Strain Name:
C57BL/6J-MtgxR5191Btlr/Mmmh
Stock Number:
043263-MU
Citation ID:
RRID:MMRRC_043263-MU
Other Names:
R5191 (G1)
Major Collection:

Strain Information

Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77569
Homologene: 18953
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99371
Homologene: 111880
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: 6330590F17Rik, D5Ertd483e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100756
Homologene: 32789
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Crh
Name: corticotropin releasing hormone
Synonyms: CRF, corticotropin releasing factor, LOC383938, corticotropin-releasing factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12918
HGNC: HGNC:2355
Homologene: 599
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Tcf4
Name: transcription factor 4
Synonyms: SEF-2, ITF-2, MITF-2B, MITF-2A, ME2, E2.2, TFE, E2-2, SEF2-1, ASP-I2, ITF-2b, 5730422P05Rik, bHLHb19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21413
Homologene: 2407
Nufip1
Name: nuclear FMR1 interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 27275
VEGA: 14
HGNC: HGNC:8057
Homologene: 8216
Atp5a1
Name: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
Synonyms: Atpm, D18Ertd206e, Mom2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 11946
HGNC: HGNC:823
Homologene: 2985
Tlr4
Name: toll-like receptor 4
Synonyms: Lps, Rasl2-8, lipopolysaccharide response
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21898
Homologene: 41317
Golga3
Name: golgi autoantigen, golgin subfamily a, 3
Synonyms: Mea-2, Mea2, 5430416E01Rik, G1-499-14, repro27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Hnrnpc
Name: heterogeneous nuclear ribonucleoprotein C
Synonyms: hnRNP C2, hnRNP C1, hnRNPC2, hnRNPC1, D14Wsu171e, Hnrpc2, Hnrpc1, Hnrpc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15381
VEGA: 14
Homologene: 74524
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb-1, spectrin R, D330027P03Rik, LOC383567, brain erythroid spectrin (235E), Spnb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20741
Homologene: 295
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Havcr1
Name: hepatitis A virus cellular receptor 1
Synonyms: Tim1, TIM-1, KIM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171283
Homologene: 136301
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329252
Homologene: 49680
Muc20
Name: mucin 20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224116
Homologene: 17135
Stmn2
Name: stathmin-like 2
Synonyms: SCG10, Scgn10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20257
Homologene: 5102
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, C030034P18Rik, TRPP2, PC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Sec31a
Name: Sec31 homolog A (S. cerevisiae)
Synonyms: 1810024J13Rik, Sec31l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69162
Homologene: 42056
Zswim1
Name: zinc finger SWIM-type containing 1
Synonyms: 2410003H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71971
Homologene: 12429
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329002
Homologene: 7198
Stk38
Name: serine/threonine kinase 38
Synonyms: 5830476G13Rik, 9530097A09Rik, Ndr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106504
Homologene: 56033
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 4932415O19Rik, 2210416H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226999
Homologene: 20661
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: STK, Fv-2, Ron, CDw136, friend virus susceptibility 2, PTK8, Fv2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Nr1h2
Name: nuclear receptor subfamily 1, group H, member 2
Synonyms: RIP15, LXRbeta, LXRB, Unr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22260
HGNC: HGNC:7965
Homologene: 21397
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246177
Homologene: 27996
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Aknad1
Name: AKNA domain containing 1
Synonyms: 4921525H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329738
Homologene: 51892
Sarm1
Name: sterile alpha and HEAT/Armadillo motif containing 1
Synonyms: MyD88-5, A830091I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237868
Homologene: 9015
Dnaaf9
Name: dynein axonemal assembly factor 9
Synonyms: 4930402H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228602
Homologene: 12623
Zc3h12d
Name: zinc finger CCCH type containing 12D
Synonyms: D730019B10Rik, TFL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237256
VEGA: 10
Homologene: 18225
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217143
Homologene: 34917
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Fyb2
Name: FYN binding protein 2
Synonyms: 1700024P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242594
Homologene: 52981
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319800
Homologene: 77136
Kcnj2
Name: potassium inwardly-rectifying channel, subfamily J, member 2
Synonyms: IRK1, Kir2.1, Kcnf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16518
HGNC: HGNC:6263
Homologene: 20249
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228846
Homologene: 18598
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11981
Homologene: 69194
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-a, Slp2, Slp2-d, Slp2-c, Slp2-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83671
