Strain Name:
C57BL/6J-MtgxR5575Btlr/Mmmh
Stock Number:
043130-MU
Citation ID:
RRID:MMRRC_043130-MU
Other Names:
R5575 (G1), C57BL/6J-MtgxR5575Btlr
Major Collection:

Strain Information

Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22427
Homologene: 6659
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76707
Homologene: 41024
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 319765
Homologene: 4774
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72103
Homologene: 49753
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237877
Homologene: 32611
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Ptbp2
Name: polypyrimidine tract binding protein 2
Synonyms: brPTB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56195
Homologene: 23162
Vapa
Name: vesicle-associated membrane protein, associated protein A
Synonyms: VAP33, synaptobrevin-associated protein of 33kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 30960
VEGA: 17
Homologene: 37824
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Acin1
Name: apoptotic chromatin condensation inducer 1
Synonyms: 2610510L13Rik, 2610036I19Rik, Acinus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56215
Homologene: 22853
Adrm1
Name: adhesion regulating molecule 1 26S proteasome ubiquitin receptor
Synonyms: ARM-1, 2510006J17Rik, Gp110, 1110063P18Rik, Rpn13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56436
Homologene: 10513
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: D12Ertd549e, 2810011H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: 5230400C17Rik, Pip5k3, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nzf2, Nztf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Rad51
Name: RAD51 recombinase
Synonyms: Reca, Rad51a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19361
HGNC: HGNC:9817
Homologene: 2155
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, 5131400N11Rik, Supt6h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20926
Homologene: 40661
Il7r
Name: interleukin 7 receptor
Synonyms: IL-7 receptor alpha chain, CD127, IL-7Ralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16197
VEGA: 15
HGNC: HGNC:6024
Homologene: 1646
Ibsp
Name: integrin binding sialoprotein
Synonyms: BSP, bone sialoprotein, Bsp2, Bsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15891
HGNC: HGNC:5341
Homologene: 3644
Gna15
Name: guanine nucleotide binding protein, alpha 15
Synonyms: G[a]15, Galpha15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14676
HGNC: HGNC:4383
Homologene: 1563
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
Ppp2r5c
Name: protein phosphatase 2, regulatory subunit B', gamma
Synonyms: Band 8A, 2610043M05Rik, 2700063L20Rik, D12Bwg0916e, B56/PP2A gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26931
VEGA: 12
HGNC: HGNC:9311
Homologene: 128665
Isx
Name: intestine specific homeobox
Synonyms: 9130012O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71597
Homologene: 28312
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: 2610306D21Rik, APC4, D5Ertd249e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52206
Homologene: 40873
Epha5
Name: Eph receptor A5
Synonyms: Cek7, bsk, Els1, Rek7, Hek7, Ehk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: Epac2, cAMP-GEFII, 1300003D15Rik, 5730402K07Rik, 6330581N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56508
Homologene: 4451
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64580
Homologene: 11208
Krt35
Name: keratin 35
Synonyms: Ha5, Krt1-24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53617
HGNC: HGNC:6453
Homologene: 1715
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, 4732499L03Rik, melastatin, LTRPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234686
Homologene: 136406
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Col9a3
Name: collagen, type IX, alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12841
HGNC: HGNC:2219
Homologene: 20438
Ogdhl
Name: oxoglutarate dehydrogenase-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239017
VEGA: 14
Homologene: 56801
Gabrb2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
Synonyms: Gabrb-2, C030021G16Rik, C030002O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: 1700067C01Rik, CATSPERG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76718
Homologene: 10915
Mmab
Name: methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)
Synonyms: ATP:Cob(I)alamin Adenosyltransferase, 9130222L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77697
Homologene: 12680
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210274
Homologene: 105965
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 332131
VEGA: 15
Homologene: 65261
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74362
