Strain Name:
C57BL/6J-MtgxR5818Btlr
Stock Number:
043398-MU
Citation ID:
RRID:MMRRC_043398-MU
Other Names:
R5818 (G1)
Major Collection:

Gene Information

Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Npl
Name: N-acetylneuraminate pyruvate lyase
Synonyms: 0610033B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74091
Homologene: 12533
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, BB001228, Cxxc6, D10Ertd17e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 52463
Homologene: 12735
Dgat1
Name: diacylglycerol O-acyltransferase 1
Synonyms: D15Ertd23e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13350
HGNC: HGNC:2843
Homologene: 7688
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Cdk18
Name: cyclin-dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18557
HGNC: HGNC:8751
Homologene: 1949
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66185
Homologene: 41043
Ppm1b
Name: protein phosphatase 1B, magnesium dependent, beta isoform
Synonyms: PP2CB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19043
VEGA: 17
HGNC: HGNC:9276
Homologene: 2027
Larp4b
Name: La ribonucleoprotein domain family, member 4B
Synonyms: Larp5, D13Wsu64e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 217980
Homologene: 18195
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: Rab11-FIP3, D030060O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 215445
Homologene: 49396
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: Zfp198, RAMP, FIM, SCLL, MYM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 76007
VEGA: 14
Homologene: 12631
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, AATYK2, KPI-2, cprk, KPI2, A330101P12Rik, BREK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231876
Homologene: 8948
Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Synonyms: MOP1, HIF1alpha, HIF-1alpha, bHLHe78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15251
HGNC: HGNC:4910
Homologene: 1171
Nusap1
Name: nucleolar and spindle associated protein 1
Synonyms: 2610201A12Rik, NuSAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 108907
Homologene: 10207
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: KRAP, Ssfa2, CS-1, SPAG13, CS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 70599
Homologene: 4912
Numb
Name: NUMB endocytic adaptor protein
Synonyms: m-numb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18222
HGNC: HGNC:8060
Homologene: 2775
Ppfia1
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms: liprin, C030014K08Rik, Liprin-alpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233977
HGNC: HGNC:9245
Homologene: 20802
Krt10
Name: keratin 10
Synonyms: cytokeratin 10, Krt-1.10, keratin 10, D130054E02Rik, suprabasal cytokeratin 10, K10, K1C1, Krt1-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16661
HGNC: HGNC:6413
Homologene: 137236
Tmem198b
Name: transmembrane protein 198b
Synonyms: 1110012D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 73827
Homologene: 77634
Adam33
Name: a disintegrin and metallopeptidase domain 33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 110751
Homologene: 11881
Tmem201
Name: transmembrane protein 201
Synonyms: Samp1, D4Ertd429e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230917
Homologene: 35319
Gm8300
Name: predicted gene 8300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 666806
Homologene: 103865
Tsku
Name: tsukushi, small leucine rich proteoglycan
Synonyms: 9530051K01Rik, Lrrc54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244152
Homologene: 41045
Dach1
Name: dachshund family transcription factor 1
Synonyms: E130112M23Rik, Dac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Sohlh2
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 2
Synonyms: 4933406N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74434
Homologene: 9864
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 269023
VEGA: 18
Homologene: 18485
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 69439
Homologene: 72545
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56523
Homologene: 23182
Fbxw26
Name: F-box and WD-40 domain protein 26
Synonyms: Gm5163
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382109
Homologene: 110776
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: vomeromodulin, 4833413D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71425
Homologene: 128535
Abca6
Name: ATP-binding cassette, sub-family A (ABC1), member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Bace1
Name: beta-site APP cleaving enzyme 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 23821
HGNC: HGNC:933
Homologene: 8014
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 53419
Homologene: 4804
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPS, D1Ucla3, CPSase I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: TBRIII, 1110036H20Rik, betaglycan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21814
Homologene: 2436
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 57764
Homologene: 10934
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226438
