Strain Name:
C57BL/6J-MtgxR5969Btlr/Mmmh
Stock Number:
044152-MU
Citation ID:
RRID:MMRRC_044152-MU
Other Names:
R5969 (G1)
Major Collection:

Strain Information

Notch3
Name: notch 3
Synonyms: hpbk, N3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Fxyd2
Name: FXYD domain-containing ion transport regulator 2
Synonyms: Atp1g1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11936
VEGA: 9
HGNC: HGNC:4026
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068
Phf21a
Name: PHD finger protein 21A
Synonyms: 80kDa, Braf35/HDAC complex (Bhc), PFTF1, Bhc80, D030065N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192285
Homologene: 9597
Cxcr4
Name: chemokine (C-X-C motif) receptor 4
Synonyms: PB-CKR, fusin, CD184, Cmkar4, Sdf1r, b2b220Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12767
HGNC: HGNC:2561
Homologene: 20739
Kif20a
Name: kinesin family member 20A
Synonyms: Rabkinesin-6, Rab6kifl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19348
VEGA: 18
HGNC: HGNC:9787
Homologene: 38093
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Mus EST 478828, Tara, EST478828
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110253
Homologene: 5104
Top3b
Name: topoisomerase (DNA) III beta
Synonyms: Topo III beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21976
Homologene: 2923
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70699
Homologene: 45971
Snx16
Name: sorting nexin 16
Synonyms: 4930522N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74718
Homologene: 11169
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Ppid
Name: peptidylprolyl isomerase D (cyclophilin D)
Synonyms: cyclophilin 40, CYP-40, 4930564J03Rik, cytoplasmic cyclophilin D, Ppidl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67738
HGNC: HGNC:9257
Homologene: 31283
Ppp4r3a
Name: protein phosphatase 4 regulatory subunit 3A
Synonyms: 1110034C04Rik, Smek1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68734
VEGA: 12
Homologene: 69510
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Zfp141
Name: zinc finger protein 141
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434178
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Glb1l2
Name: galactosidase, beta 1-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244757
Homologene: 71790
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104401
Homologene: 17000
Prcp
Name: prolylcarboxypeptidase (angiotensinase C)
Synonyms: 2610104A14Rik, 2510048K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72461
HGNC: HGNC:9344
Homologene: 55867
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 665113
Homologene: 77943
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
Fhip2a
Name: FHF complex subunit HOOK interacting protein 2A
Synonyms: Fam160b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20536
Homologene: 129474
Pdlim4
Name: PDZ and LIM domain 4
Synonyms: Ril
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 30794
Homologene: 2735
Gpr35
Name: G protein-coupled receptor 35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64095
HGNC: HGNC:4492
Homologene: 3874
Exoc3
Name: exocyst complex component 3
Synonyms: E430013E20Rik, Sec6l1, 2810050O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 211446
VEGA: 13
Homologene: 38296
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: RalGDS, Rgds, Gnds
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108857
Homologene: 87006
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230806
Homologene: 19232
Mto1
Name: mitochondrial tRNA translation optimization 1
Synonyms: 2310039H01Rik, 5730419A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68291
Homologene: 5876
P2ry14
Name: purinergic receptor P2Y, G-protein coupled, 14
Synonyms: A330108O13Rik, P2Y14, Gpr105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 140795
Homologene: 15769
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228846
Homologene: 18598
Trim40
Name: tripartite motif-containing 40
Synonyms: LOC240093, LOC195359, LOC333872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 195359
Homologene: 34709
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 626596
Homologene: 75047
Edc3
Name: enhancer of mRNA decapping 3
Synonyms: Yjdc, Lsm16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 353190
Homologene: 11827
Cnnm1
Name: cyclin M1
Synonyms: Acdp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83674
VEGA: 19
HGNC: HGNC:102
Homologene: 10673
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243628
