Strain Name:
C57BL/6J-MtgxR5608Btlr
Stock Number:
043272-MU
Citation ID:
RRID:MMRRC_043272-MU
Other Names:
R5608 (G1)
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Dyrk3
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: 2310032E02Rik, Zfp289
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77038
Homologene: 8735
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, A430032G04Rik, A430040A19Rik, D630005A10Rik, Bruce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: 4933422O15Rik, C030034J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Smndc1
Name: survival motor neuron domain containing 1
Synonyms: 2410004J23Rik, 4933440I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76479
VEGA: 19
Homologene: 4290
Mex3c
Name: mex3 RNA binding family member C
Synonyms: A130001D14Rik, BM-013, Rkhd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240396
Homologene: 9601
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, Lphn1, 2900070I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: SLC41A1-L2, 1010001P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71699
Homologene: 23052
Msh6
Name: mutS homolog 6
Synonyms: Gtmbp, Msh6, GTBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Helq
Name: helicase, POLQ-like
Synonyms: Hel308, D430018E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 191578
Homologene: 14667
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Cenpe
Name: centromere protein E
Synonyms: 312kDa, Kif10, N-7 kinesin, CENP-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Ankrd26
Name: ankyrin repeat domain 26
Synonyms: 5730521P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232339
Homologene: 45968
Zscan22
Name: zinc finger and SCAN domain containing 22
Synonyms: D530006B18Rik, Hkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232878
HGNC: HGNC:4929
Homologene: 68122
Nhlrc3
Name: NHL repeat containing 3
Synonyms: 8030451K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 212114
Homologene: 35239
Colec12
Name: collectin sub-family member 12
Synonyms: Scara4, SRCL, CL-P1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 140792
VEGA: 18
Homologene: 34248
Rnf157
Name: ring finger protein 157
Synonyms: 2610036E23Rik, A130073L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217340
Homologene: 28235
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: LigI, mLigI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: Ugcgl2, 1810064L21Rik, 3110027P15Rik, 3110001A05Rik, A230065J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Cdh13
Name: cadherin 13
Synonyms: T-cadherin, 4932416G01Rik, Tcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12554
HGNC: HGNC:1753
Homologene: 20335
Tubgcp6
Name: tubulin, gamma complex associated protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328580
Homologene: 32477
Dpysl4
Name: dihydropyrimidinase-like 4
Synonyms: Ulip4, DPY4, unc-33-like phosphoprotein 4, Crmp3, CRMP-3, Drp-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26757
HGNC: HGNC:3016
Homologene: 4691
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
4931408C20Rik
Name: RIKEN cDNA 4931408C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210940
Homologene: 86827
Bmpr1b
Name: bone morphogenetic protein receptor, type 1B
Synonyms: BMPR-IB, Acvrlk6, Alk6, CFK-43a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12167
HGNC: HGNC:1077
Homologene: 20322
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: Rab6ip1, ORF37, 1500012B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Olfr591
Name: olfactory receptor 591
Synonyms: GA_x6K02T2PBJ9-5889409-5888465, MOR24-1P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258139
Homologene: 79429
Olfr353
Name: olfactory receptor 353
Synonyms: MOR127-3, GA_x6K02T2NLDC-33585366-33584431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258943
HGNC: HGNC:8221
Homologene: 115503
Serpina5
Name: serine (or cysteine) peptidase inhibitor, clade A, member 5
Synonyms: antitrypsin, PAI-3, Pci, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268591
HGNC: HGNC:8723
Homologene: 20159
Xkr4
Name: X-linked Kx blood group related 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 497097
Homologene: 45848
Plag1
Name: pleiomorphic adenoma gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56711
