Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR6043Btlr
Stock Number:
044211-MU
Citation ID:
RRID:MMRRC_044211-MU
Other Names:
R6043 (G1)
Major Collection:

Gene Information

Kitl
Name: kit ligand
Synonyms: Gb, SCF, Steel, Mgf, Sl, Kitlg, SF, grizzle-belly, blz, stem cell factor, Steel factor, SLF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17311
HGNC: HGNC:6343
Homologene: 692
Egf
Name: epidermal growth factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Pcm1
Name: pericentriolar material 1
Synonyms: 2600002H09Rik, C030044G17Rik, 9430077F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Kif16b
Name: kinesin family member 16B
Synonyms: 8430434E15Rik, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16558
Homologene: 135708
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: AP-3, beta3A, rim2, Hps2, recombination induced mutation 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: 9530003A05Rik, PRO2405
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227634
Homologene: 19202
Tjp1
Name: tight junction protein 1
Synonyms: ZO1, ZO-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 21872
Homologene: 2445
Map2k3
Name: mitogen-activated protein kinase kinase 3
Synonyms: Prkmk3, MKK3, MAP kinase kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 26397
HGNC: HGNC:6843
Homologene: 56430
Nmd3
Name: NMD3 ribosome export adaptor
Synonyms: C87860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 97112
Homologene: 6127
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229474
Homologene: 18920
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80892
Homologene: 23477
Adamts4
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
Synonyms: ADAM-TS4, aggrecanase-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240913
HGNC: HGNC:220
Homologene: 36169
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 672511
Homologene: 45439
Mob3b
Name: MOB kinase activator 3B
Synonyms: A430018A01Rik, Mobkl2b, MOB3B, 8430436F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 214944
Homologene: 69385
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, 1500037O19Rik, D9Ertd414e, Unc13h3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208898
Homologene: 45443
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Trav6n-5
Name: T cell receptor alpha variable 6N-5
Synonyms: Gm10894, ENSMUSG00000072087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 100126451
HGNC: null
Homologene: null
Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Synonyms: Cyp2b20, phenobarbitol inducible, type b, Cyp2b, p16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13088
HGNC: HGNC:2615
Homologene: 73894
Sema4f
Name: sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Synonyms: Sema W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20355
Homologene: 3147
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Flnc
Name: filamin C, gamma
Synonyms: actin binding protein 280, Fln2, 1110055E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227058
Homologene: 41287
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49q1, Ly49Q, Ly-49Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 170733
HGNC: null
Homologene: null
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320082
Homologene: 110776
Fcgr4
Name: Fc receptor, IgG, low affinity IV
Synonyms: 4833442P21Rik, FcgammaRIV, Fcgr3a, CD16-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 246256
Homologene: 477
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74464
Homologene: 18958
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: kintoun, Ktu, 1110034A24Rik, 2810020C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 109065
Homologene: 10026
Ptdss1
Name: phosphatidylserine synthase 1
Synonyms: PtdSer Synthase-1, PSS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19210
VEGA: 13
HGNC: HGNC:9587
Homologene: 7494
Plcd1
Name: phospholipase C, delta 1
Synonyms: PLC-delta 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18799
VEGA: 9
HGNC: HGNC:9060
Homologene: 21252
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 225004
VEGA: 17
Homologene: 19792
Olfr309
Name: olfactory receptor 309
Synonyms: GA_x6K02T2NHDJ-9801340-9802266, MOR251-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258196
Homologene: 47595
Olfr1180
Name: olfactory receptor 1180
Synonyms: GA_x6K02T2Q125-49900552-49899623, MOR225-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258920
HGNC: null
Homologene: 74240
Hspa2
Name: heat shock protein 2
Synonyms: 70kDa, Hsp70-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 50702
HGNC: HGNC:4888
Homologene: 55632
Vmn1r212
Name: vomeronasal 1 receptor 212
Synonyms: V1rh18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171275
HGNC: null
Homologene: 110880
Medag
Name: mesenteric estrogen dependent adipogenesis
Synonyms: MEDA-4, 6330406I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70717
Homologene: 12364
Mvb12b
Name: multivesicular body subunit 12B
Synonyms: 2610200O14Rik, Fam125b, 2610528K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 72543
Homologene: 25444
Ccl17
Name: chemokine (C-C motif) ligand 17
Synonyms: ABCD-2, Scya17, TARC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20295
Homologene: 2246
Naaladl2
Name: N-acetylated alpha-linked acidic dipeptidase-like 2
Synonyms: EG635702, 2810043G22Rik, LOC381500
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 635702
Homologene: 45786
Trbv2
Name: T cell receptor beta, variable 2
Synonyms: Gm16752, Tcrb-V4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 100124659
HGNC: null
Homologene: null
Mettl21b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 46,139,789 bp
  • T to A, chromosome 1 at 139,550,868 bp
  • T to C, chromosome 1 at 171,020,130 bp
  • T to C, chromosome 1 at 171,252,601 bp
  • T to C, chromosome 2 at 25,929,925 bp
  • G to T, chromosome 2 at 33,874,390 bp
  • C to T, chromosome 2 at 88,412,245 bp
  • A to C, chromosome 2 at 91,935,889 bp
  • A to G, chromosome 2 at 142,711,900 bp
  • T to G, chromosome 3 at 5,403,427 bp
  • A to G, chromosome 3 at 24,058,214 bp
  • T to C, chromosome 3 at 55,786,475 bp
  • T to C, chromosome 3 at 69,745,247 bp
  • T to C, chromosome 3 at 84,448,886 bp
  • A to G, chromosome 3 at 129,736,785 bp
  • C to T, chromosome 4 at 34,985,993 bp
  • A to C, chromosome 4 at 116,962,621 bp
  • T to C, chromosome 4 at 148,008,788 bp
  • G to A, chromosome 5 at 124,801,860 bp
  • T to G, chromosome 5 at 149,422,207 bp
  • G to T, chromosome 6 at 29,446,608 bp
  • A to G, chromosome 6 at 41,047,970 bp
  • T to C, chromosome 6 at 82,919,653 bp
  • A to G, chromosome 6 at 129,872,187 bp
  • T to C, chromosome 7 at 25,917,339 bp
  • A to T, chromosome 7 at 65,324,089 bp
  • A to G, chromosome 7 at 86,306,339 bp
  • A to G, chromosome 8 at 41,328,778 bp
  • A to G, chromosome 8 at 94,810,472 bp
  • A to G, chromosome 9 at 66,408,154 bp
  • T to C, chromosome 9 at 73,736,651 bp
  • T to C, chromosome 9 at 109,145,539 bp
  • A to G, chromosome 9 at 119,072,599 bp
  • T to A, chromosome 10 at 100,064,085 bp
  • A to T, chromosome 10 at 127,033,278 bp
  • A to G, chromosome 11 at 60,946,746 bp
  • C to T, chromosome 11 at 115,979,386 bp
  • T to C, chromosome 11 at 119,442,101 bp
  • A to T, chromosome 12 at 69,197,348 bp
  • C to T, chromosome 12 at 76,406,322 bp
  • A to G, chromosome 13 at 22,884,088 bp
  • T to A, chromosome 13 at 66,963,369 bp
  • A to T, chromosome 13 at 94,476,993 bp
  • T to C, chromosome 14 at 53,105,151 bp
  • T to C, chromosome 17 at 71,750,042 bp
  • T to A, chromosome 18 at 38,203,274 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6043 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044211-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.