Strain Name:
C57BL/6J-MtgxR6368Btlr/Mmmh
Stock Number:
044518-MU
Citation ID:
RRID:MMRRC_044518-MU
Other Names:
R6368 (G1)
Major Collection:

Strain Information

Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: MRFX3, C230093O12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Kdm5b
Name: lysine demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Rb-Bp2, Plu1, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Rpl3
Name: ribosomal protein L3
Synonyms: J1, F2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27367
Homologene: 747
Slk
Name: STE20-like kinase
Synonyms: 9A2, mSLK, Etk4, SLK, Stk2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20874
Homologene: 22515
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Luzp1
Name: leucine zipper protein 1
Synonyms: Luzp, 2700072H04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269593
Homologene: 11545
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Mtf1
Name: metal response element binding transcription factor 1
Synonyms: MTF-1, metal response element-binding transcription factor 1, metalloregulatory transcription factor, Thyls
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17764
HGNC: HGNC:7428
Homologene: 4347
Abi2
Name: abl interactor 2
Synonyms: 8430425M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329165
Homologene: 4209
Ddx6
Name: DEAD-box helicase 6
Synonyms: mRCK/P54, HLR2, E230023J21Rik, p54, rck, 1110001P04Rik, C430015D01Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13209
VEGA: 9
HGNC: HGNC:2747
Homologene: 3238
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: B230217J03Rik, 9330189K18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Ralgps2
Name: Ral GEF with PH domain and SH3 binding motif 2
Synonyms: 1810020P17Rik, 9130014M22Rik, 4921528G01Rik, 2210408F11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78255
Homologene: 23421
Cyb5r3
Name: cytochrome b5 reductase 3
Synonyms: Dia-1, 2500002N19Rik, 0610016L08Rik, Dia1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109754
HGNC: HGNC:2873
Homologene: 47921
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: mTAFI68, 4930408G01Rik, A230108M10Rik, p63
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21340
VEGA: 12
Homologene: 31331
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Tph2
Name: tryptophan hydroxylase 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216343
Homologene: 27831
Zfp148
Name: zinc finger protein 148
Synonyms: beta enolase repressor factor 1, BERF-1, BFCOL1, 2210405J08Rik, ZBP-89
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: PheRS alpha, Frsb, Farsl, Farslb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23874
Homologene: 4160
Twf2
Name: twinfilin actin binding protein 2
Synonyms: A6-related, Twf2, Twinfilin-2, Ptk9l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23999
HGNC: HGNC:9621
Homologene: 5272
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 5730465C04Rik, 1700087N07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81910
Homologene: 68138
Slain1
Name: SLAIN motif family, member 1
Synonyms: 9630044O09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105439
Homologene: 16943
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Cxxc8, Fbl7, lalina, Jhdm1a, Fbxl11, Gm4560, 5530401A10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Apeh
Name: acylpeptide hydrolase
Synonyms: N-acylaminoacyl peptide hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235606
HGNC: HGNC:586
Homologene: 1240
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: Nna1-l1, EG244071, Ccp4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244071
Homologene: 17552
Pnldc1
Name: poly(A)-specific ribonuclease (PARN)-like domain containing 1
Synonyms: LOC240023
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240023
VEGA: 17
Homologene: 15054
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: ESTM15, 1810073P09Rik, X83337
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75607
Homologene: 19155
Ifit1bl2
Name: interferon induced protein with tetratricopeptide repeats 1B like 2
Synonyms: 2010002M12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 112419
Homologene: 78213
Or7e169
Name: olfactory receptor family 7 subfamily E member 169
Synonyms: GA_x6K02T2PVTD-13586614-13585661, MOR146-2, Olfr860
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258521
Homologene: 134093
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108151
Homologene: 23664
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: mSNM1, SNM1, 2810043H12Rik, SMN1a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 55947
Homologene: 8920
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, enterokinase, A130097D21Rik, Prss7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: 6720451F06Rik, 6230400G14Rik, mpk2, Pk2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243548
Homologene: 17889
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Krt16
Name: keratin 16
Synonyms: K16, Krt1-16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Spsb4
