Strain Name:
C57BL/6J-MtgxR6059Btlr
Stock Number:
044225-MU
Citation ID:
RRID:MMRRC_044225-MU
Other Names:
R6059 (G1)
Major Collection:

Gene Information

Gene Symbol: Ppp5c [MGI:102666] (Mus musculus (mouse))
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Chromosome: 7
Alteration at locus: Chemically Induced
Gene Symbol: Mov10 [MGI:97054] (Mus musculus (mouse))
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Plcd3 [MGI:107451] (Mus musculus (mouse))
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Ttc5 [MGI:2683584] (Mus musculus (mouse))
Name: tetratricopeptide repeat domain 5
Chromosome: 14
Alteration at locus: Chemically Induced
Gene Symbol: Luzp1 [MGI:107629] (Mus musculus (mouse))
Name: leucine zipper protein 1
Synonyms: 2700072H04Rik, Luzp
Chromosome: 4
Alteration at locus: Chemically Induced
Gene Symbol: Ythdf3 [MGI:1918850] (Mus musculus (mouse))
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Vps53 [MGI:1915549] (Mus musculus (mouse))
Name: VPS53 GARP complex subunit
Synonyms: 2010002A08Rik, 2310040I21Rik, 3100002B05Rik
Chromosome: 11
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 140,118,690 bp
  • T to A, chromosome 1 at 150,449,997 bp
  • A to T, chromosome 1 at 192,119,940 bp
  • C to A, chromosome 1 at 194,810,971 bp
  • C to A, chromosome 2 at 25,824,725 bp
  • A to G, chromosome 2 at 26,843,353 bp
  • A to T, chromosome 2 at 65,334,745 bp
  • T to A, chromosome 3 at 16,203,192 bp
  • A to G, chromosome 3 at 35,814,177 bp
  • A to G, chromosome 3 at 83,355,736 bp
  • G to A, chromosome 3 at 104,817,950 bp
  • G to A, chromosome 3 at 144,810,770 bp
  • T to A, chromosome 4 at 115,438,104 bp
  • C to T, chromosome 4 at 136,541,480 bp
  • T to G, chromosome 4 at 143,793,980 bp
  • A to G, chromosome 5 at 14,811,700 bp
  • G to T, chromosome 5 at 30,945,384 bp
  • A to G, chromosome 5 at 35,857,164 bp
  • A to T, chromosome 5 at 134,223,487 bp
  • C to T, chromosome 7 at 4,942,744 bp
  • A to G, chromosome 7 at 11,756,611 bp
  • C to T, chromosome 7 at 17,027,907 bp
  • A to T, chromosome 7 at 27,656,822 bp
  • G to A, chromosome 7 at 34,245,463 bp
  • A to G, chromosome 7 at 45,455,288 bp
  • T to C, chromosome 8 at 88,664,414 bp
  • T to C, chromosome 8 at 123,267,823 bp
  • C to A, chromosome 8 at 123,914,596 bp
  • A to C, chromosome 9 at 49,544,666 bp
  • A to T, chromosome 9 at 105,783,917 bp
  • A to G, chromosome 9 at 119,930,006 bp
  • A to T, chromosome 10 at 51,590,307 bp
  • A to T, chromosome 10 at 63,018,862 bp
  • T to C, chromosome 10 at 112,083,518 bp
  • T to A, chromosome 11 at 66,224,974 bp
  • A to T, chromosome 11 at 71,217,010 bp
  • T to C, chromosome 11 at 76,066,867 bp
  • T to A, chromosome 11 at 103,080,401 bp
  • T to C, chromosome 11 at 105,036,769 bp
  • T to A, chromosome 12 at 73,941,800 bp
  • G to T, chromosome 12 at 103,408,300 bp
  • C to A, chromosome 12 at 110,574,788 bp
  • G to A, chromosome 13 at 33,257,774 bp
  • C to T, chromosome 14 at 34,397,591 bp
  • C to G, chromosome 14 at 50,777,846 bp
  • T to C, chromosome 14 at 69,032,438 bp
  • A to T, chromosome 15 at 8,295,568 bp
  • G to C, chromosome 16 at 10,784,530 bp
  • G to A, chromosome 16 at 13,806,604 bp
  • G to A, chromosome 17 at 19,378,980 bp
  • C to A, chromosome 17 at 48,090,327 bp
  • T to A, chromosome 17 at 58,313,712 bp
  • A to G, chromosome 17 at 69,284,642 bp
  • C to T, chromosome 17 at 69,286,798 bp
  • A to T, chromosome 18 at 20,110,242 bp
  • T to A, chromosome 18 at 37,690,025 bp
  • A to G, chromosome 19 at 20,377,700 bp
  • T to C, chromosome 19 at 46,265,248 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6059 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044225-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.