Strain Name:
C57BL/6J-MtgxR6301Btlr/Mmmh
Stock Number:
044466-MU
Citation ID:
RRID:MMRRC_044466-MU
Other Names:
R6301 (G1)
Major Collection:

Strain Information

Sgca
Name: sarcoglycan, alpha (dystrophin-associated glycoprotein)
Synonyms: adhalin, Asg, 50DAG
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20391
Homologene: 9
Npl
Name: N-acetylneuraminate pyruvate lyase
Synonyms: 0610033B02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74091
Homologene: 12533
Rilpl1
Name: Rab interacting lysosomal protein-like 1
Synonyms: 6330559I19Rik, 2900002H16Rik, GOSPEL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75695
Homologene: 15619
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, Phr1, C130061D10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: Listerin, Rnf160, Zfp294, 4930528H02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24128
Homologene: 6927
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: rim2, AP-3, Hps2, recombination induced mutation 2, beta3A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Clcc1
Name: chloride channel CLIC-like 1
Synonyms: Mclc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229725
Homologene: 9032
Ccdc167
Name: coiled-coil domain containing 167
Synonyms: 1110021J02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68597
Homologene: 79796
Npc1
Name: NPC intracellular cholesterol transporter 1
Synonyms: A430089E03Rik, nmf164, lcsd, D18Ertd723e, C85354, D18Ertd139e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18145
HGNC: HGNC:7897
Homologene: 228
St8sia5
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms: ST8SiaV, Siat8e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225742
Homologene: 8331
Lrrtm3
Name: leucine rich repeat transmembrane neuronal 3
Synonyms: 9630044H04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216028
Homologene: 37110
Tbl2
Name: transducin (beta)-like 2
Synonyms: C76179, WS-bTRP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27368
Homologene: 8260
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Fgf10
Name: fibroblast growth factor 10
Synonyms: Gsfaey17, AEY17, FGF-10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14165
HGNC: HGNC:3666
Homologene: 3284
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Large2
Name: LARGE xylosyl- and glucuronyltransferase 2
Synonyms: 5730485C17Rik, Gyltl1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228366
Homologene: 27362
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Mag
Name: myelin-associated glycoprotein
Synonyms: siglec-4a, Gma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17136
HGNC: HGNC:6783
Homologene: 1771
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Dusp8
Name: dual specificity phosphatase 8
Synonyms: 5530400B01Rik, Nttp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18218
HGNC: HGNC:3074
Homologene: 31239
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: AS250, RGC2, A230067G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27028
Homologene: 22782
Arhgef25
Name: Rho guanine nucleotide exchange factor 25
Synonyms: 2410008H17Rik, D10Ertd610e, GEFT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52666
VEGA: 10
Homologene: 32691
Bpifb5
Name: BPI fold containing family B, member 5
Synonyms: BC018465
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228802
Homologene: 64814
Kif1a
Name: kinesin family member 1A
Synonyms: LOC381283, N-3 kinesin, C630002N23Rik, ATSV, Kns1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: MINK, Map4k6, Misshapen/NIKs-related kinase, Ysk2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Acot10
Name: acyl-CoA thioesterase 10
Synonyms: p48, MT-ACT48, Acate3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64833
VEGA: 15
Homologene: 8206
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Dcdc3, mG145, oxygen-regulated protein 1, Orp1, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Elac1
Name: elaC ribonuclease Z 1
Synonyms: 8430417G19Rik, 2610018O07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 114615
Homologene: 10272
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: Olfr743-ps1, Olfr265, MOR106-8P, MOR106-14, GA_x6K02T2PMLR-6243196-6244132, GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, Olfr264, Olfr743
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219019
Homologene: 74163
Coq2
Name: coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
Synonyms: 2310002F18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71883
Homologene: 69192
Ssmem1
Name: serine-rich single-pass membrane protein 1
Synonyms: 1700025E21Rik, 1700016K02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75647
Homologene: 12615
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: Minimsc, Myhsf, Minmus, MyHC-IIb, MHC2B, MYH-2B, MM
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Aadacl4fm2
Name: AADACL4 family member 2
Synonyms: Gm13124
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627085
Homologene: 135767
Cmklr1
Name: chemerin chemokine-like receptor 1
Synonyms: ChemR23, Gpcr27
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14747
HGNC: HGNC:2121
Homologene: 129967
Chrna1
Name: cholinergic receptor nicotinic alpha 1 subunit
Synonyms: Achr-1, Acra
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11435
HGNC: HGNC:1955
Homologene: 59
Cd248
Name: CD248 antigen, endosialin
Synonyms: Tem1, 2610111G01Rik, Cd164l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70445
VEGA: 19
Homologene: 10699
Ankdd1a
Name: ankyrin repeat and death domain containing 1A
