Strain Name:
C57BL/6J-MtgxR5738Btlr
Stock Number:
043350-MU
Citation ID:
RRID:MMRRC_043350-MU
Other Names:
R5738 (G1)
Major Collection:

Strain Information

Ighm
Name: immunoglobulin heavy constant mu
Synonyms: Ig mu, Igh6, IgM, muH, Igh-M
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16019
HGNC: HGNC:5541
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: spectrin G, brain spectrin, non-erythrocytic, elf1, 9930031C03Rik, beta fodrin, Spnb-2, Spnb2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
P2rx7
Name: purinergic receptor P2X, ligand-gated ion channel, 7
Synonyms: P2X7R, P2X7 receptor, P2X(7)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18439
HGNC: HGNC:8537
Homologene: 1925
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Mybl2
Name: myeloblastosis oncogene-like 2
Synonyms: Bmyb, B-Myb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17865
HGNC: HGNC:7548
Homologene: 1847
Ppm1b
Name: protein phosphatase 1B, magnesium dependent, beta isoform
Synonyms: PP2CB
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19043
VEGA: 17
HGNC: HGNC:9276
Homologene: 2027
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: binding factor for early enhancer, MusTRD1, WBSCR11, BEN, ESTM9, GTF3, Cream1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Phka2
Name: phosphorylase kinase alpha 2
Synonyms: 6330505C01Rik, Phk, k
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 110094
HGNC: HGNC:8926
Homologene: 246
Cbfb
Name: core binding factor beta
Synonyms: Pebp2, PEA2, Pebpb2, PEBP2b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12400
HGNC: HGNC:1539
Homologene: 11173
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17279
Homologene: 32111
Mettl1
Name: methyltransferase 1, tRNA methylguanosine
Synonyms: 2810012D02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17299
HGNC: HGNC:7030
Homologene: 3918
Fbxl5
Name: F-box and leucine-rich repeat protein 5
Synonyms: Fbl4, Fir4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242960
Homologene: 8129
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: NCU-G1, 0610031J06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56700
Homologene: 10562
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: CI-MPR, IGF-II/CI-MPR, Mpr300, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Tmem230
Name: transmembrane protein 230
Synonyms: 5730494N06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70612
Homologene: 8561
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333050
Homologene: 45469
Rnf168
Name: ring finger protein 168
Synonyms: 3110001H15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70238
Homologene: 87044
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211936
Homologene: 52235
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Wdr41
Name: WD repeat domain 41
Synonyms: MSTP048, B830029I03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218460
Homologene: 23087
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: Gnds, Rgds, RalGDS
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: 4933431N12Rik, C76116
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 1190002B08Rik, Cog2, 2700012E02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
Rgs17
Name: regulator of G-protein signaling 17
Synonyms: 6430507P11Rik, RGSZ2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56533
Homologene: 8242
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: AI414108, LOC235086
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235086
Homologene: 19472
Pga5
Name: pepsinogen 5, group I
Synonyms: pepsinogen A5, Pepf, 1110035E17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58803
VEGA: 19
Homologene: 105932
Or4k2
Name: olfactory receptor family 4 subfamily K member 2
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1, Olfr730
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258486
Homologene: 17269
Or7g16
Name: olfactory receptor family 7 subfamily G member 16
Synonyms: MOR149-1, GA_x6K02T2PVTD-12559294-12558356, Olfr828
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258598
HGNC: HGNC:8466
Homologene: 133690
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Slc25a19