Homologene: 135915
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58909
Homologene: 135847
Apba2
Name: amyloid beta (A4) precursor protein-binding, family A, member 2
Synonyms: X11-like, X11L, Mint 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11784
HGNC: HGNC:579
Homologene: 4021
Klk10
Name: kallikrein related-peptidase 10
Synonyms: PRSSL1, NES1, 2300002A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69540
HGNC: HGNC:6358
Homologene: 26428
Cpa6
Name: carboxypeptidase A6
Synonyms: 9030616D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329093
Homologene: 75130
Or51b6
Name: olfactory receptor family 51 subfamily B member 6
Synonyms: 5'[b]3, MOR1-2, GA_x6K02T2PBJ9-6634906-6633983, Olfr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18365
Homologene: 66459
Vgll3
Name: vestigial like family member 3
Synonyms: 1700110N18Rik, Vito-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73569
VEGA: 16
Homologene: 53442
Cenpn
Name: centromere protein N
Synonyms: 2610510J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72155
Homologene: 12450
Gapt
Name: Grb2-binding adaptor, transmembrane
Synonyms: 9830130M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238875
VEGA: 13
Homologene: 51887
Aaas
Name: achalasia, adrenocortical insufficiency, alacrimia
Synonyms: Aladin, GL003, D030041N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223921
VEGA: 15
Homologene: 9232
Eif1ad14
Name: eukaryotic translation initiation factor 1A domain containing 14
Synonyms: Gm2035
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100039076
VEGA: 12
Tmem185b
Name: transmembrane protein 185B
Synonyms: 2500001K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226351
Homologene: 15760
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 10,488,883 bp
  • T to C, chromosome 1 at 75,549,979 bp
  • T to C, chromosome 1 at 92,983,220 bp
  • T to G, chromosome 1 at 119,527,463 bp
  • T to A, chromosome 1 at 128,589,847 bp
  • T to C, chromosome 2 at 28,542,414 bp
  • T to G, chromosome 2 at 69,979,386 bp
  • A to T, chromosome 2 at 92,221,611 bp
  • G to T, chromosome 2 at 158,217,708 bp
  • A to T, chromosome 3 at 10,438,157 bp
  • C to T, chromosome 3 at 28,620,948 bp
  • T to A, chromosome 3 at 59,115,158 bp
  • T to A, chromosome 3 at 79,597,717 bp
  • G to A, chromosome 4 at 58,070,977 bp
  • T to A, chromosome 4 at 134,075,692 bp
  • T to C, chromosome 4 at 137,961,740 bp
  • C to T, chromosome 6 at 35,177,578 bp
  • A to G, chromosome 6 at 58,965,198 bp
  • G to A, chromosome 6 at 123,779,022 bp
  • C to A, chromosome 7 at 42,489,488 bp
  • A to G, chromosome 7 at 43,784,985 bp
  • T to A, chromosome 7 at 64,744,447 bp
  • C to T, chromosome 7 at 92,917,766 bp
  • T to A, chromosome 7 at 103,906,910 bp
  • A to G, chromosome 7 at 125,645,676 bp
  • T to A, chromosome 8 at 16,071,353 bp
  • C to A, chromosome 8 at 116,940,537 bp
  • C to T, chromosome 9 at 26,780,742 bp
  • T to A, chromosome 9 at 45,408,330 bp
  • T to C, chromosome 9 at 57,713,428 bp
  • A to G, chromosome 9 at 78,452,905 bp
  • A to T, chromosome 10 at 20,984,393 bp
  • T to A, chromosome 11 at 9,292,214 bp
  • T to C, chromosome 11 at 54,063,656 bp
  • T to C, chromosome 12 at 51,959,040 bp
  • T to C, chromosome 12 at 87,919,478 bp
  • T to C, chromosome 12 at 101,043,579 bp
  • T to C, chromosome 12 at 102,405,827 bp
  • A to C, chromosome 13 at 13,687,813 bp
  • G to A, chromosome 13 at 74,172,186 bp
  • A to T, chromosome 13 at 93,089,544 bp
  • A to G, chromosome 13 at 110,353,946 bp
  • G to A, chromosome 14 at 21,670,792 bp
  • G to A, chromosome 15 at 36,015,636 bp
  • G to T, chromosome 15 at 47,947,990 bp
  • A to T, chromosome 15 at 78,764,382 bp
  • T to A, chromosome 15 at 78,967,540 bp
  • A to C, chromosome 15 at 102,350,564 bp
  • T to C, chromosome 16 at 16,883,565 bp
  • A to G, chromosome 16 at 65,839,563 bp
  • C to A, chromosome 17 at 32,153,884 bp
  • C to T, chromosome 17 at 36,882,427 bp
  • A to G, chromosome 17 at 64,625,380 bp
  • G to A, chromosome 18 at 34,632,415 bp
  • A to T, chromosome 18 at 36,600,834 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • T to C, chromosome 19 at 5,685,535 bp
  • T to C, chromosome 19 at 9,016,585 bp
  • T to C, chromosome 19 at 43,491,472 bp
  • C to T, chromosome 19 at 57,384,123 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5969 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044152-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.