Strain Name:
C57BL/6J-MtgxR5406Btlr/Mmmh
Stock Number:
042976-MU
Citation ID:
RRID:MMRRC_042976-MU
Other Names:
R5406 (G1), C57BL/6J-MtgxR5406Btlr
Major Collection:

Gene Information

Gon4l
Name: gon-4-like (C.elegans)
Synonyms: 2610100B20Rik, 1500041I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76022
Homologene: 13002
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Tns3
Name: tensin 3
Synonyms: Tens1, TEM6, F830010I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319939
Homologene: 49713
Tbcd
Name: tubulin-specific chaperone d
Synonyms: A030005L14Rik, 2310057L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108903
Homologene: 4368
Nup214
Name: nucleoporin 214
Synonyms: CAN, D2H9S46E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Slc3a2
Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Synonyms: 4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17254
Homologene: 1795
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: C030034P18Rik, polycystin-2, TRPP2, PC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Gdap2
Name: ganglioside-induced differentiation-associated-protein 2
Synonyms: D3Ertd801e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14547
Homologene: 7728
Ncstn
Name: nicastrin
Synonyms: nicastrin, D1Dau13e, 9430068N19Rik, Nct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59287
Homologene: 41029
Aasdhppt
Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms: CGI-80, AASD-PPT, LYS2, 2810407B07Rik, 2010309J24Rik, LYS5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67618
Homologene: 9130
Bmt2
Name: base methyltransferase of 25S rRNA 2
Synonyms: B630005N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101148
Homologene: 34695
G2e3
Name: G2/M-phase specific E3 ubiquitin ligase
Synonyms: 6030408C04Rik, D930034K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217558
Homologene: 32362
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: mZaADAR, Adar1p150, ADAR1, Adar1p110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: Raldh2, retinaldehyde dehydrogenase, Aldh1a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19378
Homologene: 68368
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Plb1
Name: phospholipase B1
Synonyms: 4930433E17Rik, 4632413E21Rik, 4930539A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665270
Homologene: 82108
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: LOC381229, Ccdc147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Ino80c
Name: INO80 complex subunit C
Synonyms: D030070L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225280
Homologene: 45426
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Atf6b
Name: activating transcription factor 6 beta
Synonyms: ATF6beta, Crebl1, Creb-rp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Olfr805
Name: olfactory receptor 805
Synonyms: GA_x6K02T2PULF-11402237-11401278, MOR110-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258548
Lipo4
Name: lipase, member O4
Synonyms: Gm6857
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 628236
Homologene: 103863
Gbp4
Name: guanylate binding protein 4
Synonyms: Mpa-2, Mpa2, Mag-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17472
Homologene: 128731
Adam26a
Name: a disintegrin and metallopeptidase domain 26A (testase 3)
Synonyms: Adam26, Dtgn4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13525
Homologene: 128363
Cntn5
Name: contactin 5
Synonyms: 6720426O10Rik, NB-2, A830025P08Rik, LOC244683
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Blk
Name: B lymphoid kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12143
VEGA: 14
HGNC: HGNC:1057
Homologene: 1297
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192166
Homologene: 5149
Sptlc3
Name: serine palmitoyltransferase, long chain base subunit 3
Synonyms: C130053K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228677
Homologene: 105590
Ppm1l
Name: protein phosphatase 1 (formerly 2C)-like
Synonyms: 5930404J21Rik, Pp2ce, PP2C-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242083
Homologene: 33158
Arsk
Name: arylsulfatase K
Synonyms: 2810429K17Rik, 4833414G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 77041
Homologene: 12670
Olfr871
