Strain Name:
C57BL/6J-MtgxR6122Btlr
Stock Number:
044269-MU
Citation ID:
RRID:MMRRC_044269-MU
Other Names:
R6122 (G1)
Major Collection:

Gene Information

Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 171286
Homologene: 11628
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 8030492O04Rik, 6720481N21Rik, C230047C07Rik, AIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16396
Homologene: 88442
Prune1
Name: prune exopolyphosphatase
Synonyms: Prune-M1, 9230112O05Rik, Prune
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229589
Homologene: 41429
Ppp1r9a
Name: protein phosphatase 1, regulatory subunit 9A
Synonyms: 4930518N04Rik, neurabin-I, A230094E16Rik, Neurabin I, NRB, 2810430P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243725
Homologene: 14247
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Cyt28, Gpr56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Rpsa
Name: ribosomal protein SA
Synonyms: Lamr1, P40-3, 67lr, P40-8, Lamr, Lamrl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 16785
VEGA: 9
HGNC: HGNC:6502
Homologene: 68249
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77987
VEGA: 10
Homologene: 4973
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 104831
Homologene: 135706
Trit1
Name: tRNA isopentenyltransferase 1
Synonyms: MOD5, 2310075G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66966
Homologene: 7010
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19386
VEGA: 10
Homologene: 87808
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 75956
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 21819
Homologene: 2430
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 1110031N14Rik, 2810429C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235559
Homologene: 38262
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: B130055D15Rik, 4632407J06Rik, 2810487N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78658
VEGA: 9
Homologene: 41021
Naf1
Name: nuclear assembly factor 1 ribonucleoprotein
Synonyms: LOC234344
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234344
Homologene: 128518
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Ahi1
Name: Abelson helper integration site 1
Synonyms: 1700015F03Rik, Ahi-1, Jouberin, D10Bwg0629e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 52906
VEGA: 10
Homologene: 9762
Neo1
Name: neogenin
Synonyms: Igdcc2, 2610028H22Rik, D930014N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11858
Homologene: 21123
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Sept2
Name: septin 2
Synonyms: Nedd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18000
HGNC: HGNC:7729
Homologene: 3243
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, A230048G03Rik, 2010013B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 320473
VEGA: 17
Homologene: 25536
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: 2210407G14Rik, Hapip, E530005C20Rik, LOC224126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Fzd5
Name: frizzled class receptor 5
Synonyms: 5330434N09Rik, Fz5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14367
HGNC: HGNC:4043
Homologene: 2590
Kcnj14
Name: potassium inwardly-rectifying channel, subfamily J, member 14
Synonyms: A930026G01Rik, Kir2.4, IRK4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 211480
HGNC: HGNC:6260
Homologene: 27086
Usf3
Name: upstream transcription factor family member 3
Synonyms: Gm608, LOC385650, 5530400K22Rik, LOC207806
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 207806
Homologene: 19504
Itgam
Name: integrin alpha M
Synonyms: CD11B (p170), Mac-1, Ly-40, complement component receptor 3 alpha, Mac-1 alpha, Mac-1a, Cd11b, CR3, CD11b/CD18, complement receptor type 3, F730045J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16409
HGNC: HGNC:6149
Homologene: 526
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: 7530426H14Rik, A930008G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Olfr575
Name: olfactory receptor 575
Synonyms: GA_x6K02T2PBJ9-5666843-5665908, MOR8-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259118
Homologene: 122786
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: PKHDL1, fibrocystin L, D86 mRNA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 192190
Homologene: 16332
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78309
Homologene: 56696
Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
Synonyms: bHLHe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11864
Homologene: 7230
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241589
Homologene: 115928
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030037J05Rik, 1110018I21Rik, Tns, E030018G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21961
Homologene: 11219
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Olfr114
Name: olfactory receptor 114
Synonyms: GA_x6K02T2PSCP-2049802-2048870, MOR218-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258284
Homologene: 133642
