Strain Name:
C57BL/6J-MtgxR5862Btlr/Mmmh
Stock Number:
043231-MU
Citation ID:
RRID:MMRRC_043231-MU
Other Names:
R5862 (G1), C57BL/6J-MtgxR5862Btlr
Major Collection:

Strain Information

Macroh2a1
Name: macroH2A.1 histone
Synonyms: H2AF12M, H2afy, mH2a1, MACROH2A1.2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26914
HGNC: HGNC:4740
Homologene: 3598
Sfmbt2
Name: Scm-like with four mbt domains 2
Synonyms: D330030P06Rik, D2Wsu23e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 353282
Homologene: 82485
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226747
Homologene: 9142
Cse1l
Name: chromosome segregation 1 like
Synonyms: Cas, 2610100P18Rik, Capts, Xpo2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110750
HGNC: HGNC:2431
Homologene: 1006
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: Hps2, recombination induced mutation 2, rim2, AP-3, beta3A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Hmgxb4
Name: HMG box domain containing 4
Synonyms: 4733401K04Rik, Hmgb2l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70823
HGNC: HGNC:5003
Homologene: 4007
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: 150kDa, TAFII150, TAF2B, CIF150, 4732460C16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
Ecel1
Name: endothelin converting enzyme-like 1
Synonyms: DINE, XCE
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13599
HGNC: HGNC:3147
Homologene: 3549
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Rnf167
Name: ring finger protein 167
Synonyms: 0610010G05Rik, 5730408C10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70510
Homologene: 41046
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213783
Homologene: 18897
Hapln3
Name: hyaluronan and proteoglycan link protein 3
Synonyms: 4930554N11Rik, Lpr3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67666
Homologene: 18654
Clec18a
Name: C-type lectin domain family 18, member A
Synonyms: Mrcl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353287
Homologene: 18755
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: LOC385628, 2210409B11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70144
Homologene: 13111
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229055
Homologene: 11395
Pja2
Name: praja ring finger ubiquitin ligase 2
Synonyms: Neurodap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224938
Homologene: 32233
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: Cyp2b, phenobarbitol inducible, type a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13094
HGNC: HGNC:2615
Homologene: 74933
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Hsf5
Name: heat shock transcription factor family member 5
Synonyms: LOC327992
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327992
Homologene: 52701
Neu4
Name: sialidase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241159
Homologene: 15433
Tmed6
Name: transmembrane p24 trafficking protein 6
Synonyms: 1810015P03Rik, 1810018I24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66269
Homologene: 11938
Shkbp1
Name: Sh3kbp1 binding protein 1
Synonyms: B930062H15Rik, SB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 192192
Homologene: 26700
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Usp20
Name: ubiquitin specific peptidase 20
Synonyms: Vdu2, 1700055M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74270
Homologene: 4861
Bphl
Name: biphenyl hydrolase like
Synonyms: 2010012D11Rik, 5730533B08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68021
VEGA: 13
HGNC: HGNC:1094
Homologene: 55812
Mboat1
Name: membrane bound O-acyltransferase domain containing 1
Synonyms: 9130215M02Rik, Oact1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218121
Homologene: 57467
Or5m9b
Name: olfactory receptor family 5 subfamily M member 9B
Synonyms: MOR262-13, Olfr1036, MOR245-25, GA_x6K02T2Q125-47549689-47550621
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258245
Ric8a
Name: RIC8 guanine nucleotide exchange factor A
Synonyms: synembryn, RIC-8, Ric8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101489
Homologene: 23331
Etnppl
Name: ethanolamine phosphate phospholyase
Synonyms: 1300019H02Rik, Agxt2l1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71760
Homologene: 69440
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99334
Homologene: 17586
Pcyox1
Name: prenylcysteine oxidase 1
Synonyms: PCL1, Pcly, 1200015P13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66881
Homologene: 9458
Dctn6
Name: dynactin 6
Synonyms: p27, WS-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22428
Homologene: 4792
Mief1
Name: mitochondrial elongation factor 1
Synonyms: Smcr7l
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239555
VEGA: 15
Homologene: 10374
Sh3bp5
Name: SH3-domain binding protein 5 (BTK-associated)
Synonyms: Sab
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24056
Homologene: 23450
Rasgef1a
Name: RasGEF domain family, member 1A
Synonyms: 6330404M18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70727
Homologene: 17067
Dnaja4
Name: DnaJ heat shock protein family (Hsp40) member A4
Synonyms: 1110021L12Rik, Hsj4, Dj4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58233
Homologene: 23110
Ndufa3
Name: NADH:ubiquinone oxidoreductase subunit A3
Synonyms: 1010001M12Rik, 1700022J01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66091
HGNC: HGNC:7686
Homologene: 3338
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 87,149,596 bp
  • A to G, chromosome 1 at 94,022,930 bp
  • A to G, chromosome 1 at 179,788,330 bp
  • C to T, chromosome 2 at 10,402,052 bp
  • T to A, chromosome 2 at 31,006,449 bp
  • T to A, chromosome 2 at 52,179,542 bp
  • T to C, chromosome 2 at 86,075,646 bp
  • G to T, chromosome 2 at 121,164,037 bp
  • A to G, chromosome 2 at 166,915,207 bp
  • T to A, chromosome 3 at 9,265,216 bp
  • T to C, chromosome 3 at 130,631,824 bp
  • A to G, chromosome 6 at 86,391,674 bp
  • A to C, chromosome 6 at 118,080,444 bp
  • G to A, chromosome 7 at 3,617,657 bp
  • G to T, chromosome 7 at 26,187,807 bp
  • G to T, chromosome 7 at 27,343,404 bp
  • A to T, chromosome 7 at 79,121,891 bp
  • G to T, chromosome 7 at 140,861,287 bp
  • A to T, chromosome 8 at 34,108,417 bp
  • A to G, chromosome 8 at 75,001,055 bp
  • G to T, chromosome 8 at 107,064,154 bp
  • G to A, chromosome 8 at 111,081,558 bp
  • G to T, chromosome 9 at 54,699,341 bp
  • A to T, chromosome 9 at 65,045,722 bp
  • C to T, chromosome 10 at 3,937,914 bp
  • T to C, chromosome 10 at 107,565,878 bp
  • A to G, chromosome 11 at 70,651,092 bp
  • C to A, chromosome 11 at 87,622,991 bp
  • C to T, chromosome 13 at 30,235,697 bp
  • G to A, chromosome 13 at 34,063,984 bp
  • T to A, chromosome 13 at 56,074,271 bp
  • T to A, chromosome 13 at 94,547,770 bp
  • C to A, chromosome 14 at 31,377,495 bp
  • A to T, chromosome 15 at 4,735,263 bp
  • C to A, chromosome 15 at 55,048,323 bp
  • G to A, chromosome 15 at 80,248,385 bp
  • A to T, chromosome 16 at 32,995,809 bp
  • A to G, chromosome 17 at 46,521,427 bp
  • T to C, chromosome 17 at 64,297,826 bp
  • T to A, chromosome 18 at 65,307,289 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5862 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043231-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.