Name: olfactory receptor 871
Synonyms: GA_x6K02T2PVTD-13952555-13953490, MOR141-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258905
Homologene: 138319
Fkbpl
Name: FK506 binding protein-like
Synonyms: NG7, DIR1, WISp39, Ppiase-X, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: Catsperg, A230107C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320225
Homologene: 10915
Xrcc3
Name: X-ray repair complementing defective repair in Chinese hamster cells 3
Synonyms: 4432412E01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74335
Homologene: 36178
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: multiple drug resistant 1a, mdr-3, MDR3, P-gp, Evi32, Pgy3, Pgp, Mdr1a, P-glycoprotein, Pgy-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Nfxl1
Name: nuclear transcription factor, X-box binding-like 1
Synonyms: TCF9, D430033A06Rik, 1700012H24Rik, LOC381696
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100978
Homologene: 26752
Olfr874
Name: olfactory receptor 874
Synonyms: GA_x6K02T2PVTD-31428850-31429782, MOR161-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258882
Homologene: 17377
Lrriq3
Name: leucine-rich repeats and IQ motif containing 3
Synonyms: 4930511J15Rik, Lrrc44, 4933403H06Rik, 4930438B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74435
Homologene: 23668
Ccdc32
Name: coiled-coil domain containing 32
Synonyms: LOC269336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269336
Homologene: 14157
Olfr877
Name: olfactory receptor 877
Synonyms: GA_x6K02T2PVTD-31540342-31541277, MOR161-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258412
Homologene: 121556
Saxo2
Name: stabilizer of axonemal microtubules 2
Synonyms: 1700129I04Rik, Fam154b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330577
Homologene: 25135
Stpg3
Name: sperm tail PG rich repeat containing 3
Synonyms: 4933433C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74472
Homologene: 52838
Spata31d1d
Name: spermatogenesis associated 31 subfamily D, member 1D
Synonyms: 4932411G14Rik, Fam75d1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238663
Homologene: 129932
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 172,072,164 bp
  • C to A, chromosome 2 at 25,213,568 bp
  • A to G, chromosome 2 at 27,211,084 bp
  • C to A, chromosome 2 at 32,002,607 bp
  • A to C, chromosome 2 at 119,022,079 bp
  • T to C, chromosome 2 at 139,546,478 bp
  • T to C, chromosome 3 at 69,317,594 bp
  • T to C, chromosome 3 at 88,895,197 bp
  • C to T, chromosome 3 at 89,736,111 bp
  • T to A, chromosome 3 at 100,191,675 bp
  • T to C, chromosome 3 at 155,129,501 bp
  • C to A, chromosome 5 at 8,702,946 bp
  • A to G, chromosome 5 at 32,341,915 bp
  • G to A, chromosome 5 at 72,556,198 bp
  • T to C, chromosome 5 at 104,480,332 bp
  • G to T, chromosome 5 at 105,119,521 bp
  • A to T, chromosome 6 at 13,677,832 bp
  • G to A, chromosome 7 at 29,185,523 bp
  • A to T, chromosome 7 at 82,635,378 bp
  • A to T, chromosome 8 at 43,569,104 bp
  • A to G, chromosome 8 at 99,196,370 bp
  • A to T, chromosome 9 at 4,309,387 bp
  • A to G, chromosome 9 at 7,467,293 bp
  • A to T, chromosome 9 at 9,833,460 bp
  • A to G, chromosome 9 at 20,213,158 bp
  • A to G, chromosome 9 at 37,746,647 bp
  • G to A, chromosome 9 at 37,855,219 bp
  • G to T, chromosome 9 at 71,255,121 bp
  • T to A, chromosome 10 at 93,001,858 bp
  • G to A, chromosome 10 at 129,722,930 bp
  • G to A, chromosome 11 at 8,451,123 bp
  • C to T, chromosome 11 at 60,713,184 bp
  • A to G, chromosome 11 at 119,440,808 bp
  • T to A, chromosome 11 at 121,452,101 bp
  • T to C, chromosome 12 at 51,372,666 bp
  • T to C, chromosome 12 at 111,812,111 bp
  • T to A, chromosome 13 at 59,728,778 bp
  • T to A, chromosome 13 at 76,093,947 bp
  • C to A, chromosome 14 at 63,380,731 bp
  • A to T, chromosome 15 at 8,153,638 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • T to A, chromosome 17 at 34,653,797 bp
  • T to A, chromosome 18 at 24,112,762 bp
  • T to C, chromosome 19 at 8,708,042 bp
  • A to G, chromosome 19 at 33,503,218 bp
  • G to A, chromosome 19 at 48,029,102 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042976-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.