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 76645
Homologene: 124481
Gabrr1
Name: gamma-aminobutyric acid (GABA) C receptor, subunit rho 1
Synonyms: GABA-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14408
HGNC: HGNC:4090
Homologene: 20470
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244810
Krt2
Name: keratin 2
Synonyms: Krt2e, Krt2-17, Krt2-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16681
HGNC: HGNC:6439
Bpifa1
Name: BPI fold containing family A, member 1
Synonyms: Plunc, SPLUNC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18843
Homologene: 7895
1700034J05Rik
Name: RIKEN cDNA 1700034J05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73344
Homologene: 53485
Neu1
Name: neuraminidase 1
Synonyms: Bat-7, Bat7, Apl, G9, Neu-1, Aglp, lysosomal sialidase, sialidase 1, Map-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18010
HGNC: HGNC:7758
Homologene: 375
Pgghg
Name: protein glucosylgalactosylhydroxylysine glucosidase
Synonyms: 5730511L01Rik, Athl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 212974
Homologene: 16023
Tprg
Name: transformation related protein 63 regulated
Synonyms: 5430420C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 71338
Homologene: 18415
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Pira2
Name: paired-Ig-like receptor A2
Synonyms: 6M23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18725
HGNC: HGNC:6607
Homologene: 134028
Cyp2j8
Name: cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms: Cyp2j8-ps, OTTMUSG00000007938
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 665095
Homologene: 133819
Blvrb
Name: biliverdin reductase B (flavin reductase (NADPH))
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233016
HGNC: HGNC:1063
Homologene: 573
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66396
VEGA: 9
Homologene: 11678
Ace3
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
Synonyms: EG217246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217246
Homologene: 80337
Abat
Name: 4-aminobutyrate aminotransferase
Synonyms: 9630038C02Rik, GABA-T
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 268860
HGNC: HGNC:23
Homologene: 542
Gm7133
Name: predicted gene 7133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 634331
Homologene: 86643
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 64,735,656 bp
  • A to G, chromosome 1 at 73,952,419 bp
  • A to G, chromosome 1 at 93,497,376 bp
  • A to G, chromosome 1 at 97,183,223 bp
  • A to T, chromosome 1 at 139,248,948 bp
  • A to T, chromosome 2 at 104,256,292 bp
  • T to A, chromosome 2 at 127,028,160 bp
  • C to T, chromosome 2 at 154,143,972 bp
  • T to A, chromosome 2 at 155,174,065 bp
  • G to T, chromosome 3 at 56,029,896 bp
  • T to C, chromosome 3 at 95,262,243 bp
  • T to A, chromosome 3 at 144,926,166 bp
  • T to C, chromosome 4 at 33,161,695 bp
  • C to T, chromosome 4 at 96,444,640 bp
  • T to C, chromosome 4 at 123,039,468 bp
  • T to A, chromosome 6 at 4,905,509 bp
  • T to C, chromosome 6 at 146,952,252 bp
  • A to T, chromosome 7 at 3,842,446 bp
  • G to A, chromosome 7 at 27,459,348 bp
  • C to A, chromosome 7 at 45,819,451 bp
  • C to A, chromosome 7 at 84,361,565 bp
  • C to A, chromosome 7 at 102,954,804 bp
  • A to G, chromosome 7 at 102,955,530 bp
  • A to C, chromosome 7 at 128,085,652 bp
  • A to C, chromosome 7 at 140,943,395 bp
  • T to C, chromosome 8 at 57,526,166 bp
  • T to A, chromosome 8 at 66,883,444 bp
  • T to C, chromosome 8 at 95,002,501 bp
  • T to C, chromosome 8 at 117,082,368 bp
  • A to G, chromosome 9 at 13,266,412 bp
  • A to G, chromosome 9 at 27,063,982 bp
  • A to T, chromosome 9 at 39,593,755 bp
  • A to T, chromosome 9 at 58,917,008 bp
  • A to T, chromosome 9 at 103,346,961 bp
  • G to T, chromosome 9 at 110,387,825 bp
  • G to T, chromosome 9 at 120,131,036 bp
  • A to G, chromosome 10 at 21,058,165 bp
  • T to A, chromosome 10 at 50,617,925 bp
  • T to A, chromosome 10 at 58,465,529 bp
  • A to G, chromosome 10 at 76,506,607 bp
  • T to A, chromosome 11 at 94,430,171 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • A to C, chromosome 11 at 105,994,938 bp
  • T to C, chromosome 11 at 110,070,423 bp
  • T to C, chromosome 15 at 44,557,940 bp
  • T to C, chromosome 15 at 66,828,457 bp
  • T to C, chromosome 15 at 98,860,692 bp
  • G to C, chromosome 15 at 101,815,914 bp
  • A to G, chromosome 16 at 8,605,550 bp
  • A to G, chromosome 16 at 25,422,401 bp
  • A to T, chromosome 16 at 33,625,014 bp
  • G to T, chromosome 16 at 33,985,191 bp
  • A to T, chromosome 16 at 44,217,307 bp
  • G to T, chromosome 17 at 23,820,356 bp
  • G to A, chromosome 17 at 34,934,754 bp
  • C to A, chromosome 17 at 37,589,926 bp
  • T to C, chromosome 17 at 46,521,928 bp
  • A to G, chromosome 17 at 78,813,173 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6122 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044269-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.