Strain Name:
C57BL/6J-MtgxR6059Btlr/Mmmh
Stock Number:
044225-MU
Citation ID:
RRID:MMRRC_044225-MU
Other Names:
R6059 (G1)
Major Collection:

Gene Information

Ppp5c
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19060
HGNC: HGNC:9322
Homologene: 4550
Mov10
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17454
HGNC: HGNC:7200
Homologene: 10365
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Ttc5
Name: tetratricopeptide repeat domain 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219022
VEGA: 14
Homologene: 14397
Luzp1
Name: leucine zipper protein 1
Synonyms: Luzp, 2700072H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269593
Homologene: 11545
Ythdf3
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229096
Homologene: 34991
Vps53
Name: VPS53 GARP complex subunit
Synonyms: 2310040I21Rik, 2010002A08Rik, 3100002B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68299
Homologene: 6264
Nup133
Name: nucleoporin 133
Synonyms: 4832420O05Rik, mermaid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234865
Homologene: 32402
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: NBL3, 4.1B, DAL1P, Epb4.1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Synonyms: MOP1, HIF-1alpha, HIF1alpha, bHLHe78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15251
HGNC: HGNC:4910
Homologene: 1171
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: CD56, NCAM-1, NCAM-120, NCAM-140, NCAM-180, E-NCAM, NCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Rrn3
Name: RRN3 RNA polymerase I transcription factor homolog (yeast)
Synonyms: E130302O19Rik, TIF-1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106298
VEGA: 16
Homologene: 39531
Ablim2
Name: actin-binding LIM protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231148
Homologene: 82366
Ddx24
Name: DEAD box helicase 24
Synonyms: 1700055J08Rik, 2510027P10Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27225
VEGA: 12
Homologene: 10702
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Hnrnph3
Name: heterogeneous nuclear ribonucleoprotein H3
Synonyms: hnRNP 2H9, Hnrph3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432467
HGNC: HGNC:5043
Homologene: 11012
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Ppp2r5c
Name: protein phosphatase 2, regulatory subunit B', gamma
Synonyms: Band 8A, 2610043M05Rik, 2700063L20Rik, D12Bwg0916e, B56/PP2A gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26931
VEGA: 12
HGNC: HGNC:9311
Homologene: 128665
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Mmrn2
Name: multimerin 2
Synonyms: EndoGlyx-1, ENDOGLYX1, Emilin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 637515
Homologene: 19080
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Garre1
Name: granule associated Rac and RHOG effector 1
Synonyms: 4931406P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233103
Homologene: 8795
Gorasp1
Name: golgi reassembly stacking protein 1
Synonyms: 5430411C10Rik, P65, GRASP65, GOLPH5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74498
VEGA: 9
Homologene: 49916
Gm11639
Name: predicted gene 11639
Synonyms: Efcab15, Gm11639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 105242472
Vmn1r73
Name: vomeronasal 1 receptor 73
Synonyms: V1rg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171237
Homologene: 103842
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80797
Homologene: 77224
Abo
Name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
Synonyms: cis-AB transferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80908
HGNC: HGNC:79
Homologene: 69306
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: Mlk2, serine/threonine kinase, MKN28 derived nonreceptor_type, mixed lineage kinase 2, MKN28 kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245026
Homologene: 18260
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76295
Homologene: 32919
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, lubricin, SZP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Pramel25
Name: PRAME like 25
Synonyms: MGC:91194, Gm13023
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194227
Homologene: 103830
Anxa1
Name: annexin A1
Synonyms: Lpc-1, Lpc1, Anx-1, Anx-A1, C430014K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16952
HGNC: HGNC:533
Homologene: 563
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd370e, D8Ertd377e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 57247
Homologene: 10731
Gys1
Name: glycogen synthase 1, muscle
Synonyms: Gys3, MGS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14936
HGNC: HGNC:4706
Homologene: 113557
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: s5d-srcrb, A430110N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269855
Homologene: 77555
Ncf1
Name: neutrophil cytosolic factor 1
Synonyms: p47phox, NADPH oxidase subunit (47kDa), Ncf-1, NOXO2, p47phox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17969
HGNC: HGNC:7660
Homologene: 30964
Vmn2r99
