Strain Name:
C57BL/6J-MtgxR5766Btlr
Stock Number:
044424-MU
Citation ID:
RRID:MMRRC_044424-MU
Other Names:
R5766 (G1)
Major Collection:

Gene Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Lamb1
Name: laminin B1
Synonyms: Lamb1-1, Lamb-1, C81607, D130003D08Rik, C80098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68510
Homologene: 53111
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: 5830462N02Rik, A130086L21Rik, E6-AP ubiquitin protein ligase, Hpve6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22215
Homologene: 7988
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: MCPH5, D330028K02Rik, Sha1, Aspm, Calmbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12316
Homologene: 7650
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77044
Homologene: 14601
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Bstk1, Mak-v
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Ppp2ca
Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Synonyms: PP2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19052
HGNC: HGNC:9299
Homologene: 37660
Kpna3
Name: karyopherin (importin) alpha 3
Synonyms: importin alpha 4, IPOA4, importin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16648
VEGA: 14
HGNC: HGNC:6396
Homologene: 20520
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Tulip1, 2310003F20Rik, Garnl1, 4930400K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20658
Homologene: 10551
Rfx2
Name: regulatory factor X, 2 (influences HLA class II expression)
Synonyms: 5430432H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19725
VEGA: 17
HGNC: HGNC:9983
Homologene: 30980
Pah
Name: phenylalanine hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18478
HGNC: HGNC:8582
Homologene: 234
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: P1-Loop, Dnahc8, Hst6.7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Mnt
Name: max binding protein
Synonyms: Rox, bHLHd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17428
HGNC: HGNC:7188
Homologene: 7842
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Fmnl2
Name: formin-like 2
Synonyms: 5430425K04Rik, man
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71409
Homologene: 70871
Sec63
Name: SEC63-like (S. cerevisiae)
Synonyms: 5730478J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 140740
Homologene: 5220
Scfd2
Name: Sec1 family domain containing 2
Synonyms: STXBP1L1, E430013M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212986
Homologene: 77411
Msh4
Name: mutS homolog 4
Synonyms: 4930485C04Rik, mMsh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Pdzd8
Name: PDZ domain containing 8
Synonyms: Pdzk8, A630041P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107368
VEGA: 19
Homologene: 14879
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: Spacrcan, PG10.2, IPM200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224224
Homologene: 9439
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: D930008O12Rik, Ncx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Zfp820
Name: zinc finger protein 820
Synonyms: 2610036F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75424
VEGA: 17
Cttnbp2
Name: cortactin binding protein 2
Synonyms: 3010022N24Rik, Cortbp2, ORF4, 4732477G22Rik, 9130022E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30785
Homologene: 14125
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381066
VEGA: 17
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: DC-LAMP, 1200002D17Rik, TSC403, Cd208
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Calhm1
Name: calcium homeostasis modulator 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 546729
VEGA: 19
Homologene: 55508
Hoxa6
Name: homeobox A6
Synonyms: Hox-1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15403
HGNC: HGNC:5107
Homologene: 7765
Pdc
Name: phosducin
Synonyms: Pdc, Rpr-1, Rpr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20028
HGNC: HGNC:8759
Homologene: 1950
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384221
Homologene: 104825
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: Flt-4, VEGFR3, VEGFR-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 433171
VEGA: 18
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217682
Homologene: 15090