Name: splA/ryanodine receptor domain and SOCS box containing 4
Synonyms: D030068E18Rik, Ssb4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211949
Homologene: 25315
Or13a21
Name: olfactory receptor family 13 subfamily A member 21
Synonyms: GA_x6K02T2PBJ9-42570051-42569122, MOR251-1, Olfr532
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259028
Homologene: 133605
Cr2
Name: complement receptor 2
Synonyms: CD21, CD35, Cr-1, Cr-2, Cr1, C3DR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Zw10
Name: zw10 kinetochore protein
Synonyms: MmZw10, 6330566F14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26951
VEGA: 9
Homologene: 37959
Or4f58
Name: olfactory receptor family 4 subfamily F member 58
Synonyms: GA_x6K02T2Q125-73069292-73068354, MOR245-21, Olfr1311
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258271
Homologene: 133656
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Cnfn
Name: cornifelin
Synonyms: 2210418J09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72383
Homologene: 13039
Caps2
Name: calcyphosphine 2
Synonyms: D630005B03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353025
Homologene: 72278
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22341
Homologene: 3962
Ttll1
Name: tubulin tyrosine ligase-like 1
Synonyms: 6330444E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319953
HGNC: HGNC:1312
Homologene: 8174
Galntl6
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
Synonyms: 1700021K10Rik, 4930431L04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270049
Homologene: 65137
Ltb4r1
Name: leukotriene B4 receptor 1
Synonyms: mBLTR, BLTR, BLT1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16995
HGNC: HGNC:6713
Homologene: 22477
Or1ad1
Name: olfactory receptor family 1 subfamily AD member 1
Synonyms: GA_x6K02T2QP88-4453480-4452557, MOR129-1, Olfr1377
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258913
Homologene: 64929
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Slc2a6
Name: solute carrier family 2 (facilitated glucose transporter), member 6
Synonyms: Glut6, F630103L12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227659
Homologene: 69236
Gm21680
Name: predicted gene, 21680
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862368
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,453,651 bp
  • A to G, chromosome 1 at 78,466,965 bp
  • T to C, chromosome 1 at 134,599,207 bp
  • A to T, chromosome 1 at 156,884,574 bp
  • A to G, chromosome 1 at 195,168,472 bp
  • T to C, chromosome 2 at 13,430,995 bp
  • T to C, chromosome 2 at 13,476,123 bp
  • G to T, chromosome 2 at 27,024,587 bp
  • A to T, chromosome 2 at 112,021,551 bp
  • C to T, chromosome 2 at 143,989,555 bp
  • A to T, chromosome 2 at 154,564,476 bp
  • C to T, chromosome 4 at 124,824,352 bp
  • T to A, chromosome 4 at 136,541,780 bp
  • C to T, chromosome 5 at 12,571,013 bp
  • T to C, chromosome 5 at 25,969,036 bp
  • T to C, chromosome 5 at 114,216,823 bp
  • A to T, chromosome 6 at 41,688,851 bp
  • A to T, chromosome 6 at 92,420,237 bp
  • C to T, chromosome 7 at 25,367,961 bp
  • A to G, chromosome 7 at 76,419,830 bp
  • G to T, chromosome 7 at 140,419,667 bp
  • A to C, chromosome 8 at 22,020,755 bp
  • T to A, chromosome 8 at 41,293,544 bp
  • T to A, chromosome 8 at 54,181,230 bp
  • T to G, chromosome 8 at 58,911,441 bp
  • T to C, chromosome 9 at 19,846,409 bp
  • T to C, chromosome 9 at 44,635,776 bp
  • C to T, chromosome 9 at 49,073,235 bp
  • C to A, chromosome 9 at 55,990,132 bp
  • T to A, chromosome 9 at 59,924,948 bp
  • G to T, chromosome 9 at 96,944,645 bp
  • T to G, chromosome 9 at 106,212,833 bp
  • A to G, chromosome 9 at 108,087,243 bp
  • C to T, chromosome 9 at 108,111,314 bp
  • G to A, chromosome 10 at 50,699,985 bp
  • C to T, chromosome 10 at 112,194,968 bp
  • T to C, chromosome 10 at 115,179,326 bp
  • T to A, chromosome 11 at 50,984,786 bp
  • A to T, chromosome 11 at 60,721,136 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • T to A, chromosome 11 at 100,246,676 bp
  • A to G, chromosome 12 at 24,558,257 bp
  • T to C, chromosome 13 at 49,061,338 bp
  • A to C, chromosome 14 at 55,767,743 bp
  • A to T, chromosome 14 at 103,656,955 bp
  • C to A, chromosome 15 at 80,082,544 bp
  • A to C, chromosome 15 at 83,160,124 bp
  • A to G, chromosome 15 at 83,489,617 bp
  • T to C, chromosome 15 at 99,943,317 bp
  • C to A, chromosome 16 at 33,497,198 bp
  • T to C, chromosome 16 at 79,006,057 bp
  • C to A, chromosome 17 at 5,332,533 bp
  • A to T, chromosome 17 at 12,905,864 bp
  • T to A, chromosome 17 at 22,571,908 bp
  • A to G, chromosome 19 at 4,350,317 bp
  • A to T, chromosome 19 at 27,768,609 bp
  • T to C, chromosome 19 at 34,619,125 bp
  • A to G, chromosome 19 at 47,620,183 bp
  • A to T, chromosome 19 at 56,546,791 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6368 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044518-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.