Strain Name:
C57BL/6J-MtgxR6080Btlr
Stock Number:
044239-MU
Citation ID:
RRID:MMRRC_044239-MU
Other Names:
R6080 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Abcc4
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Synonyms: D630049P08Rik, MOAT-B, MRP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: 1110020K19Rik, F830021D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224648
Homologene: 9816
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Vipas39
Name: VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Synonyms: SPE-39, Vipar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104799
VEGA: 12
Homologene: 41464
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: NMHC II-C, 2400004E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71960
Homologene: 23480
Zc3h18
Name: zinc finger CCCH-type containing 18
Synonyms: 1190001B23Rik, 5830416A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76014
Homologene: 44894
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: D18Ertd723e, D18Ertd139e, C85354, lcsd, A430089E03Rik, nmf164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
Smg5
Name: SMG5 nonsense mediated mRNA decay factor
Synonyms: Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229512
Homologene: 9095
Rnase9
Name: ribonuclease, RNase A family, 9 (non-active)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328401
VEGA: 14
Homologene: 18830
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GlcT-1, Epcs21, Ugcgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22234
Homologene: 37763
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Gm4922
Name: predicted gene 4922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237300
VEGA: 10
Homologene: 50497
Plag1
Name: pleiomorphic adenoma gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56711
HGNC: HGNC:9045
Homologene: 1993
Or4f15
Name: olfactory receptor family 4 subfamily F member 15
Synonyms: GA_x6K02T2Q125-73031456-73030518, MOR245-5, Olfr1309
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258439
Homologene: 74054
Or9i2
Name: olfactory receptor family 9 subfamily I member 2
Synonyms: GA_x6K02T2RE5P-4171358-4170411, MOR212-3, Olfr1501
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258626
Homologene: 64899
Or52n4
Name: olfactory receptor family 52 subfamily N member 4
Synonyms: GA_x6K02T2PBJ9-7273558-7272587, MOR34-5, Olfr658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259051
Homologene: 105161
Zfp819
Name: zinc finger protein 819
Synonyms: 4930427I11Rik, 4933405K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74400
Homologene: 128446
Zfp946
Name: zinc finger protein 946
Synonyms: 1300003B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74149
Cep44
Name: centrosomal protein 44
Synonyms: 4933440G23Rik, BC088983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382010
Homologene: 12738
Naga
Name: N-acetyl galactosaminidase, alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17939
VEGA: 15
HGNC: HGNC:7631
Homologene: 221
Or56a3b
Name: olfactory receptor family 56 subfamily A member 3B
Synonyms: GA_x6K02T2PBJ9-7750163-7751110, MOR40-14, Olfr681
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404318
Homologene: 81538
Rps6kb2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: S6K2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58988
Homologene: 68374
Vgll4
Name: vestigial like family member 4
Synonyms: VGL-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232334
Homologene: 18603
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: LOC380650, C030032C09Rik, E530015N03Rik, AIDA-1b, Gm10937
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77531
Homologene: 51570
Vmn1r224
Name: vomeronasal 1 receptor 224
Synonyms: Gm7673
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665525
Homologene: 85978
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67370
Homologene: 23514
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380654
Homologene: 133438
Gm14326
Name: predicted gene 14326
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665211
Homologene: 134324
Vwa9
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 91,502,000 bp
  • T to G, chromosome 2 at 111,983,705 bp
  • T to A, chromosome 2 at 177,936,546 bp
  • A to G, chromosome 3 at 88,351,509 bp
  • T to C, chromosome 4 at 3,903,815 bp
  • T to C, chromosome 4 at 59,218,524 bp
  • A to T, chromosome 5 at 124,805,897 bp
  • T to C, chromosome 6 at 114,921,338 bp
  • T to A, chromosome 7 at 12,494,116 bp
  • A to G, chromosome 7 at 43,616,696 bp
  • T to A, chromosome 7 at 44,655,611 bp
  • T to C, chromosome 7 at 104,645,310 bp
  • T to C, chromosome 7 at 105,121,909 bp
  • T to C, chromosome 8 at 56,539,841 bp
  • A to G, chromosome 8 at 122,416,544 bp
  • G to A, chromosome 9 at 64,966,762 bp
  • A to C, chromosome 10 at 18,784,752 bp
  • C to A, chromosome 10 at 90,966,349 bp
  • A to T, chromosome 10 at 93,045,335 bp
  • A to T, chromosome 11 at 21,999,406 bp
  • T to A, chromosome 12 at 87,241,953 bp
  • T to C, chromosome 14 at 51,039,270 bp
  • C to T, chromosome 14 at 118,669,050 bp
  • A to G, chromosome 15 at 82,334,847 bp
  • A to G, chromosome 17 at 20,419,556 bp
  • T to A, chromosome 17 at 22,455,109 bp
  • T to C, chromosome 17 at 27,880,297 bp
  • C to T, chromosome 18 at 12,219,351 bp
  • A to G, chromosome 18 at 80,738,808 bp
  • T to C, chromosome 19 at 3,628,316 bp
  • T to A, chromosome 19 at 4,158,672 bp
  • C to A, chromosome 19 at 13,839,100 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044239-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.