Strain Name:
C57BL/6J-MtgxR6125Btlr/Mmmh
Stock Number:
044272-MU
Citation ID:
RRID:MMRRC_044272-MU
Other Names:
R6125 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Ins2
Name: insulin II
Synonyms: Ins-2, Mody4, Mody, InsII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16334
Homologene: 173
Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms: Atpa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11928
HGNC: HGNC:799
Homologene: 564
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20564
Homologene: 2303
Mdm4
Name: transformed mouse 3T3 cell double minute 4
Synonyms: Mdmx, 4933417N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17248
HGNC: HGNC:6974
Homologene: 1794
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226409
Homologene: 32770
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217342
Homologene: 11113
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66185
Homologene: 41043
Hsf2
Name: heat shock factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15500
VEGA: 10
HGNC: HGNC:5225
Homologene: 37931
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2, 4933406G05Rik, 4930551I19Rik, UFD2a, Ufd2p, D4Bwg0973e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 63958
Homologene: 107623
Stk39
Name: serine/threonine kinase 39
Synonyms: DCHT, SPAK, RF005, Rnl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53416
Homologene: 22739
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: 5830451P18Rik, Duplin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67772
Homologene: 72405
Rgs2
Name: regulator of G-protein signaling 2
Synonyms: GOS8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19735
HGNC: HGNC:9998
Homologene: 2192
Zfp980
Name: zinc finger protein 980
Synonyms: Gm13242
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041379
Homologene: 133076
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, 2610524E03Rik, YR-23, D1Bwg0491e, Neg, Rw1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56030
Homologene: 32428
Triml2
Name: tripartite motif family-like 2
Synonyms: EG622117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 622117
Homologene: 18316
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381280
Homologene: 10184
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Trmt44
Name: tRNA methyltransferase 44
Synonyms: 2310079F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78890
Homologene: 12708
Gar1
Name: GAR1 ribonucleoprotein
Synonyms: GAR1, C430047J18Rik, Nola1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68147
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: MD44, MTSG1, Atip1, B430305I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102103
Homologene: 100292
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Tbx1
Name: T-box 1
Synonyms: nmf219
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21380
VEGA: 16
Homologene: 7966
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408066
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237954
Homologene: 138824
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Pcdhb10
Name: protocadherin beta 10
Synonyms: Pcdhb5D, PcdhbJ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93881
HGNC: HGNC:8690
Homologene: 88834
Slc9b2
Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms: C80638, NHA2, nha-oc, NHE10, Nhedc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97086
Homologene: 45381
Galnt18
Name: polypeptide N-acetylgalactosaminyltransferase 18
Synonyms: 2900011G21Rik, Galntl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233733
Homologene: 18347
Scyl3
Name: SCY1-like 3 (S. cerevisiae)
Synonyms: Pace1, 1200016D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240880
Homologene: 10706
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Dlgap2
Name: DLG associated protein 2
Synonyms: SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2, 6430596N04Rik, DAP2, Sapap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244310
HGNC: HGNC:2906
Homologene: 3484
Fer1l4
Name: fer-1-like 4 (C. elegans)
Synonyms: 9130402C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74562
Homologene: 19075
Arhgef11
Name: Rho guanine nucleotide exchange factor (GEF) 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213498
Homologene: 11409
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74183
Homologene: 135954
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: MJAM, OATP-D, 5830414C08Rik, Anr1, Slc21a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108116
Homologene: 40862
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: 1200006O19Rik, iPLA2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67452
Homologene: 12136
Lratd2
Name: LRAT domain containing 1
Synonyms: D330050I23Rik, Fam84b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 399603
Homologene: 18379
Vmn2r9
Name: vomeronasal 2, receptor 9
Synonyms: EG435864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 435864
Homologene: 129606
Tcf21
Name: transcription factor 21
Synonyms: epc, epicardin, capsulin, Pod1, podocyte-expressed 1, Pod-1, bHLHa23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21412
VEGA: 10
Homologene: 2414
Or5b123
Name: olfactory receptor family 5 subfamily B member 123
Synonyms: GA_x6K02T2RE5P-3951719-3952666, MOR202-18, Olfr1487
