Strain Name:
C57BL/6J-MtgxR5710Btlr
Stock Number:
044396-MU
Citation ID:
RRID:MMRRC_044396-MU
Other Names:
R5710 (G1)
Major Collection:

Gene Information

Ccnd1
Name: cyclin D1
Synonyms: cD1, CycD1, PRAD1, bcl-1, Cyl-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12443
HGNC: HGNC:1582
Homologene: 1334
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268980
Homologene: 2380
Prtg
Name: protogenin
Synonyms: Igdcc5, A230098A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: 2700059D02Rik, nucling
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Btbd9
Name: BTB (POZ) domain containing 9
Synonyms: 1700023F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224671
VEGA: 17
Homologene: 14995
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: Cdc46, Mcmd5, mCD46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Tbl1xr1
Name: transducin (beta)-like 1X-linked receptor 1
Synonyms: C230089I12Rik, Ira1, A630076E03Rik, TBLR1, DC42, 8030499H02Rik, C21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 81004
Homologene: 69382
Znhit1
Name: zinc finger, HIT domain containing 1
Synonyms: 2700001K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70103
Homologene: 4630
Lipc
Name: lipase, hepatic
Synonyms: HL, Hpl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Havcr1
Name: hepatitis A virus cellular receptor 1
Synonyms: Tim1, KIM-1, TIM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171283
Homologene: 136301
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Peg10
Name: paternally expressed 10
Synonyms: Rtl2, Mart2, Edr, MyEF-3 like, MyEF-3, HB-1, MEF3L, Mar2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170676
Homologene: 116067
Fgd3
Name: FYVE, RhoGEF and PH domain containing 3
Synonyms: 5830461L01Rik, ZFYVE5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 30938
Homologene: 22925
Ttn
Name: titin
Synonyms: D830007G01Rik, L56, 1100001C23Rik, mdm, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, shru, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zhx2
Name: zinc fingers and homeoboxes 2
Synonyms: Raf, Afr1, Afr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 387609
Homologene: 8968
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218865
Homologene: 41261
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: Tg(CAG-sb10)1Dla, CAGGS-SB10, Tg(ACTB-sb10)1Dla, 2610207F23Rik, 4931421F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67161
Homologene: 27031
4932411E22Rik
Name: RIKEN cDNA 4932411E22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Micall1
Name: microtubule associated monooxygenase, calponin and LIM domain containing -like 1
Synonyms: D15N2e, D15Mit260, Mus EST 820961
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27008
VEGA: 15
Homologene: 24911
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
T
Name: brachyury, T-box transcription factor T
Synonyms: Bra, Tbxt, T1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20997
Homologene: 2393
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mamdc1, 9330209L04Rik, 6720489L24Rik, Tg(Prnp-PFN1*G118V)838Kiaei, Adp, Mdga2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: fsn, 1110035E02Rik, hea, 1700007L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225049
Homologene: 12515
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: C130072N01Rik, Dtgn1, MDC-L, D430033C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: HER-2, ErbB-2, l11Jus8, HER2, c-erbB2, Neu oncogene, c-neu, Neu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPT I, M-CPTI, Cpt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Bcl2a1b
Name: B cell leukemia/lymphoma 2 related protein A1b
Synonyms: A1-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12045
HGNC: HGNC:991
Homologene: 2988
Vdr
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
Synonyms: Nr1i1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22337
Homologene: 37297
Saxo1
Name: stabilizer of axonemal microtubules 1
Synonyms: 4930500O09Rik, Fam154a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75811
Homologene: 27548
Shfl
Name: shiftless antiviral inhibitor of ribosomal frameshifting
Synonyms: A230050P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319278
Homologene: 10165
Arhgap18
Name: Rho GTPase activating protein 18
Synonyms: 4833419J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73910
Homologene: 14135
Aqp7
Name: aquaporin 7
Synonyms: AQP7L, AQPap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11832
HGNC: HGNC:640
Homologene: 48000
Cldn9
Name: claudin 9
Synonyms: nmf329
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56863
HGNC: HGNC:2051
Homologene: 10656
Fkbp14
Name: FK506 binding protein 14
Synonyms: FKBP22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 231997
Homologene: 23059
Mxd4
Name: Max dimerization protein 4
Synonyms: Mad4, bHLHc12, 2810410A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17122
Homologene: 4712
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 2 at 76,917,442 bp
  • T to C, chromosome 2 at 91,154,476 bp
  • A to G, chromosome 3 at 22,210,414 bp
  • C to A, chromosome 3 at 41,663,963 bp
  • G to A, chromosome 4 at 41,035,510 bp
  • C to T, chromosome 4 at 86,445,035 bp
  • A to G, chromosome 5 at 34,187,327 bp
  • C to T, chromosome 5 at 136,982,602 bp
  • CC to CCCCATCAGGC, chromosome 6 at 4,756,350 bp
  • C to CCCATCAGGA, chromosome 6 at 4,756,351 bp
  • T to A, chromosome 6 at 54,589,270 bp
  • T to A, chromosome 6 at 70,883,733 bp
  • T to C, chromosome 7 at 144,938,044 bp
  • A to T, chromosome 8 at 40,824,647 bp
  • A to C, chromosome 8 at 75,120,910 bp
  • G to T, chromosome 9 at 20,872,896 bp
  • T to A, chromosome 9 at 60,871,811 bp
  • T to A, chromosome 9 at 70,812,697 bp
  • T to A, chromosome 9 at 72,809,640 bp
  • A to C, chromosome 9 at 89,199,679 bp
  • G to A, chromosome 10 at 26,860,733 bp
  • A to G, chromosome 10 at 75,647,018 bp
  • T to C, chromosome 11 at 46,752,526 bp
  • T to C, chromosome 11 at 89,503,925 bp
  • T to A, chromosome 11 at 98,427,080 bp
  • C to A, chromosome 12 at 66,506,782 bp
  • T to A, chromosome 13 at 49,296,729 bp
  • C to A, chromosome 14 at 30,034,627 bp
  • G to A, chromosome 14 at 68,609,908 bp
  • T to A, chromosome 15 at 57,821,470 bp
  • C to A, chromosome 15 at 79,127,090 bp
  • T to A, chromosome 15 at 89,425,206 bp
  • T to C, chromosome 15 at 97,859,127 bp
  • A to T, chromosome 15 at 97,867,208 bp
  • T to C, chromosome 15 at 98,854,106 bp
  • T to C, chromosome 17 at 8,441,642 bp
  • T to C, chromosome 17 at 23,683,447 bp
  • A to G, chromosome 17 at 30,228,868 bp
  • G to A, chromosome 17 at 78,687,599 bp
  • A to C, chromosome 17 at 87,290,246 bp
  • T to C, chromosome 18 at 20,272,351 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5710 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044396-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.