Strain Name:
C57BL/6J-MtgxR5868Btlr/Mmmh
Stock Number:
044076-MU
Citation ID:
RRID:MMRRC_044076-MU
Other Names:
R5868 (G1)
Major Collection:

Gene Information

Npr1
Name: natriuretic peptide receptor 1
Synonyms: NPRA, GC-A, NPR-A, guanylyl cyclase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16579
Homologene: 7799
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: P140SRA-1, Shyc, pl-1, l(7)1Rl, Sra-1, E030028J09Rik, l7Rl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20430
Homologene: 22628
Apbb2
Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: WOX1, 9030416C10Rik, 5330426P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80707
Homologene: 56334
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225432
VEGA: 18
Homologene: 35410
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Rnpc3
Name: RNA-binding region (RNP1, RRM) containing 3
Synonyms: C030014B17Rik, 2810441O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67225
Homologene: 9746
Sh3gl1
Name: SH3-domain GRB2-like 1
Synonyms: SH3P8, EEN, endophilin II, Sh3d2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20405
VEGA: 17
Homologene: 55709
Cul5
Name: cullin 5
Synonyms: 4921514I20Rik, C330021I08Rik, C030032G03Rik, VACM-1, 8430423K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Pld3
Name: phospholipase D family, member 3
Synonyms: Sam-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18807
Homologene: 7893
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: crn, 1200013P10Rik, 5730590A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66877
Homologene: 6462
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225115
Homologene: 25090
Tmtc1
Name: transmembrane and tetratricopeptide repeat containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387314
Homologene: 65299
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 2610510G03Rik, TFIIIC-BETA, TFIIIC110, 1300004C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Mfsd14a
Name: major facilitator superfamily domain containing 14A
Synonyms: Hiat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15247
Homologene: 22456
Dennd4a
Name: DENN/MADD domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Elmo2
Name: engulfment and cell motility 2
Synonyms: 1190002F24Rik, CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140579
Homologene: 44338
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: Gnn, BC030307
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Neu2
Name: neuraminidase 2
Synonyms: brain sialidase, cystolic sialidase, MSS, MBS, MTS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23956
HGNC: HGNC:7759
Homologene: 3927
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: F830007N14Rik, Card4, Nlrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107607
Homologene: 4440
Adamts18
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 208936
Homologene: 65241
Serpinf2
Name: serine (or cysteine) peptidase inhibitor, clade F, member 2
Synonyms: alpha 2 antiplasmin, Pli
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18816
HGNC: HGNC:9075
Homologene: 719
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Fggy
Name: FGGY carbohydrate kinase domain containing
Synonyms: 2310009E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75578
Homologene: 49535
Bpifa1
Name: BPI fold containing family A, member 1
Synonyms: SPLUNC1, Plunc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18843
Homologene: 7895
Noxred1
Name: NADP+ dependent oxidoreductase domain containing 1
Synonyms: 4933437F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71275
VEGA: 12
Homologene: 51388
Nid1
Name: nidogen 1
Synonyms: entactin, entactin 1, nidogen-1, entactin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Pdcd6
Name: programmed cell death 6
Synonyms: PS2, MA-3, Alg2, alg-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18570
VEGA: 13
HGNC: HGNC:8765
Homologene: 7880
Dnaaf8
Name: dynein axonemal assembly factor 8
Synonyms: 4930451G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74684
VEGA: 16
Synpo
Name: synaptopodin