HGNC: HGNC:9045
Homologene: 1993
Bpifa1
Name: BPI fold containing family A, member 1
Synonyms: SPLUNC1, Plunc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18843
Homologene: 7895
Lrrc31
Name: leucine rich repeat containing 31
Synonyms: E230002P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320352
Qrfpr
Name: pyroglutamylated RFamide peptide receptor
Synonyms: AQ27, Gpr103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229214
Homologene: 18865
Apoo-ps
Name: apolipoprotein O, pseudogene
Synonyms: Apoo, EG621156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 621156
VEGA: 13
Olfr145
Name: olfactory receptor 145
Synonyms: K21, GA_x6K02T2PVTD-31578734-31579666, MOR161-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258310
HGNC: HGNC:8477
Homologene: 56568
Alkbh7
Name: alkB homolog 7
Synonyms: 2310045B01Rik, Spata11, 2510008E23Rik, Abh7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66400
Homologene: 11964
Olfr617
Name: olfactory receptor 617
Synonyms: MOR31-10, GA_x6K02T2PBJ9-6306819-6307775
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258838
Homologene: 105208
Adamtsl5
Name: ADAMTS-like 5
Synonyms: 2010109H09Rik, Thsd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66548
Homologene: 19803
Blvrb
Name: biliverdin reductase B (flavin reductase (NADPH))
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233016
HGNC: HGNC:1063
Homologene: 573
H2-Aa
Name: histocompatibility 2, class II antigen A, alpha
Synonyms: Aalpha, A alpha, Ia-1, H-2Aa, Ia1, I-Aalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14960
HGNC: HGNC:4942
Homologene: 123820
Pcdhga6
Name: protocadherin gamma subfamily A, 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93714
HGNC: HGNC:8704
Homologene: 129611
Marcks
Name: myristoylated alanine rich protein kinase C substrate
Synonyms: Macs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17118
HGNC: HGNC:6759
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 3,671,380 bp
  • T to C, chromosome 1 at 26,683,048 bp
  • T to C, chromosome 1 at 131,128,715 bp
  • A to G, chromosome 2 at 36,890,515 bp
  • G to A, chromosome 2 at 91,270,202 bp
  • T to C, chromosome 2 at 154,147,575 bp
  • C to A, chromosome 3 at 30,689,845 bp
  • A to G, chromosome 3 at 36,180,965 bp
  • C to T, chromosome 3 at 53,462,311 bp
  • C to A, chromosome 3 at 135,235,076 bp
  • C to A, chromosome 3 at 141,857,522 bp
  • T to A, chromosome 4 at 3,905,463 bp
  • C to T, chromosome 5 at 100,790,219 bp
  • A to G, chromosome 6 at 90,640,907 bp
  • C to A, chromosome 6 at 118,511,622 bp
  • G to A, chromosome 7 at 12,906,992 bp
  • C to A, chromosome 7 at 13,306,008 bp
  • C to T, chromosome 7 at 27,459,469 bp
  • T to C, chromosome 7 at 103,172,849 bp
  • G to A, chromosome 7 at 103,584,299 bp
  • C to A, chromosome 7 at 109,919,423 bp
  • T to A, chromosome 7 at 122,997,086 bp
  • T to C, chromosome 7 at 139,098,543 bp
  • G to T, chromosome 8 at 83,937,257 bp
  • A to T, chromosome 8 at 118,757,474 bp
  • G to A, chromosome 9 at 37,897,782 bp
  • A to T, chromosome 10 at 12,671,837 bp
  • A to T, chromosome 10 at 37,136,916 bp
  • T to C, chromosome 10 at 80,342,947 bp
  • A to T, chromosome 11 at 116,396,320 bp
  • A to C, chromosome 12 at 84,787,464 bp
  • T to A, chromosome 12 at 98,688,777 bp
  • A to C, chromosome 12 at 104,103,744 bp
  • T to C, chromosome 13 at 81,155,276 bp
  • T to C, chromosome 13 at 107,414,209 bp
  • A to G, chromosome 14 at 31,370,707 bp
  • TTGTTGTCTTTGTGTT to TTGTT, chromosome 14 at 47,734,097 bp
  • C to T, chromosome 14 at 119,089,199 bp
  • A to G, chromosome 15 at 89,111,150 bp
  • T to C, chromosome 17 at 34,283,842 bp
  • A to T, chromosome 17 at 56,998,446 bp
  • G to A, chromosome 17 at 74,613,544 bp
  • A to G, chromosome 17 at 87,986,901 bp
  • T to A, chromosome 18 at 9,848,267 bp
  • A to G, chromosome 18 at 37,707,461 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • T to A, chromosome 18 at 73,589,943 bp
  • CGCTGCTGCTGC to CGCTGCTGCTGCTGC, chromosome 19 at 9,893,868 bp
  • A to G, chromosome 19 at 53,383,653 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5608 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043272-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.