Strain Name:
C57BL/6J-MtgxR5451Btlr/Mmmh
Stock Number:
043016-MU
Citation ID:
RRID:MMRRC_043016-MU
Other Names:
R5451 (G1), C57BL/6J-MtgxR5451Btlr
Major Collection:

Gene Information

Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: MRFX3, C230093O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: coronin 3, CRN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Cep85
Name: centrosomal protein 85
Synonyms: 2410030J07Rik, Ccdc21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70012
Homologene: 11254
Slc12a3
Name: solute carrier family 12, member 3
Synonyms: NCC, TSC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20497
Homologene: 287
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p67MBP, p160MBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Lingo1
Name: leucine rich repeat and Ig domain containing 1
Synonyms: UNQ201, LERN1, 4930471K13Rik, LINGO-1, Lrrn6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235402
Homologene: 41891
Lsm2
Name: LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms: G7b, Sm-X5, SmX5, D17H6S56E2, snRNP, D17H6S56E-2, Dmapl, Dmpkap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 27756
Homologene: 48535
Fbxo7
Name: F-box protein 7
Synonyms: 2410015K21Rik, A230052G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69754
Homologene: 8136
Mpp7
Name: membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Synonyms: 5430426E14Rik, 2810038M04Rik, LOC381166, 1110068J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75739
VEGA: 18
Homologene: 1455
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: C6orf170, Bromi, D630037F22Rik, b2b2284Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Igflr1
Name: IGF-like family receptor 1
Synonyms: F630003I17Rik, Tmem149
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101883
Homologene: 49779
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: D330020E01Rik, pcy, nephrocystin 3, 3632410F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94090
VEGA: 12
Homologene: 9045
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 373864
Homologene: 69400
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Olfr835
Name: olfactory receptor 835
Synonyms: GA_x6K02T2PVTD-12771995-12772930, MOR150-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257872
Homologene: 133702
Trp53i11
Name: transformation related protein 53 inducible protein 11
Synonyms: Tp53i11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277414
Homologene: 4404
Gsap
Name: gamma-secretase activating protein
Synonyms: A530088I07Rik, Pion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212167
Homologene: 45504
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Naip-rs6, Birc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Jkampl
Name: JNK1/MAPK8 associated membrane protein like
Synonyms: 4931417E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66740
Homologene: 75225
Micall1
Name: microtubule associated monooxygenase, calponin and LIM domain containing -like 1
Synonyms: Mus EST 820961, D15N2e, D15Mit260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27008
VEGA: 15
Homologene: 24911
Slco1c1
Name: solute carrier organic anion transporter family, member 1c1
Synonyms: OATP-F, Slc21a14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58807
Homologene: 23008
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Rab42
Name: RAB42, member RAS oncogene family
Synonyms: 9530096D07Rik, Rab42-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242681
Homologene: 85237
Cwh43
Name: cell wall biogenesis 43 C-terminal homolog
Synonyms: C130090K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231293
Homologene: 5474
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gababr2, LOC242425, Gpr51, GB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Gemin6
Name: gem nuclear organelle associated protein 6
Synonyms: 2610019B15Rik, 2810470M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67242
Homologene: 11711
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 636808
Homologene: 43974
Lrrc14
Name: leucine rich repeat containing 14
Synonyms: E130306I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223664
Homologene: 40970
Galnt15
Name: polypeptide N-acetylgalactosaminyltransferase 15
Synonyms: 4631401E18Rik, Galntl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78754