Homologene: 52601
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Tyro 12, Nyk, Eyk, Mer, nmf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Hoxb5
Name: homeobox B5
Synonyms: Hox-2.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15413
HGNC: HGNC:5116
Homologene: 37585
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 63913
Homologene: 62170
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1291.1Clo, b2b1163.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329795
Homologene: 71886
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Themis3
Name: thymocyte selection associated family member 3
Synonyms: 9130404H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74556
Homologene: 137389
Hmbox1
Name: homeobox containing 1
Synonyms: F830020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219150
Homologene: 11589
Marchf1
Name: membrane associated ring-CH-type finger 1
Synonyms: 2900024D24Rik, March1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72925
Homologene: 113749
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78774
Hk3
Name: hexokinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212032
HGNC: HGNC:4925
Homologene: 55633
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76074
B9d2
Name: B9 protein domain 2
Synonyms: stumpy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232987
Homologene: 12733
Tinf2
Name: Terf1 (TRF1)-interacting nuclear factor 2
Synonyms: TIN2, D14Wsu146e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 28113
VEGA: 14
Homologene: 8264
Vmn2r38
Name: vomeronasal 2, receptor 38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434110
Homologene: 113703
Gm28379
Name: predicted gene 28379
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Scgb1c1
Name: secretoglobin, family 1C, member 1
Synonyms: Ryd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338417
Homologene: 87936
Gm3453
Name: predicted gene 3453
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 45,378,482 bp
  • A to C, chromosome 1 at 65,273,730 bp
  • G to T, chromosome 1 at 118,497,737 bp
  • A to T, chromosome 1 at 151,718,240 bp
  • G to A, chromosome 2 at 72,034,120 bp
  • A to G, chromosome 2 at 119,134,433 bp
  • T to C, chromosome 2 at 128,736,565 bp
  • G to A, chromosome 2 at 146,017,393 bp
  • T to G, chromosome 2 at 180,175,716 bp
  • A to T, chromosome 2 at 180,598,846 bp
  • T to C, chromosome 2 at 181,826,092 bp
  • G to A, chromosome 3 at 100,053,822 bp
  • A to T, chromosome 3 at 119,720,783 bp
  • G to A, chromosome 3 at 119,720,789 bp
  • T to A, chromosome 3 at 125,437,830 bp
  • A to T, chromosome 4 at 12,047,886 bp
  • T to A, chromosome 5 at 52,855,871 bp
  • G to A, chromosome 5 at 84,416,502 bp
  • A to T, chromosome 5 at 104,310,059 bp
  • A to T, chromosome 5 at 105,014,902 bp
  • A to T, chromosome 5 at 114,436,771 bp
  • A to C, chromosome 6 at 87,646,147 bp
  • A to T, chromosome 6 at 89,324,541 bp
  • A to T, chromosome 7 at 9,075,636 bp
  • A to G, chromosome 7 at 25,683,332 bp
  • T to A, chromosome 7 at 29,078,693 bp
  • T to C, chromosome 7 at 29,705,590 bp
  • T to C, chromosome 7 at 64,220,270 bp
  • G to A, chromosome 7 at 140,846,111 bp
  • T to C, chromosome 7 at 144,410,134 bp
  • G to A, chromosome 8 at 33,336,130 bp
  • T to A, chromosome 8 at 66,468,310 bp
  • T to C, chromosome 8 at 74,892,801 bp
  • T to C, chromosome 8 at 105,333,564 bp
  • T to A, chromosome 9 at 66,418,565 bp
  • T to C, chromosome 10 at 58,492,583 bp
  • T to C, chromosome 10 at 81,523,873 bp
  • G to A, chromosome 11 at 42,529,538 bp
  • T to C, chromosome 11 at 78,228,961 bp
  • A to G, chromosome 11 at 80,100,323 bp
  • T to C, chromosome 11 at 84,009,552 bp
  • C to T, chromosome 11 at 96,303,928 bp
  • T to C, chromosome 11 at 100,094,624 bp
  • T to C, chromosome 12 at 110,552,832 bp
  • T to C, chromosome 12 at 111,542,306 bp
  • T to A, chromosome 12 at 112,735,632 bp
  • A to T, chromosome 13 at 55,014,770 bp
  • A to G, chromosome 14 at 5,978,205 bp
  • T to C, chromosome 14 at 32,325,847 bp
  • C to T, chromosome 14 at 54,678,738 bp
  • T to C, chromosome 14 at 55,680,174 bp
  • C to T, chromosome 14 at 64,030,984 bp
  • T to C, chromosome 14 at 64,823,164 bp
  • A to G, chromosome 15 at 9,508,187 bp
  • A to T, chromosome 15 at 35,929,919 bp
  • G to A, chromosome 15 at 101,947,352 bp
  • T to C, chromosome 16 at 22,083,974 bp
  • T to C, chromosome 16 at 32,754,933 bp
  • A to G, chromosome 17 at 65,613,252 bp
  • A to G, chromosome 17 at 66,555,326 bp
  • A to C, chromosome 17 at 84,416,399 bp
  • A to T, chromosome 18 at 20,035,390 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5575 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043130-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.