Strain Name:
C57BL/6J-MtgxR5401Btlr/Mmmh
Stock Number:
042972-MU
Citation ID:
RRID:MMRRC_042972-MU
Other Names:
R5401 (G1), C57BL/6J-MtgxR5401Btlr
Major Collection:

Gene Information

Camkk2
Name: calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms: 6330570N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207565
HGNC: HGNC:1470
Homologene: 32756
Get3
Name: guided entry of tail-anchored proteins factor 3, ATPase
Synonyms: ArsA, Asna1, 1810048H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56495
HGNC: HGNC:752
Homologene: 31513
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Phf21a
Name: PHD finger protein 21A
Synonyms: Bhc80, D030065N23Rik, 80kDa, Braf35/HDAC complex (Bhc), PFTF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192285
Homologene: 9597
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 2610019N13Rik, 0610009J05Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69207
Homologene: 36164
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68420
Homologene: 23814
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, 2810403B08Rik, Lrriq2, E130116N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74201
Homologene: 11579
Srrm1
Name: serine/arginine repetitive matrix 1
Synonyms: SRm160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 51796
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: 9330175N20Rik, RPC155, RPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Fancc
Name: Fanconi anemia, complementation group C
Synonyms: Facc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14088
HGNC: HGNC:3584
Homologene: 109
Tex9
Name: testis expressed gene 9
Synonyms: tsec-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21778
Homologene: 32072
Kat14
Name: lysine acetyltransferase 14
Synonyms: D2Ertd473e, Csrp2bp, 2510008M08Rik, D2Wsu131e, ATAC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228714
Homologene: 10745
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: tbl, D130015N03Rik, 2810449H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Prom1
Name: prominin 1
Synonyms: Prom-1, 4932416E19Rik, CD133, Prom, AC133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, NSL-TP, ns-LTP, nonspecific lipid transfer protein, SCP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20280
Homologene: 37717
Arfgap1
Name: ADP-ribosylation factor GTPase activating protein 1
Synonyms: ARF1 GAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228998
Homologene: 5517
Ano10
Name: anoctamin 10
Synonyms: Tmem16k
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102566
VEGA: 9
Homologene: 14314
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Olfr734
Name: olfactory receptor 734
Synonyms: GA_x6K02T2PMLR-6013665-6012724, MOR242-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258658
Homologene: 51759
Smad5
Name: SMAD family member 5
Synonyms: MusMLP, Smad 5, Madh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17129
HGNC: HGNC:6771
Homologene: 4313
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: GIV, C330012F17Rik, Girdin, HkRP1, A430106J12Rik, D130005J21Rik, C130096N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108686
Homologene: 41180
Tsc1
Name: TSC complex subunit 1
Synonyms: hamartin, tuberous sclerosis 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64930
Homologene: 314
Cdv3
Name: carnitine deficiency-associated gene expressed in ventricle 3
Synonyms: C230084J24Rik, TPP36, 2510010F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 321022
Homologene: 133862
2410141K09Rik
Name: RIKEN cDNA 2410141K09 gene
Synonyms: Gt(pU21)35Imeg, Gt(Ayu21)35Imeg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76803
Homologene: 136362
Ret
Name: ret proto-oncogene
Synonyms: RET51, RET9, c-Ret
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19713
HGNC: HGNC:9967
Homologene: 7517
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: D5Ertd249e, APC4, 2610306D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52206
Homologene: 40873
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E16Rik, 2310076E21Rik, Myospryn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, 9030411M15Rik, Fam38b, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Avl9
Name: AVL9 cell migration associated
Synonyms: D730049P16Rik, 5830411G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78937
Homologene: 62425
Kctd19
Name: potassium channel tetramerisation domain containing 19
Synonyms: 4922504H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 279499
Homologene: 18630
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114875
Homologene: 23815
Cracr2b
Name: calcium release activated channel regulator 2B
Synonyms: 6330520A15Rik, Efcab4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 213573
Homologene: 45468
Entpd5
Name: ectonucleoside triphosphate diphosphohydrolase 5
Synonyms: Cd39l4, NTPDase-5, mNTPase, Pcph, NTPDase5, ER-UDPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12499
HGNC: HGNC:3367
Homologene: 37457
Sugct
Name: succinyl-CoA glutarate-CoA transferase
Synonyms: 5033411D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 192136
VEGA: 13
Homologene: 11681
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: b2b1304Clo, prh, 4921507O14Rik, b2b2025.1Clo, b2b1735Clo, D3Ertd789e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51938
