Strain Name:
C57BL/6J-MtgxR6314Btlr/Mmmh
Stock Number:
044471-MU
Citation ID:
RRID:MMRRC_044471-MU
Other Names:
R6314 (G1)
Major Collection:

Strain Information

Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Atn1
Name: atrophin 1
Synonyms: atrophin-1, Atr1, Drpla
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: Epb4.1l4a, NBL4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Npps2, Pdnp2, PD-Ialpha, Autotaxin, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Ddx5
Name: DEAD box helicase 5
Synonyms: Hlr1, p68, 2600009A06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13207
HGNC: HGNC:2746
Homologene: 6797
Armc8
Name: armadillo repeat containing 8
Synonyms: HSPC056, 1200015K23Rik, Gid5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74125
Homologene: 9121
Agfg1
Name: ArfGAP with FG repeats 1
Synonyms: D730048C23Rik, C130049H11Rik, Rip, Hrb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15463
HGNC: HGNC:5175
Homologene: 37929
Tmem245
Name: transmembrane protein 245
Synonyms: D730040F13Rik, A630051L19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Orc3
Name: origin recognition complex, subunit 3
Synonyms: Orc3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50793
HGNC: HGNC:8489
Homologene: 8225
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Zfp622
Name: zinc finger protein 622
Synonyms: ZPR9, 1110033B05Rik, D15Ertd806e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52521
VEGA: 15
Homologene: 74377
Lmnb2
Name: lamin B2
Synonyms: lamin B3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16907
HGNC: HGNC:6638
Homologene: 7818
Erap1
Name: endoplasmic reticulum aminopeptidase 1
Synonyms: Arts1, ERAAP, PILSAP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 80898
VEGA: 13
Homologene: 56754
Adss2
Name: adenylosuccinate synthase 2
Synonyms: Adss, AS
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11566
HGNC: HGNC:292
Homologene: 875
Dnmt3l
Name: DNA methyltransferase 3-like
Synonyms: ecat7, D6Ertd14e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54427
HGNC: HGNC:2980
Homologene: 8362
Hk1
Name: hexokinase 1
Synonyms: Hk-1, mHk1-s, Hk1-s
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Nte, Swiss-cheese, MSws
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Snap29
Name: synaptosomal-associated protein 29
Synonyms: 1300018G05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67474
Homologene: 3512
Mettl16
Name: methyltransferase 16, N6-methyladenosine
Synonyms: 2810013M15Rik, Mett10d, 2610100D03Rik, A830095F14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67493
Homologene: 34653
Lsr
Name: lipolysis stimulated lipoprotein receptor
Synonyms: ILDR3, Lisch7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54135
Homologene: 9306
Gorab
Name: golgin, RAB6-interacting
Synonyms: Scyl1bp1, NTKL-BP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98376
Homologene: 45113
Sec24b
Name: SEC24 homolog B, COPII coat complex component
Synonyms: SEC24
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99683
Homologene: 55968
Tubgcp3
Name: tubulin, gamma complex component 3
Synonyms: GCP3, Spc98p
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 259279
Homologene: 4609
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76131
Homologene: 9834
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: 68kDa, bIG-h3, Beta-ig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21810
VEGA: 13
Homologene: 37294
Gdpd4
Name: glycerophosphodiester phosphodiesterase domain containing 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233537
Homologene: 18606
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: LOC232313, Glt8d4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232313
Homologene: 16823
Or5h18
Name: olfactory receptor family 5 subfamily H member 18
Synonyms: Olfr186, GA_x54KRFPKG5P-55257214-55256285, MOR183-9
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258318
Homologene: 133671
Fcrl6
Name: Fc receptor-like 6
Synonyms: mIFGP6, moFcRH6, FcRH6, ENSMUSG00000070504
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 677296
Homologene: 88414
Vmn1r20
Name: vomeronasal 1 receptor 20
Synonyms: Gm5569
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434017
Homologene: 79462
Fads2b
Name: fatty acid desaturase 2B
Synonyms: 4833423E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228151
Homologene: 105643
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: mNaDC-1, sodium/dicarboxylate co-transporter, Nadc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20500
Homologene: 2965
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Serpina1d
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1D
Synonyms: Spi1-4, PI4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20703
HGNC: HGNC:8941
Homologene: 20103
Ankdd1a
Name: ankyrin repeat and death domain containing 1A
Synonyms: EG330963, LOC384945
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330963
VEGA: 9
Homologene: 65619
