Strain Name:
C57BL/6J-MtgxR5541Btlr/Mmmh
Stock Number:
043099-MU
Citation ID:
RRID:MMRRC_043099-MU
Other Names:
R5541 (G1), C57BL/6J-MtgxR5541Btlr
Major Collection:

Gene Information

Zfp143
Name: zinc finger protein 143
Synonyms: Zfp79, pHZ-1, D7Ertd805e, Zfp80-rs1, Staf, KRAB14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20841
Homologene: 56444
Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: nNOS, Nos-1, bNOS, NO, 2310005C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: AP-2(beta), E130018K07Rik, Tcfap2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21419
Homologene: 20688
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Zfp568
Name: zinc finger protein 568
Synonyms: LOC381866, chato
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243905
Homologene: 136307
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 277854
Homologene: 34718
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: GAC-1, 2900001A12Rik, ANCO-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106585
Homologene: 9059
Zfhx3
Name: zinc finger homeobox 3
Synonyms: Sci, Atbf1, A230102L03Rik, WBP9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: Zfp289, 2310032E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77038
Homologene: 8735
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: A330063D19Rik, 1810014J18Rik, AD013, 9030205D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Taf1d
Name: TATA-box binding protein associated factor, RNA polymerase I, D
Synonyms: TAF(I)41, Josd3, 4930553M18Rik, TAFI41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75316
VEGA: 9
Homologene: 11472
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 2610207I05Rik, C130002K18Rik, 5430435M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Wapl
Name: WAPL cohesin release factor
Synonyms: A530089A20Rik, Wapal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218914
Homologene: 41002
Ptbp1
Name: polypyrimidine tract binding protein 1
Synonyms: hnRNP I, Ptb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19205
HGNC: HGNC:9583
Homologene: 49188
Dcp1a
Name: decapping mRNA 1A
Synonyms: 4930568L04Rik, D14Ertd817e, 1110066A22Rik, SMIF, Mitc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75901
VEGA: 14
Homologene: 10178
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, perlecan, Pcn, Plc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: Erp72, ERp72, U48620, Cai
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12304
Homologene: 21020
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: A330015D16Rik, 4930418J05Rik, 4930473A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320226
Homologene: 27942
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Zfp574
Name: zinc finger protein 574
Synonyms: A630056B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232976
Homologene: 11238
Gm14411
Name: predicted gene 14411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 628239
Pcdh17
Name: protocadherin 17
Synonyms: C030033F14Rik, LOC219228
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, calcium release channel isoform 1, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Macroh2a2
Name: macroH2A.2 histone
Synonyms: H2afy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 404634
Homologene: 10246
0610009B22Rik
Name: RIKEN cDNA 0610009B22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66050
Homologene: 133292
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Klb
Name: klotho beta
Synonyms: betaKlotho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83379
Homologene: 12820
Arhgap30
Name: Rho GTPase activating protein 30
Synonyms: 6030405P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226652
Homologene: 18766
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Cercam
Name: cerebral endothelial cell adhesion molecule
Synonyms: CerCAM, Ceecam1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99151
Homologene: 22954
Intu
Name: inturned planar cell polarity protein
Synonyms: 9430087H23Rik, 9230116I04Rik, Pdzd6, Pdzk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 380614
Homologene: 41059
Olfr1502
Name: olfactory receptor 1502
Synonyms: GA_x6K02T2RE5P-4193992-4194942, MOR211-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258793
Homologene: 17394
Zfand4
Name: zinc finger, AN1-type domain 4
Synonyms: 2810002D23Rik, Anubl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67492
VEGA: 6
Homologene: 18373
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Faap100
Name: Fanconi anemia core complex associated protein 100
Synonyms: 2310003H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71885
Homologene: 69394
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 1810008K04Rik, PAR3B, PAR3L, PAR3beta, 2810455B10Rik, 2010002N16Rik, Als2cr19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72823
Homologene: 35389
Tnfaip3
Name: tumor necrosis factor, alpha-induced protein 3
Synonyms: zinc finger protein A20, Tnfip3, A20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21929
Homologene: 4582
St8sia2
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Synonyms: Siat8b, ST8SiaII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20450
Homologene: 4384
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: 4632428N09Rik, Aof1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218214
Homologene: 14695
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Gpr22
Name: G protein-coupled receptor 22
Synonyms: 2900068K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73010
HGNC: HGNC:4477
Homologene: 18420
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57782
Homologene: 23287