Homologene: 130054
Onecut2
Name: one cut domain, family member 2
Synonyms: Oc2, OC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225631
HGNC: HGNC:8139
Homologene: 113592
Vmn1r60
Name: vomeronasal 1 receptor 60
Synonyms: Gm7184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 636697
Homologene: 41799
Kctd8
Name: potassium channel tetramerisation domain containing 8
Synonyms: A730087N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243043
Homologene: 18464
Ccdc155
Name: coiled-coil domain containing 155
Synonyms: LOC384619, KASH5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384619
Homologene: 16973
Olfr149
Name: olfactory receptor 149
Synonyms: M31, GA_x6K02T2PVTD-33400306-33399371, MOR224-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235256
VEGA: 9
Homologene: 28452
Cyp4a29
Name: cytochrome P450, family 4, subfamily a, polypeptide 29
Synonyms: Cyp4a29-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230639
Thnsl2
Name: threonine synthase-like 2 (bacterial)
Synonyms: TSH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232078
Homologene: 5489
Bend6
Name: BEN domain containing 6
Synonyms: B230209C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320705
Homologene: 27394
Hyou1
Name: hypoxia up-regulated 1
Synonyms: Cab140, Grp170, Orp150, CBP-140, 140 kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12282
Homologene: 4658
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 675969
Homologene: 104330
Zscan26
Name: zinc finger and SCAN domain containing 26
Synonyms: Zfp187
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 432731
Homologene: 43739
Gabrd
Name: gamma-aminobutyric acid (GABA) A receptor, subunit delta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14403
HGNC: HGNC:4084
Homologene: 55489
Chrng
Name: cholinergic receptor, nicotinic, gamma polypeptide
Synonyms: Acrg, Achr-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11449
HGNC: HGNC:1967
Homologene: 3810
Krtap4-16
Name: keratin associated protein 4-16
Synonyms: OTTMUSG00000002196
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 435285
Homologene: 128438
Smim8
Name: small integral membrane protein 8
Synonyms: 2810406B13Rik, 1810030N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66291
Homologene: 10708
Ucn2
Name: urocortin 2
Synonyms: Ucn-2, Urocortin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 171530
Homologene: 50048
Gm11677
Name: predicted gene 11677
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 629967
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 33,883,573 bp
  • A to T, chromosome 1 at 67,166,488 bp
  • G to A, chromosome 1 at 87,209,801 bp
  • A to G, chromosome 1 at 132,119,098 bp
  • A to T, chromosome 1 at 135,966,126 bp
  • G to A, chromosome 1 at 153,535,915 bp
  • T to A, chromosome 2 at 79,644,593 bp
  • A to C, chromosome 2 at 119,635,513 bp
  • A to T, chromosome 2 at 131,054,358 bp
  • T to G, chromosome 2 at 154,262,295 bp
  • A to G, chromosome 3 at 55,190,501 bp
  • T to G, chromosome 4 at 11,513,319 bp
  • TTTAATGAAGAGCT to TT, chromosome 4 at 34,771,261 bp
  • T to C, chromosome 4 at 115,247,032 bp
  • G to A, chromosome 4 at 149,727,392 bp
  • G to A, chromosome 4 at 155,388,361 bp
  • C to T, chromosome 5 at 69,296,711 bp
  • G to T, chromosome 5 at 72,435,395 bp
  • A to T, chromosome 5 at 107,133,003 bp
  • G to A, chromosome 5 at 144,156,900 bp
  • T to C, chromosome 6 at 71,134,143 bp
  • T to A, chromosome 7 at 5,545,099 bp
  • A to G, chromosome 7 at 28,919,019 bp
  • C to T, chromosome 7 at 45,193,959 bp
  • T to C, chromosome 7 at 86,229,934 bp
  • T to C, chromosome 7 at 98,352,098 bp
  • T to C, chromosome 7 at 144,520,568 bp
  • T to C, chromosome 8 at 109,538,679 bp
  • T to C, chromosome 9 at 39,702,365 bp
  • G to A, chromosome 9 at 44,388,926 bp
  • T to C, chromosome 9 at 45,859,049 bp
  • A to T, chromosome 9 at 108,986,497 bp
  • G to T, chromosome 9 at 109,732,566 bp
  • C to A, chromosome 10 at 62,816,408 bp
  • A to G, chromosome 10 at 93,644,764 bp
  • G to A, chromosome 10 at 128,802,188 bp
  • G to A, chromosome 11 at 60,497,951 bp
  • C to A, chromosome 11 at 94,418,120 bp
  • A to G, chromosome 11 at 99,388,771 bp
  • T to A, chromosome 11 at 99,851,523 bp
  • A to T, chromosome 11 at 110,219,643 bp
  • C to T, chromosome 11 at 111,724,711 bp
  • A to G, chromosome 12 at 73,939,564 bp
  • C to T, chromosome 12 at 83,825,254 bp
  • T to G, chromosome 12 at 87,517,060 bp
  • T to A, chromosome 13 at 9,158,560 bp
  • A to G, chromosome 13 at 21,445,761 bp
  • A to G, chromosome 14 at 56,946,529 bp
  • T to C, chromosome 14 at 98,168,684 bp
  • A to G, chromosome 15 at 74,611,982 bp
  • G to A, chromosome 15 at 76,502,207 bp
  • T to C, chromosome 17 at 26,016,116 bp
  • A to G, chromosome 17 at 84,993,719 bp
  • C to T, chromosome 18 at 54,895,396 bp
  • T to A, chromosome 18 at 64,340,975 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5818 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043398-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.