Strain Name:
C57BL/6J-MtgxR5606Btlr/Mmmh
Stock Number:
043157-MU
Citation ID:
RRID:MMRRC_043157-MU
Other Names:
R5606 (G1), C57BL/6J-MtgxR5606Btlr
Major Collection:

Gene Information

Blm
Name: Bloom syndrome, RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12144
VEGA: 7
HGNC: HGNC:1058
Homologene: 47902
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70797
VEGA: 5
Homologene: 19076
Ddx27
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228889
VEGA: 2
Homologene: 6431
Armc8
Name: armadillo repeat containing 8
Synonyms: HSPC056, Gid5, 1200015K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74125
VEGA: 9
Homologene: 9121
Parg
Name: poly (ADP-ribose) glycohydrolase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 26430
VEGA: 14
HGNC: HGNC:8605
Homologene: 50532
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: ZFYVE24, Etohd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13998
VEGA: 10
Homologene: 14209
Ckap2l
Name: cytoskeleton associated protein 2-like
Synonyms: Radmis, 2610318C08Rik, 2010016H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 70466
VEGA: 2
Homologene: 51866
Cep135
Name: centrosomal protein 135
Synonyms: Cep4, LOC381644
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381644
VEGA: 5
Homologene: 45709
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 2310038O07Rik, D10Ertd516e, 6330512O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 71902
VEGA: 10
Homologene: 10202
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 319262
VEGA: 18
Homologene: 14127
Hnrnph3
Name: heterogeneous nuclear ribonucleoprotein H3
Synonyms: Hnrph3, hnRNP 2H9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 432467
VEGA: 10
HGNC: HGNC:5043
Homologene: 11012
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 545471
VEGA: 2
Homologene: 134546
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269951
VEGA: 7
HGNC: HGNC:5383
Homologene: 37590
Mmrn2
Name: multimerin 2
Synonyms: ENDOGLYX1, EndoGlyx-1, Emilin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105450
VEGA: 14
Homologene: 11697
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: erythroid, Spna1, Spna-1, ihj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20739
VEGA: 1
Homologene: 74460
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: ACSVL1, FATP2, VLCS, FATP2, Vlacs, Vlac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26458
VEGA: 2
Homologene: 37830
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 103967
VEGA: 1
Homologene: 22906
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628444
VEGA: 7
Homologene: 129683
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: PreP, Ntup1, 2310012C15Rik, MP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69617
VEGA: 13
Homologene: 5742
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239081
VEGA: 14
Homologene: 77905
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22625
VEGA: 1
Homologene: 19318
Aldh1a7
Name: aldehyde dehydrogenase family 1, subfamily A7
Synonyms: Aldh-pb, Ahd2-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 26358
VEGA: 19
HGNC: HGNC:402
Homologene: 137245
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Tmem260
Name: transmembrane protein 260
Synonyms: 6720456H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218989
VEGA: 14
Homologene: 49506
Ankmy2
Name: ankyrin repeat and MYND domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217473
VEGA: 12
Homologene: 10662
Hs3st4
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 4
Synonyms: Gm6915
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628779
VEGA: 7
HGNC: HGNC:5200
Homologene: 82444
Slc25a21
Name: solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Synonyms: 9930033G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217593
VEGA: 12
Homologene: 6988
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100042165
VEGA: 5
Tbpl2
Name: TATA box binding protein like 2
Synonyms: Trf3, LOC227606
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227606
VEGA: 2
Homologene: 133152
Noxa1
Name: NADPH oxidase activator 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241275
VEGA: 2
Homologene: 18156
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 269437
VEGA: 3
Homologene: 88833
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: Desc4, 9930032O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320454
VEGA: 5
Homologene: 82239
Vmn1r74
Name: vomeronasal 1 receptor 74
Synonyms: V1rg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 171240
VEGA: 7
Homologene: 110796
Gm7534
Name: predicted gene 7534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 665186
VEGA: 4
Homologene: 104039
Hyal3
Name: hyaluronoglucosaminidase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 109685
VEGA: 9
HGNC: HGNC:5322
Homologene: 2626
Olfr129
Name: olfactory receptor 129
Synonyms: GA_x6K02T2PSCP-2503741-2502776, MOR263-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258324
VEGA: 17
Homologene: 133641
Uox
Name: urate oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 22262
VEGA: 3
Homologene: 7584
Olfr1356
Name: olfactory receptor 1356
Synonyms: MOR142-1, GA_x6K02T2QGN0-2962025-2962987, MOR142-2_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258305
VEGA: 10
HGNC: HGNC:8374
Homologene: 71958
Trim21
Name: tripartite motif-containing 21
Synonyms: Ro52, Ssa1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20821
VEGA: 7
Homologene: 2365
Olfr536
Name: olfactory receptor 536
Synonyms: MOR252-4, GA_x6K02T2PBJ9-42653501-42652578, MOR252-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258513
VEGA: 7
Homologene: 51731
Olfr550
Name: olfactory receptor 550
Synonyms: MOR16-1, GA_x6K02T2PBJ9-5297243-5298193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259108
VEGA: 7
Homologene: 17507
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 127,822,957 bp
  • T to C, chromosome 1 at 162,286,018 bp
  • A to T, chromosome 1 at 174,219,902 bp
  • G to A, chromosome 2 at 24,087,233 bp
  • T to A, chromosome 2 at 25,086,280 bp
  • C to T, chromosome 2 at 126,564,690 bp
  • A to T, chromosome 2 at 129,286,039 bp
  • A to T, chromosome 2 at 150,474,868 bp
  • T to A, chromosome 2 at 167,019,966 bp
  • A to T, chromosome 3 at 63,740,687 bp
  • T to A, chromosome 3 at 146,610,302 bp
  • A to C, chromosome 4 at 134,200,212 bp
  • A to T, chromosome 5 at 3,701,907 bp
  • T to C, chromosome 5 at 76,624,635 bp
  • T to A, chromosome 5 at 86,487,410 bp
  • T to C, chromosome 5 at 104,521,878 bp
  • A to G, chromosome 7 at 11,846,895 bp
  • A to C, chromosome 7 at 42,045,894 bp
  • GCCAGGGCC to GC, chromosome 7 at 80,098,344 bp
  • C to A, chromosome 7 at 80,460,832 bp
  • C to G, chromosome 7 at 102,559,606 bp
  • T to C, chromosome 7 at 102,579,274 bp
  • C to A, chromosome 7 at 124,397,142 bp
  • T to A, chromosome 7 at 140,503,800 bp
  • G to A, chromosome 9 at 75,275,508 bp
  • T to C, chromosome 9 at 99,536,262 bp
  • T to C, chromosome 9 at 107,585,066 bp
  • C to T, chromosome 10 at 63,019,443 bp
  • A to G, chromosome 10 at 78,847,561 bp
  • C to A, chromosome 10 at 94,138,328 bp
  • C to A, chromosome 10 at 119,211,454 bp
  • A to G, chromosome 12 at 36,165,921 bp
  • A to G, chromosome 12 at 56,858,071 bp
  • T to A, chromosome 13 at 6,560,065 bp
  • T to A, chromosome 14 at 32,262,736 bp
  • G to A, chromosome 14 at 34,397,624 bp
  • T to A, chromosome 14 at 48,484,980 bp
  • T to C, chromosome 14 at 50,362,260 bp
  • T to C, chromosome 17 at 38,054,802 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • A to G, chromosome 19 at 20,722,367 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5606 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043157-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.