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: Rnf190, March10, OTTMUSG00000002847, 4933417C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 632687
Homologene: 34988
Stxbp3-ps
Name: syntaxin-binding protein 3, pseudogene
Synonyms: Stxbp3b, Munc18c(L)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 619371
Ube2q2
Name: ubiquitin-conjugating enzyme E2Q family member 2
Synonyms: 3010021M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109161
Homologene: 45455
1700113H08Rik
Name: RIKEN cDNA 1700113H08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76640
Homologene: 45695
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74053
Homologene: 12938
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: Pyk1, ACK1, P21cdc42Hs kinase, activated p21cdc42Hs kinase, Ack
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 51789
Homologene: 4224
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382105
Homologene: 110776
Klrb1a
Name: killer cell lectin-like receptor subfamily B member 1A
Synonyms: NKR-P1A, Nkrp1-a, Ly55a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17057
HGNC: HGNC:6373
Homologene: 84369
Asb7
Name: ankyrin repeat and SOCS box-containing 7
Synonyms: D030055C23Rik, Asb-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 117589
Homologene: 34130
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627367
Homologene: 115024
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933425F06Rik, 4933405P16Rik, Als2cr12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108812
Homologene: 51399
Olfr887
Name: olfactory receptor 887
Synonyms: GA_x6K02T2PVTD-31764095-31765024, MOR162-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258415
Homologene: 133625
Gm10610
Name: predicted gene 10610
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100038384
Pde6g
Name: phosphodiesterase 6G, cGMP-specific, rod, gamma
Synonyms: Pdeg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18588
HGNC: HGNC:8789
Homologene: 1955
Rpl11
Name: ribosomal protein L11
Synonyms: 2010203J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67025
Homologene: 37376
Ccdc86
Name: coiled-coil domain containing 86
Synonyms: 4933411H20Rik, D19Ertd678e, 6720480F16Rik, cyclon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 108673
Homologene: 41531
Ucma
Name: upper zone of growth plate and cartilage matrix associated
Synonyms: 1110017I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68527
Homologene: 12272
Stk-ps1
Name: serine/threonine kinase, pseudogene 1
Synonyms: LOC333716, Gm318, LOC240091
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 545204
Homologene: 141143
Defa17
Name: defensin, alpha, 17
Synonyms: cryptdin 17, Crypt defensin 17, Defcr17, Cryp17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23855
Homologene: 113382
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 19,214,026 bp
  • A to G, chromosome 1 at 58,658,429 bp
  • A to G, chromosome 1 at 61,639,343 bp
  • T to C, chromosome 1 at 171,404,139 bp
  • A to G, chromosome 2 at 4,981,330 bp
  • A to G, chromosome 2 at 29,875,629 bp
  • T to A, chromosome 2 at 66,324,633 bp
  • G to A, chromosome 2 at 91,275,769 bp
  • T to A, chromosome 2 at 177,125,847 bp
  • A to G, chromosome 3 at 40,692,587 bp
  • A to T, chromosome 4 at 83,696,283 bp
  • A to G, chromosome 4 at 136,052,732 bp
  • C to T, chromosome 4 at 137,520,551 bp
  • C to A, chromosome 4 at 137,542,825 bp
  • A to T, chromosome 5 at 32,864,629 bp
  • T to C, chromosome 5 at 41,791,933 bp
  • A to T, chromosome 5 at 65,379,234 bp
  • A to G, chromosome 5 at 117,905,394 bp
  • G to A, chromosome 5 at 143,173,990 bp
  • C to T, chromosome 6 at 47,796,637 bp
  • A to T, chromosome 6 at 73,192,988 bp
  • T to A, chromosome 6 at 116,314,295 bp
  • G to A, chromosome 6 at 128,609,736 bp
  • C to T, chromosome 7 at 25,081,950 bp
  • G to T, chromosome 7 at 29,086,185 bp
  • T to A, chromosome 7 at 30,022,876 bp
  • T to C, chromosome 7 at 66,679,269 bp
  • T to C, chromosome 7 at 73,966,900 bp
  • A to G, chromosome 7 at 83,549,406 bp
  • G to T, chromosome 7 at 110,070,480 bp
  • T to A, chromosome 7 at 118,157,163 bp
  • T to A, chromosome 8 at 21,656,549 bp
  • A to T, chromosome 8 at 91,051,504 bp
  • A to G, chromosome 8 at 108,948,951 bp
  • T to A, chromosome 9 at 15,308,850 bp
  • T to C, chromosome 9 at 38,085,123 bp
  • T to A, chromosome 9 at 55,191,879 bp
  • T to G, chromosome 9 at 109,565,430 bp
  • A to G, chromosome 10 at 19,002,923 bp
  • T to C, chromosome 10 at 61,747,717 bp
  • A to G, chromosome 10 at 79,863,211 bp
  • A to G, chromosome 10 at 87,225,946 bp
  • A to T, chromosome 10 at 120,072,718 bp
  • T to C, chromosome 11 at 9,291,545 bp
  • T to C, chromosome 11 at 51,685,969 bp
  • T to C, chromosome 11 at 66,145,336 bp
  • C to T, chromosome 11 at 105,390,131 bp
  • T to A, chromosome 11 at 120,377,632 bp
  • A to T, chromosome 11 at 120,448,172 bp
  • A to G, chromosome 12 at 31,709,349 bp
  • T to G, chromosome 12 at 59,071,930 bp
  • T to C, chromosome 13 at 47,079,196 bp
  • A to G, chromosome 13 at 112,940,374 bp
  • T to A, chromosome 14 at 30,502,839 bp
  • T to C, chromosome 14 at 34,730,662 bp
  • T to A, chromosome 14 at 84,447,416 bp
  • A to G, chromosome 15 at 90,968,113 bp
  • C to T, chromosome 16 at 32,669,523 bp
  • C to T, chromosome 17 at 18,928,355 bp
  • T to A, chromosome 17 at 36,398,213 bp
  • A to G, chromosome 17 at 65,982,839 bp
  • C to T, chromosome 19 at 9,557,970 bp
  • T to C, chromosome 19 at 10,948,554 bp
  • T to C, chromosome 19 at 13,861,964 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5541 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043099-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.