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Strain Name:
C57BL/6J-MtgxR6242Btlr/Mmmh
Stock Number:
044434-MU
Citation ID:
RRID:MMRRC_044434-MU
Other Names:
R6242 (G1)
Major Collection:

Strain Information

Prph
Name: peripherin
Synonyms: Prph1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19132
VEGA: 15
HGNC: HGNC:9461
Homologene: 4559
Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: RPC5, Sin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26939
Homologene: 14052
Tagln3
Name: transgelin 3
Synonyms: 2900005O10Rik, 2700038H05Rik, Np25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56370
Homologene: 22337
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 1110013E22Rik, 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Lrrc59
Name: leucine rich repeat containing 59
Synonyms: C78668
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 98238
Homologene: 10229
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 96,839,283 bp
  • A to G, chromosome 1 at 151,407,614 bp
  • T to A, chromosome 1 at 170,793,976 bp
  • T to A, chromosome 2 at 52,176,812 bp
  • T to C, chromosome 2 at 66,700,766 bp
  • A to T, chromosome 2 at 69,197,211 bp
  • T to A, chromosome 2 at 80,128,792 bp
  • G to A, chromosome 2 at 165,898,947 bp
  • T to A, chromosome 2 at 180,280,974 bp
  • C to A, chromosome 3 at 87,728,078 bp
  • T to C, chromosome 3 at 129,915,795 bp
  • A to G, chromosome 3 at 132,694,428 bp
  • A to T, chromosome 4 at 43,165,800 bp
  • G to A, chromosome 4 at 43,533,145 bp
  • C to T, chromosome 4 at 46,629,912 bp
  • A to G, chromosome 4 at 88,414,287 bp
  • T to A, chromosome 4 at 115,454,390 bp
  • T to C, chromosome 4 at 129,139,895 bp
  • T to C, chromosome 4 at 129,616,846 bp
  • A to G, chromosome 5 at 34,846,012 bp
  • A to G, chromosome 5 at 65,031,352 bp
  • T to A, chromosome 6 at 31,526,245 bp
  • T to A, chromosome 6 at 67,766,078 bp
  • A to G, chromosome 6 at 123,704,400 bp
  • A to G, chromosome 6 at 128,323,087 bp
  • A to C, chromosome 7 at 86,165,384 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • T to G, chromosome 7 at 104,084,564 bp
  • A to T, chromosome 7 at 120,940,467 bp
  • T to G, chromosome 7 at 143,073,182 bp
  • A to T, chromosome 8 at 24,438,895 bp
  • A to T, chromosome 8 at 117,663,197 bp
  • G to T, chromosome 8 at 119,941,838 bp
  • T to A, chromosome 9 at 8,900,979 bp
  • A to T, chromosome 9 at 31,341,252 bp
  • C to T, chromosome 9 at 50,763,915 bp
  • G to A, chromosome 9 at 60,870,044 bp
  • A to G, chromosome 9 at 75,273,611 bp
  • G to A, chromosome 10 at 79,976,179 bp
  • T to A, chromosome 10 at 91,062,163 bp
  • A to G, chromosome 10 at 115,372,926 bp
  • T to C, chromosome 10 at 121,034,461 bp
  • A to G, chromosome 11 at 5,716,691 bp
  • T to C, chromosome 11 at 76,000,155 bp
  • A to T, chromosome 11 at 77,018,358 bp
  • G to T, chromosome 11 at 94,634,983 bp
  • A to T, chromosome 11 at 101,182,538 bp
  • G to A, chromosome 12 at 11,208,525 bp
  • A to T, chromosome 12 at 65,116,442 bp
  • C to A, chromosome 12 at 65,116,449 bp
  • T to C, chromosome 12 at 104,116,001 bp
  • A to G, chromosome 13 at 4,436,362 bp
  • A to T, chromosome 13 at 28,142,555 bp
  • C to T, chromosome 13 at 73,822,786 bp
  • T to A, chromosome 13 at 105,109,540 bp
  • T to A, chromosome 14 at 56,595,399 bp
  • T to C, chromosome 14 at 124,676,528 bp
  • A to T, chromosome 15 at 80,155,770 bp
  • C to A, chromosome 15 at 89,584,352 bp
  • G to T, chromosome 15 at 98,604,015 bp
  • A to G, chromosome 15 at 99,057,123 bp
  • A to G, chromosome 15 at 99,939,907 bp
  • T to A, chromosome 16 at 45,724,338 bp
  • T to C, chromosome 16 at 59,555,690 bp
  • A to T, chromosome 16 at 59,682,662 bp
  • C to T, chromosome 16 at 88,751,496 bp
  • T to G, chromosome 16 at 94,442,695 bp
  • A to G, chromosome 17 at 94,735,374 bp
  • C to G, chromosome 18 at 21,129,172 bp
  • A to T, chromosome 18 at 22,522,376 bp
  • G to A, chromosome 18 at 37,743,555 bp
  • A to C, chromosome 18 at 80,459,212 bp
  • T to A, chromosome 19 at 13,146,086 bp
  • A to T, chromosome 19 at 24,099,603 bp
  • G to T, chromosome 19 at 57,642,478 bp
  • G to T, chromosome X at 20,860,100 bp
  • C to T, chromosome X at 74,277,038 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6242 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044434-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.