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Strain Name:
C57BL/6J-MtgxR5632Btlr/Mmmh
Stock Number:
043283-MU
Citation ID:
RRID:MMRRC_043283-MU
Other Names:
R5632 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-Ma, H-2Ma, H2-M alpha
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57138
Homologene: 10665
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Pex7
Name: peroxisomal biogenesis factor 7
Synonyms: peroxisome biogenesis factor 7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18634
HGNC: HGNC:8860
Homologene: 242
Wnt7a
Name: wingless-type MMTV integration site family, member 7A
Synonyms: Wnt-7a, tw
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22421
Homologene: 20969
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22390
Homologene: 31152
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 63,150,059 bp
  • A to T, chromosome 1 at 83,278,285 bp
  • T to A, chromosome 1 at 93,217,853 bp
  • T to C, chromosome 1 at 130,907,428 bp
  • T to C, chromosome 1 at 153,131,890 bp
  • T to C, chromosome 1 at 165,185,088 bp
  • T to C, chromosome 2 at 24,927,828 bp
  • G to A, chromosome 2 at 25,408,945 bp
  • T to C, chromosome 2 at 25,579,264 bp
  • T to C, chromosome 2 at 76,705,820 bp
  • T to C, chromosome 2 at 85,770,269 bp
  • A to T, chromosome 2 at 87,645,229 bp
  • T to C, chromosome 2 at 119,070,352 bp
  • T to A, chromosome 2 at 121,360,592 bp
  • C to T, chromosome 2 at 122,281,455 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • T to G, chromosome 2 at 131,053,442 bp
  • A to G, chromosome 2 at 164,987,221 bp
  • C to T, chromosome 2 at 181,585,668 bp
  • G to T, chromosome 3 at 87,366,107 bp
  • A to G, chromosome 3 at 103,836,062 bp
  • A to T, chromosome 4 at 145,074,882 bp
  • A to T, chromosome 4 at 145,292,633 bp
  • A to G, chromosome 4 at 148,469,006 bp
  • G to A, chromosome 5 at 76,230,338 bp
  • T to A, chromosome 5 at 105,480,297 bp
  • T to A, chromosome 5 at 123,864,469 bp
  • T to C, chromosome 6 at 34,957,022 bp
  • A to G, chromosome 6 at 85,484,504 bp
  • A to C, chromosome 6 at 91,394,655 bp
  • T to C, chromosome 7 at 17,050,655 bp
  • A to C, chromosome 7 at 102,877,797 bp
  • G to C, chromosome 7 at 105,641,122 bp
  • TCCCC to TCCC, chromosome 7 at 110,124,569 bp
  • C to T, chromosome 8 at 25,679,969 bp
  • T to C, chromosome 8 at 106,079,057 bp
  • T to C, chromosome 9 at 56,257,774 bp
  • C to A, chromosome 9 at 58,253,370 bp
  • A to G, chromosome 9 at 92,266,424 bp
  • A to T, chromosome 10 at 19,888,737 bp
  • G to A, chromosome 10 at 75,904,418 bp
  • T to C, chromosome 10 at 80,382,594 bp
  • A to G, chromosome 11 at 31,889,877 bp
  • T to C, chromosome 11 at 62,338,234 bp
  • G to A, chromosome 11 at 68,954,051 bp
  • A to T, chromosome 11 at 75,445,906 bp
  • G to A, chromosome 12 at 80,397,752 bp
  • T to A, chromosome 12 at 81,917,730 bp
  • T to C, chromosome 12 at 84,617,302 bp
  • A to G, chromosome 12 at 114,538,881 bp
  • A to G, chromosome 13 at 44,896,290 bp
  • C to A, chromosome 13 at 100,230,662 bp
  • C to A, chromosome 14 at 51,994,338 bp
  • T to C, chromosome 16 at 55,915,583 bp
  • C to T, chromosome 17 at 15,403,082 bp
  • A to G, chromosome 17 at 34,138,001 bp
  • T to C, chromosome 17 at 34,201,240 bp
  • T to C, chromosome 18 at 12,171,583 bp
  • A to G, chromosome 18 at 86,498,643 bp
  • A to G, chromosome 19 at 3,622,512 bp
  • C to T, chromosome 19 at 3,968,522 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5632 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043283-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.