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Strain Name:
C57BL/6J-MtgxR6056Btlr/Mmmh
Stock Number:
044223-MU
Citation ID:
RRID:MMRRC_044223-MU
Other Names:
R6056 (G1)
Major Collection:

Strain Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Aggf1
Name: angiogenic factor with G patch and FHA domains 1
Synonyms: 2310029P06Rik, VG5Q, 2010009L17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66549
Homologene: 41220
Angpt2
Name: angiopoietin 2
Synonyms: Ang2, Ang-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11601
HGNC: HGNC:485
Homologene: 22401
Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Synonyms: alpha4 nAChR, Acra-4, Acra4, a4 nicotinic receptor, alpha4-nAChR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11438
HGNC: HGNC:1958
Homologene: 592
Upf1
Name: UPF1 RNA helicase and ATPase
Synonyms: PNORF-1, B430202H16Rik, Rent1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,319,392 bp
  • A to T, chromosome 1 at 58,169,859 bp
  • T to C, chromosome 1 at 93,024,648 bp
  • T to C, chromosome 1 at 107,079,722 bp
  • T to G, chromosome 1 at 136,105,836 bp
  • T to C, chromosome 1 at 136,625,440 bp
  • C to A, chromosome 1 at 150,663,909 bp
  • G to A, chromosome 1 at 153,074,734 bp
  • C to T, chromosome 1 at 159,886,909 bp
  • A to C, chromosome 1 at 182,974,038 bp
  • A to G, chromosome 2 at 17,450,234 bp
  • A to T, chromosome 2 at 26,407,848 bp
  • A to G, chromosome 2 at 29,996,782 bp
  • A to G, chromosome 2 at 36,177,221 bp
  • C to A, chromosome 2 at 59,484,713 bp
  • A to T, chromosome 2 at 82,985,673 bp
  • T to C, chromosome 2 at 89,591,101 bp
  • T to C, chromosome 2 at 118,927,733 bp
  • A to T, chromosome 2 at 126,121,052 bp
  • T to A, chromosome 2 at 155,671,074 bp
  • A to T, chromosome 2 at 164,895,098 bp
  • G to T, chromosome 2 at 181,029,442 bp
  • C to G, chromosome 2 at 181,864,488 bp
  • A to G, chromosome 3 at 36,450,691 bp
  • A to T, chromosome 3 at 89,946,221 bp
  • A to T, chromosome 3 at 129,789,355 bp
  • A to T, chromosome 4 at 34,809,784 bp
  • A to G, chromosome 4 at 55,382,540 bp
  • G to T, chromosome 4 at 59,379,687 bp
  • G to T, chromosome 4 at 62,625,906 bp
  • A to T, chromosome 4 at 73,942,878 bp
  • A to G, chromosome 4 at 108,012,261 bp
  • G to T, chromosome 4 at 116,137,402 bp
  • A to G, chromosome 4 at 137,961,647 bp
  • A to G, chromosome 4 at 139,354,222 bp
  • T to G, chromosome 4 at 140,717,024 bp
  • T to A, chromosome 4 at 147,862,335 bp
  • G to A, chromosome 4 at 148,537,435 bp
  • C to A, chromosome 4 at 151,978,126 bp
  • A to G, chromosome 4 at 154,160,095 bp
  • T to A, chromosome 5 at 35,041,629 bp
  • C to A, chromosome 5 at 38,106,564 bp
  • C to T, chromosome 5 at 100,067,901 bp
  • C to T, chromosome 5 at 142,720,077 bp
  • T to A, chromosome 5 at 146,955,528 bp
  • GAT to GATCAT, chromosome 6 at 4,756,449 bp
  • T to C, chromosome 6 at 84,106,862 bp
  • T to C, chromosome 6 at 124,732,435 bp
  • T to C, chromosome 6 at 129,100,809 bp
  • T to C, chromosome 7 at 6,709,571 bp
  • T to A, chromosome 7 at 45,490,373 bp
  • T to A, chromosome 7 at 46,767,097 bp
  • A to G, chromosome 7 at 79,714,094 bp
  • T to A, chromosome 7 at 99,223,513 bp
  • A to T, chromosome 7 at 109,833,013 bp
  • A to G, chromosome 7 at 120,030,031 bp
  • T to A, chromosome 7 at 126,676,452 bp
  • G to T, chromosome 7 at 144,915,286 bp
  • C to T, chromosome 8 at 13,388,782 bp
  • T to C, chromosome 8 at 15,027,577 bp
  • T to C, chromosome 8 at 18,698,116 bp
  • T to C, chromosome 8 at 70,333,037 bp
  • G to A, chromosome 8 at 70,652,451 bp
  • T to C, chromosome 8 at 95,075,051 bp
  • G to A, chromosome 8 at 105,396,450 bp
  • A to C, chromosome 8 at 119,515,602 bp
  • G to T, chromosome 9 at 119,121,923 bp
  • T to A, chromosome 9 at 121,272,955 bp
  • A to G, chromosome 10 at 9,770,686 bp
  • A to G, chromosome 10 at 80,786,095 bp
  • A to G, chromosome 11 at 32,267,432 bp
  • G to A, chromosome 11 at 53,479,087 bp
  • C to A, chromosome 11 at 58,293,638 bp
  • C to T, chromosome 11 at 67,087,545 bp
  • A to T, chromosome 11 at 69,786,939 bp
  • T to A, chromosome 11 at 73,308,752 bp
  • A to G, chromosome 11 at 78,009,515 bp
  • C to A, chromosome 11 at 78,271,384 bp
  • C to A, chromosome 11 at 102,011,689 bp
  • G to T, chromosome 11 at 103,497,658 bp
  • A to G, chromosome 12 at 30,312,561 bp
  • A to T, chromosome 12 at 111,985,041 bp
  • A to T, chromosome 12 at 113,685,500 bp
  • T to G, chromosome 12 at 117,928,456 bp
  • T to C, chromosome 13 at 30,900,829 bp
  • T to A, chromosome 13 at 93,708,743 bp
  • T to C, chromosome 13 at 93,752,326 bp
  • C to T, chromosome 13 at 95,371,615 bp
  • C to T, chromosome 14 at 60,298,170 bp
  • C to T, chromosome 14 at 119,035,969 bp
  • A to T, chromosome 15 at 10,378,877 bp
  • A to G, chromosome 15 at 10,488,074 bp
  • T to C, chromosome 15 at 97,758,861 bp
  • A to C, chromosome 15 at 100,482,382 bp
  • G to A, chromosome 16 at 3,708,042 bp
  • T to A, chromosome 17 at 20,267,544 bp
  • A to T, chromosome 17 at 35,665,788 bp
  • C to A, chromosome 17 at 47,690,210 bp
  • T to G, chromosome 18 at 37,686,330 bp
  • T to C, chromosome 18 at 37,743,112 bp
  • T to A, chromosome 18 at 44,840,210 bp
  • T to A, chromosome 18 at 70,580,803 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6056 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044223-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.