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258629
Homologene: 110492
Bbs12
Name: Bardet-Biedl syndrome 12 (human)
Synonyms: LOC241950, LOC241950, LOC386537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241950
Homologene: 17634
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230612
Homologene: 17081
H2-DMb1
Name: histocompatibility 2, class II, locus Mb1
Synonyms: H2-Mb1, H-2Mb1, H2-M beta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14999
HGNC: HGNC:4935
Homologene: 68231
Mlip
Name: muscular LMNA-interacting protein
Synonyms: 2310046A06Rik, cardiac ISL1-interacting protein, CIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69642
Homologene: 90445
Or10ag59
Name: olfactory receptor family 10 subfamily AG member 59
Synonyms: GA_x6K02T2Q125-49078087-49079031, MOR264-9P, MOR264-23, Olfr1129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258111
Homologene: 133705
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74691
Homologene: 14311
Fstl4
Name: follistatin-like 4
Synonyms: B230374F23Rik, SPIG1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320027
Homologene: 18543
Slc30a8
Name: solute carrier family 30 (zinc transporter), member 8
Synonyms: ZnT-8, C820002P14Rik, ZnT8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239436
Homologene: 13795
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21892
Homologene: 49202
Ugp2
Name: UDP-glucose pyrophosphorylase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216558
Homologene: 121676
H1f0
Name: H1.0 linker histone
Synonyms: H1fv, D130017D06Rik, H1-0
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14958
VEGA: 15
HGNC: HGNC:4714
Homologene: 136788
Dusp29
Name: dual specificity phosphatase 29
Synonyms: EG435391, Dupd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 435391
VEGA: 14
Homologene: 51120
Gm826
Name: predicted gene 826
Synonyms: LOC329554
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329554
Calm5
Name: calmodulin 5
Synonyms: Scarf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 494124
Gm19402
Name: predicted gene, 19402
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100502831
VEGA: 10
Homologene: 115744
Trdv5
Name: T cell receptor delta variable 5
Synonyms: Gm6683
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 626545
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 36,808,306 bp
  • A to G, chromosome 1 at 40,003,965 bp
  • GT to GTT, chromosome 1 at 88,266,524 bp
  • T to A, chromosome 1 at 127,959,745 bp
  • G to A, chromosome 1 at 132,994,510 bp
  • T to C, chromosome 1 at 144,004,025 bp
  • A to T, chromosome 1 at 163,950,576 bp
  • C to A, chromosome 2 at 68,392,124 bp
  • T to C, chromosome 2 at 87,575,246 bp
  • A to G, chromosome 2 at 91,152,452 bp
  • A to C, chromosome 2 at 156,046,987 bp
  • A to G, chromosome 2 at 160,327,114 bp
  • A to G, chromosome 3 at 5,398,811 bp
  • A to G, chromosome 3 at 37,320,551 bp
  • T to C, chromosome 3 at 87,729,602 bp
  • G to A, chromosome 3 at 101,590,707 bp
  • C to A, chromosome 3 at 129,830,750 bp
  • G to A, chromosome 3 at 135,330,696 bp
  • T to C, chromosome 4 at 11,521,172 bp
  • A to T, chromosome 4 at 81,297,527 bp
  • G to T, chromosome 4 at 111,883,805 bp
  • T to A, chromosome 4 at 145,702,638 bp
  • T to C, chromosome 4 at 149,398,746 bp
  • A to G, chromosome 4 at 156,217,719 bp
  • A to G, chromosome 5 at 16,598,161 bp
  • C to A, chromosome 5 at 35,565,498 bp
  • A to G, chromosome 5 at 108,842,970 bp
  • A to T, chromosome 6 at 41,690,786 bp
  • C to A, chromosome 7 at 27,327,755 bp
  • C to T, chromosome 7 at 74,318,506 bp
  • A to G, chromosome 7 at 111,485,193 bp
  • C to A, chromosome 7 at 142,679,693 bp
  • A to T, chromosome 8 at 14,727,193 bp
  • A to G, chromosome 8 at 41,084,539 bp
  • G to A, chromosome 8 at 43,187,622 bp
  • T to C, chromosome 8 at 61,028,701 bp
  • A to G, chromosome 8 at 64,051,487 bp
  • T to C, chromosome 9 at 7,168,706 bp
  • G to A, chromosome 9 at 77,230,482 bp
  • G to A, chromosome 9 at 86,521,133 bp
  • G to T, chromosome 10 at 22,819,766 bp
  • T to C, chromosome 10 at 57,512,005 bp
  • T to C, chromosome 10 at 77,690,673 bp
  • A to T, chromosome 11 at 21,329,815 bp
  • T to C, chromosome 11 at 35,570,733 bp
  • T to C, chromosome 11 at 53,186,303 bp
  • T to C, chromosome 11 at 103,501,560 bp
  • C to T, chromosome 11 at 116,541,378 bp
  • T to C, chromosome 11 at 116,544,750 bp
  • C to T, chromosome 12 at 44,307,989 bp
  • T to A, chromosome 12 at 112,068,198 bp
  • A to T, chromosome 13 at 3,854,491 bp
  • A to G, chromosome 13 at 113,317,683 bp
  • C to A, chromosome 14 at 21,686,690 bp
  • T to A, chromosome 14 at 52,207,034 bp
  • T to C, chromosome 14 at 54,148,841 bp
  • A to G, chromosome 15 at 52,335,134 bp
  • T to C, chromosome 15 at 60,823,297 bp
  • T to A, chromosome 15 at 79,028,870 bp
  • T to C, chromosome 15 at 85,816,384 bp
  • A to G, chromosome 16 at 18,583,466 bp
  • G to A, chromosome 17 at 25,385,694 bp
  • A to G, chromosome 17 at 34,157,465 bp
  • T to C, chromosome 18 at 37,413,626 bp
  • C to T, chromosome 19 at 13,619,885 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6125 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044272-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.