Strain Name:
C57BL/6J-MtgxR6270Btlr/Mmmh
Stock Number:
044441-MU
Citation ID:
RRID:MMRRC_044441-MU
Other Names:
R6270 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: SCO1, Steel Factor Receptor, belly-spot, SCO5, Tr-kit, Dominant white spotting, Gsfsco1, SOW3, c-KIT, CD117, Gsfsco5, Gsfsow3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Ark2n
Name: arkadia (RNF111) N-terminal like PKA signaling regulator 2N
Synonyms: 8030462N17Rik, Ark2N
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 212163
VEGA: 18
Homologene: 17035
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 1810061H24Rik, SAP130, 5730409A01Rik, D8Ertd633e, RSE1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101943
Homologene: 6579
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382034
Homologene: 40964
Gphn
Name: gephyrin
Synonyms: geph, 5730552E08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268566
VEGA: 12
Homologene: 10820
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 55935
Homologene: 9087
Dhx40
Name: DEAH-box helicase 40
Synonyms: ARG147, 2410016C14Rik, DDX40
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67487
Homologene: 57000
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Tgif1
Name: TGFB-induced factor homeobox 1
Synonyms: Tgif
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21815
Homologene: 7574
Mcf2l
Name: mcf.2 transforming sequence-like
Synonyms: Dbs, C130040G20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17207
Homologene: 11804
Hyls1
Name: HYLS1, centriolar and ciliogenesis associated
Synonyms: 3010015K02Rik, hydrolethalus syndrome 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76832
Homologene: 82283
Serinc5
Name: serine incorporator 5
Synonyms: TPO1, AIGP3, A130038L21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218442
VEGA: 13
Homologene: 65246
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Magel2
Name: MAGE family member L2
Synonyms: Mage-l2, ns7, nM15, NDNL1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Lhfpl3
Name: lipoma HMGIC fusion partner-like 3
Synonyms: A930031L14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269629
HGNC: HGNC:6589
Homologene: 26732
Eng
Name: endoglin
Synonyms: Endo, CD105
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13805
HGNC: HGNC:3349
Homologene: 92
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Odz3, Ten-m3, 2610100B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Dolpp1
Name: dolichyl pyrophosphate phosphatase 1
Synonyms: LSFR2, 0610011H20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57170
Homologene: 10663
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212168
Homologene: 18183
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Foxn3
Name: forkhead box N3
Synonyms: 5430426H20Rik, Ches1, Ches1l, HTLFL1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71375
HGNC: HGNC:1928
Homologene: 135955
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: ECaC1, CaT2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: B430006D22Rik, D230004J03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108151
Homologene: 23664
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 403088
Homologene: 74374
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Ttc14
Name: tetratricopeptide repeat domain 14
Synonyms: 2700016E08Rik, cI-44, 4930434D01Rik, 4933402I15Rik, 4931403I22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67120
Homologene: 12085
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdh3, Pcdhb5F, PcdhbL
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93883
HGNC: HGNC:8690
Homologene: 87126
Pga5
Name: pepsinogen 5, group I
Synonyms: 1110035E17Rik, pepsinogen A5, Pepf
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58803
VEGA: 19
Homologene: 105932
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Krt7
Name: keratin 7
Synonyms: Krt2-7, K7, D15Wsu77e, Cytokeratin 7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110310
HGNC: HGNC:6445
Homologene: 4058
Krt16
Name: keratin 16
Synonyms: Krt1-16, K16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56233
Homologene: 9124
Pnpla1
Name: patatin-like phospholipase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433091
Homologene: 25324
Sult1b1
Name: sulfotransferase family 1B, member 1
Synonyms: Dopa/tyrosine sulfotransferase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56362
