Strain Name:
C57BL/6J-MtgxR5591Btlr/Mmmh
Stock Number:
043269-MU
Citation ID:
RRID:MMRRC_043269-MU
Other Names:
R5591 (G1)
Major Collection:

Gene Information

Itga6
Name: integrin alpha 6
Synonyms: Cd49f, 5033401O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, C030040A15Rik, OTTMUSG00000012483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109241
Homologene: 81861
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Luc7l3
Name: LUC7-like 3 (S. cerevisiae)
Synonyms: 3300001P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67684
Homologene: 75056
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: A330076K04Rik, 1100001C18Rik, 2500002E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70097
Homologene: 69182
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: D330022K21Rik, 2810449C13Rik, Usp31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 170707
Homologene: 12988
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, LOC381139, 6430585N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Mtrex
Name: Mtr4 exosome RNA helicase
Synonyms: 2610528A15Rik, Skiv2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72198
VEGA: 13
Homologene: 6257
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Pals2
Name: protein associated with LIN7 2, MAGUK family member
Synonyms: P55t, Pals2, Mpp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56524
Homologene: 22976
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69748
Homologene: 34938
Zfp869
Name: zinc finger protein 869
Synonyms: U 2-7-1, 1200003I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66869
VEGA: 8
Homologene: 134644
Vamp4
Name: vesicle-associated membrane protein 4
Synonyms: D1Ertd147e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53330
Homologene: 37847
Sympk
Name: symplekin
Synonyms: 4632415H16Rik, 1500016F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68188
Homologene: 37969
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: C730009O10Rik, 9430025M21Rik, lamellipodin, Lpd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77300
Homologene: 71030
Gm7102
Name: predicted gene 7102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 633057
Gnai1
Name: guanine nucleotide binding protein (G protein), alpha inhibiting 1
Synonyms: Gialpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14677
HGNC: HGNC:4384
Homologene: 74417
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ttn
Name: titin
Synonyms: connectin, L56, 1100001C23Rik, mdm, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Sim2
Name: single-minded family bHLH transcription factor 2
Synonyms: bHLHe15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20465
VEGA: 16
Homologene: 3716
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142682
Homologene: 9037
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14789
Homologene: 8401
Olfr170
Name: olfactory receptor 170
Synonyms: GA_x54KRFPKG5P-16052703-16051765, MOR273-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258959
Homologene: 128058
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217143
Homologene: 34917
Olfr320
Name: olfactory receptor 320
Synonyms: GA_x6K02T2NKPP-733777-732813, GA_x6K02T2NKPP-730312-729392, MOR285-4, MOR285-5, Olfr320, Olfr321-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216783
Homologene: 133825
Olfr347
Name: olfactory receptor 347
Synonyms: GA_x6K02T2NLDC-33428755-33429693, MOR136-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258945
Homologene: 51790
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Olfr1261
Name: olfactory receptor 1261
Synonyms: GA_x6K02T2Q125-51425355-51426275, MOR234-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258466
Homologene: 138310
Pramel28
Name: PRAME like 28
Synonyms: Gm13101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626922
Olfr1328
Name: olfactory receptor 1328
Synonyms: GA_x6K02T2QD9B-18602750-18603691, MOR259-1, MOR259-13, MOR259-1, Olfr1519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258394
Homologene: 121524
Loxl3
Name: lysyl oxidase-like 3
Synonyms: Lor2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16950
Homologene: 56591
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: OTTMUSG00000007939, Cyp2j12-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242546
Homologene: 133195
Olfr635
Name: olfactory receptor 635
Synonyms: GA_x6K02T2PBJ9-6713641-6714588, MOR5-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259122
Homologene: 133592
Spam1
Name: sperm adhesion molecule 1
Synonyms: Ph-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20690
Homologene: 7547
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Isg20l2
Name: interferon stimulated exonuclease gene 20-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229504
