Strain Name:
C57BL/6J-MtgxR5753Btlr/Mmmh
Stock Number:
043358-MU
Citation ID:
RRID:MMRRC_043358-MU
Other Names:
R5753 (G1)
Major Collection:

Strain Information

Sort1
Name: sortilin 1
Synonyms: Ntr3, 2900053A11Rik, sortilin, Ntsr3, neurotensin receptor 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20661
Homologene: 136097
Pcdh9
Name: protocadherin 9
Synonyms: LOC382930, 1500001L12Rik, C630029H24Rik, C530050I23Rik, A730003J17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, D14Wsu89e, B230309H04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 9530048I21Rik, 3010027A04Rik, 2410104C19Rik, Yod
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Rnps1
Name: RNA binding protein with serine rich domain 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19826
VEGA: 17
Homologene: 40648
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A330106J01Rik, A930009A08Rik, Gpr48
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107515
Homologene: 10226
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Slc10a7
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 7
Synonyms: 2410193C02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76775
Homologene: 81628
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: Cream1, GTF3, BEN, ESTM9, binding factor for early enhancer, MusTRD1, WBSCR11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Bcas3
Name: BCAS3 microtubule associated cell migration factor
Synonyms: rudhira, breast carcinoma amplified sequence 3, Phaf2, 1500019F07Rik, 2610028P08Rik, K20D4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192197
Homologene: 9778
Rho
Name: rhodopsin
Synonyms: Rod Opsin, RP4, Long Wavelength Sensitive opsin, LWS opsin, Ops, Opn2, Noerg1, Red Opsin, opsin 2, L opsin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 212541
Homologene: 68068
Adcy1
Name: adenylate cyclase 1
Synonyms: D11Bwg1392e, I-AC, AC1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: Dbs, C130040G20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17207
Homologene: 11804
Cldn1
Name: claudin 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12737
HGNC: HGNC:2032
Homologene: 9620
Slc39a7
Name: solute carrier family 39 (zinc transporter), member 7
Synonyms: Ring5, KE4, Zip7, H2-Ke4, Ke-4, H-2Ke4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14977
HGNC: HGNC:4927
Homologene: 5072
Tusc3
Name: tumor suppressor candidate 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80286
Homologene: 6937
Fgd3
Name: FYVE, RhoGEF and PH domain containing 3
Synonyms: ZFYVE5, 5830461L01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 30938
Homologene: 22925
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: Dpde3, 9630011N22Rik, dunce
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Vax1
Name: ventral anterior homeobox 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22326
Homologene: 7593
Adamts6
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6
Synonyms: ADAM-TS6, b2b2182Clo, b2b1879.1Clo, b2b2228Clo, A930019D11Rik, b2b2029Clo, b2b2187.1Clo
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108154
VEGA: 13
HGNC: HGNC:222
Homologene: 82573
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: TR1, OCIF, osteoclastogenesis inhibitory factor, OPG, Opg
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Fam124a
Name: family with sequence similarity 124, member A
Synonyms: EG629059
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 629059
Homologene: 86241
Grk2
Name: G protein-coupled receptor kinase 2
Synonyms: Adrbk1, betaARK1, beta ARK1, beta-adrenergic receptor kinase-1, beta-AR kinase-1, Adrbk-1, beta ARK, Bark-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 110355
HGNC: HGNC:289
Homologene: 1223
Or5d18
Name: olfactory receptor family 5 subfamily D member 18
Synonyms: GA_x6K02T2Q125-49527073-49526132, mOR-EG, MOR174-9, Olfr73
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 117004
Homologene: 133889
Or4k51
Name: olfactory receptor family 4 subfamily K member 51
Synonyms: GA_x6K02T2Q125-72805651-72806589, MOR248-5, Olfr1301
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258889
Homologene: 74057
Zkscan2
Name: zinc finger with KRAB and SCAN domains 2
Synonyms: Zfp694, 9430065N20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210162
Homologene: 19671
Sync
Name: syncoilin
Synonyms: 1110057H03Rik, SNIP4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68828
Homologene: 11351
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Ada
Name: adenosine deaminase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11486
HGNC: HGNC:186
Homologene: 37249
Trim30b
Name: tripartite motif-containing 30B
Synonyms: A530023O14Rik, Trim30-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244183
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: 1200014I03Rik, Factor XIIIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Nos1ap
Name: nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms: 6330408P19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70729
Homologene: 135990
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Actn3
Name: actinin alpha 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11474
HGNC: HGNC:165
Homologene: 862
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381066
VEGA: 17
