homologene: 133693
Olfr353
Name: olfactory receptor 353
Synonyms: MOR127-3, GA_x6K02T2NLDC-33585366-33584431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258943
HGNC: HGNC:8221
Homologene: 115503
Zfp658
Name: zinc finger protein 658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210104
Homologene: 134007
Epsti1
Name: epithelial stromal interaction 1 (breast)
Synonyms: BRESI1, 5033415K03Rik, 2310046K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108670
VEGA: 14
Homologene: 12630
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 104349
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74121
Homologene: 75083
Cyth4
Name: cytohesin 4
Synonyms: 2510004M07Rik, 5830469K17Rik, Pscd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72318
VEGA: 15
HGNC: HGNC:9505
Homologene: 22750
Vmn1r174
Name: vomeronasal 1 receptor 174
Synonyms: V1rd22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404291
Homologene: 79577
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Krtcap2
Name: keratinocyte associated protein 2
Synonyms: 0610010I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66059
Homologene: 15494
Olfr809
Name: olfactory receptor 809
Synonyms: GA_x6K02T2PULF-11454600-11455541, MOR108-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258321
Homologene: 138308
Vps9d1
Name: VPS9 domain containing 1
Synonyms: 2410004N05Rik, 1300018I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72325
Homologene: 21021
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435916
Homologene: 135826
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: spastic paraplegia 7 homolog (human), Cmar, paraplegin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234847
Homologene: 31133
Cpa5
Name: carboxypeptidase A5
Synonyms: 4930430M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74649
Homologene: 62246
Acyp1
Name: acylphosphatase 1, erythrocyte (common) type
Synonyms: 1110039O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66204
HGNC: HGNC:179
Homologene: 11932
Spink2
Name: serine peptidase inhibitor, Kazal type 2
Synonyms: 1700007F22Rik, HUSI-II, acrosin-trypsin inhibitor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69982
Homologene: 134017
Zfp51
Name: zinc finger protein 51
Synonyms: Zfp-51, zfec12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22709
VEGA: 17
Homologene: 134003
Gm21759
Name: predicted gene, 21759
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 102633023
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 90,801,295 bp
  • T to A, chromosome 1 at 106,753,241 bp
  • A to G, chromosome 1 at 134,744,021 bp
  • C to T, chromosome 2 at 4,594,573 bp
  • T to A, chromosome 2 at 36,890,674 bp
  • T to A, chromosome 2 at 37,469,489 bp
  • T to C, chromosome 2 at 128,010,168 bp
  • A to T, chromosome 3 at 27,465,787 bp
  • C to T, chromosome 3 at 89,246,879 bp
  • A to G, chromosome 4 at 99,008,006 bp
  • A to G, chromosome 4 at 106,711,251 bp
  • T to C, chromosome 5 at 8,179,735 bp
  • T to A, chromosome 5 at 77,207,025 bp
  • T to C, chromosome 5 at 120,916,940 bp
  • A to T, chromosome 5 at 122,351,578 bp
  • C to T, chromosome 6 at 30,630,830 bp
  • A to G, chromosome 6 at 87,077,157 bp
  • A to G, chromosome 6 at 116,582,418 bp
  • G to A, chromosome 6 at 119,206,487 bp
  • A to T, chromosome 6 at 123,704,364 bp
  • A to G, chromosome 7 at 23,754,802 bp
  • A to C, chromosome 7 at 43,572,931 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • C to A, chromosome 7 at 120,135,764 bp
  • A to G, chromosome 8 at 86,860,420 bp
  • G to A, chromosome 8 at 93,071,962 bp
  • T to C, chromosome 8 at 123,087,363 bp
  • T to C, chromosome 8 at 123,254,013 bp
  • A to G, chromosome 9 at 49,395,628 bp
  • T to C, chromosome 9 at 122,996,295 bp
  • T to A, chromosome 10 at 5,348,661 bp
  • A to G, chromosome 10 at 129,776,315 bp
  • T to C, chromosome 12 at 85,278,985 bp
  • T to C, chromosome 12 at 113,133,236 bp
  • C to A, chromosome 13 at 14,245,762 bp
  • T to C, chromosome 13 at 22,005,155 bp
  • T to C, chromosome 14 at 77,986,744 bp
  • T to A, chromosome 15 at 78,606,985 bp
  • A to T, chromosome 15 at 94,556,684 bp
  • T to C, chromosome 15 at 94,556,685 bp
  • C to A, chromosome 16 at 18,404,196 bp
  • A to T, chromosome 17 at 21,465,322 bp
  • T to C, chromosome 17 at 23,820,329 bp
  • T to C, chromosome 17 at 55,866,328 bp
  • T to C, chromosome 19 at 3,802,127 bp
  • T to C, chromosome 19 at 6,063,968 bp
  • T to G, chromosome 19 at 6,071,033 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5392 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042964-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.