Homologene: 131343
Ccdc69
Name: coiled-coil domain containing 69
Synonyms: 2210021E03Rik, D11Ertd461e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52570
Homologene: 77613
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382007
Homologene: 128363
Zfp954
Name: zinc finger protein 954
Synonyms: 5730403M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232853
Homologene: 129792
Acvrl1
Name: activin A receptor, type II-like 1
Synonyms: Alk1, activin receptor-like kinase-1, Acvrlk1, Alk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11482
HGNC: HGNC:175
Homologene: 20058
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13099
Homologene: 74936
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2510025K24Rik, 2810422M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Tyk2
Name: tyrosine kinase 2
Synonyms: JTK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54721
VEGA: 9
Homologene: 20712
Or7e166
Name: olfactory receptor family 7 subfamily E member 166
Synonyms: GA_x6K02T2PVTD-13452606-13453535, MOR146-8P, Olfr857
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257963
Homologene: 134093
Or2a54
Name: olfactory receptor family 2 subfamily A member 54
Synonyms: GA_x6K02T2P3E9-4442577-4441645, MOR261-3, Olfr441
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258649
Homologene: 88438
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: SIP1, Zfx1b, 9130203F04Rik, D130016B08Rik, Zfhx1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 24136
Homologene: 8868
Or12k8
Name: olfactory receptor family 12 subfamily K member 8
Synonyms: GA_x6K02T2NLDC-33777519-33776551, MOR159-3, Olfr361
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258365
Homologene: 27142
Mcpt4
Name: mast cell protease 4
Synonyms: myonase, MMCP-4B, MMCP-4A, MMCP-4, Mcp-4, Mcp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17227
VEGA: 14
Homologene: 130645
Mfsd4b5
Name: major facilitator superfamily domain containing 4B5
Synonyms: BC021785
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215928
Homologene: 129849
Vmn1r175
Name: vomeronasal 1 receptor 175
Synonyms: Gm6299
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 622222
Homologene: 128341
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 111175
Homologene: 69255
Dact3
Name: dishevelled-binding antagonist of beta-catenin 3
Synonyms: EG666671
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 629378
Homologene: 77340
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 40,743,893 bp
  • A to T, chromosome 1 at 72,274,977 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • G to T, chromosome 2 at 20,339,999 bp
  • T to G, chromosome 2 at 37,084,978 bp
  • T to C, chromosome 2 at 45,002,600 bp
  • T to C, chromosome 2 at 66,093,706 bp
  • C to T, chromosome 2 at 76,879,088 bp
  • A to T, chromosome 2 at 130,737,403 bp
  • C to T, chromosome 2 at 158,201,035 bp
  • G to A, chromosome 2 at 164,826,019 bp
  • A to G, chromosome 2 at 166,876,511 bp
  • C to T, chromosome 2 at 168,662,063 bp
  • A to T, chromosome 3 at 8,545,575 bp
  • T to C, chromosome 3 at 19,693,929 bp
  • T to C, chromosome 3 at 108,751,990 bp
  • G to A, chromosome 3 at 108,752,551 bp
  • A to T, chromosome 4 at 66,841,379 bp
  • G to T, chromosome 4 at 104,995,797 bp
  • A to G, chromosome 4 at 123,472,962 bp
  • T to C, chromosome 5 at 67,027,561 bp
  • T to C, chromosome 5 at 100,405,511 bp
  • G to A, chromosome 5 at 104,486,681 bp
  • T to A, chromosome 5 at 110,184,307 bp
  • C to T, chromosome 5 at 114,065,694 bp
  • T to A, chromosome 6 at 43,115,866 bp
  • A to G, chromosome 7 at 7,116,023 bp
  • T to G, chromosome 7 at 16,875,450 bp
  • A to G, chromosome 7 at 23,809,022 bp
  • C to A, chromosome 7 at 44,550,416 bp
  • A to T, chromosome 7 at 90,375,652 bp
  • A to G, chromosome 7 at 141,858,539 bp
  • T to C, chromosome 8 at 43,519,991 bp
  • A to G, chromosome 8 at 85,084,459 bp
  • G to A, chromosome 9 at 19,713,334 bp
  • G to T, chromosome 9 at 21,107,497 bp
  • G to A, chromosome 9 at 107,911,551 bp
  • C to A, chromosome 10 at 7,867,818 bp
  • T to C, chromosome 10 at 39,970,672 bp
  • C to T, chromosome 11 at 6,515,105 bp
  • A to T, chromosome 11 at 46,756,197 bp
  • A to T, chromosome 11 at 55,052,893 bp
  • G to A, chromosome 11 at 78,497,119 bp
  • T to A, chromosome 11 at 97,338,149 bp
  • C to T, chromosome 11 at 111,072,471 bp
  • T to C, chromosome 12 at 16,580,828 bp
  • C to A, chromosome 12 at 76,612,834 bp
  • A to T, chromosome 14 at 52,077,507 bp
  • T to A, chromosome 14 at 56,061,009 bp
  • A to G, chromosome 14 at 76,111,989 bp
  • C to T, chromosome 14 at 118,911,393 bp
  • A to G, chromosome 15 at 11,327,757 bp
  • T to C, chromosome 15 at 76,175,165 bp
  • A to G, chromosome 15 at 101,137,065 bp
  • A to G, chromosome 16 at 14,146,078 bp
  • G to A, chromosome 16 at 32,794,476 bp
  • A to C, chromosome 17 at 28,974,370 bp
  • A to G, chromosome 17 at 30,746,765 bp
  • A to G, chromosome 18 at 69,642,883 bp
  • C to T, chromosome 18 at 77,780,229 bp
  • T to A, chromosome 18 at 82,621,423 bp
  • G to A, chromosome 19 at 8,344,393 bp
  • A to C, chromosome 19 at 39,802,591 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5191 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043263-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.