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: Bklhd3, 2200003A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69149
Homologene: 12300
Spag6l
Name: sperm associated antigen 6-like
Synonyms: PF16, Spag6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50525
Homologene: 8252
Or51b17
Name: olfactory receptor family 51 subfamily B member 17
Synonyms: 5'[b]2, Olfr64, MOR1-2, GA_x6K02T2PBJ9-6648196-6649143
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18366
Homologene: 56593
Or5w18
Name: olfactory receptor family 5 subfamily W member 18
Synonyms: MOR177-14, Olfr1143, GA_x6K02T2Q125-49303473-49304405
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258290
Homologene: 74079
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 1200004E02Rik, 2810483I07Rik, 6330514E22Rik, UBP-M
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627569
Homologene: 129606
Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Synonyms: MDR3, Pgp, P-glycoprotein, Pgy-3, Evi32, mdr-3, Mdr1a, multiple drug resistant 1a, Pgy3, P-gp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Erp27
Name: endoplasmic reticulum protein 27
Synonyms: 1810033M07Rik, 1810047B09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69187
Homologene: 12303
Or4q3
Name: olfactory receptor family 4 subfamily Q member 3
Synonyms: Olfr735, MOR243-1, GA_x6K02T2PMLR-6042130-6041183
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 257909
Homologene: 71977
Itpripl2
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 2
Synonyms: E030018N11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319622
Homologene: 45882
2310003L06Rik
Name: RIKEN cDNA 2310003L06 gene
Type: Gene
Species: Mouse
Chromosome: 5
Or4c3
Name: olfactory receptor family 4 subfamily C member 3
Synonyms: MOR236-1, GA_x6K02T2Q125-51454183-51453257, Olfr1264
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258206
Homologene: 66365
Saxo5
Name: stabilizer of axonemal microtubules 5
Synonyms: Tex45, 1700019B03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76406
Homologene: 52367
Or7a40
Name: olfactory receptor family 7 subfamily A member 40
Synonyms: Olfr19, MTPCR15, MOR140-1, M12, GA_x54KRFPKG5P-13123979-13123050
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18316
Homologene: 137402
Timm8a2
Name: translocase of inner mitochondrial membrane 8A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223262
Homologene: 86868
Rgs13
Name: regulator of G-protein signaling 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246709
HGNC: HGNC:9995
Homologene: 14774
H4c4
Name: H4 clustered histone 4
Synonyms: Hist1h4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319156
Homologene: 134481
Gm12508
Name: predicted gene 12508
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 670211
Homologene: 136501
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 144,140,740 bp
  • T to A, chromosome 1 at 170,349,399 bp
  • A to T, chromosome 2 at 87,803,252 bp
  • G to A, chromosome 2 at 88,034,576 bp
  • T to C, chromosome 2 at 90,021,503 bp
  • C to T, chromosome 2 at 110,002,512 bp
  • T to A, chromosome 2 at 111,754,801 bp
  • A to T, chromosome 2 at 163,735,398 bp
  • G to C, chromosome 3 at 108,345,774 bp
  • C to A, chromosome 4 at 55,254,787 bp
  • T to A, chromosome 4 at 129,293,386 bp
  • A to G, chromosome 5 at 8,723,160 bp
  • C to T, chromosome 5 at 87,972,515 bp
  • A to T, chromosome 5 at 109,091,804 bp
  • A to G, chromosome 5 at 134,410,983 bp
  • T to C, chromosome 6 at 29,433,489 bp
  • T to A, chromosome 6 at 115,935,487 bp
  • A to G, chromosome 6 at 136,919,877 bp
  • A to T, chromosome 6 at 140,537,004 bp
  • A to G, chromosome 7 at 103,893,201 bp
  • A to G, chromosome 7 at 104,357,337 bp
  • A to G, chromosome 7 at 118,491,009 bp
  • A to G, chromosome 7 at 123,480,700 bp
  • A to T, chromosome 8 at 3,484,112 bp
  • T to C, chromosome 8 at 12,999,993 bp
  • T to C, chromosome 8 at 39,096,946 bp
  • G to T, chromosome 8 at 78,525,299 bp
  • C to T, chromosome 8 at 85,878,230 bp
  • T to C, chromosome 8 at 122,895,304 bp
  • A to T, chromosome 9 at 4,331,404 bp
  • A to T, chromosome 11 at 7,130,300 bp
  • A to G, chromosome 11 at 85,822,084 bp
  • G to A, chromosome 13 at 23,581,604 bp
  • G to A, chromosome 13 at 36,898,108 bp
  • T to A, chromosome 13 at 49,274,940 bp
  • A to G, chromosome 13 at 104,347,350 bp
  • T to A, chromosome 13 at 109,772,722 bp
  • T to A, chromosome 14 at 50,345,588 bp
  • T to C, chromosome 14 at 62,606,539 bp
  • T to A, chromosome 14 at 93,888,161 bp
  • T to C, chromosome 14 at 121,634,625 bp
  • T to C, chromosome 14 at 122,034,877 bp
  • C to A, chromosome 15 at 54,254,059 bp
  • A to G, chromosome 15 at 76,173,420 bp
  • A to T, chromosome 16 at 16,673,620 bp
  • A to G, chromosome 16 at 16,766,967 bp
  • C to A, chromosome 16 at 26,363,121 bp
  • T to A, chromosome 16 at 87,482,899 bp
  • A to G, chromosome 17 at 20,462,917 bp
  • A to G, chromosome 17 at 21,586,894 bp
  • T to C, chromosome 17 at 24,418,164 bp
  • C to T, chromosome 17 at 34,030,176 bp
  • T to C, chromosome 18 at 43,559,116 bp
  • C to T, chromosome 19 at 4,290,468 bp
  • T to C, chromosome 19 at 4,864,567 bp
  • G to T, chromosome 19 at 59,166,382 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5753 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043358-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.