Synonyms: 9330140I15Rik, 9030217H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 104027
Homologene: 5274
Fam205c
Name: family with sequence similarity 205, member C
Synonyms: BC049635
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277773
Homologene: 77625
Hacl1
Name: 2-hydroxyacyl-CoA lyase 1
Synonyms: Hpcl, 1600020H07Rik, Phyh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56794
Homologene: 5794
Prh1
Name: proline rich protein HaeIII subfamily 1
Synonyms: A-type, MP2, Prp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19131
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435916
Homologene: 135826
Ripor1
Name: RHO family interacting cell polarization regulator 1
Synonyms: 2310066E14Rik, Fam65a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75687
Homologene: 11564
Mzf1
Name: myeloid zinc finger 1
Synonyms: Znf42, Mzf2, Zfp121, Zfp98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109889
Homologene: 9633
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 194126
Homologene: 82382
Slc16a9
Name: solute carrier family 16 (monocarboxylic acid transporters), member 9
Synonyms: 4930425B13Rik, 1200003C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66859
Homologene: 32642
2810408A11Rik
Name: RIKEN cDNA 2810408A11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70419
Homologene: 49883
BC035947
Name: cDNA sequence BC035947
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
H4f16
Name: H4 histone 16
Synonyms: B130044J01Rik, Hist4h4, H4-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320332
Homologene: 134493
Cfap91
Name: cilia and flagella associated protein 91
Synonyms: Spata26, 4932425I24Rik, Maats1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 320214
Homologene: 33470
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 78,498,323 bp
  • G to T, chromosome 1 at 87,596,756 bp
  • T to C, chromosome 1 at 163,865,472 bp
  • G to A, chromosome 2 at 22,685,067 bp
  • A to T, chromosome 2 at 145,918,553 bp
  • A to G, chromosome 2 at 154,143,876 bp
  • A to T, chromosome 2 at 165,294,272 bp
  • A to G, chromosome 3 at 86,319,604 bp
  • A to G, chromosome 3 at 90,459,493 bp
  • T to A, chromosome 3 at 96,171,202 bp
  • T to C, chromosome 3 at 113,616,711 bp
  • T to C, chromosome 3 at 116,633,750 bp
  • A to T, chromosome 4 at 42,871,711 bp
  • A to G, chromosome 4 at 95,696,988 bp
  • A to C, chromosome 5 at 31,168,081 bp
  • T to A, chromosome 5 at 66,452,096 bp
  • C to A, chromosome 6 at 54,939,327 bp
  • T to C, chromosome 6 at 89,322,722 bp
  • T to C, chromosome 6 at 123,712,942 bp
  • A to G, chromosome 6 at 132,572,211 bp
  • C to T, chromosome 6 at 136,804,294 bp
  • A to T, chromosome 6 at 148,237,855 bp
  • A to T, chromosome 7 at 13,053,189 bp
  • G to T, chromosome 7 at 27,537,668 bp
  • A to C, chromosome 7 at 55,926,313 bp
  • T to C, chromosome 8 at 105,616,004 bp
  • T to A, chromosome 8 at 113,777,748 bp
  • T to A, chromosome 8 at 114,679,846 bp
  • A to G, chromosome 9 at 53,570,124 bp
  • C to A, chromosome 9 at 53,658,673 bp
  • T to C, chromosome 9 at 64,896,729 bp
  • C to A, chromosome 9 at 72,809,717 bp
  • C to T, chromosome 10 at 50,842,183 bp
  • T to C, chromosome 10 at 70,282,490 bp
  • A to G, chromosome 10 at 80,882,746 bp
  • T to C, chromosome 10 at 86,750,264 bp
  • C to A, chromosome 11 at 69,897,575 bp
  • T to C, chromosome 11 at 75,433,239 bp
  • T to A, chromosome 12 at 87,224,202 bp
  • T to C, chromosome 13 at 13,489,157 bp
  • T to C, chromosome 13 at 74,304,014 bp
  • G to A, chromosome 14 at 21,634,479 bp
  • C to A, chromosome 14 at 31,619,916 bp
  • T to C, chromosome 16 at 4,974,068 bp
  • T to A, chromosome 16 at 38,332,242 bp
  • T to C, chromosome 17 at 56,019,119 bp
  • G to A, chromosome 18 at 5,056,854 bp
  • T to A, chromosome 18 at 42,300,385 bp
  • C to A, chromosome 18 at 57,943,996 bp
  • A to G, chromosome 18 at 60,604,046 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5868 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044076-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.