Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR6077Btlr
Stock Number:
044238-MU
Citation ID:
RRID:MMRRC_044238-MU
Other Names:
R6077 (G1)
Major Collection:

Gene Information

Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Kansl2
Name: KAT8 regulatory NSL complex subunit 2
Synonyms: 2310037I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 69612
VEGA: 15
Homologene: 32367
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75796
Homologene: 41779
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Ube2g2
Name: ubiquitin-conjugating enzyme E2G 2
Synonyms: UBC7, Ubc7p, 1110003O05Rik, D10Xrf369
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22213
Homologene: 6599
Tcf7l2
Name: transcription factor 7 like 2, T cell specific, HMG box
Synonyms: Tcf4, Tcf-4, mTcf-4B, mTcf-4E, TCF4B, TCF4E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 21416
Homologene: 7564
Safb
Name: scaffold attachment factor B
Synonyms: 5330423C17Rik, 3110021E02Rik, SAFB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224903
Homologene: 2229
Xpo6
Name: exportin 6
Synonyms: C230091E20Rik, 2610005L19Rik, Ranbp20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74204
Homologene: 12544
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, 4832420A03Rik, C030033M12Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, Ankyrin-G, Ankyrin-3, 2900054D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 1110031N14Rik, 2810429C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235559
Homologene: 38262
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10, D16Ium10e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 21844
Homologene: 2443
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, Emv66, par
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Mastl
Name: microtubule associated serine/threonine kinase-like
Synonyms: 2700091H24Rik, THC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67121
Homologene: 12086
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 58996
Homologene: 104145
Zfp317
Name: zinc finger protein 317
Synonyms: D230022C05Rik, KRAB9, Zfp75, Zfp67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244713
Homologene: 36389
Adgre5
Name: adhesion G protein-coupled receptor E5
Synonyms: Cd97, EGF-TM7 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 26364
HGNC: HGNC:1711
Homologene: 8050
Mettl23
Name: methyltransferase like 23
Synonyms: 1500035B17Rik, 1110005A03Rik, 4933424L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74319
Homologene: 12552
Mtmr4
Name: myotubularin related protein 4
Synonyms: ESTM44, FYVE-DSP2, ZFYVE11, FYVE zinc finger phosphatase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Tmprss3
Name: transmembrane protease, serine 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 140765
Homologene: 56985
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Slc16a4
Name: solute carrier family 16 (monocarboxylic acid transporters), member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229699
Homologene: 74529
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, 1110034K09Rik, Nax, Scn6a, Nav2, NaG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20272
Homologene: 55706
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 229003
Homologene: 14118
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329628
Homologene: 14377
Kif1a
Name: kinesin family member 1A
Synonyms: C630002N23Rik, ATSV, Kns1, LOC381283, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22635
Homologene: 124417
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 75196
Homologene: 35506
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: myosin heavy chain 2X, IId, IId/x, Myhsf2, Myhs-f, Myhs-f2, MyHC-IId/x, A530084A17Rik, MYHC-IIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242838
Homologene: 18247
Cdh17
Name: cadherin 17
Synonyms: LI-cadherin, HPT-1, BILL-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Unc5d
Name: unc-5 netrin receptor D
Synonyms: D930029E11Rik, Unc5h4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 210801
Homologene: 15450
P2ry14
Name: purinergic receptor P2Y, G-protein coupled, 14
Synonyms: P2Y14, Gpr105, A330108O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 140795
Homologene: 15769
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide, Itih-1, Intin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18080
Homologene: 40632
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: 1700030F18Rik, LOC380973
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 72277
Homologene: null
Tmc4
Name: transmembrane channel-like gene family 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 353499