Taar7a
Name: trace amine-associated receptor 7A
Synonyms: Taar7a, LOC215856
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215856
Homologene: 110833
Aadacl3
Name: arylacetamide deacetylase like 3
Synonyms: LOC230883
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230883
Homologene: 28426
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Or13a25
Name: olfactory receptor family 13 subfamily A member 25
Synonyms: Olfr539, GA_x6K02T2PBJ9-42813436-42814368, MOR253-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258963
Homologene: 79393
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74075
Homologene: 77044
AI429214
Name: expressed sequence AI429214
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 621080
Homologene: 82747
Arrdc1
Name: arrestin domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215705
Homologene: 34835
Efcab8
Name: EF-hand calcium binding domain 8
Synonyms: EG329541
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100504221
Vgll2
Name: vestigial like family member 2
Synonyms: Vgl-2, VITO-1, C130057C21Rik, Vito1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215031
Homologene: 35066
Scp2d1
Name: SCP2 sterol-binding domain containing 1
Synonyms: 1700010M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66328
Homologene: 11947
Caly
Name: calcyon neuron-specific vesicular protein
Synonyms: Calcyon, 0710001P07Rik, 1110004A22Rik, Drd1ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68566
Homologene: 9256
Lrrc48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Ighv1-18
Name: immunoglobulin heavy variable V1-18
Synonyms: Gm16856
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629871
Gm13872
Name: predicted gene 13872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 102637542
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 87,880,449 bp
  • T to C, chromosome 1 at 139,479,002 bp
  • T to A, chromosome 1 at 150,333,500 bp
  • G to A, chromosome 2 at 24,926,405 bp
  • T to C, chromosome 2 at 53,101,454 bp
  • T to A, chromosome 2 at 102,737,909 bp
  • T to A, chromosome 2 at 144,824,037 bp
  • A to G, chromosome 2 at 153,780,992 bp
  • G to A, chromosome 3 at 38,889,468 bp
  • A to T, chromosome 3 at 83,046,176 bp
  • T to C, chromosome 3 at 135,248,413 bp
  • A to G, chromosome 3 at 153,867,840 bp
  • A to G, chromosome 4 at 144,455,869 bp
  • A to T, chromosome 5 at 74,462,651 bp
  • A to T, chromosome 5 at 96,731,689 bp
  • A to T, chromosome 5 at 109,427,273 bp
  • A to G, chromosome 5 at 139,772,145 bp
  • A to G, chromosome 6 at 18,381,033 bp
  • A to G, chromosome 6 at 52,208,414 bp
  • G to A, chromosome 7 at 28,137,329 bp
  • A to T, chromosome 7 at 59,276,059 bp
  • A to T, chromosome 7 at 119,978,222 bp
  • T to C, chromosome 7 at 140,070,397 bp
  • T to A, chromosome 7 at 140,667,353 bp
  • T to C, chromosome 7 at 140,777,981 bp
  • TCCCTGATGAAC to TC, chromosome 8 at 36,994,229 bp
  • G to T, chromosome 10 at 23,993,362 bp
  • A to T, chromosome 10 at 42,801,681 bp
  • A to G, chromosome 10 at 52,027,563 bp
  • A to C, chromosome 10 at 87,567,347 bp
  • G to T, chromosome 10 at 127,742,688 bp
  • G to C, chromosome 11 at 49,626,686 bp
  • A to G, chromosome 11 at 52,113,187 bp
  • T to C, chromosome 11 at 60,393,821 bp
  • C to T, chromosome 11 at 74,843,078 bp
  • A to G, chromosome 12 at 31,299,931 bp
  • A to T, chromosome 12 at 55,820,766 bp
  • A to T, chromosome 12 at 80,722,366 bp
  • A to C, chromosome 12 at 114,682,907 bp
  • G to T, chromosome 14 at 61,403,014 bp
  • A to G, chromosome 15 at 96,372,205 bp
  • T to C, chromosome 16 at 19,701,317 bp
  • T to G, chromosome 16 at 56,259,820 bp
  • T to A, chromosome 16 at 90,453,739 bp
  • T to A, chromosome 16 at 91,664,987 bp
  • T to C, chromosome 17 at 21,584,816 bp
  • T to A, chromosome 17 at 21,820,002 bp
  • A to G, chromosome 17 at 30,690,261 bp
  • T to A, chromosome 17 at 56,803,587 bp
  • T to C, chromosome 17 at 81,648,961 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • C to T, chromosome 19 at 47,143,703 bp
  • A to T, chromosome 19 at 59,300,540 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5766 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044424-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.