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Strain Name:
C57BL/6J-MtgxR5982Btlr/Mmmh
Stock Number:
044163-MU
Citation ID:
RRID:MMRRC_044163-MU
Other Names:
R5982 (G1)
Major Collection:

Strain Information

Trp53
Name: transformation related protein 53
Synonyms: p53, p44
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22059
Homologene: 460
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Foxm1
Name: forkhead box M1
Synonyms: Mpm2, WIN, HFH-11B, Trident, Fkh16, Foxm1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14235
HGNC: HGNC:3818
Homologene: 7318
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Styx
Name: serine/threonine/tyrosine interaction protein
Synonyms: STNS (alternatively spliced intron of Styx), 0610039A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56291
VEGA: 14
Homologene: 41331
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319939
Homologene: 49713
Pmepa1
Name: prostate transmembrane protein, androgen induced 1
Synonyms: N4wbp4, 2210418I02Rik, PMEPA1, STAG1, Tmepai
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65112
Homologene: 10608
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 174,502,453 bp
  • C to T, chromosome 1 at 186,739,755 bp
  • G to T, chromosome 2 at 20,781,015 bp
  • G to T, chromosome 2 at 140,660,916 bp
  • A to T, chromosome 2 at 148,700,491 bp
  • A to G, chromosome 2 at 173,234,312 bp
  • A to T, chromosome 2 at 177,508,552 bp
  • A to T, chromosome 3 at 29,657,270 bp
  • G to A, chromosome 3 at 88,091,592 bp
  • T to C, chromosome 4 at 15,998,908 bp
  • C to A, chromosome 4 at 143,654,464 bp
  • G to T, chromosome 5 at 30,622,670 bp
  • A to T, chromosome 5 at 31,820,620 bp
  • A to G, chromosome 5 at 32,146,873 bp
  • T to C, chromosome 5 at 76,915,265 bp
  • T to A, chromosome 5 at 121,373,279 bp
  • C to A, chromosome 6 at 68,862,448 bp
  • C to A, chromosome 6 at 86,445,975 bp
  • A to G, chromosome 6 at 128,371,035 bp
  • A to C, chromosome 7 at 4,746,791 bp
  • A to G, chromosome 7 at 19,480,032 bp
  • T to C, chromosome 7 at 24,353,037 bp
  • C to A, chromosome 7 at 29,713,017 bp
  • T to C, chromosome 7 at 42,046,067 bp
  • A to T, chromosome 7 at 48,447,820 bp
  • T to G, chromosome 7 at 104,011,910 bp
  • G to T, chromosome 8 at 13,781,399 bp
  • T to A, chromosome 8 at 71,348,396 bp
  • A to T, chromosome 8 at 125,911,430 bp
  • G to T, chromosome 9 at 6,955,986 bp
  • A to C, chromosome 9 at 18,647,146 bp
  • A to G, chromosome 9 at 48,450,590 bp
  • G to C, chromosome 9 at 70,586,804 bp
  • A to G, chromosome 9 at 79,630,560 bp
  • G to T, chromosome 9 at 104,184,615 bp
  • C to T, chromosome 10 at 20,323,063 bp
  • T to C, chromosome 10 at 62,393,810 bp
  • C to A, chromosome 10 at 67,897,607 bp
  • C to A, chromosome 10 at 75,176,416 bp
  • T to A, chromosome 10 at 75,725,560 bp
  • T to G, chromosome 10 at 78,879,953 bp
  • T to G, chromosome 10 at 79,827,894 bp
  • A to G, chromosome 10 at 111,495,368 bp
  • T to A, chromosome 10 at 117,004,417 bp
  • C to T, chromosome 11 at 5,867,911 bp
  • A to G, chromosome 11 at 8,492,245 bp
  • A to G, chromosome 11 at 69,587,418 bp
  • A to G, chromosome 11 at 79,690,775 bp
  • T to A, chromosome 11 at 82,764,977 bp
  • T to C, chromosome 11 at 83,575,874 bp
  • T to A, chromosome 11 at 84,899,400 bp
  • C to T, chromosome 11 at 88,294,339 bp
  • T to A, chromosome 11 at 109,953,597 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • A to G, chromosome 12 at 13,393,430 bp
  • T to C, chromosome 12 at 69,185,680 bp
  • A to G, chromosome 12 at 83,671,951 bp
  • A to G, chromosome 12 at 87,444,014 bp
  • A to T, chromosome 13 at 95,976,063 bp
  • A to G, chromosome 14 at 45,368,452 bp
  • G to A, chromosome 14 at 50,950,543 bp
  • A to C, chromosome 15 at 23,474,216 bp
  • T to A, chromosome 15 at 44,489,504 bp
  • A to G, chromosome 15 at 58,898,838 bp
  • A to G, chromosome 15 at 71,448,669 bp
  • T to C, chromosome 15 at 74,751,415 bp
  • T to A, chromosome 15 at 80,880,816 bp
  • A to T, chromosome 15 at 83,033,124 bp
  • C to T, chromosome 15 at 97,857,596 bp
  • G to A, chromosome 16 at 4,770,082 bp
  • T to C, chromosome 16 at 32,144,593 bp
  • T to C, chromosome 16 at 44,261,708 bp
  • A to T, chromosome 17 at 7,345,026 bp
  • A to G, chromosome 17 at 25,345,372 bp
  • A to G, chromosome 17 at 74,648,158 bp
  • T to A, chromosome 18 at 20,465,169 bp
  • T to C, chromosome 18 at 21,148,351 bp
  • T to C, chromosome 18 at 37,643,445 bp
  • A to C, chromosome 18 at 37,768,031 bp
  • T to A, chromosome 18 at 67,497,316 bp
  • A to G, chromosome 19 at 7,374,595 bp
  • A to G, chromosome 19 at 32,639,236 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5982 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044163-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.