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Strain Name:
C57BL/6J-MtgxR5790Btlr
Stock Number:
043384-MU
Citation ID:
RRID:MMRRC_043384-MU
Other Names:
R5790 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, neuroaxonal dystrophy, 5830426A08Rik, ROSA62, nmf261, 1700022P15Rik, Spnb4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: RPC5, Sin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26939
Homologene: 14052
Eno1
Name: enolase 1, alpha non-neuron
Synonyms: 2-phospho-D-glycerate hydrolase, alpha-enolase, Eno-1, MBP-1, c-Myc promoter binding protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Irx3
Name: Iroquois related homeobox 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16373
Homologene: 7385
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Ciapin1
Name: cytokine induced apoptosis inhibitor 1
Synonyms: anamorsin, 2810413N20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109006
Homologene: 10658
Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 70,750,983 bp
  • G to T, chromosome 1 at 80,505,170 bp
  • T to A, chromosome 1 at 191,908,885 bp
  • A to G, chromosome 2 at 18,307,087 bp
  • T to A, chromosome 2 at 25,621,075 bp
  • T to C, chromosome 3 at 72,928,174 bp
  • T to A, chromosome 3 at 90,277,450 bp
  • T to C, chromosome 3 at 106,202,578 bp
  • A to G, chromosome 4 at 11,814,945 bp
  • A to G, chromosome 4 at 49,792,717 bp
  • C to A, chromosome 4 at 140,732,258 bp
  • G to T, chromosome 4 at 150,245,253 bp
  • T to C, chromosome 4 at 152,113,935 bp
  • A to T, chromosome 5 at 28,339,298 bp
  • A to T, chromosome 5 at 30,894,358 bp
  • T to C, chromosome 5 at 72,136,484 bp
  • T to G, chromosome 5 at 112,966,976 bp
  • C to T, chromosome 5 at 137,524,255 bp
  • T to C, chromosome 5 at 140,442,131 bp
  • T to C, chromosome 6 at 5,134,363 bp
  • A to G, chromosome 6 at 40,480,870 bp
  • A to T, chromosome 6 at 66,612,214 bp
  • A to T, chromosome 6 at 90,689,880 bp
  • G to T, chromosome 6 at 113,759,309 bp
  • A to T, chromosome 6 at 123,815,540 bp
  • T to C, chromosome 6 at 130,484,998 bp
  • T to A, chromosome 7 at 27,366,428 bp
  • T to C, chromosome 7 at 46,701,928 bp
  • G to A, chromosome 7 at 105,655,774 bp
  • A to G, chromosome 7 at 120,927,967 bp
  • C to T, chromosome 7 at 140,048,953 bp
  • T to C, chromosome 7 at 141,441,392 bp
  • C to A, chromosome 8 at 22,131,297 bp
  • T to A, chromosome 8 at 22,131,298 bp
  • A to G, chromosome 8 at 83,297,891 bp
  • T to C, chromosome 8 at 86,631,490 bp
  • T to C, chromosome 8 at 91,799,676 bp
  • C to A, chromosome 8 at 94,825,183 bp
  • C to T, chromosome 8 at 104,833,936 bp
  • A to T, chromosome 8 at 105,092,638 bp
  • A to C, chromosome 9 at 114,625,917 bp
  • A to G, chromosome 9 at 123,061,743 bp
  • A to G, chromosome 10 at 59,354,362 bp
  • G to A, chromosome 10 at 81,509,384 bp
  • T to C, chromosome 10 at 81,590,315 bp
  • A to G, chromosome 10 at 129,625,888 bp
  • C to T, chromosome 11 at 5,082,263 bp
  • T to A, chromosome 11 at 24,163,650 bp
  • T to A, chromosome 11 at 62,281,514 bp
  • T to A, chromosome 11 at 67,764,799 bp
  • T to A, chromosome 11 at 98,762,951 bp
  • C to T, chromosome 12 at 87,057,636 bp
  • T to G, chromosome 12 at 87,127,378 bp
  • T to C, chromosome 13 at 21,638,876 bp
  • G to A, chromosome 13 at 114,868,206 bp
  • G to A, chromosome 14 at 27,500,447 bp
  • T to A, chromosome 15 at 4,763,486 bp
  • A to G, chromosome 15 at 33,249,997 bp
  • A to T, chromosome 15 at 39,681,045 bp
  • T to C, chromosome 15 at 52,333,647 bp
  • T to C, chromosome 15 at 58,126,594 bp
  • T to A, chromosome 15 at 64,094,265 bp
  • G to T, chromosome 16 at 45,397,258 bp
  • C to T, chromosome 17 at 25,964,547 bp
  • T to A, chromosome 17 at 30,875,004 bp
  • T to C, chromosome 17 at 34,977,240 bp
  • C to A, chromosome 17 at 48,449,019 bp
  • T to A, chromosome 18 at 15,833,186 bp
  • T to C, chromosome 18 at 58,076,696 bp
  • T to C, chromosome 19 at 9,015,248 bp
  • A to G, chromosome 19 at 26,676,724 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5790 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043384-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.