Synonyms: LOC384945, EG330963
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330963
VEGA: 9
Homologene: 65619
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Try10
Name: trypsin 10
Synonyms: trypsinogen 10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 436522
Homologene: 134623
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231093
Homologene: 11053
Pgghg
Name: protein glucosylgalactosylhydroxylysine glucosidase
Synonyms: 5730511L01Rik, Athl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212974
Homologene: 16023
Hook3
Name: hook microtubule tethering protein 3
Synonyms: 5830454D03Rik, E330005F07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320191
Homologene: 13022
Krt6b
Name: keratin 6B
Synonyms: mK6[b], Krt2-6b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16688
VEGA: 15
Homologene: 136794
Ltk
Name: leukocyte tyrosine kinase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17005
HGNC: HGNC:6721
Homologene: 130502
Gabrd
Name: gamma-aminobutyric acid (GABA) A receptor, subunit delta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14403
HGNC: HGNC:4084
Homologene: 55489
Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Synonyms: p65, p65 NF kappaB
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19697
HGNC: HGNC:9955
Homologene: 32064
Oxsm
Name: 3-oxoacyl-ACP synthase, mitochondrial
Synonyms: 4933425A18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71147
Homologene: 5820
Ccdc121rt2
Name: coiled-coil domain containing 121, retrogene 2
Synonyms: Gm6588
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 625464
Homologene: 116059
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: GA_x6K02T2PVTD-31705144-31706073, Olfr883, MOR162-6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258414
Homologene: 86689
Trim72
Name: tripartite motif-containing 72
Synonyms: mitsugumin 53, MG53
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434246
Homologene: 66924
Or2m13
Name: olfactory receptor family 2 subfamily M member 13
Synonyms: GA_x54KRFPKG5P-15855164-15854223, MOR279-1, Olfr165
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258458
Homologene: 128262
Defa24
Name: defensin, alpha, 24
Synonyms: Defcr24
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 503491
Homologene: 113382
Bcas2
Name: BCAS2 pre-mRNA processing factor
Synonyms: breast carcinoma amplified sequence 2, 6430539P16Rik, C76366
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68183
HGNC: HGNC:975
Homologene: 4291
Or10w3
Name: olfactory receptor family 10 subfamily W member 3
Synonyms: GA_x6K02T2RE5P-4059239-4060188, Olfr1493, MOR266-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258735
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,347,254 bp
  • C to A, chromosome 1 at 93,054,941 bp
  • A to G, chromosome 1 at 153,518,881 bp
  • A to G, chromosome 2 at 13,478,078 bp
  • A to G, chromosome 2 at 73,570,484 bp
  • A to G, chromosome 2 at 92,369,516 bp
  • A to G, chromosome 2 at 119,751,757 bp
  • A to T, chromosome 2 at 146,327,411 bp
  • A to G, chromosome 2 at 147,063,342 bp
  • A to C, chromosome 2 at 154,230,219 bp
  • T to C, chromosome 3 at 19,243,163 bp
  • T to A, chromosome 3 at 103,171,871 bp
  • T to G, chromosome 3 at 108,673,366 bp
  • A to T, chromosome 4 at 119,185,603 bp
  • C to T, chromosome 4 at 144,558,654 bp
  • A to G, chromosome 4 at 155,387,267 bp
  • A to G, chromosome 5 at 30,891,833 bp
  • A to G, chromosome 5 at 100,661,863 bp
  • A to T, chromosome 5 at 112,450,468 bp
  • T to A, chromosome 5 at 113,614,938 bp
  • T to G, chromosome 5 at 121,254,220 bp
  • C to A, chromosome 5 at 124,514,539 bp
  • A to T, chromosome 5 at 135,159,369 bp
  • A to G, chromosome 6 at 30,519,759 bp
  • T to A, chromosome 6 at 41,355,589 bp
  • C to T, chromosome 6 at 73,086,217 bp
  • T to A, chromosome 7 at 30,900,679 bp
  • A to T, chromosome 7 at 121,648,276 bp
  • A to T, chromosome 7 at 128,004,614 bp
  • A to T, chromosome 7 at 140,946,376 bp
  • T to A, chromosome 7 at 142,083,019 bp
  • T to C, chromosome 8 at 21,735,283 bp
  • C to T, chromosome 8 at 26,034,940 bp
  • ATTGCTGTTT to ATTGCTGTTTGCTGTTT, chromosome 9 at 38,026,540 bp
  • C to T, chromosome 9 at 65,508,061 bp
  • A to G, chromosome 10 at 7,703,107 bp
  • T to C, chromosome 10 at 64,089,222 bp
  • T to C, chromosome 10 at 127,185,882 bp
  • G to A, chromosome 11 at 67,255,333 bp
  • A to G, chromosome 11 at 70,612,294 bp
  • A to C, chromosome 11 at 94,972,567 bp
  • A to T, chromosome 11 at 103,618,930 bp
  • A to T, chromosome 13 at 94,528,295 bp
  • T to A, chromosome 13 at 118,715,511 bp
  • A to T, chromosome 14 at 16,242,220 bp
  • T to A, chromosome 14 at 50,534,254 bp
  • T to A, chromosome 14 at 103,155,426 bp
  • T to C, chromosome 15 at 20,666,262 bp
  • G to A, chromosome 15 at 44,589,525 bp
  • T to C, chromosome 15 at 101,678,951 bp
  • A to T, chromosome 16 at 19,407,417 bp
  • T to C, chromosome 16 at 59,530,338 bp
  • T to C, chromosome 16 at 87,420,306 bp
  • A to G, chromosome 17 at 29,705,582 bp
  • A to G, chromosome 17 at 57,892,037 bp
  • C to T, chromosome 18 at 12,197,245 bp
  • G to A, chromosome 18 at 60,828,825 bp
  • T to C, chromosome 18 at 73,738,868 bp
  • A to T, chromosome 18 at 77,246,140 bp
  • A to G, chromosome 19 at 5,069,981 bp
  • G to A, chromosome 19 at 5,645,410 bp
  • A to G, chromosome 19 at 13,726,389 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6301 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044466-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.