Strain Name:
C57BL/6J-MtgxR5859Btlr
Stock Number:
044071-MU
Citation ID:
RRID:MMRRC_044071-MU
Other Names:
R5859 (G1)
Major Collection:

Gene Information

Neurog2
Name: neurogenin 2
Synonyms: ngn2, Math4A, Atoh4, bHLHa8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11924
Homologene: 7633
Slk
Name: STE20-like kinase
Synonyms: SLK, mSLK, Etk4, 9A2, Stk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20874
Homologene: 22515
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: l7Rl1, Sra-1, P140SRA-1, pl-1, Shyc, l(7)1Rl, E030028J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20430
Homologene: 22628
Sec24d
Name: Sec24 related gene family, member D (S. cerevisiae)
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69608
Homologene: 40986
Slain2
Name: SLAIN motif family, member 2
Synonyms: 8030444K12Rik, 5033405K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75991
Homologene: 18952
Ncbp1
Name: nuclear cap binding protein subunit 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433702
HGNC: HGNC:7658
Homologene: 1859
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, 4832420A03Rik, C030033M12Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 24088
Homologene: 20695
Wdr5
Name: WD repeat domain 5
Synonyms: Big-3, 2410008O07Rik, Bmp2-induced gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 140858
Homologene: 59931
Ascc2
Name: activating signal cointegrator 1 complex subunit 2
Synonyms: ASC1p100, 1700011I11Rik, 2610034L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 75452
Homologene: 41774
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: E430018P19Rik, 8030453L17Rik, KMT2H, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192195
Homologene: 10225
Btla
Name: B and T lymphocyte associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208154
Homologene: 52233
Spag5
Name: sperm associated antigen 5
Synonyms: D11Bhm180e, s17, Deepest, Mastrin, S17, Astrin, MAP126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 54141
Homologene: 4718
Flii
Name: flightless I actin binding protein
Synonyms: Fliih, 3632430F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68750
Homologene: 2218
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74241
Homologene: 11574
Chrdl2
Name: chordin-like 2
Synonyms: Chl2, 1810022C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69121
Homologene: 128795
Glt8d2
Name: glycosyltransferase 8 domain containing 2
Synonyms: 1110021D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74782
Homologene: 41826
Gramd1c
Name: GRAM domain containing 1C
Synonyms: 4921521N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 207798
Homologene: 129735
Drg1
Name: developmentally regulated GTP binding protein 1
Synonyms: Nedd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13494
HGNC: HGNC:3029
Homologene: 3060
Copb2
Name: coatomer protein complex, subunit beta 2 (beta prime)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 50797
HGNC: HGNC:2232
Homologene: 3499
Ltbr
Name: lymphotoxin B receptor
Synonyms: Ltar, LT beta-R, TNF-R-III, TNFRrp, TNFCR, TNFR2-RP, LTbetaR, Tnfbr, Tnfrsf3, LT-beta receptor, TNF receptor-related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12807
Homologene: 13019
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: XT2, Xtrp2, D630001K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 22598
VEGA: 13
Homologene: 40785
Kif17
Name: kinesin family member 17
Synonyms: 5930435E01Rik, Kif17b, N-4 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16559
Homologene: 5883
Olfr543
Name: olfactory receptor 543
Synonyms: MOR42-2, GA_x6K02T2PBJ9-5199377-5198367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 257947
HGNC: null
Homologene: 81631
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14918
HGNC: null
Homologene: 71540
Scap
Name: SREBF chaperone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235623
Homologene: 8160
Olfr213
Name: olfactory receptor 213
Synonyms: GA_x54KRFPKN04-58174409-58175392, MOR119-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 258020
HGNC: null
Homologene: 74186
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 2010200K21Rik, 4833414G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75767
Homologene: 11853
St8sia2
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Synonyms: ST8SiaII, Siat8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20450
Homologene: 4384
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382090
Homologene: 8930
Adam5
Name: a disintegrin and metallopeptidase domain 5
Synonyms: tMDCII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11499
HGNC: HGNC:212
Homologene: 49138
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: Nlrc1, Card4, F830007N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 107607
Homologene: 4440
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232367
HGNC: null
Homologene: null
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: TBRIII, 1110036H20Rik, betaglycan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21814
Homologene: 2436
Hs3st4
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 4
Synonyms: Gm6915
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628779
HGNC: HGNC:5200
Homologene: 82444
