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Strain Name:
C57BL/6J-MtgxR6077Btlr
Stock Number:
044238-MU
Citation ID:
RRID:MMRRC_044238-MU
Other Names:
R6077 (G1)
Major Collection:

Strain Information

Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Kansl2
Name: KAT8 regulatory NSL complex subunit 2
Synonyms: 2310037I24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69612
VEGA: 15
Homologene: 32367
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75796
Homologene: 41779
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Ube2g2
Name: ubiquitin-conjugating enzyme E2G 2
Synonyms: D10Xrf369, Ubc7p, UBC7, 1110003O05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22213
Homologene: 6599
Tcf7l2
Name: transcription factor 7 like 2, T cell specific, HMG box
Synonyms: TCF4E, TCF4B, mTcf-4E, mTcf-4B, Tcf-4, Tcf4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21416
Homologene: 7564
Safb
Name: scaffold attachment factor B
Synonyms: 5330423C17Rik, SAFB1, 3110021E02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224903
Homologene: 2229
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 25,094,000 bp
  • T to C, chromosome 1 at 93,054,896 bp
  • T to C, chromosome 1 at 130,812,926 bp
  • A to T, chromosome 2 at 23,155,794 bp
  • T to A, chromosome 2 at 66,697,596 bp
  • C to T, chromosome 2 at 92,366,570 bp
  • G to A, chromosome 2 at 181,233,038 bp
  • C to T, chromosome 3 at 39,002,802 bp
  • T to A, chromosome 3 at 59,115,377 bp
  • A to T, chromosome 3 at 94,364,308 bp
  • A to G, chromosome 3 at 107,301,065 bp
  • T to A, chromosome 4 at 11,803,969 bp
  • A to G, chromosome 4 at 45,802,525 bp
  • A to G, chromosome 5 at 3,850,837 bp
  • T to A, chromosome 5 at 137,414,297 bp
  • C to G, chromosome 5 at 150,953,001 bp
  • T to A, chromosome 6 at 18,868,072 bp
  • T to C, chromosome 7 at 3,667,527 bp
  • G to A, chromosome 7 at 18,957,869 bp
  • G to A, chromosome 7 at 30,715,919 bp
  • GCGGCGGC to GCGGCGGCGTCGGCGGC, chromosome 7 at 97,579,928 bp
  • A to G, chromosome 7 at 126,109,952 bp
  • G to T, chromosome 8 at 28,675,307 bp
  • A to G, chromosome 8 at 83,727,966 bp
  • G to T, chromosome 8 at 116,589,390 bp
  • T to A, chromosome 9 at 19,646,888 bp
  • A to G, chromosome 9 at 70,631,081 bp
  • A to G, chromosome 9 at 103,332,990 bp
  • C to A, chromosome 10 at 22,181,988 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • G to T, chromosome 10 at 77,622,305 bp
  • T to C, chromosome 10 at 80,326,239 bp
  • G to A, chromosome 11 at 67,211,447 bp
  • T to A, chromosome 11 at 87,611,019 bp
  • T to A, chromosome 11 at 97,491,232 bp
  • C to T, chromosome 11 at 100,519,757 bp
  • T to C, chromosome 11 at 116,848,902 bp
  • A to G, chromosome 11 at 118,399,742 bp
  • C to T, chromosome 12 at 70,019,232 bp
  • A to T, chromosome 13 at 21,133,293 bp
  • A to T, chromosome 14 at 30,929,876 bp
  • A to G, chromosome 14 at 53,882,056 bp
  • T to C, chromosome 15 at 27,611,610 bp
  • T to C, chromosome 15 at 98,531,431 bp
  • C to A, chromosome 15 at 99,942,703 bp
  • A to G, chromosome 16 at 89,798,030 bp
  • T to A, chromosome 17 at 31,189,167 bp
  • G to A, chromosome 17 at 56,602,956 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • T to C, chromosome 19 at 3,389,260 bp
  • T to C, chromosome 19 at 4,170,876 bp
  • A to T, chromosome 19 at 55,917,436 bp
  • T to C, chromosome 19 at 59,235,314 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6077 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044238-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.