Name: solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
Synonyms: DNC, TPC, 2900089E13Rik, MUP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67283
Homologene: 5982
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73945
Homologene: 35370
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74121
Homologene: 75083
Naga
Name: N-acetyl galactosaminidase, alpha
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17939
VEGA: 15
HGNC: HGNC:7631
Homologene: 221
Sav1
Name: salvador family WW domain containing 1
Synonyms: Salv, WW45, 1700040G09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 64010
VEGA: 12
Homologene: 32517
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Ap3m2
Name: adaptor-related protein complex 3, mu 2 subunit
Synonyms: AP-3B, 5830445E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64933
HGNC: HGNC:570
Homologene: 4950
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: Tas2r36, mt2r52
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353165
Homologene: 136304
Or2y3
Name: olfactory receptor family 2 subfamily Y member 3
Synonyms: GA_x6K02T2PSCP-2531299-2530355, Olfr131, MOR256-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258867
Homologene: 105889
Hepacam
Name: hepatocyte cell adhesion molecule
Synonyms: Glialcam, 2900042E01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72927
Homologene: 17652
Bhmt2
Name: betaine-homocysteine methyltransferase 2
Synonyms: D13Ucla2, C81077
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 64918
HGNC: HGNC:1048
Homologene: 49496
Fscn3
Name: fascin actin-bundling protein 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56223
HGNC: HGNC:3961
Homologene: 10475
Hipk4
Name: homeodomain interacting protein kinase 4
Synonyms: LOC233020
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233020
Homologene: 16970
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 14,875,950 bp
  • C to A, chromosome 1 at 155,866,078 bp
  • A to T, chromosome 1 at 184,731,557 bp
  • G to A, chromosome 2 at 28,542,526 bp
  • A to C, chromosome 2 at 104,930,986 bp
  • G to A, chromosome 2 at 127,877,766 bp
  • G to A, chromosome 2 at 132,244,128 bp
  • C to T, chromosome 2 at 163,068,283 bp
  • T to A, chromosome 3 at 63,773,655 bp
  • T to A, chromosome 3 at 88,326,138 bp
  • A to T, chromosome 4 at 3,782,987 bp
  • A to G, chromosome 4 at 44,310,333 bp
  • A to G, chromosome 5 at 43,762,828 bp
  • G to T, chromosome 5 at 89,708,668 bp
  • T to C, chromosome 5 at 117,748,799 bp
  • C to T, chromosome 5 at 122,652,789 bp
  • C to T, chromosome 5 at 134,383,818 bp
  • A to G, chromosome 6 at 28,430,031 bp
  • A to G, chromosome 6 at 132,777,744 bp
  • G to A, chromosome 7 at 27,528,416 bp
  • T to C, chromosome 8 at 22,803,861 bp
  • T to C, chromosome 8 at 79,673,461 bp
  • A to G, chromosome 8 at 83,271,026 bp
  • A to C, chromosome 8 at 105,202,561 bp
  • A to G, chromosome 8 at 124,546,038 bp
  • T to C, chromosome 9 at 18,815,829 bp
  • T to C, chromosome 9 at 27,328,530 bp
  • A to G, chromosome 9 at 37,383,425 bp
  • G to T, chromosome 9 at 42,373,178 bp
  • T to A, chromosome 9 at 72,912,006 bp
  • A to C, chromosome 10 at 5,833,140 bp
  • G to T, chromosome 10 at 127,041,994 bp
  • A to T, chromosome 11 at 9,621,917 bp
  • T to C, chromosome 11 at 30,145,941 bp
  • A to G, chromosome 11 at 83,336,430 bp
  • T to C, chromosome 11 at 97,351,406 bp
  • T to C, chromosome 11 at 115,624,234 bp
  • T to C, chromosome 12 at 69,976,043 bp
  • T to C, chromosome 12 at 113,421,495 bp
  • A to T, chromosome 13 at 93,663,290 bp
  • A to T, chromosome 13 at 94,978,488 bp
  • C to T, chromosome 14 at 50,186,648 bp
  • C to T, chromosome 15 at 82,334,853 bp
  • A to G, chromosome 16 at 32,282,374 bp
  • A to T, chromosome 17 at 12,717,367 bp
  • T to G, chromosome 17 at 25,387,049 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to C, chromosome 17 at 38,082,456 bp
  • T to C, chromosome 17 at 84,993,946 bp
  • A to T, chromosome 19 at 10,669,660 bp
  • ACC to AC, chromosome X at 160,559,866 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5738 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043350-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.