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Strain Name:
C57BL/6J-MtgxR6014Btlr/Mmmh
Stock Number:
044190-MU
Citation ID:
RRID:MMRRC_044190-MU
Other Names:
R6014 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: MVa, MyoVA, Myo5, flail, 9630007J19Rik, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: Fadk, FAK, FRNK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Inpp5a
Name: inositol polyphosphate-5-phosphatase A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212111
HGNC: HGNC:6076
Homologene: 4045
Adcy9
Name: adenylate cyclase 9
Synonyms: D16Wsu65e, ACtp10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 4,808,371 bp
  • T to C, chromosome 1 at 34,264,834 bp
  • T to A, chromosome 1 at 45,321,579 bp
  • T to A, chromosome 1 at 87,980,016 bp
  • A to C, chromosome 1 at 132,256,725 bp
  • T to C, chromosome 1 at 175,805,990 bp
  • A to T, chromosome 1 at 188,850,040 bp
  • A to G, chromosome 1 at 192,930,695 bp
  • C to T, chromosome 2 at 20,881,805 bp
  • C to A, chromosome 2 at 27,197,528 bp
  • A to G, chromosome 2 at 28,543,661 bp
  • C to T, chromosome 2 at 30,031,751 bp
  • A to T, chromosome 2 at 35,354,869 bp
  • T to G, chromosome 2 at 97,629,212 bp
  • T to C, chromosome 3 at 138,286,798 bp
  • A to T, chromosome 4 at 32,641,400 bp
  • G to A, chromosome 4 at 46,542,261 bp
  • A to G, chromosome 4 at 132,785,980 bp
  • G to T, chromosome 4 at 133,665,429 bp
  • G to A, chromosome 5 at 20,611,093 bp
  • A to T, chromosome 5 at 30,345,649 bp
  • A to G, chromosome 5 at 34,559,627 bp
  • T to A, chromosome 5 at 57,721,155 bp
  • C to T, chromosome 5 at 114,733,877 bp
  • C to T, chromosome 5 at 120,867,166 bp
  • C to T, chromosome 5 at 134,603,454 bp
  • C to T, chromosome 5 at 135,217,394 bp
  • T to A, chromosome 5 at 143,387,823 bp
  • T to C, chromosome 6 at 33,475,997 bp
  • C to T, chromosome 6 at 128,571,985 bp
  • T to A, chromosome 6 at 142,396,217 bp
  • T to C, chromosome 7 at 4,891,626 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to G, chromosome 7 at 23,409,947 bp
  • T to A, chromosome 7 at 26,939,180 bp
  • T to A, chromosome 7 at 44,625,078 bp
  • T to G, chromosome 7 at 55,823,609 bp
  • T to C, chromosome 7 at 114,416,440 bp
  • A to T, chromosome 7 at 127,538,750 bp
  • A to G, chromosome 7 at 139,574,982 bp
  • A to C, chromosome 8 at 84,675,071 bp
  • C to A, chromosome 9 at 75,167,207 bp
  • G to T, chromosome 9 at 119,924,709 bp
  • T to C, chromosome 10 at 12,690,876 bp
  • G to A, chromosome 10 at 39,118,993 bp
  • T to A, chromosome 11 at 5,019,364 bp
  • A to C, chromosome 11 at 59,038,864 bp
  • C to A, chromosome 11 at 60,797,557 bp
  • A to T, chromosome 11 at 100,117,611 bp
  • A to G, chromosome 11 at 120,289,789 bp
  • A to T, chromosome 12 at 104,131,097 bp
  • A to G, chromosome 13 at 97,151,661 bp
  • C to A, chromosome 14 at 30,892,629 bp
  • A to T, chromosome 14 at 50,847,000 bp
  • A to T, chromosome 14 at 50,925,525 bp
  • A to T, chromosome 14 at 59,629,908 bp
  • A to T, chromosome 14 at 78,512,499 bp
  • T to G, chromosome 15 at 73,304,444 bp
  • A to G, chromosome 15 at 98,520,316 bp
  • A to T, chromosome 16 at 4,418,819 bp
  • T to A, chromosome 16 at 10,784,493 bp
  • T to A, chromosome 17 at 23,479,561 bp
  • T to C, chromosome 17 at 49,069,906 bp
  • A to T, chromosome 17 at 69,283,960 bp
  • T to A, chromosome 18 at 37,302,653 bp
  • T to A, chromosome 18 at 43,361,067 bp
  • A to T, chromosome 19 at 43,826,735 bp
  • G to A, chromosome Y at 921,528 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6014 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044190-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.