Homologene: 14286
Calhm2
Name: calcium homeostasis modulator family member 2
Synonyms: 2810048G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72691
Homologene: 9303
Clca1
Name: chloride channel accessory 1
Synonyms: gob-5, gob5, Clca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Slfn5
Name: schlafen 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327978
Homologene: 18839
Olfr1112
Name: olfactory receptor 1112
Synonyms: GA_x6K02T2Q125-48676316-48677272, MOR264-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258655
Homologene: 64901
Olfr1107
Name: olfactory receptor 1107
Synonyms: GA_x6K02T2Q125-48565383-48564445, MOR172-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258841
Homologene: 131138
Rps13-ps2
Name: ribosomal protein S13, pseudogene 2
Synonyms: Gm10159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039924
Ccnq
Name: cyclin Q
Synonyms: 1810009O10Rik, cyclin M, Fam58b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69109
Homologene: 13362
Slc25a15
Name: solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15
Synonyms: Ornt1, D630044L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18408
Homologene: 6957
Tle7
Name: TLE family member 7
Synonyms: Gm21964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102638837
VEGA: 8
Homologene: 131708
Srxn1
Name: sulfiredoxin 1 homolog (S. cerevisiae)
Synonyms: 1700127B04Rik, Srx, Npn3, Srx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76650
Homologene: 32722
Ighv13-2
Name: immunoglobulin heavy variable 13-2
Synonyms: Gm15449
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629842
Trgj4
Name: T cell receptor gamma joining 4
Synonyms: Gm16673
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100126434
Vmn1r190-ps
Name: vomeronasal 1 receptor 190, pseudogene
Synonyms: V1ri8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 252908
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 46,242,019 bp
  • A to G, chromosome 1 at 71,294,917 bp
  • T to C, chromosome 1 at 115,685,143 bp
  • T to A, chromosome 2 at 76,754,824 bp
  • T to C, chromosome 2 at 87,071,997 bp
  • T to A, chromosome 2 at 87,192,452 bp
  • T to C, chromosome 2 at 93,199,855 bp
  • G to A, chromosome 2 at 152,105,879 bp
  • T to C, chromosome 3 at 145,027,986 bp
  • G to A, chromosome 4 at 46,684,293 bp
  • T to A, chromosome 4 at 46,684,294 bp
  • G to A, chromosome 4 at 63,225,239 bp
  • T to C, chromosome 4 at 132,302,516 bp
  • T to C, chromosome 4 at 134,131,300 bp
  • T to A, chromosome 5 at 21,217,447 bp
  • T to C, chromosome 5 at 73,431,913 bp
  • G to A, chromosome 5 at 113,848,539 bp
  • A to G, chromosome 6 at 73,468,867 bp
  • A to T, chromosome 6 at 141,559,878 bp
  • A to G, chromosome 7 at 30,566,322 bp
  • G to T, chromosome 7 at 88,530,828 bp
  • G to A, chromosome 8 at 22,389,967 bp
  • A to G, chromosome 8 at 94,357,027 bp
  • A to T, chromosome 8 at 110,109,871 bp
  • T to C, chromosome 9 at 19,035,491 bp
  • T to G, chromosome 9 at 56,620,427 bp
  • A to G, chromosome 9 at 104,042,022 bp
  • C to T, chromosome 9 at 110,037,783 bp
  • T to A, chromosome 10 at 56,195,475 bp
  • A to G, chromosome 10 at 86,029,037 bp
  • A to G, chromosome 11 at 72,448,113 bp
  • T to A, chromosome 11 at 78,751,289 bp
  • T to G, chromosome 11 at 82,960,086 bp
  • G to A, chromosome 11 at 110,319,796 bp
  • T to A, chromosome 12 at 17,359,102 bp
  • A to G, chromosome 12 at 70,346,829 bp
  • A to G, chromosome 12 at 86,882,072 bp
  • A to G, chromosome 12 at 114,357,853 bp
  • G to T, chromosome 13 at 19,342,165 bp
  • A to G, chromosome 13 at 22,144,731 bp
  • A to G, chromosome 13 at 100,188,860 bp
  • A to G, chromosome 14 at 32,029,911 bp
  • A to G, chromosome 15 at 76,713,973 bp
  • T to A, chromosome 15 at 79,126,904 bp
  • T to C, chromosome 16 at 36,509,908 bp
  • G to T, chromosome 17 at 3,428,996 bp
  • T to C, chromosome 17 at 34,982,209 bp
  • T to G, chromosome 17 at 80,227,749 bp
  • T to C, chromosome 18 at 7,442,855 bp
  • T to A, chromosome 19 at 17,463,356 bp
  • T to G, chromosome 19 at 27,849,959 bp
  • T to A, chromosome 19 at 47,132,875 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5451 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043016-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.