Homologene: 16971
Otulin
Name: OTU deubiquitinase with linear linkage specificity
Synonyms: Fam105b, m7-1Sapc, gumby, m3Sapc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 432940
VEGA: 15
Homologene: 106591
Lgals3bp
Name: lectin, galactoside-binding, soluble, 3 binding protein
Synonyms: 90K, Tango10b, CyCAP, MAC-2BP, Ppicap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19039
HGNC: HGNC:6564
Homologene: 4067
Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
Synonyms: PC4, SPC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18551
HGNC: HGNC:8746
Homologene: 22495
Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
Synonyms: 2700007F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72535
HGNC: HGNC:407
Homologene: 115470
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 64435
Homologene: 12929
Trdv1
Name: T cell receptor delta variable 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 627813
HGNC: null
Homologene: null
Carns1
Name: carnosine synthase 1
Synonyms: Atpgd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107239
VEGA: 19
Homologene: 26439
Kcnk18
Name: potassium channel, subfamily K, member 18
Synonyms: Tresk, Tresk-2, LOC332396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 332396
VEGA: 19
Homologene: 133808
Nova2
Name: neuro-oncological ventral antigen 2
Synonyms: LOC384569
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384569
HGNC: HGNC:7887
Homologene: 134398
Olfr263
Name: olfactory receptor 263
Synonyms: MOR256-61, MOR256-31, IA3, Olfr42, GA_x6K02T2N5E5-9379-8514, Olfr263-ps1, MOR256-37P, GA_x6K02T2QHY8-12114828-12113875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18341
HGNC: HGNC:8281
Homologene: 12791
C2cd4d
Name: C2 calcium-dependent domain containing 4D
Synonyms: LOC271944, Gm659
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 271944
Homologene: 86310
Raet1e
Name: retinoic acid early transcript 1E
Synonyms: Rae-1 epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 379043
HGNC: null
Homologene: 134115
Gyltl1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Fam63b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Mtl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 25,094,000 bp
  • T to C, chromosome 1 at 93,054,896 bp
  • T to C, chromosome 1 at 130,812,926 bp
  • A to T, chromosome 2 at 23,155,794 bp
  • T to A, chromosome 2 at 66,697,596 bp
  • C to T, chromosome 2 at 92,366,570 bp
  • G to A, chromosome 2 at 181,233,038 bp
  • C to T, chromosome 3 at 39,002,802 bp
  • T to A, chromosome 3 at 59,115,377 bp
  • A to T, chromosome 3 at 94,364,308 bp
  • A to G, chromosome 3 at 107,301,065 bp
  • T to A, chromosome 4 at 11,803,969 bp
  • A to G, chromosome 4 at 45,802,525 bp
  • A to G, chromosome 5 at 3,850,837 bp
  • T to A, chromosome 5 at 137,414,297 bp
  • C to G, chromosome 5 at 150,953,001 bp
  • T to A, chromosome 6 at 18,868,072 bp
  • T to C, chromosome 7 at 3,667,527 bp
  • G to A, chromosome 7 at 18,957,869 bp
  • G to A, chromosome 7 at 30,715,919 bp
  • GCGGCGGC to GCGGCGGCGTCGGCGGC, chromosome 7 at 97,579,928 bp
  • A to G, chromosome 7 at 126,109,952 bp
  • G to T, chromosome 8 at 28,675,307 bp
  • A to G, chromosome 8 at 83,727,966 bp
  • G to T, chromosome 8 at 116,589,390 bp
  • T to A, chromosome 9 at 19,646,888 bp
  • A to G, chromosome 9 at 70,631,081 bp
  • A to G, chromosome 9 at 103,332,990 bp
  • C to A, chromosome 10 at 22,181,988 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • G to T, chromosome 10 at 77,622,305 bp
  • T to C, chromosome 10 at 80,326,239 bp
  • G to A, chromosome 11 at 67,211,447 bp
  • T to A, chromosome 11 at 87,611,019 bp
  • T to A, chromosome 11 at 97,491,232 bp
  • C to T, chromosome 11 at 100,519,757 bp
  • T to C, chromosome 11 at 116,848,902 bp
  • A to G, chromosome 11 at 118,399,742 bp
  • C to T, chromosome 12 at 70,019,232 bp
  • A to T, chromosome 13 at 21,133,293 bp
  • A to T, chromosome 14 at 30,929,876 bp
  • A to G, chromosome 14 at 53,882,056 bp
  • T to C, chromosome 15 at 27,611,610 bp
  • T to C, chromosome 15 at 98,531,431 bp
  • C to A, chromosome 15 at 99,942,703 bp
  • A to G, chromosome 16 at 89,798,030 bp
  • T to A, chromosome 17 at 31,189,167 bp
  • G to A, chromosome 17 at 56,602,956 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • T to C, chromosome 19 at 3,389,260 bp
  • T to C, chromosome 19 at 4,170,876 bp
  • A to T, chromosome 19 at 55,917,436 bp
  • T to C, chromosome 19 at 59,235,314 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6077 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044238-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.