Strain Name:
C57BL/6J-MtgxR5811Btlr/Mmmh
Stock Number:
043213-MU
Citation ID:
RRID:MMRRC_043213-MU
Other Names:
R5811 (G1), C57BL/6J-MtgxR5811Btlr
Major Collection:

Gene Information

Dct
Name: dopachrome tautomerase
Synonyms: tyrosinase-related protein-2, TRP-2, Tyrp-2, Tyrp2, TRP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13190
VEGA: 14
HGNC: HGNC:2709
Homologene: 1447
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20348
Homologene: 36201
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 0610009J05Rik, 2610019N13Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69207
Homologene: 36164
Sap130
Name: Sin3A associated protein
Synonyms: 2610304F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269003
VEGA: 18
Homologene: 11577
Mark4
Name: MAP/microtubule affinity regulating kinase 4
Synonyms: Markl1, 2410090P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232944
Homologene: 57146
Wdr33
Name: WD repeat domain 33
Synonyms: 2810021O11Rik, 8430413N20Rik, 2310011G05Rik, 1110001N06Rik, WDC146
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 74320
VEGA: 18
Homologene: 56807
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: NHE8, 1200006P13Rik, 6430709P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77031
Homologene: 75041
Pabpc1
Name: poly(A) binding protein, cytoplasmic 1
Synonyms: Pabpl1, Pabp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18458
HGNC: HGNC:8554
Homologene: 37638
Dnmt3l
Name: DNA (cytosine-5-)-methyltransferase 3-like
Synonyms: D6Ertd14e, ecat7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54427
HGNC: HGNC:2980
Homologene: 8362
Mcm6
Name: minichromosome maintenance complex component 6
Synonyms: Mcmd6, D1Wsu22e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17219
HGNC: HGNC:6949
Homologene: 4322
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: LOC385628, 2210409B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70144
Homologene: 13111
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70584
Homologene: 4300
Pdia5
Name: protein disulfide isomerase associated 5
Synonyms: 2700053F16Rik, Pdir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72599
VEGA: 16
Homologene: 4957
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99326
Homologene: 13003
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: ZNFPR1B1, Prdm3, MDS1-EVI1, Evi-1, D630039M04Rik, Jbo, Evi1, Mds1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Kcnn4
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Synonyms: SK4, IK1, mIKCa1, IKCa1, KCa3.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16534
HGNC: HGNC:6293
Homologene: 1696
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Btnl1
Name: butyrophilin-like 1
Synonyms: NG10, LOC240074, LOC240074, Btnl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100038862
Homologene: 103816
Epas1
Name: endothelial PAS domain protein 1
Synonyms: MOP2, HIF-2alpha, Hif like protein, hypoxia inducible transcription factor 2alpha, HLF, HRF, HIF2A, bHLHe73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13819
VEGA: 17
HGNC: HGNC:3374
Homologene: 1095
Gsdme
Name: gasdermin E
Synonyms: 4932441K13Rik, 2310037D07Rik, Fin15, Dfna5h, Dfna5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54722
HGNC: HGNC:2810
Homologene: 3242
Kctd16
Name: potassium channel tetramerisation domain containing 16
Synonyms: 4930434H12Rik, LOC383347, 2900055J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 73001
VEGA: 18
Homologene: 44779
Vmn2r89
Name: vomeronasal 2, receptor 89
Synonyms: V2r11, V2r10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22301
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Hcls1
Name: hematopoietic cell specific Lyn substrate 1
Synonyms: HS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15163
HGNC: HGNC:4844
Homologene: 38034
Lrrc66
Name: leucine rich repeat containing 66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231296
Homologene: 51944
Clnk
Name: cytokine-dependent hematopoietic cell linker
Synonyms: MIST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27278
Homologene: 8450
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Pih1d2
Name: PIH1 domain containing 2
Synonyms: 2700059L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72614
Homologene: 12474
Olfr92
Name: olfactory receptor 92
Synonyms: MOR256-29, GA_x6K02T2PSCP-1552066-1551128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8253
Homologene: 115562
Zfp873
Name: zinc finger protein 873
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 408062
Homologene: 134319
Chid1
Name: chitinase domain containing 1
Synonyms: 3110023E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68038
Homologene: 12229
Cryba4
Name: crystallin, beta A4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12959
HGNC: HGNC:2396
Homologene: 1422
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78749
Homologene: 37121
Nr2e3
Name: nuclear receptor subfamily 2, group E, member 3
Synonyms: RNR, photoreceptor-specific nuclear receptor, Pnr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23958
HGNC: HGNC:7974
Homologene: 84397
Rit1
Name: Ras-like without CAAX 1
Synonyms: Rit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19769
Homologene: 56003
Gjd3
Name: gap junction protein, delta 3
Synonyms: Gja11, connexin-30.2, cx30.2, connexin 30.2, Gjc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 353155
Homologene: 17530
Gpr135
Name: G protein-coupled receptor 135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238252
VEGA: 12
Homologene: 11211
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 128,335,728 bp
  • C to T, chromosome 1 at 153,166,253 bp
  • A to G, chromosome 2 at 33,006,899 bp
  • C to T, chromosome 2 at 167,471,387 bp
  • C to T, chromosome 3 at 29,961,000 bp
  • C to T, chromosome 3 at 38,891,787 bp
  • A to G, chromosome 3 at 88,726,082 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • C to T, chromosome 4 at 154,992,567 bp
  • T to A, chromosome 5 at 17,675,190 bp
  • A to G, chromosome 5 at 38,713,147 bp
  • T to A, chromosome 5 at 73,615,517 bp
  • T to A, chromosome 5 at 108,625,036 bp
  • C to T, chromosome 5 at 112,251,071 bp
  • T to A, chromosome 6 at 50,245,945 bp
  • T to C, chromosome 7 at 19,448,639 bp
  • T to C, chromosome 7 at 24,377,605 bp
  • T to C, chromosome 7 at 28,408,020 bp
  • G to A, chromosome 7 at 141,530,253 bp
  • T to C, chromosome 7 at 141,798,984 bp
  • T to C, chromosome 9 at 50,621,074 bp
  • TCCATCGGAGTGTTCCC to TC, chromosome 9 at 59,943,418 bp
  • A to G, chromosome 10 at 78,052,095 bp
  • T to A, chromosome 10 at 82,060,733 bp
  • A to T, chromosome 11 at 98,982,400 bp
  • A to T, chromosome 12 at 72,069,867 bp
  • A to T, chromosome 14 at 51,456,108 bp
  • A to G, chromosome 14 at 118,013,188 bp
  • G to T, chromosome 15 at 36,600,953 bp
  • A to G, chromosome 16 at 32,988,496 bp
  • A to T, chromosome 16 at 35,449,420 bp
  • A to G, chromosome 16 at 36,957,340 bp
  • T to C, chromosome 16 at 57,570,294 bp
  • A to T, chromosome 17 at 34,385,529 bp
  • C to A, chromosome 17 at 37,111,757 bp
  • A to G, chromosome 17 at 86,823,775 bp
  • T to C, chromosome 18 at 31,689,442 bp
  • T to C, chromosome 18 at 31,902,620 bp
  • T to C, chromosome 18 at 40,258,452 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5811 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043213-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.