Homologene: 12814
Plekhg3
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms: MGC40768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 263406
VEGA: 12
Homologene: 77478
Mlip
Name: muscular LMNA-interacting protein
Synonyms: 2310046A06Rik, CIP, cardiac ISL1-interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69642
Homologene: 90445
Lca5l
Name: Leber congenital amaurosis 5-like
Synonyms: 4921526F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385668
HGNC: HGNC:1255
Homologene: 47978
Rnf144b
Name: ring finger protein 144B
Synonyms: E130105P19Rik, Ibrdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218215
VEGA: 13
Homologene: 27092
Pramel16
Name: PRAME like 16
Synonyms: Gm13109, Pramef25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329984
Homologene: 83161
Tmem192
Name: transmembrane protein 192
Synonyms: 3110005G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73067
Homologene: 16751
Sirt5
Name: sirtuin 5
Synonyms: 0610012J09Rik, 1500032M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68346
VEGA: 13
Homologene: 40825
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: CYSLT2R, Cyslt2, CysLT2, 2300001H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70086
VEGA: 14
Homologene: 10688
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
Olfr709-ps1
Name: olfactory receptor 709, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-9307730-9306814, MOR260-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258146
Ifi27l2b
Name: interferon, alpha-inducible protein 27 like 2B
Synonyms: 1810023F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217845
Homologene: 137395
Ankrd39
Name: ankyrin repeat domain 39
Synonyms: C030004B10Rik, 9130416N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109346
Homologene: 9519
Casp14
Name: caspase 14
Synonyms: mini-ICE, MICE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12365
VEGA: 10
HGNC: HGNC:1502
Homologene: 36304
Rnmtl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Gm3676
Name: predicted gene 3676
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
E430025E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 36,541,981 bp
  • G to A, chromosome 1 at 60,501,746 bp
  • A to T, chromosome 1 at 72,591,253 bp
  • A to G, chromosome 1 at 162,588,242 bp
  • C to T, chromosome 2 at 31,344,047 bp
  • A to T, chromosome 2 at 36,735,232 bp
  • A to C, chromosome 2 at 49,274,669 bp
  • A to G, chromosome 2 at 71,840,590 bp
  • T to A, chromosome 2 at 76,709,668 bp
  • A to G, chromosome 2 at 89,993,407 bp
  • A to T, chromosome 2 at 127,819,343 bp
  • C to T, chromosome 2 at 181,240,258 bp
  • C to T, chromosome 3 at 87,930,424 bp
  • A to G, chromosome 4 at 96,141,122 bp
  • A to T, chromosome 4 at 118,934,461 bp
  • A to G, chromosome 4 at 137,652,652 bp
  • T to C, chromosome 4 at 143,948,807 bp
  • G to T, chromosome 4 at 143,964,960 bp
  • A to T, chromosome 5 at 18,271,846 bp
  • A to G, chromosome 6 at 24,800,546 bp
  • A to G, chromosome 6 at 50,180,179 bp
  • T to A, chromosome 6 at 83,048,037 bp
  • C to T, chromosome 6 at 124,854,695 bp
  • A to G, chromosome 7 at 19,054,039 bp
  • T to C, chromosome 7 at 45,144,652 bp
  • G to T, chromosome 7 at 103,980,113 bp
  • A to T, chromosome 7 at 106,927,282 bp
  • A to G, chromosome 8 at 64,965,602 bp
  • T to A, chromosome 8 at 69,707,692 bp
  • C to T, chromosome 8 at 121,605,448 bp
  • T to A, chromosome 9 at 13,272,503 bp
  • G to A, chromosome 9 at 77,230,482 bp
  • A to T, chromosome 10 at 8,725,718 bp
  • A to T, chromosome 10 at 78,714,345 bp
  • A to G, chromosome 11 at 58,684,125 bp
  • G to A, chromosome 11 at 76,250,081 bp
  • T to C, chromosome 11 at 94,293,234 bp
  • C to T, chromosome 11 at 97,345,755 bp
  • C to T, chromosome 12 at 76,560,292 bp
  • A to G, chromosome 12 at 103,451,307 bp
  • T to C, chromosome 12 at 111,323,087 bp
  • A to G, chromosome 13 at 11,595,014 bp
  • T to G, chromosome 13 at 13,743,333 bp
  • A to G, chromosome 13 at 43,371,841 bp
  • G to A, chromosome 13 at 47,242,954 bp
  • A to T, chromosome 13 at 112,927,356 bp
  • T to A, chromosome 14 at 33,107,130 bp
  • T to C, chromosome 14 at 41,643,224 bp
  • T to C, chromosome 14 at 73,029,491 bp
  • T to C, chromosome 15 at 9,583,836 bp
  • C to A, chromosome 15 at 59,369,163 bp
  • T to A, chromosome 16 at 19,605,858 bp
  • A to G, chromosome 16 at 37,011,885 bp
  • T to C, chromosome 16 at 94,097,189 bp
  • T to C, chromosome 16 at 96,178,729 bp
  • T to C, chromosome 17 at 33,911,688 bp
  • A to G, chromosome 18 at 84,561,137 bp
  • C to T, chromosome 19 at 61,175,926 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5591 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043269-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.