Name: vomeronasal 2, receptor 99
Synonyms: EG665376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665376
Homologene: 115024
Cfh
Name: complement component factor h
Synonyms: Sas-1, Mud-1, Sas1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Serpinb9e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms: Spi14, NK26, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20710
HGNC: HGNC:8955
Homologene: 69093
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: F830032C23Rik, Nlrc2, Card15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Stc1
Name: stanniocalcin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20855
VEGA: 14
Homologene: 2374
Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13118
Homologene: 134044
Shisa6
Name: shisa family member 6
Synonyms: LOC380702, Gm879, CKAMP52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380702
Homologene: 66164
Dsc1
Name: desmocollin 1
Synonyms: Dsc1b, Dsc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
1700067P10Rik
Name: RIKEN cDNA 1700067P10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68224
VEGA: 17
Homologene: 87035
Glipr1l2
Name: GLI pathogenesis-related 1 like 2
Synonyms: 4921508O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67537
Homologene: 17579
Slc38a11
Name: solute carrier family 38, member 11
Synonyms: 9330158F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320106
Homologene: 5775
Rcor3
Name: REST corepressor 3
Synonyms: E130101E15Rik, 4921514E24Rik, C730034D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214742
Homologene: 135671
Socs1
Name: suppressor of cytokine signaling 1
Synonyms: SSI-1, JAK2-binding protein, STAT-induced STAT inhibitor 1, JAK-binding protein, JAB, Cish7, Cish1, SOCS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12703
VEGA: 16
Homologene: 2776
Fam162b
Name: family with sequence similarity 162, member B
Synonyms: 9430073N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77296
VEGA: 10
Homologene: 82459
Cgref1
Name: cell growth regulator with EF hand domain 1
Synonyms: 1110004G24Rik, CGR11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68567
Homologene: 4790
Lcn9
Name: lipocalin 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77704
Homologene: 12681
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100534287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 140,118,690 bp
  • T to A, chromosome 1 at 150,449,997 bp
  • A to T, chromosome 1 at 192,119,940 bp
  • C to A, chromosome 1 at 194,810,971 bp
  • C to A, chromosome 2 at 25,824,725 bp
  • A to G, chromosome 2 at 26,843,353 bp
  • A to T, chromosome 2 at 65,334,745 bp
  • T to A, chromosome 3 at 16,203,192 bp
  • A to G, chromosome 3 at 35,814,177 bp
  • A to G, chromosome 3 at 83,355,736 bp
  • G to A, chromosome 3 at 104,817,950 bp
  • G to A, chromosome 3 at 144,810,770 bp
  • T to A, chromosome 4 at 115,438,104 bp
  • C to T, chromosome 4 at 136,541,480 bp
  • T to G, chromosome 4 at 143,793,980 bp
  • A to G, chromosome 5 at 14,811,700 bp
  • G to T, chromosome 5 at 30,945,384 bp
  • A to G, chromosome 5 at 35,857,164 bp
  • A to T, chromosome 5 at 134,223,487 bp
  • C to T, chromosome 7 at 4,942,744 bp
  • A to G, chromosome 7 at 11,756,611 bp
  • C to T, chromosome 7 at 17,027,907 bp
  • A to T, chromosome 7 at 27,656,822 bp
  • G to A, chromosome 7 at 34,245,463 bp
  • A to G, chromosome 7 at 45,455,288 bp
  • T to C, chromosome 8 at 88,664,414 bp
  • T to C, chromosome 8 at 123,267,823 bp
  • C to A, chromosome 8 at 123,914,596 bp
  • A to C, chromosome 9 at 49,544,666 bp
  • A to T, chromosome 9 at 105,783,917 bp
  • A to G, chromosome 9 at 119,930,006 bp
  • A to T, chromosome 10 at 51,590,307 bp
  • A to T, chromosome 10 at 63,018,862 bp
  • T to C, chromosome 10 at 112,083,518 bp
  • T to A, chromosome 11 at 66,224,974 bp
  • A to T, chromosome 11 at 71,217,010 bp
  • T to C, chromosome 11 at 76,066,867 bp
  • T to A, chromosome 11 at 103,080,401 bp
  • T to C, chromosome 11 at 105,036,769 bp
  • T to A, chromosome 12 at 73,941,800 bp
  • G to T, chromosome 12 at 103,408,300 bp
  • C to A, chromosome 12 at 110,574,788 bp
  • G to A, chromosome 13 at 33,257,774 bp
  • C to T, chromosome 14 at 34,397,591 bp
  • C to G, chromosome 14 at 50,777,846 bp
  • T to C, chromosome 14 at 69,032,438 bp
  • A to T, chromosome 15 at 8,295,568 bp
  • G to C, chromosome 16 at 10,784,530 bp
  • G to A, chromosome 16 at 13,806,604 bp
  • G to A, chromosome 17 at 19,378,980 bp
  • C to A, chromosome 17 at 48,090,327 bp
  • T to A, chromosome 17 at 58,313,712 bp
  • A to G, chromosome 17 at 69,284,642 bp
  • C to T, chromosome 17 at 69,286,798 bp
  • A to T, chromosome 18 at 20,110,242 bp
  • T to A, chromosome 18 at 37,690,025 bp
  • A to G, chromosome 19 at 20,377,700 bp
  • T to C, chromosome 19 at 46,265,248 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6059 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044225-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.