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242721
Homologene: 17567
Alg11
Name: asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 207958
Homologene: 68893
Lvrn
Name: laeverin
Synonyms: Aqpep, 4833403I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 74574
VEGA: 18
Homologene: 51352
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224576
HGNC: null
Homologene: 135824
Btnl10
Name: butyrophilin-like 10
Synonyms: Butr1, BUTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192194
Homologene: 138184
Ms4a13
Name: membrane-spanning 4-domains, subfamily A, member 13
Synonyms: 1700060E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 73466
Homologene: 77851
Psph
Name: phosphoserine phosphatase
Synonyms: PSPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100678
HGNC: HGNC:9577
Homologene: 31245
Klk15
Name: kallikrein related-peptidase 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 317652
Homologene: 77571
Nelfcd
Name: negative elongation factor complex member C/D, Th1l
Synonyms: 2410003I03Rik, trihydrophobin 1, Th1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 57314
Homologene: 9496
Olfr726
Name: olfactory receptor 726
Synonyms: GA_x6K02T2PMLR-5775299-5774334, MOR246-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258313
Homologene: 44957
Erich3
Name: glutamate rich 3
Synonyms: 5031409G23Rik, 4922501L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 209601
Homologene: 27877
Olfr103
Name: olfactory receptor 103
Synonyms: GA_x6K02T2PSCP-1798423-1797482, MOR250-3, MOR250-8_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258830
HGNC: null
Homologene: 115555
Plpp7
Name: phospholipid phosphatase 7 (inactive)
Synonyms: NET39, Ppapdc3, D830019K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227721
Homologene: 41885
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: Gm872, LOC380653, 4930485B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 380654
Homologene: 133438
Pcdha11
Name: protocadherin alpha 11
Synonyms: A830022B16Rik, Crnr7, Cnr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Arl14ep
Name: ADP-ribosylation factor-like 14 effector protein
Synonyms: 4930448O08Rik, 2700007P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 212772
Homologene: 17546
Gm21136
Name: predicted gene, 21136
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100861686
HGNC: null
Homologene: 45597
Lnpk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Wbscr28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
6330408A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 75,475,428 bp
  • A to G, chromosome 2 at 27,533,350 bp
  • A to G, chromosome 2 at 32,095,984 bp
  • G to A, chromosome 2 at 74,569,028 bp
  • C to T, chromosome 2 at 106,969,053 bp
  • T to G, chromosome 2 at 174,427,063 bp
  • G to A, chromosome 3 at 20,008,870 bp
  • T to G, chromosome 3 at 83,836,503 bp
  • C to T, chromosome 3 at 89,068,993 bp
  • A to T, chromosome 3 at 123,279,312 bp
  • T to C, chromosome 3 at 127,634,015 bp
  • A to G, chromosome 3 at 154,762,497 bp
  • A to G, chromosome 4 at 46,163,026 bp
  • T to A, chromosome 4 at 138,291,433 bp
  • T to A, chromosome 4 at 139,967,574 bp
  • T to C, chromosome 5 at 72,948,545 bp
  • T to A, chromosome 5 at 107,140,515 bp
  • A to T, chromosome 5 at 129,790,621 bp
  • A to G, chromosome 5 at 134,902,884 bp
  • A to T, chromosome 6 at 54,930,177 bp
  • T to C, chromosome 6 at 116,540,900 bp
  • T to G, chromosome 6 at 124,200,688 bp
  • T to C, chromosome 6 at 125,312,808 bp
  • C to T, chromosome 7 at 13,261,445 bp
  • T to A, chromosome 7 at 38,867,741 bp
  • G to A, chromosome 7 at 43,938,376 bp
  • T to C, chromosome 7 at 55,925,181 bp
  • T to C, chromosome 7 at 73,966,906 bp
  • C to T, chromosome 7 at 97,685,559 bp
  • T to A, chromosome 7 at 98,451,883 bp
  • A to G, chromosome 7 at 100,020,907 bp
  • T to C, chromosome 7 at 102,477,750 bp
  • A to T, chromosome 7 at 123,983,608 bp
  • A to G, chromosome 8 at 22,065,841 bp
  • A to T, chromosome 8 at 24,813,461 bp
  • A to C, chromosome 8 at 27,154,720 bp
  • C to T, chromosome 9 at 87,204,092 bp
  • G to A, chromosome 9 at 98,568,108 bp
  • A to G, chromosome 9 at 110,374,047 bp
  • T to C, chromosome 10 at 82,672,081 bp
  • T to A, chromosome 10 at 93,016,524 bp
  • G to A, chromosome 11 at 3,259,273 bp
  • G to A, chromosome 11 at 4,658,284 bp
  • C to T, chromosome 11 at 58,922,312 bp
  • G to T, chromosome 11 at 60,716,311 bp
  • G to A, chromosome 11 at 78,313,534 bp
  • A to G, chromosome 12 at 84,794,063 bp
  • C to A, chromosome 13 at 37,947,408 bp
  • C to T, chromosome 13 at 37,947,409 bp
  • G to T, chromosome 13 at 73,668,159 bp
  • T to A, chromosome 14 at 50,084,027 bp
  • T to C, chromosome 16 at 43,992,091 bp
  • T to G, chromosome 16 at 45,239,039 bp
  • T to A, chromosome 17 at 20,285,321 bp
  • T to C, chromosome 17 at 37,336,369 bp
  • A to T, chromosome 18 at 37,007,283 bp
  • T to C, chromosome 18 at 46,893,749 bp
  • A to T, chromosome 19 at 11,183,916 bp
  • T to A, chromosome 19 at 47,609,042 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5859 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044071-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.