Strain Name:
C57BL/6J-MtgxR6117Btlr
Stock Number:
044266-MU
Citation ID:
RRID:MMRRC_044266-MU
Other Names:
R6117 (G1)
Major Collection:

Gene Information

Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74996
Homologene: 9929
Pde1b
Name: phosphodiesterase 1B, Ca2+-calmodulin dependent
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18574
VEGA: 15
HGNC: HGNC:8775
Homologene: 37370
Kcnj1
Name: potassium inwardly-rectifying channel, subfamily J, member 1
Synonyms: ROMK, Kir1.1, ROMK-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56379
VEGA: 9
HGNC: HGNC:6255
Homologene: 56764
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100683
Homologene: 39246
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66691
Homologene: 32637
Dmap1
Name: DNA methyltransferase 1-associated protein 1
Synonyms: 1500016M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66233
Homologene: 41311
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Eya3
Name: EYA transcriptional coactivator and phosphatase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14050
HGNC: HGNC:3521
Homologene: 1508
Crim1
Name: cysteine rich transmembrane BMP regulator 1 (chordin like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50766
VEGA: 17
HGNC: HGNC:2359
Homologene: 9510
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Stard3
Name: START domain containing 3
Synonyms: es64, Mln64
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 59045
Homologene: 38227
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225115
Homologene: 25090
Cmtr1
Name: cap methyltransferase 1
Synonyms: 1300018I05Rik, Ftsjd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74157
Homologene: 9003
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: smrl, nmf352, Ccha1a, alpha1A, SCA6, Cacnl1a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212728
Homologene: 38082
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1154Clo, b2b1537Clo, Dnahc5, b2b3491Clo, b2b1565Clo, Mdnah5, b2b1134Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E21Rik, 2310076E16Rik, Myospryn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Crsh, crash, Scy, Adgrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: Nna1-l1, Ccp4, EG244071
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244071
Homologene: 17552
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: 2810003K23Rik, LOC382552, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Cdsn
Name: corneodesmosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 386463
HGNC: HGNC:1802
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: OATP-D, Slc21a11, MJAM, Anr1, 5830414C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108116
Homologene: 40862
Frmd4a
Name: FERM domain containing 4A
Synonyms: 2700017I06Rik, Gm13190, C230040M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Olfr1331
Name: olfactory receptor 1331
Synonyms: GA_x6K02T2QD9B-18670866-18669913, MOR259-3P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258159
Homologene: 134082
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cchra1, Cav2.3, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Pcdhb12
Name: protocadherin beta 12
Synonyms: PcdhbL, Pcdh3, Pcdhb5F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93883
Homologene: 87126
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241158
Homologene: 9561
Prss54
Name: protease, serine 54
Synonyms: 4931432M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70993
Homologene: 19278
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192950
Homologene: 135717
Stk32c
Name: serine/threonine kinase 32C
Synonyms: Pkek, YANK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57740
Homologene: 75157
Fads3
Name: fatty acid desaturase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60527
VEGA: 19
HGNC: HGNC:3576
Homologene: 11025
Gm5592
Name: predicted gene 5592
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434172
Homologene: 45597
Olfr811
Name: olfactory receptor 811
Synonyms: MOR110-6, GA_x6K02T2PULF-11481207-11480248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258545
Homologene: 133725
Apmap
Name: adipocyte plasma membrane associated protein
Synonyms: 2310001A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71881
Homologene: 41380
Sox15
Name: SRY (sex determining region Y)-box 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20670
Homologene: 74586
Hoxa10
Name: homeobox A10
Synonyms: Hoxa-10, Hox-1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15395
HGNC: HGNC:5100
Homologene: 7365
Taar7e
Name: trace amine-associated receptor 7E
Synonyms: LOC276742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 276742
Homologene: 134040
Fam179b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Gm2178
Name: predicted gene 2178
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100039353
VEGA: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,675,067 bp
  • A to G, chromosome 1 at 92,861,274 bp
  • A to T, chromosome 1 at 154,561,791 bp
  • T to C, chromosome 2 at 4,602,249 bp
  • T to C, chromosome 2 at 34,690,459 bp
  • A to T, chromosome 2 at 112,635,396 bp
  • T to A, chromosome 2 at 140,660,445 bp
  • T to C, chromosome 2 at 150,600,332 bp
  • T to A, chromosome 4 at 117,675,535 bp
  • A to T, chromosome 4 at 118,869,144 bp
  • T to A, chromosome 4 at 132,711,862 bp
  • T to C, chromosome 5 at 144,802,961 bp
  • T to A, chromosome 6 at 52,234,820 bp
  • A to G, chromosome 7 at 41,288,464 bp
  • C to T, chromosome 7 at 74,318,506 bp
  • A to G, chromosome 7 at 76,698,786 bp
  • C to T, chromosome 7 at 112,087,932 bp
  • G to A, chromosome 7 at 139,122,923 bp
  • A to G, chromosome 8 at 84,614,721 bp
  • T to A, chromosome 8 at 95,565,458 bp
  • T to A, chromosome 8 at 126,427,541 bp
  • A to G, chromosome 9 at 32,397,182 bp
  • T to A, chromosome 10 at 24,038,529 bp
  • C to T, chromosome 10 at 24,787,852 bp
  • T to C, chromosome 10 at 78,788,988 bp
  • G to A, chromosome 10 at 129,801,820 bp
  • C to A, chromosome 10 at 129,801,821 bp
  • T to C, chromosome 11 at 6,599,810 bp
  • G to T, chromosome 11 at 69,655,890 bp
  • T to C, chromosome 11 at 98,372,262 bp
  • T to C, chromosome 11 at 118,119,571 bp
  • A to G, chromosome 12 at 64,967,487 bp
  • A to G, chromosome 13 at 93,095,166 bp
  • T to A, chromosome 13 at 100,444,737 bp
  • T to C, chromosome 14 at 26,514,840 bp
  • T to C, chromosome 15 at 25,805,659 bp
  • T to A, chromosome 15 at 28,270,420 bp
  • A to T, chromosome 15 at 85,932,411 bp
  • A to T, chromosome 15 at 89,158,000 bp
  • T to C, chromosome 15 at 103,521,482 bp
  • A to G, chromosome 17 at 29,682,165 bp
  • C to A, chromosome 17 at 35,555,034 bp
  • A to C, chromosome 17 at 78,303,088 bp
  • T to A, chromosome 18 at 5,116,016 bp
  • G to A, chromosome 18 at 37,435,642 bp
  • A to T, chromosome 19 at 10,054,267 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6117 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044266-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.