Strain Name:
C57BL/6J-MtgxR5588Btlr
Stock Number:
043268-MU
Citation ID:
RRID:MMRRC_043268-MU
Other Names:
R5588 (G1)
Major Collection:

Gene Information

Gene Symbol: Rtel1 [MGI:2139369] (Mus musculus (mouse))
Name: regulator of telomere elongation helicase 1
Chromosome: 2
Alteration at locus: Chemically Induced
Gene Symbol: Nup155 [MGI:2181182] (Mus musculus (mouse))
Name: nucleoporin 155
Synonyms: D930027M19Rik
Chromosome: 15
Alteration at locus: Chemically Induced
Gene Symbol: Pdzd2 [MGI:1922394] (Mus musculus (mouse))
Name: PDZ domain containing 2
Synonyms: Pdzk3, A930022H17Rik, 4930537L06Rik, Gm21706, LOC223364
Chromosome: 15
Alteration at locus: Chemically Induced
Gene Symbol: Slc37a1 [MGI:2446181] (Mus musculus (mouse))
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 1
Synonyms: G3PP
Chromosome: 17
Alteration at locus: Chemically Induced
Gene Symbol: Ticrr [MGI:1924261] (Mus musculus (mouse))
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Chromosome: 7
Alteration at locus: Chemically Induced
Gene Symbol: Pcnt [MGI:102722] (Mus musculus (mouse))
Name: pericentrin (kendrin)
Synonyms: m275Asp, m239Asp, Pcnt2
Chromosome: 10
Alteration at locus: Chemically Induced
Gene Symbol: Kif5b [MGI:1098268] (Mus musculus (mouse))
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Chromosome: 18
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 83,023,055 bp
  • T to C, chromosome 1 at 90,931,599 bp
  • T to A, chromosome 2 at 34,709,154 bp
  • T to C, chromosome 2 at 38,960,035 bp
  • T to C, chromosome 2 at 89,439,416 bp
  • T to A, chromosome 2 at 89,943,792 bp
  • A to T, chromosome 2 at 177,387,272 bp
  • T to C, chromosome 2 at 181,352,100 bp
  • T to G, chromosome 3 at 5,403,138 bp
  • T to C, chromosome 3 at 64,504,076 bp
  • A to C, chromosome 3 at 65,376,555 bp
  • A to G, chromosome 3 at 69,025,857 bp
  • A to G, chromosome 3 at 84,465,476 bp
  • T to A, chromosome 4 at 45,992,225 bp
  • T to G, chromosome 4 at 64,006,422 bp
  • A to T, chromosome 4 at 111,936,892 bp
  • T to A, chromosome 5 at 14,788,398 bp
  • A to C, chromosome 5 at 21,251,149 bp
  • A to T, chromosome 5 at 31,192,173 bp
  • G to A, chromosome 5 at 32,329,949 bp
  • A to G, chromosome 5 at 67,814,684 bp
  • T to C, chromosome 7 at 16,198,900 bp
  • C to T, chromosome 7 at 29,293,284 bp
  • C to T, chromosome 7 at 79,679,105 bp
  • T to A, chromosome 7 at 104,149,132 bp
  • C to A, chromosome 7 at 112,560,062 bp
  • T to A, chromosome 8 at 3,388,878 bp
  • T to A, chromosome 8 at 22,284,967 bp
  • T to C, chromosome 8 at 33,577,187 bp
  • G to A, chromosome 9 at 71,283,450 bp
  • G to T, chromosome 9 at 103,198,849 bp
  • C to T, chromosome 9 at 121,965,181 bp
  • G to A, chromosome 10 at 51,481,326 bp
  • T to C, chromosome 10 at 76,442,611 bp
  • T to C, chromosome 10 at 96,023,910 bp
  • T to G, chromosome 10 at 129,681,836 bp
  • T to C, chromosome 11 at 4,066,138 bp
  • A to T, chromosome 11 at 12,343,886 bp
  • T to A, chromosome 11 at 55,282,277 bp
  • G to A, chromosome 11 at 69,107,627 bp
  • A to C, chromosome 11 at 119,296,126 bp
  • T to C, chromosome 12 at 108,211,534 bp
  • T to C, chromosome 12 at 116,413,077 bp
  • T to C, chromosome 13 at 22,244,342 bp
  • A to T, chromosome 13 at 41,315,961 bp
  • A to T, chromosome 13 at 49,287,310 bp
  • A to T, chromosome 13 at 62,773,770 bp
  • T to C, chromosome 14 at 101,896,590 bp
  • G to A, chromosome 15 at 8,119,253 bp
  • A to C, chromosome 15 at 12,374,281 bp
  • T to C, chromosome 15 at 78,673,876 bp
  • C to A, chromosome 15 at 82,065,216 bp
  • T to C, chromosome 16 at 31,438,119 bp
  • A to T, chromosome 17 at 23,063,829 bp
  • T to A, chromosome 17 at 31,346,457 bp
  • G to A, chromosome 17 at 33,066,275 bp
  • A to T, chromosome 17 at 56,779,890 bp
  • T to G, chromosome 18 at 6,225,787 bp
  • A to G, chromosome 18 at 62,526,177 bp
  • A to T, chromosome 18 at 67,440,207 bp
  • A to G, chromosome 19 at 39,163,414 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5588 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043268-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.