Homologene: 69169
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: EC1-VR2, V2rf2, pheromone recepter
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Or51b6b
Name: olfactory receptor family 51 subfamily B member 6B
Synonyms: GA_x6K02T2PBJ9-6384836-6383883, Olfr623, MOR1-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259126
Homologene: 133591
Habp2
Name: hyaluronic acid binding protein 2
Synonyms: FSAP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226243
HGNC: HGNC:4798
Homologene: 3050
Lrrc18
Name: leucine rich repeat containing 18
Synonyms: mtLR1, 4930442L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67580
Homologene: 81914
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, Facl6, A330035H04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Or5k8
Name: olfactory receptor family 5 subfamily K member 8
Synonyms: MOR184-1, Olfr175-ps1, Olfr174, GA_x54KRFPKG5P-54993816-54992890, GA_x54KRFPKG5P-55026345-55025418, Olfr175, MOR184-10P
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259004
Homologene: 17461
Zfp474
Name: zinc finger protein 474
Synonyms: 4933409D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66758
Homologene: 12027
Or51f1d
Name: olfactory receptor family 51 subfamily F member 1D
Synonyms: Olfr583, MOR14-6, GA_x6K02T2PBJ9-5762668-5763618
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258752
Homologene: 133721
Nudt18
Name: nudix hydrolase 18
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 18
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213484
VEGA: 14
Homologene: 32604
Esrra
Name: estrogen related receptor, alpha
Synonyms: Estrra, ERRalpha, Err1, Nr3b1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26379
HGNC: HGNC:3471
Homologene: 20941
Trav15-2-dv6-2
Name: T cell receptor alpha variable 15-2-DV6-2
Synonyms: Trav15-2/dv6-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 436545
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 71,637,275 bp
  • T to G, chromosome 1 at 169,988,540 bp
  • C to A, chromosome 2 at 30,392,269 bp
  • A to G, chromosome 2 at 32,673,643 bp
  • T to C, chromosome 2 at 62,547,788 bp
  • T to C, chromosome 2 at 90,757,463 bp
  • C to A, chromosome 3 at 33,800,388 bp
  • A to T, chromosome 5 at 12,448,107 bp
  • T to A, chromosome 5 at 23,273,351 bp
  • A to G, chromosome 5 at 75,609,509 bp
  • A to T, chromosome 5 at 87,517,554 bp
  • T to A, chromosome 6 at 41,674,359 bp
  • T to C, chromosome 6 at 42,593,791 bp
  • T to C, chromosome 6 at 83,375,791 bp
  • C to A, chromosome 7 at 62,380,658 bp
  • T to C, chromosome 7 at 103,051,331 bp
  • T to C, chromosome 7 at 103,660,413 bp
  • T to C, chromosome 8 at 13,018,701 bp
  • G to A, chromosome 8 at 48,367,394 bp
  • C to T, chromosome 8 at 84,230,951 bp
  • T to C, chromosome 8 at 110,841,820 bp
  • T to C, chromosome 8 at 120,569,163 bp
  • G to A, chromosome 9 at 35,561,184 bp
  • A to T, chromosome 10 at 79,194,325 bp
  • A to G, chromosome 10 at 79,293,815 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to G, chromosome 11 at 54,352,107 bp
  • A to G, chromosome 11 at 86,799,605 bp
  • C to A, chromosome 11 at 100,247,203 bp
  • G to A, chromosome 12 at 13,324,293 bp
  • T to G, chromosome 12 at 78,522,950 bp
  • T to C, chromosome 12 at 99,388,417 bp
  • A to G, chromosome 12 at 105,768,701 bp
  • C to T, chromosome 13 at 3,581,891 bp
  • T to C, chromosome 13 at 92,688,662 bp
  • A to T, chromosome 14 at 33,009,121 bp
  • A to G, chromosome 14 at 53,649,866 bp
  • T to C, chromosome 14 at 70,579,390 bp
  • T to C, chromosome 14 at 78,518,799 bp
  • G to T, chromosome 15 at 85,821,105 bp
  • AGGG to AGGGG, chromosome 15 at 97,808,495 bp
  • A to G, chromosome 15 at 101,419,558 bp
  • A to T, chromosome 16 at 58,824,419 bp
  • G to A, chromosome 17 at 28,881,368 bp
  • T to C, chromosome 17 at 70,844,866 bp
  • A to T, chromosome 18 at 37,436,785 bp
  • A to G, chromosome 18 at 52,638,364 bp
  • T to C, chromosome 18 at 77,674,421 bp
  • C to T, chromosome 19 at 6,914,120 bp
  • T to C, chromosome 19 at 10,674,861 bp
  • T to C, chromosome 19 at 38,158,436 bp
  • A to G, chromosome 19 at 56,306,863 bp
  • C to T, chromosome 19 at 56,320,198 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6270 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044441-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.