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Strain Name:
C57BL/6J-MtgxR5851Btlr/Mmmh
Stock Number:
044067-MU
Citation ID:
RRID:MMRRC_044067-MU
Other Names:
R5851 (G1)
Major Collection:

Strain Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Myo1e
Name: myosin IE
Synonyms: 2310020N23Rik, 9130023P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Fubp3
Name: far upstream element (FUSE) binding protein 3
Synonyms: FBP3, A330051M14Rik, Marta2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320267
HGNC: HGNC:4005
Homologene: 45954
Csrnp1
Name: cysteine-serine-rich nuclear protein 1
Synonyms: taip-3, 4931429D10Rik, CSRNP-1, Axud1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215418
VEGA: 9
Homologene: 13196
Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: D030053O22Rik, A430078G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 95,325,143 bp
  • A to G, chromosome 1 at 164,049,574 bp
  • T to A, chromosome 1 at 180,669,198 bp
  • A to G, chromosome 2 at 25,442,310 bp
  • T to A, chromosome 2 at 31,598,610 bp
  • A to T, chromosome 2 at 32,761,607 bp
  • A to G, chromosome 2 at 88,486,860 bp
  • A to G, chromosome 2 at 90,707,038 bp
  • T to A, chromosome 2 at 157,167,325 bp
  • G to A, chromosome 3 at 92,080,539 bp
  • T to A, chromosome 3 at 94,479,126 bp
  • G to A, chromosome 4 at 41,206,268 bp
  • T to C, chromosome 4 at 56,916,770 bp
  • A to G, chromosome 4 at 59,913,906 bp
  • A to G, chromosome 4 at 111,885,600 bp
  • A to G, chromosome 4 at 114,986,970 bp
  • C to T, chromosome 5 at 30,114,290 bp
  • G to A, chromosome 5 at 111,235,469 bp
  • A to G, chromosome 5 at 138,126,478 bp
  • G to A, chromosome 5 at 141,962,669 bp
  • A to G, chromosome 6 at 30,089,976 bp
  • T to C, chromosome 6 at 132,847,308 bp
  • C to A, chromosome 7 at 7,115,625 bp
  • T to C, chromosome 7 at 25,474,600 bp
  • G to T, chromosome 7 at 28,523,511 bp
  • A to G, chromosome 7 at 104,003,452 bp
  • A to G, chromosome 7 at 120,039,362 bp
  • C to T, chromosome 7 at 140,228,027 bp
  • T to C, chromosome 8 at 3,434,980 bp
  • T to C, chromosome 8 at 105,890,867 bp
  • G to T, chromosome 8 at 107,347,727 bp
  • T to A, chromosome 9 at 35,670,501 bp
  • G to A, chromosome 9 at 70,383,804 bp
  • C to T, chromosome 9 at 119,973,078 bp
  • C to A, chromosome 10 at 76,236,740 bp
  • A to T, chromosome 10 at 81,364,877 bp
  • A to T, chromosome 11 at 58,994,700 bp
  • T to C, chromosome 11 at 77,518,447 bp
  • C to A, chromosome 11 at 102,457,601 bp
  • A to T, chromosome 11 at 107,110,862 bp
  • A to T, chromosome 12 at 69,756,564 bp
  • A to G, chromosome 13 at 73,691,740 bp
  • G to T, chromosome 13 at 92,215,522 bp
  • G to A, chromosome 13 at 112,908,952 bp
  • T to C, chromosome 13 at 119,440,765 bp
  • A to T, chromosome 14 at 50,892,878 bp
  • A to G, chromosome 14 at 53,430,115 bp
  • G to A, chromosome 15 at 66,783,723 bp
  • T to A, chromosome 16 at 14,920,436 bp
  • C to T, chromosome 17 at 34,309,771 bp
  • C to T, chromosome 17 at 55,967,582 bp
  • T to C, chromosome 17 at 57,211,612 bp
  • T to G, chromosome 17 at 58,973,746 bp
  • A to G, chromosome 18 at 37,412,758 bp
  • C to T, chromosome 19 at 17,395,198 bp
  • T to C, chromosome 19 at 53,236,774 bp
  • G to A, chromosome 19 at 58,673,792 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5851 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044067-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.