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: MDC2, 2900022I03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Or7a37
Name: olfactory receptor family 7 subfamily A member 37
Synonyms: GA_x6K02T2QGN0-2842591-2841662, MOR139-2, Olfr1353
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259044
Homologene: 131345
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Aadacl2
Name: arylacetamide deacetylase like 2
Synonyms: EG639634
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 639634
Homologene: 28634
Hook3
Name: hook microtubule tethering protein 3
Synonyms: 5830454D03Rik, E330005F07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320191
Homologene: 13022
Selenbp1
Name: selenium binding protein 1
Synonyms: Lp56, Lpsb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20341
Homologene: 2930
Hk3
Name: hexokinase 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212032
HGNC: HGNC:4925
Homologene: 55633
Spef1l
Name: sperm flagellar 1 like
Synonyms: 6430531B16Rik, LOC381933
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381933
Homologene: 134514
Tmem225
Name: transmembrane protein 225
Synonyms: 1700030E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75667
VEGA: 9
Homologene: 52854
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22770
Homologene: 5225
Or7e173
Name: olfactory receptor family 7 subfamily E member 173
Synonyms: MOR145-5, GA_x6K02T2PVTD-13768406-13767468, Olfr866
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258551
HGNC: HGNC:8396
Homologene: 133687
Tor4a
Name: torsin family 4, member A
Synonyms: A830007P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227612
Homologene: 17140
Pm20d1
Name: peptidase M20 domain containing 1
Synonyms: 4732466D17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212933
Homologene: 65049
Fv1
Name: Friend virus susceptibility 1
Synonyms: Rv-1, Fv-1, Rv1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14349
S100a7l2
Name: S100 calcium binding protein A7 like 2
Synonyms: LOC229550, 9130204L05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229550
Homologene: 135857
4930449I24Rik
Name: RIKEN cDNA 4930449I24 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67410
Homologene: 86127
Pitx1
Name: paired-like homeodomain transcription factor 1
Synonyms: P-OTX, Bft, Ptx1, Potx
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18740
HGNC: HGNC:9004
Homologene: 20584
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 82,858,434 bp
  • T to C, chromosome 1 at 131,816,016 bp
  • T to C, chromosome 1 at 163,397,089 bp
  • T to A, chromosome 1 at 172,598,619 bp
  • T to A, chromosome 1 at 177,767,768 bp
  • T to C, chromosome 2 at 25,194,782 bp
  • T to C, chromosome 2 at 85,502,176 bp
  • A to T, chromosome 3 at 60,017,403 bp
  • A to T, chromosome 3 at 91,088,376 bp
  • A to G, chromosome 3 at 94,937,265 bp
  • G to T, chromosome 3 at 95,068,121 bp
  • A to T, chromosome 3 at 130,007,245 bp
  • T to A, chromosome 3 at 159,498,414 bp
  • C to A, chromosome 4 at 34,579,797 bp
  • A to T, chromosome 4 at 56,888,592 bp
  • T to C, chromosome 4 at 144,394,587 bp
  • A to T, chromosome 4 at 147,869,699 bp
  • A to T, chromosome 5 at 8,127,365 bp
  • C to A, chromosome 5 at 22,152,484 bp
  • A to C, chromosome 5 at 146,504,892 bp
  • T to C, chromosome 6 at 12,554,997 bp
  • A to T, chromosome 6 at 57,432,057 bp
  • A to T, chromosome 6 at 100,798,203 bp
  • A to T, chromosome 6 at 124,747,050 bp
  • A to G, chromosome 7 at 30,958,599 bp
  • T to A, chromosome 7 at 97,973,953 bp
  • A to C, chromosome 7 at 139,976,489 bp
  • C to T, chromosome 8 at 3,521,572 bp
  • T to C, chromosome 8 at 12,648,625 bp
  • T to A, chromosome 8 at 26,088,108 bp
  • C to A, chromosome 9 at 20,027,662 bp
  • C to G, chromosome 9 at 40,150,720 bp
  • C to T, chromosome 9 at 65,508,061 bp
  • A to G, chromosome 9 at 99,535,884 bp
  • A to G, chromosome 10 at 62,292,444 bp
  • A to T, chromosome 10 at 78,059,687 bp
  • A to G, chromosome 10 at 78,970,345 bp
  • G to A, chromosome 10 at 80,909,970 bp
  • C to T, chromosome 11 at 28,914,603 bp
  • A to T, chromosome 11 at 74,796,006 bp
  • CGTTATCTGT to CGT, chromosome 11 at 78,403,480 bp
  • T to C, chromosome 11 at 106,788,521 bp
  • T to A, chromosome 12 at 103,764,700 bp
  • T to C, chromosome 13 at 55,013,580 bp
  • A to T, chromosome 13 at 55,826,353 bp
  • A to T, chromosome 13 at 56,626,163 bp
  • A to T, chromosome 13 at 74,674,775 bp
  • T to C, chromosome 15 at 25,986,981 bp
  • T to C, chromosome 15 at 54,865,970 bp
  • C to T, chromosome 15 at 58,054,002 bp
  • T to C, chromosome 16 at 17,419,319 bp
  • A to T, chromosome 16 at 59,027,457 bp
  • G to T, chromosome 16 at 91,660,410 bp
  • T to G, chromosome 17 at 71,752,457 bp
  • A to G, chromosome 18 at 33,874,155 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6314 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044471-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.