Homologene: 12149
Tbx3
Name: T-box 3
Synonyms: D5Ertd189e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21386
Homologene: 4371
2210016F16Rik
Name: RIKEN cDNA 2210016F16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70153
Homologene: 13005
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78796
Homologene: 14632
Fndc8
Name: fibronectin type III domain containing 8
Synonyms: 4930466G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78919
Homologene: 9716
Pklr
Name: pyruvate kinase liver and red blood cell
Synonyms: Pk-1, R-PK, Pk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18770
HGNC: HGNC:9020
Homologene: 37286
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319800
Homologene: 77136
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, Mtap1, 6330416M19Rik, Mtap1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Vmn2r55
Name: vomeronasal 2, receptor 55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042499
Homologene: 104040
9330159F19Rik
Name: RIKEN cDNA 9330159F19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212448
VEGA: 10
Homologene: 8804
Sptlc3
Name: serine palmitoyltransferase, long chain base subunit 3
Synonyms: C130053K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228677
Homologene: 105590
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252905
Homologene: 74318
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: Flt-4, VEGFR-3, VEGFR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Fam170a
Name: family with sequence similarity 170, member A
Synonyms: Znfd, LOC225497
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225497
VEGA: 18
Homologene: 86702
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620672
Homologene: 115466
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: 4933437F18Rik, 1700025P14Rik, MEX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71861
Homologene: 32689
C330011M18Rik
Name: RIKEN cDNA C330011M18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Sh3bp5
Name: SH3-domain binding protein 5 (BTK-associated)
Synonyms: Sab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 24056
Homologene: 23450
Defa27
Name: defensin, alpha, 27
Synonyms: ENSMUSG00000074438, Gm15299
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100041811
Homologene: 113382
1700001J11Rik
Name: RIKEN cDNA 1700001J11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72224
Ighv11-2
Name: immunoglobulin heavy variable V11-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 780818
1700025H01Rik
Name: RIKEN cDNA 1700025H01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,631,653 bp
  • C to A, chromosome 2 at 28,686,908 bp
  • C to T, chromosome 2 at 83,925,245 bp
  • C to A, chromosome 2 at 92,351,752 bp
  • T to C, chromosome 2 at 121,299,672 bp
  • T to C, chromosome 2 at 139,636,723 bp
  • T to C, chromosome 2 at 144,389,260 bp
  • T to C, chromosome 2 at 180,971,114 bp
  • C to T, chromosome 3 at 33,813,155 bp
  • A to G, chromosome 3 at 89,141,866 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • A to T, chromosome 4 at 108,144,779 bp
  • A to G, chromosome 4 at 135,324,069 bp
  • A to T, chromosome 5 at 44,000,805 bp
  • A to G, chromosome 5 at 52,807,077 bp
  • A to G, chromosome 5 at 52,863,649 bp
  • C to A, chromosome 5 at 110,683,171 bp
  • A to G, chromosome 5 at 114,209,853 bp
  • A to C, chromosome 5 at 114,792,173 bp
  • C to T, chromosome 5 at 119,680,762 bp
  • T to A, chromosome 5 at 122,746,335 bp
  • A to G, chromosome 6 at 56,736,877 bp
  • A to T, chromosome 6 at 118,181,975 bp
  • G to T, chromosome 6 at 139,993,052 bp
  • T to C, chromosome 7 at 11,669,916 bp
  • A to G, chromosome 7 at 12,651,944 bp
  • A to T, chromosome 7 at 85,136,557 bp
  • A to G, chromosome 7 at 141,466,223 bp
  • A to G, chromosome 8 at 21,315,694 bp
  • C to A, chromosome 8 at 84,066,376 bp
  • A to T, chromosome 8 at 85,018,544 bp
  • C to T, chromosome 8 at 105,382,985 bp
  • A to G, chromosome 9 at 40,051,042 bp
  • T to C, chromosome 9 at 66,502,056 bp
  • A to T, chromosome 9 at 72,486,778 bp
  • G to T, chromosome 9 at 103,365,117 bp
  • A to T, chromosome 9 at 122,261,290 bp
  • T to C, chromosome 10 at 29,225,140 bp
  • C to A, chromosome 10 at 128,465,504 bp
  • A to G, chromosome 11 at 29,463,279 bp
  • AC to ACC, chromosome 11 at 49,651,034 bp
  • A to G, chromosome 11 at 60,706,471 bp
  • T to G, chromosome 11 at 82,897,850 bp
  • A to G, chromosome 12 at 84,382,275 bp
  • A to T, chromosome 12 at 114,048,339 bp
  • T to A, chromosome 13 at 16,857,870 bp
  • T to C, chromosome 13 at 56,727,469 bp
  • C to A, chromosome 13 at 58,382,591 bp
  • C to A, chromosome 13 at 63,402,953 bp
  • T to C, chromosome 13 at 66,431,663 bp
  • T to C, chromosome 13 at 93,091,968 bp
  • T to C, chromosome 14 at 24,454,941 bp
  • C to A, chromosome 14 at 31,377,495 bp
  • C to A, chromosome 14 at 50,320,109 bp
  • G to T, chromosome 16 at 30,199,983 bp
  • A to G, chromosome 16 at 55,924,952 bp
  • T to A, chromosome 18 at 50,280,551 bp
  • T to A, chromosome 18 at 63,084,740 bp
  • G to A, chromosome 19 at 8,344,393 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5401 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042972-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.